{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T08:14:58Z","timestamp":1788423298205,"version":"build-2803163510"},"reference-count":35,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2007,7,1]],"date-time":"2007-07-01T00:00:00Z","timestamp":1183248000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2007,7]]},"DOI":"10.1016\/j.leukres.2006.09.003","type":"journal-article","created":{"date-parts":[[2006,10,15]],"date-time":"2006-10-15T06:56:30Z","timestamp":1160895390000},"page":"939-945","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["T-cell large granular lymphocytic (T-LGL) leukemia: Experience in a single institution over 8 years"],"prefix":"10.1016","volume":"31","author":[{"given":"Ahmed","family":"Aribi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Huh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Keating","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"O\u2019Brien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Ferrajoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Faderl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Wierda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagop","family":"Kantarjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Farhad","family":"Ravandi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2006.09.003_bib1","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1002\/cncr.21405","article-title":"Mature T-cell leukemias","volume":"104","author":"Ravandi","year":"2005","journal-title":"Cancer"},{"key":"10.1016\/j.leukres.2006.09.003_bib2","doi-asserted-by":"crossref","first-page":"1660","DOI":"10.4065\/80.12.1660","article-title":"Chronic lymphoid leukemias other than chronic lymphocytic leukemia: diagnosis and treatment","volume":"80","author":"Ravandi","year":"2005","journal-title":"Mayo Clin Proc"},{"key":"10.1016\/j.leukres.2006.09.003_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1182\/blood.V82.1.1.bloodjournal8211","article-title":"Clonal diseases of large granular lymphocytes","volume":"82","author":"Loughran","year":"1993","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.09.003_bib4","doi-asserted-by":"crossref","first-page":"1786","DOI":"10.1182\/blood.V69.6.1786.1786","article-title":"Clinical features in large granular lymphocytic leukaemia","volume":"69","author":"Loughran","year":"1987","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.09.003_bib5","doi-asserted-by":"crossref","first-page":"2971","DOI":"10.1002\/1097-0142(19871215)60:12<2971::AID-CNCR2820601220>3.0.CO;2-O","article-title":"The lymphoproliferative disease of granular lymphocytes. A heterogeneous disorder ranging from indolent to aggressive conditions","volume":"60","author":"Semenzato","year":"1987","journal-title":"Cancer"},{"key":"10.1016\/j.leukres.2006.09.003_bib6","first-page":"617","article-title":"Granular lymphocyte proliferative disorders: report of 12 cases and review of the literature","volume":"2","author":"Oshimi","year":"1988","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.09.003_bib7","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S0037-1963(03)00133-1","article-title":"Clinical features of large granular lymphocyte leukemia","volume":"40","author":"Lamy","year":"2003","journal-title":"Semin Hematol"},{"key":"10.1016\/j.leukres.2006.09.003_bib8","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1046\/j.1365-2141.1997.d01-2113.x","article-title":"Constitutive expression of Fas ligand in large granular lymphocyte leukaemia","volume":"97","author":"Perzova","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.09.003_bib9","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1182\/blood.V75.3.704.704","article-title":"Perforin gene expression in granular lymphocyte proliferative disorders","volume":"75","author":"Oshimi","year":"1990","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.09.003_bib10","first-page":"33","article-title":"Constitutive expression of cytotoxic proteases and down regulation of protease inhibitors in LGL leukemia","volume":"22","author":"Kothapalli","year":"2003","journal-title":"Int J Oncol"},{"key":"10.1016\/j.leukres.2006.09.003_bib11","doi-asserted-by":"crossref","first-page":"1116","DOI":"10.1182\/blood.V80.5.1116.1116","article-title":"Detection of human T-cell leukemia\/lymphoma virus, type II, in a patient with large granular lymphocyte leukemia","volume":"80","author":"Loughran","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.09.003_bib12","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1046\/j.1365-2141.1998.00691.x","article-title":"Epitope mapping of HTLV envelope seroreactivity in LGL leukaemia","volume":"101","author":"Loughran","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.09.003_bib13","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1182\/asheducation-2001.1.259","article-title":"T cell and NK cell lymphoproliferative disorders","author":"Greer","year":"2001","journal-title":"Hematology (Am Soc Hematol Educ Program)"},{"key":"10.1016\/j.leukres.2006.09.003_bib14","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1182\/blood.V95.10.3219","article-title":"Chronic neutropenia mediated by fas ligand","volume":"95","author":"Liu","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.09.003_bib15","series-title":"World Health Organization classification of tumours: tumours of haematopoietic and lymphoid tissues","first-page":"197","article-title":"T-cell large granular lymphocyte leukemia","author":"Chan","year":"2001"},{"key":"10.1016\/j.leukres.2006.09.003_bib16","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1182\/blood.V89.1.256","article-title":"The lymphoproliferative disease of granular lymphocytes: updated criteria for diagnosis","volume":"89","author":"Semenzato","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.09.003_bib17","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1046\/j.1365-2141.2001.02561.x","article-title":"Coincident myelodysplastic syndrome and T-cell large granular lymphocytic disease: clinical and pathophysiological features","volume":"112","author":"Saunthahararajah","year":"2001","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.09.003_bib18","first-page":"3671","article-title":"Report of an international working group to standardize response criteria for myelodysplastic syndromes","volume":"96","author":"Cheson","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.09.003_bib19","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1634\/theoncologist.9-3-247","article-title":"T-cell large granular lymphocyte leukemia and related disorders","volume":"9","author":"Rose","year":"2004","journal-title":"Oncologist"},{"key":"10.1016\/j.leukres.2006.09.003_bib20","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/sj.leu.2401304","article-title":"Spontaneous remission of large granular lymphocyte T cell leukemia","volume":"13","author":"Takeuchi","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.09.003_bib21","doi-asserted-by":"crossref","first-page":"1620","DOI":"10.1182\/blood.V84.5.1620.1620","article-title":"Clinical spectrum of clonal proliferations of T-large granular lymphocytes: a T-cell clonopathy of undetermined significance?","volume":"84","author":"Dhodapkar","year":"1994","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.leukres.2006.09.003_bib22","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.leukres.2004.05.023","article-title":"Lessons from a case of T-cell large granular lymphocytic leukaemia suggesting that immunomodulatory therapy is more effective than intensive treatment","volume":"29","author":"Osuji","year":"2005","journal-title":"Leuk Res"},{"key":"10.1016\/j.leukres.2006.09.003_bib23","doi-asserted-by":"crossref","first-page":"2164","DOI":"10.1182\/blood.V84.7.2164.2164","article-title":"Treatment of large granular lymphocyte leukemia with oral low-dose methotrexate","volume":"84","author":"Loughran","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.09.003_bib24","doi-asserted-by":"crossref","first-page":"3372","DOI":"10.1182\/blood.V91.9.3372","article-title":"Neutropenia associated with T-cell large granular lymphocyte leukemia: long-term response to cyclosporine therapy despite persistence of abnormal cells","volume":"91","author":"Sood","year":"1998","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.09.003_bib25","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1182\/blood.V98.2.483","article-title":"Acquired pure red cell aplasia associated with lymphoproliferative disease of granular T lymphocytes","volume":"98","author":"Go","year":"2001","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.leukres.2006.09.003_bib26","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1046\/j.1365-2141.2003.04613.x","article-title":"HLA-DR4 predicts haematological response to cyclosporine in T-large granular lymphocyte lymphoproliferative disorders","volume":"123","author":"Battiwalla","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.09.003_bib27","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1046\/j.1365-2141.2003.04148.x","article-title":"Neutropenia and anaemia associated with T-cell large granular lymphocyte leukaemia responds to fludarabine with minimal toxicity","volume":"120","author":"Sternberg","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.09.003_bib28","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1038\/sj.leu.2400907","article-title":"Induction of clinical remission in T-large granular lymphocyte leukemia with cyclosporin A, monitored by use of immunophenotyping with Vbeta antibodies","volume":"12","author":"Brinkman","year":"1998","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.09.003_bib29","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1007\/BF00329495","article-title":"Severe neutropenia associated with large granular lymphocyte lymphocytosis: successful control with cyclosporin A","volume":"59","author":"Pastor","year":"1989","journal-title":"Blut"},{"issue":"9","key":"10.1016\/j.leukres.2006.09.003_bib30","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/S0002-9343(00)00406-X","article-title":"Low-dose methotrexate for the treatment of patients with large granular lymphocyte leukemia associated with rheumatoid arthritis","volume":"108","author":"Hamidou","year":"2000","journal-title":"Am J Med"},{"issue":"3","key":"10.1016\/j.leukres.2006.09.003_bib31","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1002\/cncr.22032","article-title":"T-cell large granular lymphocyte leukemia: a report on the treatment of 29 patients and a review of the literature","volume":"107","author":"Osuji","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.leukres.2006.09.003_bib32","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1046\/j.1365-2141.2003.04609.x","article-title":"Successful treatment of refractory pure red cell aplasia associated with lymphoproliferative disorders with the anti-CD52 monoclonal antibody alemtuzumab (Campath-1H)","volume":"123","author":"Ru","year":"2003","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.09.003_bib33","doi-asserted-by":"crossref","first-page":"1969","DOI":"10.1182\/blood-2003-11-3951","article-title":"Efficacy of alemtuzumab treatment for refractory T-cell large granular lymphocytic leukaemia","volume":"103","author":"Rosenblum","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.09.003_bib34","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1080\/10428190500052156","article-title":"CD52 expression in T-cell large granular lymphocyte leukaemia\u2014implications for treatment with alemtuzumab","volume":"46","author":"Osuji","year":"2005","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.leukres.2006.09.003_bib35","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1097\/00000441-200507000-00008","article-title":"T-cell lymphopenia associated with infliximab and cyclophosphamide","volume":"330","author":"Wachi","year":"2005","journal-title":"Am J Med Sci"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212606003419?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212606003419?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T07:45:25Z","timestamp":1788421525000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212606003419"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,7]]},"references-count":35,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2007,7]]}},"alternative-id":["S0145212606003419"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2006.09.003","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2007,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T-cell large granular lymphocytic (T-LGL) leukemia: Experience in a single institution over 8 years","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2006.09.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}