{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:24:12Z","timestamp":1788168252899,"version":"build-2803163510"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T00:00:00Z","timestamp":1783468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008373","name":"Takeda Pharmaceutical Company Limited","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008373","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002241","name":"Japan Science and Technology Agency","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002241","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","thelancet.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["The Lancet Regional Health - Western Pacific"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.lanwpc.2026.101932","type":"journal-article","created":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T08:57:58Z","timestamp":1784883478000},"page":"101932","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Data-driven subphenotyping uncovers ulcerative colitis subtype with high risk for relapse in Japan: a prospective multicenter cohort study"],"prefix":"10.1016","volume":"73","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5104-4415","authenticated-orcid":false,"given":"Yohei","family":"Mikami","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajime","family":"Yamazaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadakazu","family":"Hisamatsu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakazu","family":"Nagahori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taku","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Yonezawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shinichiro","family":"Shinzaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshimitsu","family":"Fujii","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masayuki","family":"Saruta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4194-8493","authenticated-orcid":false,"given":"Satoshi","family":"Motoya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Yamamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minoru","family":"Matsuura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teppei","family":"Omori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shunichi","family":"Fukuhara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2950-7660","authenticated-orcid":false,"given":"Katsuyoshi","family":"Matsuoka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.lanwpc.2026.101932_bib1","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1007\/s00535-019-01580-y","article-title":"Management of elderly ulcerative colitis in Japan","volume":"54","author":"Higashiyama","year":"2019","journal-title":"J Gastroenterol"},{"issue":"9853","key":"10.1016\/j.lanwpc.2026.101932_bib2","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.1016\/S0140-6736(12)60150-0","article-title":"Ulcerative colitis","volume":"380","author":"Ordas","year":"2012","journal-title":"Lancet"},{"issue":"8067","key":"10.1016\/j.lanwpc.2026.101932_bib3","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/s41586-025-08940-0","article-title":"Global evolution of inflammatory bowel disease across epidemiologic stages","volume":"642","author":"Hracs","year":"2025","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.lanwpc.2026.101932_bib4","doi-asserted-by":"crossref","first-page":"1513","DOI":"10.1007\/s00535-025-02295-z","article-title":"Nationwide estimates of patient numbers and prevalence rates of ulcerative colitis and Crohn\u2019s disease in Japan in 2023","volume":"60","author":"Tsutsui","year":"2025","journal-title":"J Gastroenterol"},{"issue":"4\u20135","key":"10.1016\/j.lanwpc.2026.101932_bib5","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/j.autrev.2014.01.028","article-title":"Diagnosis and classification of ulcerative colitis","volume":"13","author":"Conrad","year":"2014","journal-title":"Autoimmun Rev"},{"issue":"1","key":"10.1016\/j.lanwpc.2026.101932_bib6","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2021.1987779","article-title":"Depression and anxiety in patients with active ulcerative colitis: crosstalk of gut microbiota, metabolomics and proteomics","volume":"13","author":"Yuan","year":"2021","journal-title":"Gut Microbes"},{"issue":"5","key":"10.1016\/j.lanwpc.2026.101932_bib7","doi-asserted-by":"crossref","first-page":"2229","DOI":"10.1007\/s12325-020-01615-4","article-title":"Real-world prescription pattern and healthcare cost among patients with ulcerative colitis in Japan: a retrospective claims data analysis","volume":"38","author":"Miyazaki","year":"2021","journal-title":"Adv Ther"},{"issue":"2","key":"10.1016\/j.lanwpc.2026.101932_bib8","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1053\/j.gastro.2016.10.005","article-title":"Advances in use of endoscopy, radiology, and biomarkers to monitor inflammatory bowel diseases","volume":"152","author":"Panes","year":"2017","journal-title":"Gastroenterology"},{"issue":"12","key":"10.1016\/j.lanwpc.2026.101932_bib9","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1016\/S2468-1253(20)30300-9","article-title":"Prevalence of irritable bowel syndrome-type symptoms in patients with inflammatory bowel disease in remission: a systematic review and meta-analysis","volume":"5","author":"Fairbrass","year":"2020","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"1","key":"10.1016\/j.lanwpc.2026.101932_bib10","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1093\/ibd\/izaa030","article-title":"Mental health costs of inflammatory bowel diseases","volume":"27","author":"Szigethy","year":"2021","journal-title":"Inflamm Bowel Dis"},{"issue":"5","key":"10.1016\/j.lanwpc.2026.101932_bib11","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00535-016-1241-x","article-title":"Impact of inflammatory bowel disease on Japanese patients' quality of life: results of a patient questionnaire survey","volume":"52","author":"Ueno","year":"2017","journal-title":"J Gastroenterol"},{"issue":"6","key":"10.1016\/j.lanwpc.2026.101932_bib12","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1016\/j.jaci.2018.04.013","article-title":"Biological exacerbation clusters demonstrate asthma and chronic obstructive pulmonary disease overlap with distinct mediator and microbiome profiles","volume":"141","author":"Ghebre","year":"2018","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"10.1016\/j.lanwpc.2026.101932_bib13","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1038\/s41591-020-1116-9","article-title":"Pathophysiology-based subphenotyping of individuals at elevated risk for type 2 diabetes","volume":"27","author":"Wagner","year":"2021","journal-title":"Nat Med"},{"issue":"11\u201312","key":"10.1016\/j.lanwpc.2026.101932_bib14","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/apt.17735","article-title":"Novel symptom clusters predict disease impact and healthcare utilisation in inflammatory bowel disease: prospective longitudinal follow-up study","volume":"58","author":"Riggott","year":"2023","journal-title":"Aliment Pharmacol Ther"},{"issue":"1","key":"10.1016\/j.lanwpc.2026.101932_bib15","doi-asserted-by":"crossref","first-page":"9510","DOI":"10.1038\/s41598-024-60137-z","article-title":"Biological characteristics of molecular subtypes of ulcerative colitis characterized by ferroptosis and neutrophil infiltration","volume":"14","author":"Sun","year":"2024","journal-title":"Sci Rep"},{"issue":"2","key":"10.1016\/j.lanwpc.2026.101932_bib16","doi-asserted-by":"crossref","first-page":"372","DOI":"10.14309\/ajg.0000000000000975","article-title":"A novel method to classify and subgroup patients with IBS based on gastrointestinal symptoms and psychological profiles","volume":"116","author":"Black","year":"2021","journal-title":"Am J Gastroenterol"},{"issue":"9","key":"10.1016\/j.lanwpc.2026.101932_bib17","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-030134","article-title":"Ulcerative colitis outcomes research in Japan: protocol for an observational prospective cohort study of YOURS (YOu and Ulcerative colitis: registry and Social network)","volume":"9","author":"Yamazaki","year":"2019","journal-title":"BMJ Open"},{"issue":"8","key":"10.1016\/j.lanwpc.2026.101932_bib18","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00535-023-02005-7","article-title":"Association of ulcerative colitis symptom severity and proctocolectomy with multidimensional patient-reported outcomes: a cross-sectional study","volume":"58","author":"Matsuoka","year":"2023","journal-title":"J Gastroenterol"},{"issue":"3","key":"10.1016\/j.lanwpc.2026.101932_bib19","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1053\/j.gastro.2022.12.007","article-title":"AGA clinical practice guideline on the role of biomarkers for the management of ulcerative colitis","volume":"164","author":"Singh","year":"2023","journal-title":"Gastroenterology"},{"issue":"2","key":"10.1016\/j.lanwpc.2026.101932_bib20","doi-asserted-by":"crossref","first-page":"225","DOI":"10.5217\/ir.2024.00199","article-title":"Lifestyle restrictions are associated with impaired quality of life but not reduction in relapse in ulcerative colitis","volume":"24","author":"Yamazaki","year":"2026","journal-title":"Intest Res"},{"issue":"6","key":"10.1016\/j.lanwpc.2026.101932_bib21","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"key":"10.1016\/j.lanwpc.2026.101932_bib22","article-title":"Large-scale clustering of longitudinal faecal calprotectin and C-reactive protein profiles in inflammatory bowel disease","volume":"2024","author":"Constantine-Cooke","year":"2025","journal-title":"medRxiv"},{"issue":"3","key":"10.1016\/j.lanwpc.2026.101932_bib23","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1002\/ueg2.12532","article-title":"Psychological symptoms and quality of life in patients with inflammatory bowel disease in China: a multicenter study","volume":"12","author":"Zhang","year":"2024","journal-title":"United Eur Gastroenterol J"},{"issue":"11","key":"10.1016\/j.lanwpc.2026.101932_bib24","doi-asserted-by":"crossref","first-page":"3184","DOI":"10.1038\/s41591-024-03211-3","article-title":"Data-driven risk stratification and precision management of pulmonary nodules detected on chest computed tomography","volume":"30","author":"Wang","year":"2024","journal-title":"Nat Med"},{"issue":"12","key":"10.1016\/j.lanwpc.2026.101932_bib25","doi-asserted-by":"crossref","first-page":"3555","DOI":"10.1038\/s41591-024-03280-4","article-title":"Noninvasive, microbiome-based diagnosis of inflammatory bowel disease","volume":"30","author":"Zheng","year":"2024","journal-title":"Nat Med"},{"issue":"2","key":"10.1016\/j.lanwpc.2026.101932_bib26","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/s41564-021-01050-3","article-title":"Multi-omics analyses of the ulcerative colitis gut microbiome link Bacteroides vulgatus proteases with disease severity","volume":"7","author":"Mills","year":"2022","journal-title":"Nat Microbiol"},{"issue":"5","key":"10.1016\/j.lanwpc.2026.101932_bib27","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/S2468-1253(24)00034-7","article-title":"A biomarker-stratified comparison of top-down versus accelerated step-up treatment strategies for patients with newly diagnosed Crohn's disease (PROFILE): a multicentre, open-label randomised controlled trial","volume":"9","author":"Noor","year":"2024","journal-title":"Lancet Gastroenterol Hepatol"},{"issue":"5","key":"10.1016\/j.lanwpc.2026.101932_bib28","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1053\/j.gastro.2020.12.031","article-title":"STRIDE-II: an update on the selecting therapeutic targets in inflammatory bowel disease (STRIDE) initiative of the international organization for the study of IBD (IOIBD): determining therapeutic goals for treat-to-target strategies in IBD","volume":"160","author":"Turner","year":"2021","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.lanwpc.2026.101932_bib29","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1097\/00054725-200407000-00010","article-title":"The role of quality of care in health-related quality of life in patients with IBD","volume":"10","author":"van der Eijk","year":"2004","journal-title":"Inflamm Bowel Dis"},{"issue":"13","key":"10.1016\/j.lanwpc.2026.101932_bib30","doi-asserted-by":"crossref","first-page":"3334","DOI":"10.1158\/1078-0432.CCR-16-2415","article-title":"Unsupervised clustering of quantitative image phenotypes reveals breast cancer subtypes with distinct prognoses and molecular pathways","volume":"23","author":"Wu","year":"2017","journal-title":"Clin Cancer Res"}],"container-title":["The Lancet Regional Health - Western Pacific"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666606526001367?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666606526001367?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T09:10:11Z","timestamp":1788167411000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666606526001367"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":30,"alternative-id":["S2666606526001367"],"URL":"https:\/\/doi.org\/10.1016\/j.lanwpc.2026.101932","relation":{},"ISSN":["2666-6065"],"issn-type":[{"value":"2666-6065","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Data-driven subphenotyping uncovers ulcerative colitis subtype with high risk for relapse in Japan: a prospective multicenter cohort study","name":"articletitle","label":"Article Title"},{"value":"The Lancet Regional Health - Western Pacific","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lanwpc.2026.101932","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"101932"}}