{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T00:38:54Z","timestamp":1790901534724,"version":"4.1.0"},"reference-count":49,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2005,7,1]],"date-time":"2005-07-01T00:00:00Z","timestamp":1120176000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2005,7]]},"DOI":"10.1016\/j.leukres.2005.01.004","type":"journal-article","created":{"date-parts":[[2005,2,25]],"date-time":"2005-02-25T17:53:21Z","timestamp":1109354001000},"page":"829-839","source":"Crossref","is-referenced-by-count":6,"title":["B-chronic lymphocytic leukemia cells exert an in vitro cytotoxicity mediated by tumor necrosis factor \u03b1"],"prefix":"10.1016","volume":"29","author":[{"given":"Emanuela","family":"Rosati","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Sabatini","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio","family":"Tabilio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mauro","family":"Di Ianni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Bartoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierfrancesco","family":"Marconi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2005.01.004_bib1","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0898-6568(98)00018-7","article-title":"TNF-related ligands and their receptors","volume":"10","author":"Orlinick","year":"1998","journal-title":"Cell Signal"},{"key":"10.1016\/j.leukres.2005.01.004_bib2","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1016\/1074-7613(95)90001-2","article-title":"Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice","volume":"2","author":"Flynn","year":"1995","journal-title":"Immunity"},{"key":"10.1016\/j.leukres.2005.01.004_bib3","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1146\/annurev.cb.09.110193.001533","article-title":"Tumor necrosis factor, other cytokines and disease","volume":"9","author":"Tracey","year":"1993","journal-title":"Annu Rev Cell Biol"},{"key":"10.1016\/j.leukres.2005.01.004_bib4","doi-asserted-by":"crossref","first-page":"810","DOI":"10.1056\/NEJM200003163421110","article-title":"Tumor necrosis factor blockers in rheumatoid arthritis","volume":"342","author":"Pisetsky","year":"2000","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2005.01.004_bib5","doi-asserted-by":"crossref","first-page":"3378","DOI":"10.1182\/blood.V85.12.3378.bloodjournal85123378","article-title":"Tumor necrosis factor ligand superfamily: involvement in the pathology of malignant lymphomas","volume":"85","author":"Gruss","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib6","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/S0962-8924(00)89088-1","article-title":"Two tumor necrosis factor receptors: structure and function","volume":"5","author":"Vandenabeele","year":"1995","journal-title":"Trends Cell Biol"},{"issue":"3","key":"10.1016\/j.leukres.2005.01.004_bib7","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/S0092-8674(00)81375-6","article-title":"Dissection of TNF receptor 1 effector functions: JNK activation is not linked to apoptosis while NF-kappa B activation prevents cell death","volume":"87","author":"Liu","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.leukres.2005.01.004_bib8","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1172\/JCI112815","article-title":"Secretory products of macrophages","volume":"79","author":"Nathan","year":"1987","journal-title":"J Clin Invest"},{"key":"10.1016\/j.leukres.2005.01.004_bib9","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1002\/eji.1830190132","article-title":"Differential secretion of tumor necrosis factor-alpha and granulocyte\/macrophage colony-stimulating factors but not interferon-gamma from CD4+ compared to CD8+ human T cell clones","volume":"19","author":"Pawelec","year":"1989","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.leukres.2005.01.004_bib10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1097\/00062752-199704040-00008","article-title":"Chronic lymphocytic leukaemia","volume":"4","author":"Kipps","year":"1997","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.leukres.2005.01.004_bib11","first-page":"107","article-title":"Chronic lymphocytic leukaemia","volume":"26","author":"Keating","year":"1999","journal-title":"Semin Oncol"},{"key":"10.1016\/j.leukres.2005.01.004_bib12","doi-asserted-by":"crossref","first-page":"1052","DOI":"10.1056\/NEJM199510193331606","article-title":"Chronic lymphocytic leukaemia","volume":"333","author":"Rozman","year":"1995","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2005.01.004_bib13","first-page":"11","article-title":"Molecular biology of chronic lymphocytic leukemia","volume":"25","author":"Reed","year":"1998","journal-title":"Semin Oncol"},{"key":"10.1016\/j.leukres.2005.01.004_bib14","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1182\/blood.V76.2.393.bloodjournal762393","article-title":"Production of tumor necrosis factor-alpha by B-cell chronic lymphocytic leukemia cells: a possible regulatory role of TNF in the progression of the disease","volume":"76","author":"Foa","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib15","doi-asserted-by":"crossref","first-page":"41","DOI":"10.3109\/10428199409051650","article-title":"TNF receptors in chronic lymphocytic leukemia","volume":"13","author":"Waage","year":"1994","journal-title":"Leuk Lymph"},{"key":"10.1016\/j.leukres.2005.01.004_bib16","doi-asserted-by":"crossref","first-page":"2577","DOI":"10.1182\/blood.V80.10.2577.2577","article-title":"p55 and p75 tumor necrosis factor receptors in patients with chronic lymphocytic leukemia","volume":"80","author":"Waage","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib17","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1182\/blood.V73.5.1242.1242","article-title":"Tumor necrosis factor induces proliferation of neoplastic B cells from chronic lymphocytic leukaemia","volume":"73","author":"Digel","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib18","doi-asserted-by":"crossref","first-page":"969","DOI":"10.1016\/S0140-6736(88)91782-5","article-title":"Tumor necrosis factor as an autocrine tumor growth factor for chronic B-cell malignancies","volume":"1","author":"Cordingley","year":"1988","journal-title":"Lancet"},{"key":"10.1016\/j.leukres.2005.01.004_bib19","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.1016\/0959-8049(94)90169-4","article-title":"Serum levels of tumour necrosis factor-alpha in patients with B-cell chronic lymphocytic leukaemia","volume":"30A","author":"Adami","year":"1994","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.leukres.2005.01.004_bib20","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1182\/blood.V100.4.1215.h81602001215_1215_1219","article-title":"The clinical significance of tumor necrosis factor-alpha plasma level in patients having chronic lymphocytic leukemia","volume":"100","author":"Ferrajoli","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib21","doi-asserted-by":"crossref","first-page":"4990","DOI":"10.1182\/blood.V87.12.4990.bloodjournal87124990","article-title":"National Cancer Institute-sponsored Working Group guidelines for chronic lymphocytic leukemia: revised guidelines for diagnosis and treatment","volume":"87","author":"Cheson","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib22","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1002\/1097-0142(197708)40:2<855::AID-CNCR2820400239>3.0.CO;2-1","article-title":"A clinical staging system for chronic lymphocytic leukemia: prognostic significance","volume":"40","author":"Binet","year":"1977","journal-title":"Cancer"},{"key":"10.1016\/j.leukres.2005.01.004_bib23","doi-asserted-by":"crossref","first-page":"9166","DOI":"10.1073\/pnas.88.20.9166","article-title":"The zeta chain is associated with a tyrosine kinase and upon T-cell antigen receptor stimulation associates with ZAP-70, a 70-kDa tyrosine phosphoprotein","volume":"88","author":"Chan","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2005.01.004_bib24","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal Biochem"},{"key":"10.1016\/j.leukres.2005.01.004_bib25","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.4049\/jimmunol.153.5.1963","article-title":"TNF receptors TR60 and TR80 can mediate apoptosis via induction of distinct signal pathways","volume":"153","author":"Grell","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.leukres.2005.01.004_bib26","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1002\/ajh.2830430202","article-title":"Heterogeneous proliferative effect of tumor necrosis factor-alpha and lymphotoxin on mitogen activated B cells from B-chronic lymphocytic leukemia","volume":"43","author":"Alvarez-Mon","year":"1993","journal-title":"Am J Hematol"},{"key":"10.1016\/j.leukres.2005.01.004_bib27","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1182\/blood.V84.12.4249.bloodjournal84124249","article-title":"Expression and regulation of tumor necrosis factor, interleukin-2, and hematopoietic growth factor receptors in B-cell chronic lymphocytic leukemia","volume":"84","author":"Trentin","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib28","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/0145-2126(91)90091-7","article-title":"Restoration of in vitro hematopoiesis in B-chronic lymphocytic leukemia by antibodies to tumor necrosis factor","volume":"15","author":"Michalevicz","year":"1991","journal-title":"Leuk Res"},{"key":"10.1016\/j.leukres.2005.01.004_bib29","doi-asserted-by":"crossref","first-page":"4273","DOI":"10.1182\/blood.V91.11.4273","article-title":"Differential sensitivity of CD4+ and CD8+ T lymphocytes to the killing efficacy of Fas (Apo-1\/CD95) ligand+ tumor cells in B chronic lymphocytic leukemia","volume":"91","author":"Tinhofer","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib30","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1046\/j.1365-2141.1999.01630.x","article-title":"Functional expression of TRAIL by lymphoid and myeloid tumour cells","volume":"106","author":"Zhao","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2005.01.004_bib31","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1189\/jlb.71.6.907","article-title":"Immune escape of tumors: apoptosis resistance and tumor counterattack","volume":"71","author":"Igney","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.leukres.2005.01.004_bib32","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1182\/blood.V99.4.1305","article-title":"Negative regulation of erythroblast maturation by Fas-L+\/TRAIL+ highly malignant plasma cells: a major pathogenetic mechanism of anemia in multiple myeloma","volume":"99","author":"Silvestris","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib33","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/s00277-002-0476-1","article-title":"Chronic lymphocytic leukaemia: one disease or two?","volume":"81","author":"Hamblin","year":"2002","journal-title":"Ann Hematol"},{"key":"10.1016\/j.leukres.2005.01.004_bib34","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1126\/science.7509083","article-title":"Sequential interactions of the TCR with two distinct cytoplasmic tyrosine kinases","volume":"263","author":"Iwashima","year":"1994","journal-title":"Science"},{"key":"10.1016\/j.leukres.2005.01.004_bib35","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1056\/NEJMp048184","article-title":"Predicting progression\u2014ZAP-70 in CLL","volume":"351","author":"Hamblin","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2005.01.004_bib36","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1056\/NEJMoa040857","article-title":"ZAP-70 compared with immunoglobulin heavy chain gene mutation status as a predictor of disease progression in chronic lymphocytic leukemia","volume":"351","author":"Rassenti","year":"2004","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2005.01.004_bib37","doi-asserted-by":"crossref","first-page":"1764","DOI":"10.1056\/NEJMoa023143","article-title":"ZAP-70 expression as a surrogate for immunoglobulin variable region mutations in chronic lymphocytic leukemia","volume":"348","author":"Crespo","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2005.01.004_bib38","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1182\/blood-2002-10-3306","article-title":"ZAP-70 expression identifies a chronic lymphocytic leukemia subtype with unmutated immunoglobulin genes, inferior clinical outcome, and distinct gene expression profile","volume":"101","author":"Wiestner","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib39","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","article-title":"Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia","volume":"94","author":"Hamblin","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib40","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1182\/blood.V98.1.181","article-title":"CD38 expression as an important prognostic factor in B-cell chronic lymphocytic leukemia","volume":"98","author":"Ibrahim","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib41","doi-asserted-by":"crossref","first-page":"1892","DOI":"10.1182\/blood.V97.6.1892","article-title":"CD38 expression is a poor predictor for VH gene mutational status and prognosis in chronic lymphocytic leukemia","volume":"97","author":"Thunberg","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib42","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1182\/blood.V95.7.2455","article-title":"Immunoglobulin V genes and CD38 expression in CLL","volume":"95","author":"Hamblin","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib43","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1182\/blood.V99.3.1023","article-title":"CD38 expression and immunoglobulin variable region mutations are independent prognostic variables in chronic lymphocytic leukemia, but CD38 expression may vary during the course of the disease","volume":"99","author":"Hamblin","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.01.004_bib44","first-page":"226","article-title":"Interleukin-2 enhances the production of tumor necrosis factor-alpha in activated B-type chronic lymphocytic leukemia (B-CLL) cells","volume":"7","author":"Larsson","year":"1993","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2005.01.004_bib45","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1046\/j.1365-2141.1998.00595.x","article-title":"Diminished production of interleukin-6 in chronic lymphocytic leukaemia (B-CLL) cells from patients at advanced stages of disease. Tampere CLL Group","volume":"100","author":"Hulkkonen","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2005.01.004_bib46","doi-asserted-by":"crossref","first-page":"1729","DOI":"10.1084\/jem.172.6.1729","article-title":"Effects of interferon alpha on autocrine growth factor loops in B lymphoproliferative disorders","volume":"172","author":"Heslop","year":"1990","journal-title":"J Exp Med"},{"key":"10.1016\/j.leukres.2005.01.004_bib47","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/hon.2900110104","article-title":"The effect of cytokines on cultured mononuclear cells from patients with B cell chronic lymphocytic leukemia","volume":"11","author":"Burke","year":"1993","journal-title":"Hematol Oncol"},{"key":"10.1016\/j.leukres.2005.01.004_bib48","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1089\/107999099314036","article-title":"IFN-alpha stimulates proliferation and cytokine secretion of CD40-stimulated B cell chronic lymphocytic leukaemia cells in vitro","volume":"19","author":"Brass","year":"1999","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.leukres.2005.01.004_bib49","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0165-2478(00)00247-9","article-title":"Cytokines in cancer therapy","volume":"74","author":"Parmiani","year":"2000","journal-title":"Immunol Lett"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521260500041X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521260500041X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,2]],"date-time":"2023-05-02T10:59:10Z","timestamp":1683025150000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014521260500041X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,7]]},"references-count":49,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2005,7]]}},"alternative-id":["S014521260500041X"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2005.01.004","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2005,7]]}}}