{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:30:59Z","timestamp":1791228659808,"version":"4.1.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2006,8,1]],"date-time":"2006-08-01T00:00:00Z","timestamp":1154390400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2006,8]]},"DOI":"10.1016\/j.leukres.2005.11.013","type":"journal-article","created":{"date-parts":[[2006,2,1]],"date-time":"2006-02-01T12:16:55Z","timestamp":1138796215000},"page":"923-934","source":"Crossref","is-referenced-by-count":46,"title":["Genomic imbalances and patterns of karyotypic variability in mantle-cell lymphoma cell lines"],"prefix":"10.1016","volume":"30","author":[{"given":"Jordi","family":"Camps","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Salaverria","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria J.","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther","family":"Prat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00edlvia","family":"Be\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jessica C.","family":"Pole","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lluis","family":"Hern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Del","family":"Rey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Cruz","family":"Cigudosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Bernu\u00e9s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Caldas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dolors","family":"Colomer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Mir\u00f3","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"El\u00edas","family":"Campo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2005.11.013_bib1","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1182\/blood.V84.8.2726.2726","article-title":"PRAD-1\/cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma","volume":"84","author":"Bosch","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib2","doi-asserted-by":"crossref","first-page":"1177","DOI":"10.1182\/blood.V88.4.1177.bloodjournal8841177","article-title":"Direct visualization of dispersed 11q13 chromosomal translocations in mantle cell lymphoma by multicolor DNA fiber fluorescence in situ hybridization","volume":"88","author":"Vaandrager","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib3","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1073\/pnas.91.2.709","article-title":"Function of a human cyclin gene as an oncogene","volume":"91","author":"Hinds","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2005.11.013_bib4","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1182\/blood.V93.4.1372","article-title":"Cytogenetic profile of lymphoma of follicle mantle lineage: correlation with clinicobiologic features","volume":"93","author":"Cuneo","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib5","first-page":"594","article-title":"Secondary chromosome changes in mantle cell lymphoma","volume":"84","author":"Wlodarska","year":"1999","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2005.11.013_bib6","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1002\/(SICI)1098-2264(199804)21:4<298::AID-GCC3>3.0.CO;2-U","article-title":"Gain of 3q and deletion of 11q22 are frequent aberrations in mantle cell lymphoma","volume":"21","author":"Monni","year":"1998","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.leukres.2005.11.013_bib7","first-page":"4365","article-title":"Increased number of chromosomal imbalances and high-level DNA amplifications in mantle cell lymphoma are associated with blastoid variants","volume":"93","author":"Bea","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib8","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1002\/(SICI)1098-2264(200003)27:3<285::AID-GCC9>3.0.CO;2-M","article-title":"t(11;14)-positive mantle cell lymphomas exhibit complex karyotypes and share similarities with B-cell chronic lymphocytic leukemia","volume":"27","author":"Bentz","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.leukres.2005.11.013_bib9","doi-asserted-by":"crossref","first-page":"3479","DOI":"10.1182\/blood.V98.12.3479","article-title":"Loss of a novel tumor suppressor gene locus at chromosome 8p is associated with leukemic mantle cell lymphoma","volume":"98","author":"Martinez-Climent","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib10","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1046\/j.1365-2141.2002.03260.x","article-title":"Identification of novel regions of amplification and deletion within mantle cell lymphoma DNA by comparative genomic hybridization","volume":"116","author":"Allen","year":"2002","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2005.11.013_bib11","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.1158\/0008-5472.CAN-03-4056","article-title":"Genome-wide array-based comparative genomic hybridization of diffuse large B-cell lymphoma: comparison between CD5-positive and CD5-negative cases","volume":"64","author":"Tagawa","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2005.11.013_bib12","doi-asserted-by":"crossref","first-page":"1686","DOI":"10.1182\/blood-2004-07-2730","article-title":"Novel chromosomal imbalances in mantle cell lymphoma detected by genome-wide array-based comparative genomic hybridization","volume":"105","author":"Schraders","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib13","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1182\/blood-2003-12-4175","article-title":"Genomic DNA-chip hybridization in t(11;14)-positive mantle cell lymphomas shows a high frequency of aberrations and allows a refined characterization of consensus regions","volume":"104","author":"Kohlhammer","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib14","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/25292","article-title":"Genetic instabilities in human cancers","volume":"396","author":"Lengauer","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2005.11.013_bib15","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1096\/fj.04-2276fje","article-title":"Comprehensive measurement of chromosomal instability in cancer cells: combination of fluorescence in situ hybridization and cytokinesis-block micronucleus assay","volume":"19","author":"Camps","year":"2005","journal-title":"FASEB J"},{"key":"10.1016\/j.leukres.2005.11.013_bib16","doi-asserted-by":"crossref","first-page":"4975","DOI":"10.1182\/blood-2002-06-1864","article-title":"A subset of t(11;14) lymphoma with mantle cell features displays mutated IgVH genes and includes patients with good prognosis, nonnodal disease","volume":"101","author":"Orchard","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib17","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/j.1365-2141.2004.04913.x","article-title":"B-prolymphocytic leukaemia with t(11;14) revisited: a splenomegalic form of mantle cell lymphoma evolving with leukaemia","volume":"125","author":"Ruchlemer","year":"2004","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2005.11.013_bib18","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/modpathol.3800139","article-title":"Case report: mantle cell lymphoma, prolymphocytoid variant, with leukostasis syndrome","volume":"17","author":"Smith","year":"2004","journal-title":"Mod Pathol"},{"key":"10.1016\/j.leukres.2005.11.013_bib19","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1359641","article-title":"Comparative genomic hybridization for molecular cytogenetic analysis of solid tumors","volume":"258","author":"Kallioniemi","year":"1992","journal-title":"Science"},{"key":"10.1016\/j.leukres.2005.11.013_bib20","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1016\/S0090-4295(01)00909-8","article-title":"Detection of chromosomal imbalances in papillary bladder tumors by comparative genomic hybridization","volume":"57","author":"Prat","year":"2001","journal-title":"Urology"},{"key":"10.1016\/j.leukres.2005.11.013_bib21","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1158\/0008-5472.CAN-04-1762","article-title":"A recurrent chromosome breakpoint in breast cancer at the NRG1\/neuregulin 1\/heregulin gene","volume":"64","author":"Huang","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2005.11.013_bib22","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/gcc.10155","article-title":"DNA microarrays for comparative genomic hybridization based on DOP-PCR amplification of BAC and PAC clones","volume":"36","author":"Fiegler","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.leukres.2005.11.013_bib23","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1038\/ng0496-368","article-title":"Karyotyping human chromosomes by combinatorial multi-fluor FISH","volume":"12","author":"Speicher","year":"1996","journal-title":"Nat Genet"},{"key":"10.1016\/j.leukres.2005.11.013_bib24","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/sj.thj.6200226","article-title":"Multicolor fluorescence in situ hybridization studies in multiple myeloma and monoclonal gammopathy of undetermined significance","volume":"4","author":"Gutierrez","year":"2003","journal-title":"Hematol J"},{"key":"10.1016\/j.leukres.2005.11.013_bib25","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1016\/S0301-472X(02)01075-5","article-title":"Genomic p16 abnormalities in the progression of chronic myeloid leukemia into blast crisis: a sequential study in 42 patients","volume":"31","author":"Hernandez-Boluda","year":"2003","journal-title":"Exp Hematol"},{"key":"10.1016\/j.leukres.2005.11.013_bib26","doi-asserted-by":"crossref","first-page":"1987","DOI":"10.1016\/S0002-9440(10)65071-7","article-title":"INK4a\/ARF locus alterations in human non-Hodgkin's lymphomas mainly occur in tumors with wild-type p53 gene","volume":"156","author":"Pinyol","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.leukres.2005.11.013_bib27","doi-asserted-by":"crossref","first-page":"1810","DOI":"10.1182\/blood-2001-12-0327","article-title":"Spontaneous and drug-induced apoptosis is mediated by conformational changes of Bax and Bak in B-cell chronic lymphocytic leukemia","volume":"100","author":"Bellosillo","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib28","unstructured":"Mitelman F. ISCN: an international system for human cytogenetic nomenclature, Basel; 1995."},{"key":"10.1016\/j.leukres.2005.11.013_bib29","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1046\/j.1365-2141.1998.00911.x","article-title":"Establishment and characterization of a mantle cell lymphoma cell line","volume":"102","author":"Jeon","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2005.11.013_bib30","doi-asserted-by":"crossref","first-page":"424","DOI":"10.5858\/2003-127-0424-COMCLC","article-title":"Characterization of 4 mantle cell lymphoma cell lines","volume":"127","author":"Amin","year":"2003","journal-title":"Arch Pathol Lab Med"},{"key":"10.1016\/j.leukres.2005.11.013_bib31","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S0145-2126(02)00026-7","article-title":"Malignant hematopoietic cell lines: in vitro models for the study of mantle cell lymphoma","volume":"26","author":"Drexler","year":"2002","journal-title":"Leuk Res"},{"key":"10.1016\/j.leukres.2005.11.013_bib32","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1002\/(SICI)1097-0320(19981201)33:4<453::AID-CYTO9>3.0.CO;2-S","article-title":"Use of platinum coproporphyrin and delayed luminescence imaging to extend the number of targets FISH karyotyping","volume":"33","author":"Tanke","year":"1998","journal-title":"Cytometry"},{"key":"10.1016\/j.leukres.2005.11.013_bib33","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.cancergencyto.2004.01.006","article-title":"Molecular cytogenetic characterization of the mantle cell lymphoma cell line GRANTA-519","volume":"153","author":"Rudolph","year":"2004","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.leukres.2005.11.013_bib34","doi-asserted-by":"crossref","first-page":"869","DOI":"10.1002\/ijc.20195","article-title":"Genetic evolution in colon cancer KM12 cells and metastatic derivates","volume":"110","author":"Camps","year":"2004","journal-title":"Int J Cancer"},{"key":"10.1016\/j.leukres.2005.11.013_bib35","doi-asserted-by":"crossref","first-page":"8941","DOI":"10.1038\/sj.onc.1208084","article-title":"Activation of mitochondrial apoptotic pathway in mantle cell lymphoma: high sensitivity to mitoxantrone in cases with functional DNA-damage response genes","volume":"23","author":"Ferrer","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2005.11.013_bib36","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1093\/hmg\/ddh195","article-title":"Comprehensive whole genome array CGH profiling of mantle cell lymphoma model genomes","volume":"13","author":"de Leeuw","year":"2004","journal-title":"Hum Mol Genet"},{"key":"10.1016\/j.leukres.2005.11.013_bib37","doi-asserted-by":"crossref","first-page":"1348","DOI":"10.1038\/sj.onc.1208300","article-title":"Genome-wide array-based CGH for mantle cell lymphoma: identification of homozygous deletions of the proapoptotic gene BIM","volume":"24","author":"Tagawa","year":"2005","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2005.11.013_bib38","doi-asserted-by":"crossref","first-page":"4445","DOI":"10.1182\/blood-2004-10-3907","article-title":"Mantle-cell lymphoma genotypes identified with CGH to BAC microarrays define a leukemic subgroup of disease and predict patient outcome","volume":"105","author":"Rubio-Moscardo","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib39","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1080\/10428190290016890","article-title":"Cytogenetic analysis in mantle cell lymphoma: a review of 214 cases","volume":"43","author":"Au","year":"2002","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.leukres.2005.11.013_bib40","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1038\/ng1215","article-title":"Chromosome aberrations in solid tumors","volume":"34","author":"Albertson","year":"2003","journal-title":"Nat Genet"},{"key":"10.1016\/j.leukres.2005.11.013_bib41","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1126\/science.959840","article-title":"The clonal evolution of tumor cell populations","volume":"194","author":"Nowell","year":"1976","journal-title":"Science"},{"key":"10.1016\/j.leukres.2005.11.013_bib42","doi-asserted-by":"crossref","first-page":"4302","DOI":"10.1182\/blood.V87.10.4302.bloodjournal87104302","article-title":"p53 mutations in mantle cell lymphoma are associated with variant cytology and predict a poor prognosis","volume":"87","author":"Greiner","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib43","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1182\/blood.V87.8.3351.bloodjournal8783351","article-title":"p53 gene mutations and protein overexpression are associated with aggressive variants of mantle cell lymphomas","volume":"87","author":"Hernandez","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib44","first-page":"4608","article-title":"Alterations of the cyclin D1\/p16-pRB pathway in mantle cell lymphoma","volume":"57","author":"Dreyling","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2005.11.013_bib45","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1182\/blood.V89.1.272","article-title":"Deletions and loss of expression of p16INK4a and p21Waf1 genes are associated with aggressive variants of mantle cell lymphomas","volume":"89","author":"Pinyol","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib46","doi-asserted-by":"crossref","first-page":"1727","DOI":"10.1038\/sj.leu.2401901","article-title":"Concurrent disruption of p16INK4a and the ARF-p53 pathway predicts poor prognosis in aggressive non-Hodgkin's lymphoma","volume":"14","author":"Gronbaek","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2005.11.013_bib47","doi-asserted-by":"crossref","first-page":"2026","DOI":"10.1182\/blood.V72.6.2026.2026","article-title":"Characterization of a new non-Hodgkin's lymphoma cell line (NCEB-1) with a chromosomal (11:14) translocation [t(11:14)(q13;q32)]","volume":"72","author":"Saltman","year":"1988","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2005.11.013_bib48","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1002\/(SICI)1097-0215(19991112)83:4<555::AID-IJC19>3.0.CO;2-2","article-title":"Widespread intraspecies cross-contamination of human tumor cell lines arising at source","volume":"83","author":"MacLeod","year":"1999","journal-title":"Int J Cancer"},{"key":"10.1016\/j.leukres.2005.11.013_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s11626-998-0040-y","article-title":"Cell cross-contamination in cell cultures: the silent and neglected danger","volume":"34","author":"Markovic","year":"1998","journal-title":"In Vitro Cell Dev Biol: Anim"},{"key":"10.1016\/j.leukres.2005.11.013_bib50","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1038\/ng0997-96","article-title":"Clustering of missense mutations in the ataxia-telangiectasia gene in a sporadic T-cell leukaemia","volume":"17","author":"Vorechovsky","year":"1997","journal-title":"Nat Genet"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212605004388?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212605004388?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,23]],"date-time":"2021-07-23T11:30:01Z","timestamp":1627039801000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212605004388"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,8]]},"references-count":50,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2006,8]]}},"alternative-id":["S0145212605004388"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2005.11.013","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2006,8]]}}}