{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T05:22:47Z","timestamp":1791264167123,"version":"4.1.0"},"reference-count":27,"publisher":"Elsevier BV","issue":"3","license":[{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2008,3,1]],"date-time":"2008-03-01T00:00:00Z","timestamp":1204329600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2008,3]]},"DOI":"10.1016\/j.leukres.2007.07.011","type":"journal-article","created":{"date-parts":[[2007,8,24]],"date-time":"2007-08-24T08:05:32Z","timestamp":1187942732000},"page":"369-377","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"title":["Most pediatric patients with essential thrombocythemia show hypersensitivity to erythropoietin in vitro, with rare JAK2 V617F-positive erythroid colonies"],"prefix":"10.1016","volume":"32","author":[{"given":"Jitka","family":"Veselovska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar","family":"Pospisilova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sona","family":"Pekova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Horvathova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Solna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Cmejlova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radek","family":"Cmejla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monika","family":"Belickova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Mihal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Stary","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir","family":"Divoky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2007.07.011_bib1","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1365-2141.2004.05329.x","article-title":"Primary and secondary thrombocytosis in childhood","volume":"129","author":"Dame Ch","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2007.07.011_bib2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.blre.2004.02.002","article-title":"Molecular pathogenesis of Philadelphia chromosome negative myeloproliferative disorders","volume":"19","author":"Kralovics","year":"2005","journal-title":"Blood Rev"},{"key":"10.1016\/j.leukres.2007.07.011_bib3","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1056\/NEJMoa051113","article-title":"A gain-of-function mutation of JAK2 in myeloproliferative disorders","volume":"352","author":"Kralovics","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2007.07.011_bib4","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(05)71142-9","article-title":"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders","volume":"365","author":"Baxter","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.leukres.2007.07.011_bib5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccr.2005.03.023","article-title":"Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis","volume":"7","author":"Levine","year":"2005","journal-title":"Cancer Cell"},{"key":"10.1016\/j.leukres.2007.07.011_bib6","doi-asserted-by":"crossref","first-page":"1865","DOI":"10.1182\/blood-2006-01-013540","article-title":"The JAK2-V617F mutation is frequently present at diagnosis in patients with essential thrombocythemia and polycythemia vera","volume":"108","author":"Lippert","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.07.011_bib7","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1182\/blood-2005-11-009605","article-title":"Acquisition of the V617F mutation of JAK2 is a late genetic event in a subset of patients with myeloproliferative disorders","volume":"108","author":"Kralovics","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.07.011_bib8","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.exphem.2006.11.012","article-title":"Polycythemia vera is not initiated by JAK2V617F mutation","volume":"35","author":"Nussenzveig","year":"2007","journal-title":"Exp Hematol"},{"key":"10.1016\/j.leukres.2007.07.011_bib9","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3109\/10428199809050941","article-title":"Clonality analysis of hematopoiesis and thrombopoietin levels in patients with essential thrombocythemia","volume":"30","author":"El-Kassar","year":"1998","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.leukres.2007.07.011_bib10","doi-asserted-by":"crossref","first-page":"3600","DOI":"10.1182\/blood-2006-04-014746","article-title":"Pediatric patients with essential thrombocythemia are mostly polyclonal and V617FJAK2 negative","volume":"108","author":"Randi","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.07.011_bib11","first-page":"29","article-title":"Experience of the polycythemia vera study group with essential thrombocythemia: a final report of diagnostic criteria, survival and leukemic transition by treatment","volume":"34","author":"Murphy","year":"1997","journal-title":"Semin Hematol"},{"key":"10.1016\/j.leukres.2007.07.011_bib12","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1159\/000100906","article-title":"Endogenous erythropoietin levels and anemia in long-term renal transplant recipients","volume":"30","author":"Zadrazil","year":"2007","journal-title":"Kidney Blood Press Res"},{"key":"10.1016\/j.leukres.2007.07.011_bib13","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1046\/j.1365-2141.1999.01641.x","article-title":"Age-related changes in thrombopoietin in children: reference interval for serum thrombopoietin levels","volume":"106","author":"Ishiguro","year":"1999","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2007.07.011_bib14","first-page":"1391","article-title":"Elevated thrombopoietin levels and alterations in the sequence of its receptor c-Mpl in patients with Diamond\u2013Blackfan anaemia","volume":"89","author":"Pospisilova","year":"2004","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2007.07.011_bib15","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1111\/j.1600-0609.1996.tb01376.x","article-title":"Benign erythrocytosis and other familial and congenital polycythaemias","volume":"57","author":"Prchal","year":"1996","journal-title":"Eur J Haematol"},{"key":"10.1016\/j.leukres.2007.07.011_bib16","doi-asserted-by":"crossref","first-page":"590","DOI":"10.1038\/274590a0","article-title":"A common progenitor for human myeloid and lymphoid cells","volume":"274","author":"Prchal","year":"1978","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2007.07.011_bib17","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1016\/S0140-6736(05)67785-9","article-title":"Definition of subtypes of essential thrombocythaemia and relation to polycythaemia vera based on JAK2 V617F mutation status: a prospective study","volume":"366","author":"Campbell","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.leukres.2007.07.011_bib18","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.leukres.2004.08.008","article-title":"The presence of clonal cell subpopulations in peripheral blood and bone marrow of patients with refractory cytopenia with multilineage dysplasia but not in patients with refractory anemia may reflect a multistep pathogenesis of myelodysplasia","volume":"29","author":"Cermak","year":"2005","journal-title":"Leuk Res"},{"key":"10.1016\/j.leukres.2007.07.011_bib19","doi-asserted-by":"crossref","first-page":"744","DOI":"10.1182\/blood.V83.3.744.744","article-title":"Identification of masked polycythemia vera from patients with idiopathic marked thrombocytosis by endogenous erythroid colony assay","volume":"83","author":"Shih","year":"1994","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.07.011_bib20","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1182\/blood-2006-10-054940","article-title":"The JAK2 V617F mutation triggers erythropoietin hypersensitivity and terminal erythroid amplification in primary cells from patients with polycythemia vera","volume":"110","author":"Dupont","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.07.011_bib21","doi-asserted-by":"crossref","unstructured":"Pospisilova D, Mihal V, Votava T, Hak J, Ptoszkova H, Blatny J, et al. Essential thrombocythemia in children in the Czech Republic. Leuk Res 2006;30(Suppl 2):S1 (abstract).","DOI":"10.1016\/S0145-2126(06)80008-1"},{"key":"10.1016\/j.leukres.2007.07.011_bib22","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1182\/blood-2005-12-4852","article-title":"Genetic and clinical implications of the Val617Phe JAK2 mutation in 72 families with myeloproliferative disorders","volume":"108","author":"Bellanne-Chantelot","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.07.011_bib23","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1002\/cncr.22240","article-title":"JAK2 (V617F) as an acquired somatic mutation and a secondary genetic event associated with disease progression in familial myeloproliferative disorders","volume":"107","author":"Rumi","year":"2006","journal-title":"Cancer"},{"key":"10.1016\/j.leukres.2007.07.011_bib24","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1182\/blood-2006-04-018259","article-title":"Progenitors homozygous for the V617F mutation occur in most patients with polycythemia vera, but not essential thrombocythemia","volume":"108","author":"Scott","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.07.011_bib25","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1038\/sj.leu.2403902","article-title":"Clinical implications of the JAK2 V617F mutation in essential thrombocythemia","volume":"19","author":"Antonioli","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2007.07.011_bib26","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1182\/blood-2006-12-064287","article-title":"Clinical profile of homozygous JAK2V617F mutation in patients with polycythemia vera or essential thrombocythemia","volume":"110","author":"Vannucchi","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2007.07.011_bib27","doi-asserted-by":"crossref","first-page":"3548","DOI":"10.1182\/blood-2005-12-013748","article-title":"Mutation of JAK2 in the myeloproliferative disorders: timing, clonality studies, cytogenetic associations and role in leukemic transformation","volume":"108","author":"Campbell","year":"2006","journal-title":"Blood"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212607002962?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212607002962?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:56:22Z","timestamp":1758934582000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212607002962"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,3]]},"references-count":27,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2008,3]]}},"alternative-id":["S0145212607002962"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2007.07.011","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2008,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Most pediatric patients with essential thrombocythemia show hypersensitivity to erythropoietin in vitro, with rare JAK2 V617F-positive erythroid colonies","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2007.07.011","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2007 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}