{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:00:46Z","timestamp":1777417246978,"version":"3.51.4"},"reference-count":50,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2007,5,1]],"date-time":"2007-05-01T00:00:00Z","timestamp":1177977600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2007,5]]},"DOI":"10.1016\/j.leukres.2006.06.012","type":"journal-article","created":{"date-parts":[[2006,8,2]],"date-time":"2006-08-02T21:43:06Z","timestamp":1154554986000},"page":"591-598","source":"Crossref","is-referenced-by-count":57,"title":["Cytokine and chemokine profiles in multiple myeloma; significance of stromal interaction and correlation of IL-8 production with disease progression"],"prefix":"10.1016","volume":"31","author":[{"given":"Michael","family":"Kline","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathleen","family":"Donovan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda","family":"Wellik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christopher","family":"Lust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wendy","family":"Jin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laurie","family":"Moon-Tasson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuning","family":"Xiong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas E.","family":"Witzig","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shaji","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. Vincent","family":"Rajkumar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John A.","family":"Lust","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2006.06.012_bib1","first-page":"2583","article-title":"Multiple myeloma","volume":"2","author":"Dispenzieri","year":"2004"},{"key":"10.1016\/j.leukres.2006.06.012_bib2","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1182\/blood-2004-01-0037","article-title":"Advances in biology of multiple myeloma: clinical applications","volume":"104","author":"Hideshima","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.06.012_bib3","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1182\/blood.V73.2.517.517","article-title":"Paracrine rather than autocrine regulation of myeloma-cell growth and differentiation by interleukin-6","volume":"73","author":"Klein","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.06.012_bib4","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1038\/sj.leu.2400873","article-title":"Contrast in cytokine expression between patients with monoclonal gammopathy of undetermined significance or multiple myeloma","volume":"12","author":"Donovan","year":"1998","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.06.012_bib5","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1182\/blood.V93.1.300","article-title":"Comparison of interleukin-1 beta expression by in situ hybridization in monoclonal gammopathy of undetermined significance and multiple myeloma","volume":"93","author":"Lacy","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.06.012_bib6","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1182\/blood.V95.8.2630","article-title":"Vascular endothelial growth factor and interleukin-6 in paracrine tumor-stromal cell interactions in multiple myeloma","volume":"95","author":"Dankbar","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.06.012_bib7","doi-asserted-by":"crossref","first-page":"4519","DOI":"10.1038\/sj.onc.1204623","article-title":"The role of tumor necrosis factor alpha in the pathophysiology of human multiple myeloma: therapeutic applications","volume":"20","author":"Hideshima","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2006.06.012_bib8","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1200\/JCO.2001.19.15.3562","article-title":"Biology of osteoclast activation in cancer","volume":"19","author":"Roodman","year":"2001","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.leukres.2006.06.012_bib9","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0093-7754(01)90022-3","article-title":"Bone marrow angiogenesis in patients with active multiple myeloma","volume":"28","author":"Vacca","year":"2001","journal-title":"Semin Oncol"},{"key":"10.1016\/j.leukres.2006.06.012_bib10","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1046\/j.1365-2141.2003.04355.x","article-title":"Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group","volume":"121","author":"International","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.06.012_bib11","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1089\/jir.2006.26.83","article-title":"Identification of two groups of smoldering multiple myeloma patients who are either high or low producers of IL-1","volume":"2","author":"Xiong","year":"2006","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.leukres.2006.06.012_bib12","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1046\/j.1365-2141.1998.01101.x","article-title":"Interleukin-1 in multiple myeloma: producer cells and their role in the control of IL-6 production","volume":"103","author":"Costes","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.06.012_bib13","doi-asserted-by":"crossref","first-page":"2196","DOI":"10.1002\/1529-0131(199812)41:12<2196::AID-ART15>3.0.CO;2-2","article-title":"Treatment of rheumatoid arthritis with recombinant human interleukin-1 receptor antagonist","volume":"41","author":"Bresnihan","year":"1998","journal-title":"Arthritis Rheum"},{"key":"10.1016\/j.leukres.2006.06.012_bib14","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1038\/sj.leu.2403285","article-title":"Effect of thalidomide therapy on bone marrow angiogenesis in multiple myeloma","volume":"18","author":"Kumar","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.06.012_bib15","first-page":"5320","article-title":"Coexistence of aneuploid subclones within a myeloma cell line that exhibits clonal immunoglobulin gene rearrangement: clinical implications","volume":"53","author":"Jelinek","year":"1993","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2006.06.012_bib16","first-page":"866","article-title":"Establishment and characterization of three myeloma cell lines that demonstrate variable cytokine responses and abilities to produce autocrine interleukin-6","volume":"10","author":"Westendorf","year":"1996","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.06.012_bib17","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095","article-title":"Biologic basis for interleukin-1 in disease","volume":"87","author":"Dinarello","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.06.012_bib18","doi-asserted-by":"crossref","first-page":"21096","DOI":"10.1074\/jbc.272.34.21096","article-title":"Novel inhibitors of cytokine-induced IkappaBalpha phosphorylation and endothelial cell adhesion molecule expression show anti-inflammatory effects in vivo","volume":"272","author":"Pierce","year":"1997","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2006.06.012_bib19","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1111\/j.1365-2249.1993.tb05943.x","article-title":"Cytokines involved in the progression of multiple myeloma","volume":"92","author":"Merico","year":"1993","journal-title":"Clin Exp Immunol"},{"key":"10.1016\/j.leukres.2006.06.012_bib20","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.1182\/blood.V84.7.2269.2269","article-title":"Primary tumor cells of myeloma patients induce interleukin-6 secretion in long-term bone marrow cultures","volume":"84","author":"Lokhorst","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.06.012_bib21","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1182\/blood.V74.1.380.380","article-title":"Production of interleukin-1 by bone marrow myeloma cells","volume":"74","author":"Cozzolino","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.06.012_bib22","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1182\/blood.V74.4.1266.1266","article-title":"Production of cytokines by bone marrow cells obtained from patients with multiple myeloma","volume":"74","author":"Lichtenstein","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.06.012_bib23","first-page":"4242","article-title":"Production of interleukin 1 beta, a potent bone resorbing cytokine, by cultured human myeloma cells","volume":"49","author":"Yamamoto","year":"1989","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2006.06.012_bib24","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1111\/j.1365-2141.1990.tb06330.x","article-title":"The role of interleukin-1 and tumour necrosis factor-alpha in human multiple myeloma","volume":"74","author":"Carter","year":"1990","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.06.012_bib25","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1089\/107999099313866","article-title":"Regulation of interleukin-8 gene expression","volume":"19","author":"Roebuck","year":"1999","journal-title":"J Interferon Cytokine Res"},{"key":"10.1016\/j.leukres.2006.06.012_bib26","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/sj.leu.2402374","article-title":"IL-1beta expression in IgM monoclonal gammopathy and its relationship to multiple myeloma","volume":"16","author":"Donovan","year":"2002","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.06.012_bib27","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1189\/jlb.72.5.847","article-title":"Multiple control of interleukin-8 gene expression","volume":"72","author":"Hoffmann","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.leukres.2006.06.012_bib28","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0092-8674(94)90482-0","article-title":"The ubiquitin-proteasome pathway is required for processing the NF-kappa B1 precursor protein and the activation of NF-kappa B","volume":"78","author":"Palombella","year":"1994","journal-title":"Cell"},{"key":"10.1016\/j.leukres.2006.06.012_bib29","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1126\/science.270.5234.286","article-title":"Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis","volume":"270","author":"Auphan","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.leukres.2006.06.012_bib30","doi-asserted-by":"crossref","first-page":"15671","DOI":"10.1073\/pnas.95.26.15671","article-title":"Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis","volume":"95","author":"Palombella","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2006.06.012_bib31","doi-asserted-by":"crossref","first-page":"22382","DOI":"10.1074\/jbc.M100938200","article-title":"Inhibition of NF-kappa B activity by thalidomide through suppression of IkappaB kinase activity","volume":"276","author":"Keifer","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2006.06.012_bib32","doi-asserted-by":"crossref","first-page":"16639","DOI":"10.1074\/jbc.M200360200","article-title":"NF-kappa B as a therapeutic target in multiple myeloma","volume":"277","author":"Hideshima","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2006.06.012_bib33","doi-asserted-by":"crossref","first-page":"3017","DOI":"10.1210\/jc.2004-1946","article-title":"Thalidomide inhibits tumor necrosis factor-alpha-induced interleukin-8 expression in endometriotic stromal cells, possibly through suppression of nuclear factor-kappaB activation","volume":"90","author":"Yagyu","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"10.1016\/j.leukres.2006.06.012_bib34","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1046\/j.1365-2796.2001.00867.x","article-title":"Chemokines in pathology and medicine","volume":"250","author":"Baggiolini","year":"2001","journal-title":"J Intern Med"},{"key":"10.1016\/j.leukres.2006.06.012_bib35","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/S1359-6101(01)00016-8","article-title":"Interleukin-8 and human cancer biology","volume":"12","author":"Xie","year":"2001","journal-title":"Cytokine Growth Factor Rev"},{"key":"10.1016\/j.leukres.2006.06.012_bib36","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nri748","article-title":"Chemokines: agents for the immunotherapy of cancer?","volume":"2","author":"Homey","year":"2002","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.leukres.2006.06.012_bib37","doi-asserted-by":"crossref","first-page":"503","DOI":"10.1111\/j.1365-2141.1994.tb08304.x","article-title":"Bone marrow angiogenesis and progression in multiple myeloma","volume":"87","author":"Vacca","year":"1994","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.06.012_bib38","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1038\/sj.leu.2401336","article-title":"Bone marrow angiogenesis in patients achieving complete response after stem cell transplantation for multiple myeloma","volume":"13","author":"Rajkumar","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.06.012_bib39","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1189\/jlb.68.1.1","article-title":"CXC chemokines in angiogenesis","volume":"68","author":"Belperio","year":"2000","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.leukres.2006.06.012_bib40","first-page":"2290","article-title":"Interleukin 8 expression regulates tumorigenicity and metastasis in human bladder cancer","volume":"60","author":"Inoue","year":"2000","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2006.06.012_bib41","first-page":"3111","article-title":"Prognostic value of bone marrow angiogenesis in multiple myeloma","volume":"6","author":"Rajkumar","year":"2000","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.leukres.2006.06.012_bib42","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1007\/s002770000236","article-title":"Bone marrow microvessel density is a prognostic factor for survival in patients with multiple myeloma","volume":"79","author":"Sezer","year":"2000","journal-title":"Ann Hematol"},{"key":"10.1016\/j.leukres.2006.06.012_bib43","doi-asserted-by":"crossref","first-page":"3369","DOI":"10.4049\/jimmunol.170.6.3369","article-title":"IL-8 directly enhanced endothelial cell survival, proliferation, and matrix metalloproteinases production and regulated angiogenesis","volume":"170","author":"Li","year":"2003","journal-title":"J Immunol"},{"key":"10.1016\/j.leukres.2006.06.012_bib44","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.it.2004.02.006","article-title":"CXC chemokines: the regulatory link between inflammation and angiogenesis","volume":"25","author":"Romagnani","year":"2004","journal-title":"Trends Immunol"},{"key":"10.1016\/j.leukres.2006.06.012_bib45","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/j.semcancer.2003.10.006","article-title":"CXC chemokines in angiogenesis of cancer","volume":"14","author":"Strieter","year":"2004","journal-title":"Semin Cancer Biol"},{"key":"10.1016\/j.leukres.2006.06.012_bib46","doi-asserted-by":"crossref","first-page":"3360","DOI":"10.4049\/jimmunol.153.7.3360.a","article-title":"IL-8 produced by human malignant melanoma cells in vitro is an essential autocrine growth factor","volume":"153","author":"Schadendorf","year":"1994","journal-title":"J Immunol"},{"key":"10.1016\/j.leukres.2006.06.012_bib47","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1006\/cyto.1999.0518","article-title":"Interleukin-8 as an autocrine growth factor for human colon carcinoma cells in vitro","volume":"12","author":"Brew","year":"2000","journal-title":"Cytokine"},{"key":"10.1016\/j.leukres.2006.06.012_bib48","first-page":"391","article-title":"Interleukin-8: an expanding universe beyond neutrophil chemotaxis and activation","volume":"72","author":"Mukaida","year":"2000","journal-title":"Int J Hematol"},{"key":"10.1016\/j.leukres.2006.06.012_bib49","doi-asserted-by":"crossref","first-page":"1970","DOI":"10.1038\/sj.bjc.6602227","article-title":"Interleukin-8\/CXCL8 is a growth factor for human lung cancer cells","volume":"91","author":"Zhu","year":"2004","journal-title":"Br J Cancer"},{"key":"10.1016\/j.leukres.2006.06.012_bib50","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/j.1365-2141.2005.05443.x","article-title":"Bone marrow endothelial cells in multiple myeloma secrete CXC-chemokines that mediate interactions with plasma cells","volume":"129","author":"Pellegrino","year":"2005","journal-title":"Br J Haematol"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521260600227X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521260600227X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T11:31:18Z","timestamp":1683545478000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014521260600227X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,5]]},"references-count":50,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2007,5]]}},"alternative-id":["S014521260600227X"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2006.06.012","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2007,5]]}}}