{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T01:52:56Z","timestamp":1791078776722,"version":"4.1.0"},"reference-count":40,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2006,3,1]],"date-time":"2006-03-01T00:00:00Z","timestamp":1141171200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2006,3]]},"DOI":"10.1016\/j.leukres.2005.08.004","type":"journal-article","created":{"date-parts":[[2005,9,13]],"date-time":"2005-09-13T07:14:21Z","timestamp":1126595661000},"page":"313-321","source":"Crossref","is-referenced-by-count":40,"title":["RETRACTED: Curcumin suppresses constitutive activation of AP-1 by downregulation of JunD protein in HTLV-1-infected T-cell lines"],"prefix":"10.1016","volume":"30","author":[{"given":"Mariko","family":"Tomita","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hirochika","family":"Kawakami","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-nosuke","family":"Uchihara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Taeko","family":"Okudaira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masato","family":"Masuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nobuyuki","family":"Takasu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Matsuda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takao","family":"Ohta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuetsu","family":"Tanaka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Mori","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2005.08.004_bib1","doi-asserted-by":"crossref","first-page":"6476","DOI":"10.1073\/pnas.78.10.6476","article-title":"Adult T-cell leukemia: antigen in an ATL cell line and detection of antibodies to the antigen in human sera","volume":"78","author":"Hinuma","year":"1981","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2005.08.004_bib2","doi-asserted-by":"crossref","first-page":"7415","DOI":"10.1073\/pnas.77.12.7415","article-title":"Detection and isolation of type C retrovirus particles from fresh and cultured lymphocytes of a patient with cutaneous T-cell lymphoma","volume":"77","author":"Poiesz","year":"1980","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2005.08.004_bib3","doi-asserted-by":"crossref","first-page":"2031","DOI":"10.1073\/pnas.79.6.2031","article-title":"Isolation and characterization of retrovirus from cell lines of human adult T-cell leukemia and its implication in the disease","volume":"79","author":"Yoshida","year":"1982","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2005.08.004_bib4","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1146\/annurev.immunol.15.1.15","article-title":"Human T cell leukemia virus type I (HTLV-I) and human diseases","volume":"15","author":"Uchiyama","year":"1997","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.leukres.2005.08.004_bib5","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1002\/ijc.2910450206","article-title":"The 4th nation-wide study of adult T-cell leukemia\/lymphoma (ATL) in Japan: estimates of risk of ATL and its geographical and clinical features. The T- and B-cell Malignancy Study Group","volume":"45","author":"Tajima","year":"1990","journal-title":"Int J Cancer"},{"key":"10.1016\/j.leukres.2005.08.004_bib6","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1046\/j.1365-2141.2001.02737.x","article-title":"A new G-CSF-supported combination chemotherapy, LSG15, for adult T-cell leukaemia-lymphoma: Japan Clinical Oncology Group Study 9303","volume":"113","author":"Yamada","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2005.08.004_bib7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1146\/annurev.immunol.19.1.475","article-title":"Multiple viral strategies of HTLV-1 for dysregulation of cell growth control","volume":"19","author":"Yoshida","year":"2001","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.leukres.2005.08.004_bib8","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.1073\/pnas.87.3.1071","article-title":"Oncogenic transformation by the tax gene of human T-cell leukemia virus type I in vitro","volume":"87","author":"Tanaka","year":"1990","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2005.08.004_bib9","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1073\/pnas.86.9.3351","article-title":"Transformation to continuous growth of primary human T lymphocytes by human T-cell leukemia virus type I X-region genes transduced by a Herpesvirus saimiri vector","volume":"86","author":"Grassmann","year":"1989","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2005.08.004_bib10","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1126\/science.2888190","article-title":"The tat gene of human T-lymphotropic virus type 1 induces mesenchymal tumors in transgenic mice","volume":"237","author":"Nerenberg","year":"1987","journal-title":"Science"},{"key":"10.1016\/j.leukres.2005.08.004_bib11","doi-asserted-by":"crossref","first-page":"1057","DOI":"10.1073\/pnas.92.4.1057","article-title":"Development of leukemia in mice transgenic for the tax gene of human T-cell leukemia virus type I","volume":"92","author":"Grossman","year":"1995","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2005.08.004_bib12","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/0092-8674(88)90024-4","article-title":"Fos and Jun: the AP-1 connection","volume":"55","author":"Curran","year":"1988","journal-title":"Cell"},{"key":"10.1016\/j.leukres.2005.08.004_bib13","doi-asserted-by":"crossref","first-page":"2438","DOI":"10.1038\/sj.onc.1204385","article-title":"Close encounters of many kinds: Fos\u2013Jun interactions that mediate transcription regulatory specificity","volume":"20","author":"Chinenov","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2005.08.004_bib14","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/ncb0502-e131","article-title":"AP-1 as a regulator of cell life and death","volume":"4","author":"Shaulian","year":"2002","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.leukres.2005.08.004_bib15","first-page":"1023","article-title":"HTLV-1 Tax induces expression of various immediate early serum responsive genes","volume":"6","author":"Fujii","year":"1991","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2005.08.004_bib16","doi-asserted-by":"crossref","first-page":"8526","DOI":"10.1073\/pnas.85.22.8526","article-title":"c-fos promoter trans-activation by the tax1 protein of human T-cell leukemia virus type I","volume":"85","author":"Fujii","year":"1988","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2005.08.004_bib17","doi-asserted-by":"crossref","first-page":"7001","DOI":"10.1128\/JVI.67.12.7001-7007.1993","article-title":"Human T-cell leukemia virus type 1 Tax activates transcription of the human fra-1 gene through multiple cis elements responsive to transmembrane signals","volume":"67","author":"Tsuchiya","year":"1993","journal-title":"J Virol"},{"key":"10.1016\/j.leukres.2005.08.004_bib18","first-page":"3993","article-title":"Human T-cell leukemia virus type I Tax transactivates human interleukin 8 gene through acting concurrently on AP-1 and nuclear factor-\u03baB-like sites","volume":"58","author":"Mori","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2005.08.004_bib19","doi-asserted-by":"crossref","first-page":"14946","DOI":"10.1016\/S0021-9258(17)36557-2","article-title":"Tax proteins of human T-cell leukemia virus type 1 and 2 induce expression of the gene encoding erythroid-potentiating activity (tissue inhibitor of metalloproteinases-1, TIMP-1)","volume":"269","author":"Uchijima","year":"1994","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2005.08.004_bib20","first-page":"3915","article-title":"Constitutive activation of transcription factor AP-1 in primary adult T-cell leukemia cells","volume":"95","author":"Mori","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.08.004_bib21","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1055\/s-2006-960004","article-title":"Pharmacology of Curcuma longa","volume":"57","author":"Ammon","year":"1991","journal-title":"Planta Med"},{"key":"10.1016\/j.leukres.2005.08.004_bib22","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1093\/carcin\/18.1.83","article-title":"Inhibitory effects of topical application of low doses of curcumin on 12-O-tetradecanoylphorbol-13-acetate-induced tumor promotion and oxidized DNA bases in mouse epidermis","volume":"18","author":"Huang","year":"1997","journal-title":"Carcinogenesis"},{"key":"10.1016\/j.leukres.2005.08.004_bib23","doi-asserted-by":"crossref","first-page":"5292","DOI":"10.1073\/pnas.88.12.5292","article-title":"Suppression of c-Jun\/AP-1 activation by an inhibitor of tumor promotion in mouse fibroblast cells","volume":"88","author":"Huang","year":"1991","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2005.08.004_bib24","doi-asserted-by":"crossref","first-page":"24995","DOI":"10.1074\/jbc.270.42.24995","article-title":"Activation of transcription factor NF-\u03baB is suppressed by curcumin (diferuloylmethane)","volume":"270","author":"Singh","year":"1995","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2005.08.004_bib25","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1038\/sj.onc.1201941","article-title":"Inhibition of the c-Jun N-terminal kinase (JNK) signaling pathway by curcumin","volume":"17","author":"Chen","year":"1998","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2005.08.004_bib26","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1349-7006.1990.tb02554.x","article-title":"Heterogeneity of antigen molecules recognized by anti-tax1 monoclonal antibody Lt-4 in cell lines bearing human T cell leukemia virus type I and related retroviruses","volume":"81","author":"Tanaka","year":"1990","journal-title":"Jpn J Cancer Res"},{"key":"10.1016\/j.leukres.2005.08.004_bib27","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1038\/294770a0","article-title":"Type C virus particles in a cord T-cell line derived by co-cultivating normal human cord leukocytes and human leukaemic T cells","volume":"294","author":"Miyoshi","year":"1981","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2005.08.004_bib28","first-page":"155","article-title":"A novel T-cell line derived from adult T-cell leukemia","volume":"71","author":"Miyoshi","year":"1980","journal-title":"Gann"},{"key":"10.1016\/j.leukres.2005.08.004_bib29","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1084\/jem.162.6.2169","article-title":"Origin of human T-lymphotrophic virus I-positive T cell lines in adult T cell leukaemia. Analysis of T cell receptor gene rearrangement","volume":"162","author":"Maeda","year":"1985","journal-title":"J Exp Med"},{"key":"10.1016\/j.leukres.2005.08.004_bib30","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1128\/JVI.71.6.4445-4451.1997","article-title":"Human T-cell leukemia virus type 1 Tax protein transforms rat fibroblasts via two distinct pathways","volume":"71","author":"Matsumoto","year":"1997","journal-title":"J Virol"},{"key":"10.1016\/j.leukres.2005.08.004_bib31","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1002\/j.1460-2075.1987.tb04767.x","article-title":"Identification of two distinct elements in the long terminal repeat of HTLV-I responsible for maximum gene expression","volume":"6","author":"Ohtani","year":"1987","journal-title":"EMBO J"},{"key":"10.1016\/j.leukres.2005.08.004_bib32","doi-asserted-by":"crossref","first-page":"1518","DOI":"10.1248\/bpb.19.1518","article-title":"A combined assay of cell viability and in vitro cytotoxicity with a highly water-soluble tetrazolium salt, neutral red and crystal violet","volume":"19","author":"Ishiyama","year":"1996","journal-title":"Biol Pharm Bull"},{"key":"10.1016\/j.leukres.2005.08.004_bib33","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1016\/0092-8674(94)90513-4","article-title":"Mouse JunD negatively regulates fibroblast growth and antagonizes transformation by ras","volume":"76","author":"Pfarr","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.leukres.2005.08.004_bib34","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1016\/S1097-2765(00)00109-X","article-title":"JunD protects cells from p53-dependent senescence and apoptosis","volume":"6","author":"Weitzman","year":"2000","journal-title":"Mol Cell"},{"key":"10.1016\/j.leukres.2005.08.004_bib35","doi-asserted-by":"crossref","first-page":"2984","DOI":"10.1101\/gad.12.19.2984","article-title":"Tumor surveillance via the ARF-p53 pathway","volume":"12","author":"Sherr","year":"1998","journal-title":"Genes Dev"},{"key":"10.1016\/j.leukres.2005.08.004_bib36","doi-asserted-by":"crossref","first-page":"2451","DOI":"10.1128\/MCB.11.5.2451","article-title":"Expression of different Jun and Fos proteins during the G0-to-G1 transition in mouse fibroblasts: in vitro and in vivo associations","volume":"11","author":"Kovary","year":"1991","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.leukres.2005.08.004_bib37","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1016\/S0955-0674(97)80068-3","article-title":"AP-1 function and regulation","volume":"9","author":"Karin","year":"1997","journal-title":"Curr Opin Cell Biol"},{"key":"10.1016\/j.leukres.2005.08.004_bib38","first-page":"135","article-title":"Constitutively activated JNK is associated with HTLV-1 mediated tumorigenesis","volume":"13","author":"Xu","year":"1996","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2005.08.004_bib39","first-page":"2360","article-title":"Constitutive activation of NF-\u03baB in primary adult T-cell leukemia cells","volume":"93","author":"Mori","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.08.004_bib40","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1126\/science.7604283","article-title":"Constitutively activated Jak-STAT pathway in T cells transformed with HTLV-I","volume":"269","author":"Migone","year":"1995","journal-title":"Science"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212605003127?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212605003127?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,17]],"date-time":"2021-07-17T06:55:17Z","timestamp":1626504917000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212605003127"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,3]]},"references-count":40,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,3]]}},"alternative-id":["S0145212605003127"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2005.08.004","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2006,3]]}}}