{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,24]],"date-time":"2025-09-24T10:19:19Z","timestamp":1758709159259},"reference-count":35,"publisher":"Elsevier BV","issue":"1","license":[{"start":{"date-parts":[[2008,1,1]],"date-time":"2008-01-01T00:00:00Z","timestamp":1199145600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2008,1]]},"DOI":"10.1016\/j.leukres.2007.05.021","type":"journal-article","created":{"date-parts":[[2007,7,17]],"date-time":"2007-07-17T11:18:31Z","timestamp":1184671111000},"page":"79-88","source":"Crossref","is-referenced-by-count":8,"title":["Cyclin D1 positive multiple myeloma: Predominance of the short, 3\u2032UTR-deficient transcript is associated with high cyclin D1 mRNA levels in cases with t(11;14) translocation, but does not correlate with proliferation rate or genomic deletions"],"prefix":"10.1016","volume":"32","author":[{"given":"Julia","family":"Slotta-Huspenina","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ina","family":"Koch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manfred","family":"Richter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karin","family":"Bink","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcus","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katja","family":"Specht","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Krugmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Quintanilla-Martinez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Falko","family":"Fend","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2007.05.021_bib1","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1182\/blood-2005-01-0034","article-title":"Cyclin D dysregulation: an early and unifying pathogenic event in multiple myeloma","volume":"106","author":"Bergsagel","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.05.021_bib2","first-page":"115","article-title":"Mantle cell lymphoma","volume":"36","author":"Campo","year":"1999","journal-title":"Semin Hematol"},{"key":"10.1016\/j.leukres.2007.05.021_bib3","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1002\/ijc.20907","article-title":"The enigmatic role of cyclin D1 in multiple myeloma","volume":"115","author":"Lesage","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.leukres.2007.05.021_bib4","doi-asserted-by":"crossref","first-page":"1588","DOI":"10.1182\/blood-2002-12-3789","article-title":"Cyclin D1 overexpression is a favorable prognostic variable for newly diagnosed multiple myeloma patients treated with high-dose chemotherapy and single or double autologous transplantation","volume":"102","author":"Soverini","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.05.021_bib5","doi-asserted-by":"crossref","first-page":"1120","DOI":"10.1182\/blood-2003-11-3837","article-title":"Different mechanisms of cyclin D1 overexpression in multiple myeloma revealed by fluorescence in situ hybridization and quantitative analysis of mRNA levels","volume":"104","author":"Specht","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.05.021_bib6","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1034\/j.1600-065X.2003.00052.x","article-title":"Critical roles for immunoglobulin translocations and cyclin D dysregulation in multiple myeloma","volume":"194","author":"Bergsagel","year":"2003","journal-title":"Immunol Rev"},{"key":"10.1016\/j.leukres.2007.05.021_bib7","doi-asserted-by":"crossref","first-page":"1546","DOI":"10.1158\/0008-5472.CAN-03-2876","article-title":"Genetics and cytogenetics of multiple myeloma: a workshop report","volume":"64","author":"Fonseca","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2007.05.021_bib8","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/S0165-4608(94)00211-8","article-title":"Molecular breakpoints of t(11;14)(q13;q32) in multiple myeloma","volume":"83","author":"Meeus","year":"1995","journal-title":"Cancer Genet Cytogenet"},{"key":"10.1016\/j.leukres.2007.05.021_bib9","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1002\/gcc.2870080204","article-title":"Expanded range of 11q13 breakpoints with differing patterns of cyclin D1 expression in B-cell malignancies","volume":"8","author":"Raynaud","year":"1993","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.leukres.2007.05.021_bib10","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1182\/blood.V93.4.1330","article-title":"Molecular analysis of 11q13 breakpoints in multiple myeloma","volume":"93","author":"Ronchetti","year":"1999","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.05.021_bib11","doi-asserted-by":"crossref","first-page":"7296","DOI":"10.1200\/JCO.2005.01.3870","article-title":"Molecular classification of multiple myeloma: a distinct transcriptional profile characterizes patients expressing CCND1 and negative for 14q32 translocations","volume":"23","author":"Agnelli","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.leukres.2007.05.021_bib12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/S0968-0004(00)89005-2","article-title":"D-type cyclins","volume":"20","author":"Sherr","year":"1995","journal-title":"Trends Biochem Sci"},{"key":"10.1016\/j.leukres.2007.05.021_bib13","doi-asserted-by":"crossref","first-page":"2699","DOI":"10.1101\/gad.1256504","article-title":"Living with or without cyclins and cyclin-dependent kinases","volume":"18","author":"Sherr","year":"2004","journal-title":"Genes Dev"},{"key":"10.1016\/j.leukres.2007.05.021_bib14","doi-asserted-by":"crossref","first-page":"2124","DOI":"10.1002\/j.1460-2075.1994.tb06488.x","article-title":"Cyclin D1 transgene impedes lymphocyte maturation and collaborates in lymphomagenesis with the myc gene","volume":"13","author":"Bodrug","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.leukres.2007.05.021_bib15","doi-asserted-by":"crossref","first-page":"3487","DOI":"10.1002\/j.1460-2075.1994.tb06655.x","article-title":"Cyclin D1\/bcl-1 cooperates with myc genes in the generation of B-cell lymphoma in transgenic mice","volume":"13","author":"Lovec","year":"1994","journal-title":"EMBO J"},{"key":"10.1016\/j.leukres.2007.05.021_bib16","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1182\/blood-2002-03-0749","article-title":"Recurrent 14q32 translocations determine the prognosis of multiple myeloma, especially in patients receiving intensive chemotherapy","volume":"100","author":"Moreau","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.05.021_bib17","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1182\/blood.V83.12.3689.3689","article-title":"Rearrangement of CCND1 (BCL1\/PRAD1) 3\u2032 untranslated region in mantle-cell lymphomas and t(11q13)-associated leukemias","volume":"83","author":"Rimokh","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.05.021_bib18","first-page":"1401","article-title":"Gene rearrangement and overexpression of PRAD1 in lymphoid malignancy with t(11;14)(q13;q32) translocation","volume":"7","author":"Seto","year":"1992","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2007.05.021_bib19","doi-asserted-by":"crossref","first-page":"7903","DOI":"10.1128\/MCB.20.21.7903-7913.2000","article-title":"Down-regulation of cyclin D1 expression by prostaglandin A(2) is mediated by enhanced cyclin D1 mRNA turnover","volume":"20","author":"Lin","year":"2000","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.leukres.2007.05.021_bib20","doi-asserted-by":"crossref","first-page":"2726","DOI":"10.1182\/blood.V84.8.2726.2726","article-title":"PRAD-1\/cyclin D1 gene overexpression in chronic lymphoproliferative disorders: a highly specific marker of mantle cell lymphoma","volume":"84","author":"Bosch","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.05.021_bib21","doi-asserted-by":"crossref","first-page":"4599","DOI":"10.1182\/blood-2006-08-039859","article-title":"Point mutations and genomic deletions in Cyclin D1 create stable truncated mRNAs that are associated with increased proliferation rate and shorter survival in mantle cell lymphoma","volume":"109","author":"Wiestner","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.05.021_bib22","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1016\/S1535-6108(03)00028-X","article-title":"The proliferation gene expression signature is a quantitative integrator of oncogenic events that predicts survival in mantle cell lymphoma","volume":"3","author":"Rosenwald","year":"2003","journal-title":"Cancer Cell"},{"key":"10.1016\/j.leukres.2007.05.021_bib23","first-page":"2902","article-title":"Identification of cyclin D1 mRNA overexpression in B-cell neoplasias by real-time reverse transcription-PCR of microdissected paraffin sections","volume":"8","author":"Specht","year":"2002","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.leukres.2007.05.021_bib24","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.1016\/S0002-9440(10)64278-2","article-title":"Analysis of signal transducer and activator of transcription 3 (Stat 3) pathway in multiple myeloma: Stat 3 activation and cyclin D1 dysregulation are mutually exclusive events","volume":"162","author":"Quintanilla-Martinez","year":"2003","journal-title":"Am J Pathol"},{"key":"10.1016\/j.leukres.2007.05.021_bib25","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1093\/ajcp\/87.3.342","article-title":"Histologic classification and staging of multiple myeloma. A retrospective and prospective study of 674 cases","volume":"87","author":"Bartl","year":"1987","journal-title":"Am J Clin Pathol"},{"key":"10.1016\/j.leukres.2007.05.021_bib26","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/01.pdm.0000213450.99655.54","article-title":"Real-time quantitative RT-PCR shows variable, assay-dependent sensitivity to formalin fixation: implications for direct comparison of transcript levels in paraffin-embedded tissues","volume":"15","author":"Koch","year":"2006","journal-title":"Diagn Mol Pathol"},{"key":"10.1016\/j.leukres.2007.05.021_bib27","doi-asserted-by":"crossref","first-page":"1505","DOI":"10.1016\/S0002-9440(10)65022-5","article-title":"Immunohistochemical analysis of cyclin D1 shows deregulated expression in multiple myeloma with the t(11;14)","volume":"156","author":"Pruneri","year":"2000","journal-title":"Am J Pathol"},{"key":"10.1016\/j.leukres.2007.05.021_bib28","first-page":"1925","article-title":"A truncated cyclin D1 gene encodes a stable mRNA in a human breast cancer cell line","volume":"9","author":"Lebwohl","year":"1994","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2007.05.021_bib29","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.semcdb.2004.11.008","article-title":"The role of the AU-rich elements of mRNAs in controlling translation","volume":"16","author":"Espel","year":"2005","journal-title":"Semin Cell Dev Biol"},{"key":"10.1016\/j.leukres.2007.05.021_bib30","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1002\/ijc.21166","article-title":"Mantle cell lymphomas with low levels of cyclin D1 long mRNA transcripts are highly proliferative and can be discriminated by elevated cyclin A2 and cyclin B1","volume":"117","author":"Sander","year":"2005","journal-title":"Int J Cancer"},{"key":"10.1016\/j.leukres.2007.05.021_bib31","doi-asserted-by":"crossref","first-page":"11345","DOI":"10.1158\/0008-5472.CAN-05-2159","article-title":"Mutually exclusive cyclin-dependent kinase 4\/cyclin D1 and cyclin-dependent kinase 6\/cyclin D2 pairing inactivates retinoblastoma protein and promotes cell cycle dysregulation in multiple myeloma","volume":"65","author":"Ely","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2007.05.021_bib32","doi-asserted-by":"crossref","first-page":"4569","DOI":"10.1182\/blood-2002-10-3017","article-title":"Clinical and biologic implications of recurrent genomic aberrations in myeloma","volume":"101","author":"Fonseca","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.05.021_bib33","doi-asserted-by":"crossref","first-page":"1323","DOI":"10.1046\/j.1365-2141.1998.00911.x","article-title":"Establishment and characterization of a mantle cell lymphoma cell line","volume":"102","author":"Jeon","year":"1998","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2007.05.021_bib34","first-page":"7056","article-title":"An alternatively spliced cyclin D1 isoform, cyclin D1b, is a nuclear oncogene","volume":"63","author":"Lu","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2007.05.021_bib35","doi-asserted-by":"crossref","first-page":"30339","DOI":"10.1074\/jbc.M303969200","article-title":"Cyclin D1 splice variants: differential effects on localization, RB phosphorylation, and cellular transformation","volume":"278","author":"Solomon","year":"2003","journal-title":"J Biol Chem"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212607002408?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212607002408?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T04:49:57Z","timestamp":1587790197000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212607002408"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,1]]},"references-count":35,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2008,1]]}},"alternative-id":["S0145212607002408"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2007.05.021","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2008,1]]}}}