{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T06:11:10Z","timestamp":1791007870677,"version":"4.1.0"},"reference-count":43,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1016\/j.leukres.2003.10.021","type":"journal-article","created":{"date-parts":[[2003,12,22]],"date-time":"2003-12-22T17:58:37Z","timestamp":1072115917000},"page":"559-565","source":"Crossref","is-referenced-by-count":60,"title":["A phase III, randomized, double-blind, placebo-controlled, study of iseganan for the reduction of stomatitis in patients receiving stomatotoxic chemotherapy"],"prefix":"10.1016","volume":"28","author":[{"given":"Francis J","family":"Giles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberto","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Weisdorf","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John R","family":"Wingard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J","family":"Martin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas R","family":"Fleming","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stuart L","family":"Goldberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elias J","family":"Anaissie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brian J","family":"Bolwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelson J","family":"Chao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas C","family":"Shea","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark M","family":"Brunvand","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Vaughan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Finn","family":"Petersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Schubert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hillard M","family":"Lazarus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard T","family":"Maziarz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margarida","family":"Silverman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roy A","family":"Beveridge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rebecca","family":"Redman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janis G","family":"Pulliam","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Devitt-Risse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry J","family":"Fuchs","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David D","family":"Hurd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2003.10.021_BIB1","first-page":"11","article-title":"Prevention and management of oral mucositis induced by antineoplastic therapy","volume":"5","author":"Sonis","year":"1991","journal-title":"Oncology (Huntingt)"},{"key":"10.1016\/j.leukres.2003.10.021_BIB2","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/0022-3913(78)90064-1","article-title":"Stomatotoxic manifestations of cancer chemotherapy","volume":"40","author":"Dreizen","year":"1978","journal-title":"J. Prosthet. Dent."},{"key":"10.1016\/j.leukres.2003.10.021_BIB3","doi-asserted-by":"crossref","first-page":"650","DOI":"10.1016\/0030-4220(86)90258-6","article-title":"Quantitative analysis of the oral complications of antileukemia chemotherapy","volume":"62","author":"Dreizen","year":"1986","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB4","doi-asserted-by":"crossref","unstructured":"Development of a staging system for chemotherapy-induced stomatitis. Western Consortium for Cancer Nursing Research. Cancer Nurs 1991;14:6\u201312.","DOI":"10.1097\/00002820-199102000-00002"},{"key":"10.1016\/j.leukres.2003.10.021_BIB5","first-page":"538","article-title":"Prevention and treatment of oral mucositis following cancer chemotherapy","volume":"25","author":"Wilkes","year":"1998","journal-title":"Semin. Oncol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB6","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1016\/S1368-8375(99)00033-0","article-title":"Prevention and treatment of chemotherapy- and radiotherapy-induced oral mucositis: a review","volume":"35","author":"Plevova","year":"1999","journal-title":"Oral Oncol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB7","first-page":"225","article-title":"Re: mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity","volume":"35","author":"Plevova","year":"1999","journal-title":"Oral Oncol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB8","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1093\/clinids\/14.6.1201","article-title":"Septicemia and shock syndrome due to viridans streptococci: a case-control study of predisposing factors","volume":"14","author":"Elting","year":"1992","journal-title":"Clin. Infect. Dis."},{"key":"10.1016\/j.leukres.2003.10.021_BIB9","doi-asserted-by":"crossref","first-page":"2275","DOI":"10.1002\/(SICI)1097-0142(19980601)82:11<2275::AID-CNCR25>3.0.CO;2-Q","article-title":"The impact of mucositis on alpha-hemolytic streptococcal infection in patients undergoing autologous bone marrow transplantation for hematologic malignancies","volume":"82","author":"Ruescher","year":"1998","journal-title":"Cancer"},{"key":"10.1016\/j.leukres.2003.10.021_BIB10","doi-asserted-by":"crossref","first-page":"2446","DOI":"10.1200\/JCO.1999.17.8.2446","article-title":"Analysis of factors that correlate with mucositis in recipients of autologous and allogeneic stem-cell transplants","volume":"17","author":"Rapoport","year":"1999","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB11","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1002\/(SICI)1097-0142(19990515)85:10<2103::AID-CNCR2>3.0.CO;2-0","article-title":"Validation of a new scoring system for the assessment of clinical trial research of oral mucositis induced by radiation or chemotherapy. Mucositis Study Group","volume":"85","author":"Sonis","year":"1999","journal-title":"Cancer"},{"key":"10.1016\/j.leukres.2003.10.021_BIB12","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1200\/JCO.2001.19.8.2201","article-title":"Oral mucositis and the clinical and economic outcomes of hematopoietic stem-cell transplantation","volume":"19","author":"Sonis","year":"2001","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB13","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/S1368-8375(97)00053-5","article-title":"Mucositis as a biological process: a new hypothesis for the development of chemotherapy-induced stomatotoxicity","volume":"34","author":"Sonis","year":"1998","journal-title":"Oral Oncol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB14","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/S1368-8375(00)00012-9","article-title":"Defining mechanisms of action of interleukin-11 on the progression of radiation-induced oral mucositis in hamsters","volume":"36","author":"Sonis","year":"2000","journal-title":"Oral Oncol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB15","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1038\/bjc.1996.359","article-title":"The reduction of radiation mucositis by selective decontamination antibiotic pastilles: a placebo-controlled double-blind trial","volume":"74","author":"Symonds","year":"1996","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.leukres.2003.10.021_BIB16","doi-asserted-by":"crossref","first-page":"43","DOI":"10.3109\/00365549309169668","article-title":"Failure of clindamycin to influence the course of severe oromucositis associated with streptococcal bacteraemia in allogeneic bone marrow transplant recipients","volume":"25","author":"Donnelly","year":"1993","journal-title":"Scand. J. Infect. Dis."},{"key":"10.1016\/j.leukres.2003.10.021_BIB17","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1016\/0030-4220(92)90009-F","article-title":"Efficacy of chlorhexidine and nystatin rinses in prevention of oral complications in leukemia and bone marrow transplantation","volume":"73","author":"Epstein","year":"1992","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB18","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/0030-4220(93)90010-2","article-title":"Effects of chlorhexidine during immunosuppressive chemotherapy. A preliminary report","volume":"76","author":"Rutkauskas","year":"1993","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB19","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1432-1033.1996.0575p.x","article-title":"Synthesis and solution structure of the antimicrobial peptide protegrin-1","volume":"237","author":"Aumelas","year":"1996","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.leukres.2003.10.021_BIB20","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S1074-5521(96)90145-3","article-title":"Solution structure of protegrin-1, a broad-spectrum antimicrobial peptide from porcine leukocytes","volume":"3","author":"Fahrner","year":"1996","journal-title":"Chem. Biol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB21","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/1097-0282(2000)55:1<88::AID-BIP80>3.0.CO;2-K","article-title":"Development of protegrins for the treatment and prevention of oral mucositis: structure\u2013activity relationships of synthetic protegrin analogues","volume":"55","author":"Chen","year":"2000","journal-title":"Biopolymers"},{"key":"10.1016\/j.leukres.2003.10.021_BIB22","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1517\/13543784.11.8.1161","article-title":"Iseganan HCl: a novel antimicrobial agent","volume":"11","author":"Giles","year":"2002","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.leukres.2003.10.021_BIB23","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1128\/AAC.44.7.1803-1808.2000","article-title":"IB-367, a protegrin peptide with in vitro and in vivo activities against the microflora associated with oral mucositis","volume":"44","author":"Mosca","year":"2000","journal-title":"Antimicrob. Agents Chemother."},{"key":"10.1016\/j.leukres.2003.10.021_BIB24","doi-asserted-by":"crossref","first-page":"1731","DOI":"10.1517\/13543784.9.8.1731","article-title":"Protegrins: new antibiotics of mammalian origin","volume":"9","author":"Bellm","year":"2000","journal-title":"Expert Opin. Invest. Drugs"},{"key":"10.1016\/j.leukres.2003.10.021_BIB25","first-page":"154a","article-title":"IB-367 reduces the number of days of severe oral mucositis complicating myeloablative chemotherapy","volume":"94","author":"Vesole","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2003.10.021_BIB26","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1080\/1042819031000079159","article-title":"A phase III, randomized, double-blind, placebo-controlled, multinational trial of iseganan for the prevention of oral mucositis in patients receiving stomatotoxic chemotherapy (PROMPT-CT TRIAL)","volume":"44","author":"Giles","year":"2003","journal-title":"Leukemia Lymphoma"},{"key":"10.1016\/j.leukres.2003.10.021_BIB27","doi-asserted-by":"crossref","first-page":"1612","DOI":"10.1002\/1097-0142(19930901)72:5<1612::AID-CNCR2820720520>3.0.CO;2-Q","article-title":"A longitudinal study of oral ulcerative mucositis in bone marrow transplant recipients","volume":"72","author":"Woo","year":"1993","journal-title":"Cancer"},{"key":"10.1016\/j.leukres.2003.10.021_BIB28","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1200\/JCO.1994.12.12.2630","article-title":"Randomized trial of a chlorhexidine mouthwash for alleviation of radiation-induced mucositis","volume":"12","author":"Foote","year":"1994","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB29","first-page":"483","article-title":"Control of oral mucositis and candidiasis in marrow transplantation: a prospective, double-blind trial of chlorhexidine digluconate oral rinse","volume":"3","author":"Ferretti","year":"1988","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.leukres.2003.10.021_BIB30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/0030-4220(90)90295-4","article-title":"Chlorhexidine prophylaxis for chemotherapy- and radiotherapy-induced stomatitis: a randomized double-blind trial","volume":"69","author":"Ferretti","year":"1990","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB31","doi-asserted-by":"crossref","first-page":"444","DOI":"10.1016\/0030-4220(90)90377-5","article-title":"Chlorhexidine inactivation by saliva","volume":"69","author":"Spijkervet","year":"1990","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB32","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1111\/j.1600-0714.1990.tb00792.x","article-title":"Mucositis prevention by selective elimination of oral flora in irradiated head and neck cancer patients","volume":"19","author":"Spijkervet","year":"1990","journal-title":"J. Oral Pathol. Med."},{"key":"10.1016\/j.leukres.2003.10.021_BIB33","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/jso.2930460309","article-title":"Effect of selective elimination of the oral flora on mucositis in irradiated head and neck cancer patients","volume":"46","author":"Spijkervet","year":"1991","journal-title":"J. Surg. Oncol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB34","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1002\/(SICI)1097-0142(19970601)79:11<2193::AID-CNCR18>3.0.CO;2-R","article-title":"A randomized trial of a nonabsorbable antibiotic lozenge given to alleviate radiation-induced mucositis","volume":"79","author":"Okuno","year":"1997","journal-title":"Cancer"},{"key":"10.1016\/j.leukres.2003.10.021_BIB35","doi-asserted-by":"crossref","first-page":"544","DOI":"10.1016\/S1079-2104(99)70131-9","article-title":"Effect of local application of the antimicrobial peptide IB-367 on the incidence and severity of oral mucositis in hamsters","volume":"87","author":"Loury","year":"1999","journal-title":"Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod."},{"key":"10.1016\/j.leukres.2003.10.021_BIB36","first-page":"61","article-title":"Pretreatment strategies for infection prevention in chemotherapy patients","volume":"9","author":"Peterson","year":"1990","journal-title":"NCI Monogr."},{"key":"10.1016\/j.leukres.2003.10.021_BIB37","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1016\/0030-4220(90)90007-F","article-title":"Effect of granulocytopenia on oral microbial relationships in patients with acute leukemia","volume":"70","author":"Peterson","year":"1990","journal-title":"Oral Surg. Oral Med. Oral Pathol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB38","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1097\/00001622-199403000-00003","article-title":"Cytokines other than growth factors in bone marrow transplantation","volume":"6","author":"Ferrara","year":"1994","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB39","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1182\/blood.V78.5.1205.1205","article-title":"Phase I\u2013II trial of pentoxifylline for the prevention of transplant-related toxicities following bone marrow transplantation","volume":"78","author":"Bianco","year":"1991","journal-title":"Blood"},{"issue":"Suppl. 2","key":"10.1016\/j.leukres.2003.10.021_BIB40","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/sj.bmt.1702863","article-title":"Mucositis associated with stem cell transplantation: current status and innovative approaches to management","volume":"27","author":"Stiff","year":"2001","journal-title":"Bone Marrow Transplant"},{"key":"10.1016\/j.leukres.2003.10.021_BIB41","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1080\/1024533021000037216","article-title":"Oral mucositis: time for more studies","volume":"7","author":"Alvarado","year":"2002","journal-title":"Hematology"},{"key":"10.1016\/j.leukres.2003.10.021_BIB42","doi-asserted-by":"crossref","first-page":"1452","DOI":"10.1200\/JCO.2003.10.079","article-title":"Randomized phase I trial of recombinant human keratinocyte growth factor plus chemotherapy: potential role as mucosal protectant","volume":"21","author":"Meropol","year":"2003","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.leukres.2003.10.021_BIB43","doi-asserted-by":"crossref","first-page":"1429","DOI":"10.1200\/JCO.2003.02.041","article-title":"Keratinocyte growth factor: not yet ready for prime time","volume":"21","author":"Loprinzi","year":"2003","journal-title":"J. Clin. Oncol."}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212603003515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212603003515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,3,28]],"date-time":"2020-03-28T05:09:31Z","timestamp":1585372171000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212603003515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":43,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S0145212603003515"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2003.10.021","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}