{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,19]],"date-time":"2026-01-19T09:27:51Z","timestamp":1768814871063,"version":"3.49.0"},"reference-count":25,"publisher":"Elsevier BV","issue":"12","license":[{"start":{"date-parts":[[2006,12,1]],"date-time":"2006-12-01T00:00:00Z","timestamp":1164931200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2006,12]]},"DOI":"10.1016\/j.leukres.2006.02.014","type":"journal-article","created":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T11:07:13Z","timestamp":1144408033000},"page":"1531-1540","source":"Crossref","is-referenced-by-count":50,"title":["Stress-induced in vitro apoptosis of native human acute myelogenous leukemia (AML) cells shows a wide variation between patients and is associated with low BCL-2:Bax ratio and low levels of heat shock protein 70 and 90"],"prefix":"10.1016","volume":"30","author":[{"given":"Anita","family":"Ryningen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisabeth","family":"Ersv\u00e6r","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne Margrete","family":"\u00d8yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl-Henning","family":"Kalland","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olav Karsten","family":"Vintermyr","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f8rn Tore","family":"Gjertsen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"\u00d8ystein","family":"Bruserud","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.leukres.2006.02.014_bib1","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.critrevonc.2003.11.002","article-title":"Adult acute myeloid leukaemia","volume":"50","author":"Smith","year":"2004","journal-title":"Crit Rev Oncol Hematol"},{"key":"10.1016\/j.leukres.2006.02.014_bib2","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1517\/14712598.2.2.197","article-title":"Use of marine toxins in combination with cytotoxic drugs for induction of apoptosis in acute myelogenous leukaemia cells","volume":"2","author":"Bruserud","year":"2002","journal-title":"Expert Opin Biol Ther"},{"key":"10.1016\/j.leukres.2006.02.014_bib3","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1196\/annals.1322.049","article-title":"Molecularly targeted therapy in acute myeloid leukemia","volume":"1028","author":"Bernasconi","year":"2004","journal-title":"Ann NY Acad Sci"},{"key":"10.1016\/j.leukres.2006.02.014_bib4","doi-asserted-by":"crossref","first-page":"30a","DOI":"10.1182\/blood.V104.11.93.93","article-title":"Hsp90 inhibitors induce apoptosis in human leukemia cells","volume":"104","author":"Campos","year":"2004","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.leukres.2006.02.014_bib5","doi-asserted-by":"crossref","first-page":"229","DOI":"10.2174\/1568009054064651","article-title":"Antiangiogenic therapy in acute myelogenous leukemia: targeting of vascular endothelial growth factor and interleukin 8 as possible antileukemic strategies","volume":"5","author":"Hatfield","year":"2005","journal-title":"Curr Cancer Drug Targets"},{"key":"10.1016\/j.leukres.2006.02.014_bib6","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1046\/j.1365-2141.2003.04418.x","article-title":"Treatment stratification based on initial in vivo response in acute myeloid leukemia in children without Down's syndrome: results of NOPHO-AML trials","volume":"122","author":"Lie","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.02.014_bib7","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/cyto.b.10056","article-title":"Comparative measurement of spontaneous apoptosis in pediatric acute leukemia by different techniques","volume":"56B","author":"Savitskiy","year":"2003","journal-title":"Cytometry"},{"issue":"11","key":"10.1016\/j.leukres.2006.02.014_bib8","doi-asserted-by":"crossref","first-page":"61a","DOI":"10.1182\/blood.V104.11.198.198","article-title":"Clinical significance of apoptosis is independent from proliferation in acute myeloid leukemia (AML)","volume":"104","author":"Del Poeta","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.02.014_bib9","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1634\/stemcells.19-1-1","article-title":"New strategies in the treatment of acute myelogenous leukemia (AML): in vitro culture of AML cells\u2014the present use in experimental studies and the possible importance for future therapeutic strategies","volume":"19","author":"Bruserud","year":"2001","journal-title":"Stem Cells"},{"key":"10.1016\/j.leukres.2006.02.014_bib10","first-page":"416","article-title":"Flt3-mediated signaling in human acute myelogenous leukemia (AML) blasts: a functional characterization of the effects of Flt3-ligand in AML cell populations with and without Flt3 abnormalities","volume":"88","author":"Bruserud","year":"2003","journal-title":"Haematologica"},{"issue":"4","key":"10.1016\/j.leukres.2006.02.014_bib11","first-page":"391","article-title":"Osteoblasts increase proliferation and release of proangiogenic interleukin 8 by native human acute myelogenous leukemia blasts","volume":"89","author":"Bruserud","year":"2004","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2006.02.014_bib12","doi-asserted-by":"crossref","first-page":"53","DOI":"10.3109\/02841869209088266","article-title":"Effects of dipyridamole, theophylline and verapamil on spontaneous proliferation of myelogenous leukemia cells","volume":"31","author":"Bruserud","year":"1992","journal-title":"Acta Oncol"},{"key":"10.1016\/j.leukres.2006.02.014_bib13","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/j.leukres.2004.06.008","article-title":"In vitro crosstalk between fibroblasts and native human acute myelogenous leukemia (AML) blasts via local cytokine networks results in increased proliferation and decreased apoptosis of AML cells as well as increased levels of proangiogenic Interleukin 8","volume":"29","author":"Ryningen","year":"2005","journal-title":"Leuk Res"},{"key":"10.1016\/j.leukres.2006.02.014_bib14","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1089\/152581600750062372","article-title":"In vitro culture of human acute myelogenous leukemia (AML) cells in serum-free media: studies of native AML blasts and AML cell lines","volume":"9","author":"Bruserud","year":"2000","journal-title":"J Hematother Stem Cell Res"},{"key":"10.1016\/j.leukres.2006.02.014_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/(SICI)1097-0320(19980101)31:1<1::AID-CYTO1>3.0.CO;2-R","article-title":"Annexin V-affinity assay: a review on an apoptosis detection system based on phosphatidylserine exposure","volume":"31","author":"Engeland","year":"1998","journal-title":"Cytometry"},{"key":"10.1016\/j.leukres.2006.02.014_bib16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1083\/jcb.130.1.157","article-title":"Alterations in mitochondrial structure and function are early events of dexamethasone-induced thymocyte apoptosis","volume":"130","author":"Petit","year":"1995","journal-title":"J Cell Biol"},{"issue":"1","key":"10.1016\/j.leukres.2006.02.014_bib17","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0014-5793(97)00669-8","article-title":"JC-1, but not DiOC6(3) or rhodamine 123, is a reliable fluorescent probe to assess delta psi changes in intact cells: implications for studies on mitochondrial functionality during apoptosis","volume":"411","author":"Salvioli","year":"1997","journal-title":"FEBS Lett"},{"key":"10.1016\/j.leukres.2006.02.014_bib18","first-page":"449","article-title":"Early changes in intramitochondrial cardiolipin distribution during apoptosis","volume":"13","author":"Garcia Fernandez","year":"2002","journal-title":"Cell Growth Differ"},{"key":"10.1016\/j.leukres.2006.02.014_bib19","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0091-679X(08)61717-3","article-title":"Lysosomal proton pump activity: supravital cell staining with acridine orange differentiates leukocyte subpopulations","volume":"41","author":"Traganos","year":"1994","journal-title":"Methods Cell Biol"},{"key":"10.1016\/j.leukres.2006.02.014_bib20","doi-asserted-by":"crossref","first-page":"3363","DOI":"10.1242\/jcs.107.12.3363","article-title":"Multiple apoptotic death types triggered through activation of separate pathways by cAMP and inhibitors of protein phosphatases in one (IPC leukemia) cell line","volume":"107","author":"Gjertsen","year":"1994","journal-title":"J Cell Sci"},{"key":"10.1016\/j.leukres.2006.02.014_bib21","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1038\/bjc.1995.479","article-title":"8-Chloro-cAMP induces apoptotic cell death in a human mammary carcinoma cell (MCF-7) line","volume":"72","author":"B\u00f8e","year":"1995","journal-title":"Br J Cancer"},{"issue":"9","key":"10.1016\/j.leukres.2006.02.014_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/sj.bjc.6602197","article-title":"Khat (Catha edulis)-induced apoptosis is inhibited by antagonists of caspase-1 and -8 in human leukaemia cells","volume":"91","author":"Dimba","year":"1726","journal-title":"Br J Cancer"},{"key":"10.1016\/j.leukres.2006.02.014_bib23","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.0300-9475.2004.01450.x","article-title":"Characterization of ribosomal P autoantibodies in relation to cell destruction and autoimmune disease","volume":"60","author":"Ersvaer","year":"2004","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.leukres.2006.02.014_bib24","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1089\/15258160260090933","article-title":"Analysis of acute myelogenous leukemia: preparation of samples for genomic and proteomic analyses","volume":"11","author":"Gjertsen","year":"2002","journal-title":"J Hematother Stem Cell Res"},{"key":"10.1016\/j.leukres.2006.02.014_bib25","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1002\/cyto.b.20044","article-title":"CD34 expression in native human acute myelogenous leukemia blasts: differences in CD34 membrane molecule expression are associated with different gene expression profiles","volume":"64","author":"Oyan","year":"2005","journal-title":"Cytometry B Clin Cytom"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212606000592?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212606000592?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,7,25]],"date-time":"2021-07-25T12:14:21Z","timestamp":1627215261000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212606000592"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2006,12]]}},"alternative-id":["S0145212606000592"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2006.02.014","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2006,12]]}}}