{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T14:09:06Z","timestamp":1761487746804,"version":"3.44.0"},"reference-count":36,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2007,10,1]],"date-time":"2007-10-01T00:00:00Z","timestamp":1191196800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2007,10]]},"DOI":"10.1016\/j.leukres.2006.11.007","type":"journal-article","created":{"date-parts":[[2006,12,23]],"date-time":"2006-12-23T07:14:10Z","timestamp":1166858050000},"page":"1373-1382","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":26,"title":["Immature and mature monocyte-derived dendritic cells in myelodysplastic syndromes of subtypes refractory anemia or refractory anemia with ringed sideroblasts display an altered cytokine profile"],"prefix":"10.1016","volume":"31","author":[{"given":"Ling","family":"Ma","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Ceuppens","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmad","family":"Kasran","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michel","family":"Delforge","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marc","family":"Boogaerts","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vandenberghe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2006.11.007_bib1","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1053\/j.seminhematol.2004.02.002","article-title":"Myelodysplastic syndromes: from pathogenesis and prognosis to treatment","volume":"41","author":"Fenaux","year":"2004","journal-title":"Semin Hematol"},{"key":"10.1016\/j.leukres.2006.11.007_bib2","doi-asserted-by":"crossref","first-page":"3660","DOI":"10.1182\/blood.V86.10.3660.bloodjournal86103660","article-title":"Polyclonal primitive hematopoietic progenitors can be detected in mobilized peripheral blood from patients with high-risk myelodysplastic syndromes","volume":"86","author":"Delforge","year":"1995","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.11.007_bib3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1046\/j.1365-2141.1998.00797.x","article-title":"Patients with high-risk myelodysplastic syndrome can have polyclonal or clonal haemopoiesis in complete haematological remission","volume":"102","author":"Delforge","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.11.007_bib4","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/1098-2264(2000)9999:9999<::AID-GCC1035>3.0.CO;2-L","article-title":"Combined immunophenotyping and FISH identifies the involvement of B-cells in 5q-syndrome","volume":"29","author":"Jaju","year":"2000","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.leukres.2006.11.007_bib5","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1182\/blood.V73.1.248.248","article-title":"Clonal analysis of myelodysplastic syndromes: evidence of multipotent stem cell origin","volume":"73","author":"Janssen","year":"1989","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.11.007_bib6","first-page":"1818","article-title":"Cytogenetic clonality analysis in myelodysplastic syndrome: monosomy 7 can be demonstrated in the myeloid and in the lymphoid lineage","volume":"9","author":"van Lom","year":"1995","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.11.007_bib7","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1182\/blood-2001-12-0188","article-title":"Involvement and functional impairment of the CD34(+)CD38(\u2212)Thy-1(+) hematopoietic stem cell pool in myelodysplastic syndromes with trisomy 8","volume":"100","author":"Nilsson","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.11.007_bib8","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1038\/sj.leu.2403430","article-title":"Circulating myeloid and lymphoid precursor dendritic cells are clonally involved in myelodysplastic syndromes","volume":"18","author":"Ma","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.11.007_bib9","first-page":"150","article-title":"Immunological abnormalities in myelodysplastic syndromes","volume":"33","author":"Hamblin","year":"1996","journal-title":"Semin Hematol"},{"key":"10.1016\/j.leukres.2006.11.007_bib10","doi-asserted-by":"crossref","first-page":"3025","DOI":"10.1182\/blood-2002-11-3325","article-title":"A simple method to predict response to immunosuppressive therapy in patients with myelodysplastic syndrome","volume":"102","author":"Saunthararajah","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.11.007_bib11","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1182\/blood.V100.5.1570.h81702001570_1570_1574","article-title":"HLA-DR15 (DR2) is overrepresented in myelodysplastic syndrome and aplastic anemia and predicts a response to immunosuppression in myelodysplastic syndrome","volume":"100","author":"Saunthararajah","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.11.007_bib12","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1046\/j.1365-2141.1997.4423249.x","article-title":"Antithymocyte globulin for patients with myelodysplastic syndrome","volume":"99","author":"Molldrem","year":"1997","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.11.007_bib13","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1046\/j.1365-2141.1998.00920.x","article-title":"Haematological response of patients with myelodysplastic syndrome to antithymocyte globulin is associated with a loss of lymphocyte-mediated inhibition of CFU-GM and alterations in T-cell receptor Vbeta profiles","volume":"102","author":"Molldrem","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.11.007_bib14","doi-asserted-by":"crossref","first-page":"156","DOI":"10.7326\/0003-4819-137-3-200208060-00007","article-title":"Antithymocyte globulin for treatment of the bone marrow failure associated with myelodysplastic syndromes","volume":"137","author":"Molldrem","year":"2002","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.leukres.2006.11.007_bib15","doi-asserted-by":"crossref","first-page":"3639","DOI":"10.1182\/blood-2002-01-0155","article-title":"Loss of T-lymphocyte clonal dominance in patients with myelodysplastic syndrome responsive to immunosuppression","volume":"100","author":"Kochenderfer","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2006.11.007_bib16","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1046\/j.1365-2141.1998.00551.x","article-title":"Cyclosporin A therapy in hypoplastic MDS patients and certain refractory anaemias without hypoplastic bone marrow","volume":"100","author":"Jonasova","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.11.007_bib17","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1007\/BF02982017","article-title":"Immunosuppressive treatment of acquired aplastic anemia and immune-mediated bone marrow failure syndromes","volume":"75","author":"Young","year":"2002","journal-title":"Int J Hematol"},{"key":"10.1016\/j.leukres.2006.11.007_bib18","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1056\/NEJM199705083361906","article-title":"The pathophysiology of acquired aplastic anemia","volume":"336","author":"Young","year":"1997","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2006.11.007_bib19","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1054\/blre.1999.0118","article-title":"Current concepts: large granular lymphocyte leukemia","volume":"13","author":"Lamy","year":"1999","journal-title":"Blood Rev"},{"key":"10.1016\/j.leukres.2006.11.007_bib20","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/32588","article-title":"Dendritic cells and the control of immunity","volume":"392","author":"Banchereau","year":"1998","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2006.11.007_bib21","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1084\/jem.189.4.611","article-title":"Mobilizing dendritic cells for tolerance, priming, and chronic inflammation","volume":"189","author":"Sallusto","year":"1999","journal-title":"J Exp Med"},{"key":"10.1016\/j.leukres.2006.11.007_bib22","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1084\/jem.184.2.695","article-title":"CD34+ hematopoietic progenitors from human cord blood differentiate along two independent dendritic cell pathways in response to GM-CSF+TNF alpha","volume":"184","author":"Caux","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.leukres.2006.11.007_bib23","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1002\/eji.1830270213","article-title":"Differentiation of human dendritic cells from monocytes in vitro","volume":"27","author":"Chapuis","year":"1997","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.leukres.2006.11.007_bib24","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1016\/j.jim.2003.12.006","article-title":"A flow cytometric method for determination of absolute counts of myeloid precursor dendritic cells in peripheral blood","volume":"285","author":"Ma","year":"2004","journal-title":"J Immunol Meth"},{"key":"10.1016\/j.leukres.2006.11.007_bib25","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1046\/j.1365-2141.1999.01781.x","article-title":"Phenotypic and functional characteristics of monocyte-derived dendritic cells from patients with myelodysplastic syndromes","volume":"107","author":"Rigolin","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.11.007_bib26","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1016\/j.clim.2004.08.007","article-title":"Defective tumor necrosis factor alpha-induced maturation of monocyte-derived dendritic cells in patients with myelodysplastic syndromes","volume":"113","author":"Micheva","year":"2004","journal-title":"Clin Immunol"},{"key":"10.1016\/j.leukres.2006.11.007_bib27","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1111\/j.1365-2141.1982.tb08475.x","article-title":"Proposals for the classification of the myelodysplastic syndromes","volume":"51","author":"Bennett","year":"1982","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.11.007_bib28","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1002\/eji.1830210203","article-title":"Immobilized anti-CD5 together with prolonged activation of protein kinase C induce interleukin 2-dependent T cell growth: evidence for signal transduction through CD5","volume":"21","author":"Vandenberghe","year":"1991","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.leukres.2006.11.007_bib29","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1046\/j.1365-2141.1999.01431.x","article-title":"Dendritic cells in chronic myelomonocytic leukaemia","volume":"105","author":"Vuckovic","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2006.11.007_bib30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1046\/j.1365-2567.1999.00888.x","article-title":"Interaction of CTLA-4 (CD152) with CD80 or CD86 inhibits human T-cell activation","volume":"98","author":"Vandenborre","year":"1999","journal-title":"Immunology"},{"key":"10.1016\/j.leukres.2006.11.007_bib31","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1093\/intimm\/13.2.181","article-title":"Effects of co-stimulation by CD58 on human T cell cytokine production: a selective cytokine pattern with induction of high IL-10 production","volume":"13","author":"Bullens","year":"2001","journal-title":"Int Immunol"},{"key":"10.1016\/j.leukres.2006.11.007_bib32","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/79758","article-title":"Kinetics of dendritic cell activation: impact on priming of TH1 TH2 and nonpolarized T cells","volume":"1","author":"Langenkamp","year":"2000","journal-title":"Nat Immunol"},{"key":"10.1016\/j.leukres.2006.11.007_bib33","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1002\/(SICI)1096-8652(199901)60:1<36::AID-AJH7>3.0.CO;2-#","article-title":"Evidence for involvement of tumor necrosis factor-alpha in apoptotic death of bone marrow cells in myelodysplastic syndromes","volume":"60","author":"Mundle","year":"1999","journal-title":"Am J Hematol"},{"key":"10.1016\/j.leukres.2006.11.007_bib34","first-page":"1268","article-title":"Measurement of serum cytokine levels in patients with myelodysplastic syndromes","volume":"6","author":"Verhoef","year":"1992","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.11.007_bib35","doi-asserted-by":"crossref","first-page":"354","DOI":"10.1038\/sj.leu.2403634","article-title":"Dendritic cells in MDS and AML\u2014cause, effect or solution to the immune pathogenesis of disease?","volume":"19","author":"Panoskaltsis","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2006.11.007_bib36","doi-asserted-by":"crossref","DOI":"10.1007\/s00262-004-0657-y","article-title":"Serum-free generation and quantification of functionally active Leukemia-derived DC is possible from malignant blasts in acute myeloid leukemia and myelodysplastic syndromes","author":"Kufner","year":"2005","journal-title":"Cancer Immunol Immunother"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212606004528?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212606004528?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:56:15Z","timestamp":1758934575000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212606004528"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,10]]},"references-count":36,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2007,10]]}},"alternative-id":["S0145212606004528"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2006.11.007","relation":{},"ISSN":["0145-2126"],"issn-type":[{"type":"print","value":"0145-2126"}],"subject":[],"published":{"date-parts":[[2007,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immature and mature monocyte-derived dendritic cells in myelodysplastic syndromes of subtypes refractory anemia or refractory anemia with ringed sideroblasts display an altered cytokine profile","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2006.11.007","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2006 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}