{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T14:39:05Z","timestamp":1759847945070,"version":"3.44.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,5,1]],"date-time":"2005-05-01T00:00:00Z","timestamp":1114905600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2005,5]]},"DOI":"10.1016\/j.leukres.2004.11.003","type":"journal-article","created":{"date-parts":[[2005,1,29]],"date-time":"2005-01-29T03:48:09Z","timestamp":1106970489000},"page":"557-564","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"title":["p15 mRNA expression detected by real-time quantitative reverse transcriptase-polymerase chain reaction correlates with the methylation density of the gene in adult acute leukemia"],"prefix":"10.1016","volume":"29","author":[{"given":"Naofumi","family":"Matsuno","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Koyu","family":"Hoshino","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tomoko","family":"Nanri","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshiro","family":"Kawakita","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hitoshi","family":"Suzushima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fumio","family":"Kawano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroaki","family":"Mitsuya","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norio","family":"Asou","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2004.11.003_bib1","first-page":"722","article-title":"Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B","volume":"56","author":"Herman","year":"1996","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2004.11.003_bib2","first-page":"837","article-title":"Distinct patterns of inactivation of p15INK4B and p16INK4A characterize the major types of hematological malignancies","volume":"57","author":"Herman","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2004.11.003_bib3","first-page":"436","article-title":"Extensive intra- and interindividual heterogeneity of p15INK4B methylation in acute myeloid leukemia","volume":"59","author":"Aggerholm","year":"1999","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2004.11.003_bib4","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1182\/blood.V90.4.1403","article-title":"Hypermethylation of the p15INK4B gene in myelodysplastic syndromes","volume":"90","author":"Uchida","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2004.11.003_bib5","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1182\/blood.V91.8.2985.2985_2985_2990","article-title":"Methylation of the p15(INK4b) gene in myelodysplastic syndromes is frequent and acquired during disease progression","volume":"91","author":"Quesnel","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2004.11.003_bib6","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1046\/j.1365-2141.2002.03451.x","article-title":"The absence of the p15INK4B gene alterations in adult patients with precursor B-cell acute lymphoblastic leukaemia is a favourable prognostic factor","volume":"117","author":"Hoshino","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2004.11.003_bib7","doi-asserted-by":"crossref","first-page":"9821","DOI":"10.1073\/pnas.93.18.9821","article-title":"Methylation-specific PCR: a novel PCR assay for methylation status of CpG islands","volume":"93","author":"Herman","year":"1996","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2004.11.003_bib8","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1182\/blood.V94.7.2445.419k19_2445_2451","article-title":"p15(INK4B) CpG island methylation in primary acute leukemia is heterogeneous and suggests density as a critical factor for transcriptional silencing","volume":"94","author":"Cameron","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2004.11.003_bib9","doi-asserted-by":"crossref","first-page":"620","DOI":"10.7326\/0003-4819-103-4-620","article-title":"Proposed revised criteria for the classification of acute myeloid leukaemia: a report of the French\u2013American\u2013British Cooperative Group","volume":"103","author":"Bennett","year":"1985","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.leukres.2004.11.003_bib10","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1038\/sj.leu.2403362","article-title":"Transcriptional repression of the p15 gene predicts the clinical outcome of acute myeloblastic leukemia with intermediate and adverse cytogenetics","volume":"18","author":"Matsuno","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2004.11.003_bib11","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1046\/j.1365-2141.1997.1012917.x","article-title":"Myelomonoblastic leukaemia cells carrying the PEBP2beta\/MYH11 fusion gene are CD34, c-KIT+ immature cells","volume":"97","author":"Osato","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2004.11.003_bib12","first-page":"1133","article-title":"Expression of p15INK4B in normal hematopoiesis","volume":"26","author":"Teofili","year":"1998","journal-title":"Exp Hematol"},{"key":"10.1016\/j.leukres.2004.11.003_bib13","doi-asserted-by":"crossref","first-page":"1942","DOI":"10.1182\/blood.V95.6.1942","article-title":"Aberrant p15 promoter methylation in adult and childhood acute leukemias of nearly all morphologic subtypes: potential prognostic implications","volume":"95","author":"Wong","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2004.11.003_bib14","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/S0092-8674(00)81887-5","article-title":"MeCP2 is a transcriptional repressor with abundant binding sites in genomic chromatin","volume":"88","author":"Nan","year":"1997","journal-title":"Cell"},{"key":"10.1016\/j.leukres.2004.11.003_bib15","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/30764","article-title":"Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex","volume":"393","author":"Nan","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2004.11.003_bib16","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1038\/sj.leu.2403054","article-title":"Methylation of p15INK4B is common, is associated with deletion of genes on chromosome arm 7q and predicts a poor prognosis in therapy-related myelodysplasia and acute myeloid leukemia","volume":"17","author":"Christiansen","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2004.11.003_bib17","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1200\/JCO.2001.19.7.2033","article-title":"Methylation of p15 and p16 genes in acute promyelocytic leukemia: potential diagnostic and prognostic significance","volume":"19","author":"Chim","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.leukres.2004.11.003_bib18","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1038\/sj.leu.2402907","article-title":"Hypermethylation of GpG islands in the promoter region of p15(INK4b) in acute promyelocytic leukemia represses p15(INK4b) expression and correlates with poor prognosis","volume":"17","author":"Teofili","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2004.11.003_bib19","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1038\/371257a0","article-title":"p15INK4B is a potential effector of TGF-beta-induced cell cycle arrest","volume":"371","author":"Hannon","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2004.11.003_bib20","doi-asserted-by":"crossref","first-page":"31577","DOI":"10.1074\/jbc.274.44.31577","article-title":"Interaction and functional cooperation of PEBP2\/CBF with Smads: synergistic induction of the immunoglobulin germline Calpha promoter","volume":"274","author":"Hanai","year":"1999","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2004.11.003_bib21","doi-asserted-by":"crossref","first-page":"40282","DOI":"10.1074\/jbc.C000485200","article-title":"Inhibition of the transforming growth factor beta 1 signaling pathway by the AML1\/ETO leukemia-associated fusion protein","volume":"275","author":"Jakubowiak","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2004.11.003_bib22","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1182\/blood-2002-02-0492","article-title":"The roles of FLT3 in hematopoiesis and leukemia","volume":"100","author":"Gilliland","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2004.11.003_bib23","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1182\/blood.V98.2.495","article-title":"Expression of p15(ink4b) gene during megakaryocytic differentiation of normal and myelodysplastic hematopoietic progenitors","volume":"98","author":"Teofili","year":"2001","journal-title":"Blood"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212604003868?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212604003868?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:55:31Z","timestamp":1758934531000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212604003868"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,5]]},"references-count":23,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2005,5]]}},"alternative-id":["S0145212604003868"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2004.11.003","relation":{},"ISSN":["0145-2126"],"issn-type":[{"type":"print","value":"0145-2126"}],"subject":[],"published":{"date-parts":[[2005,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"p15 mRNA expression detected by real-time quantitative reverse transcriptase-polymerase chain reaction correlates with the methylation density of the gene in adult acute leukemia","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2004.11.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}