{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:00:18Z","timestamp":1761058818346},"reference-count":21,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2008,9,1]],"date-time":"2008-09-01T00:00:00Z","timestamp":1220227200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2008,9]]},"DOI":"10.1016\/j.leukres.2008.02.012","type":"journal-article","created":{"date-parts":[[2008,4,3]],"date-time":"2008-04-03T12:13:13Z","timestamp":1207224793000},"page":"1358-1365","source":"Crossref","is-referenced-by-count":19,"title":["KIS induces proliferation and the cell cycle progression through the phosphorylation of p27Kip1 in leukemia cells"],"prefix":"10.1016","volume":"32","author":[{"given":"Satoki","family":"Nakamura","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiji","family":"Okinaka","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isao","family":"Hirano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takaaki","family":"Ono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuya","family":"Sugimoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyuki","family":"Shigeno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shinya","family":"Fujisawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaori","family":"Shinjo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazunori","family":"Ohnishi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2008.02.012_bib1","doi-asserted-by":"crossref","first-page":"1501","DOI":"10.1101\/gad.13.12.1501","article-title":"CDK inhibitors: positive and negative regulators of G1-phase progression","volume":"13","author":"Sherr","year":"1999","journal-title":"Genes Dev"},{"key":"10.1016\/j.leukres.2008.02.012_bib2","first-page":"1259","article-title":"The cell cycle inhibitor p27 is an independent prognostic marker in small (T1a, b) invasive breast carcinomas","volume":"57","author":"Tan","year":"1997","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2008.02.012_bib3","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1038\/nm0297-227","article-title":"Decreased levels of the cell-cycle inhibitor p27Kip1 protein: prognostic implications in primary breast cancer","volume":"3","author":"Catzavelos","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.leukres.2008.02.012_bib4","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.1073\/pnas.94.12.6380","article-title":"High level expression of p27(Kip1) and cyclin D1 in some human breast cells: inverse correlation between the expression of p27(Kip1) and degree of malignancy in human breast and colorectal cancers","volume":"94","author":"Fredersdorf","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2008.02.012_bib5","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1038\/nm0297-231","article-title":"Increased proteasome-dependent degradation of the cyclin-dependent kinase inhibitor p27 in aggressive colorectal cancers","volume":"3","author":"Loda","year":"1997","journal-title":"Nat Med"},{"key":"10.1016\/j.leukres.2008.02.012_bib6","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1038\/sj.leu.2401640","article-title":"Prognostic significance of the cell cycle inhibitor p27Kip1 in acute myeloid leukemia","volume":"14","author":"Yokozawa","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2008.02.012_bib7","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1182\/blood.V95.2.619","article-title":"Increased proteasome degradation of cyclin-dependent kinase inhibitor p27 is associated with a decreased overall survival in mantle cell lymphoma","volume":"95","author":"Chiarle","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2008.02.012_bib8","doi-asserted-by":"crossref","first-page":"5225","DOI":"10.1158\/0008-5472.CAN-04-0174","article-title":"Cytoplasmic mislocalization of p27Kip1 protein is associated with constitutive phosphorylation of Akt or protein kinase B and poor prognosis in acute myelogenous leukemia","volume":"64","author":"Min","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2008.02.012_bib9","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1002\/gcc.2870080402","article-title":"Cytogenetic deletion maps of hematologic neoplasms: circumstantial evidence for tumor suppressor loci","volume":"8","author":"Johansson","year":"1993","journal-title":"Genes Chromosome Cancer"},{"key":"10.1016\/j.leukres.2008.02.012_bib10","doi-asserted-by":"crossref","first-page":"3368","DOI":"10.1182\/blood.V87.8.3368.bloodjournal8783368","article-title":"Acute lymphoblastic leukemia of childhood: identification of two distinct regions of deletion on the short arm of chromosome 12 in the region of TEL and KIP1","volume":"87","author":"Takeuchi","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2008.02.012_bib11","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1126\/science.7624798","article-title":"Role of the ubiquitin\u2013proteasome pathway in regulating abundance of the cyclin-dependent kinase inhibitor p27","volume":"269","author":"Pagano","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.leukres.2008.02.012_bib12","doi-asserted-by":"crossref","first-page":"25146","DOI":"10.1074\/jbc.M001144200","article-title":"Phosphorylation at serine 10, a major phosphorylation site of p27(Kip1), increases its protein stability","volume":"275","author":"Ishida","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2008.02.012_bib13","doi-asserted-by":"crossref","first-page":"3390","DOI":"10.1093\/emboj\/cdf343","article-title":"A growth factor-dependent nuclear kinase phosphorylates p27(Kip1) and regulates cell cycle progression","volume":"21","author":"Boehm","year":"2002","journal-title":"EMBO J"},{"key":"10.1016\/j.leukres.2008.02.012_bib14","doi-asserted-by":"crossref","first-page":"32413","DOI":"10.1074\/jbc.C200311200","article-title":"Jab1 co-activation of c-Jun is abrogated by the serine 10-phosphorylated form of p27Kip1","volume":"277","author":"Chopra","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2008.02.012_bib15","doi-asserted-by":"crossref","first-page":"14355","DOI":"10.1074\/jbc.C100762200","article-title":"Phosphorylation of p27Kip1 on serine 10 is required for its binding to CRM1 and nuclear export","volume":"277","author":"Ishida","year":"2002","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2008.02.012_bib16","doi-asserted-by":"crossref","first-page":"6672","DOI":"10.1093\/emboj\/20.23.6672","article-title":"p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis","volume":"20","author":"Rodier","year":"2001","journal-title":"EMBO J"},{"key":"10.1016\/j.leukres.2008.02.012_bib17","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1038\/nbt0502-497","article-title":"U6 promoter-driven siRNAs with four uridine 3\u2032 overhangs efficiently suppress targeted gene expression in mammalian cells","volume":"20","author":"Miyagishi","year":"2002","journal-title":"Nat Biotechnol"},{"key":"10.1016\/j.leukres.2008.02.012_bib18","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/(SICI)1097-4652(200004)183:1<10::AID-JCP2>3.0.CO;2-I","article-title":"Regulation of cdk inhibitor p27 and its deregulation in cancer","volume":"183","author":"Slingerland","year":"2000","journal-title":"J Cell Physiol"},{"key":"10.1016\/j.leukres.2008.02.012_bib19","doi-asserted-by":"crossref","first-page":"6641","DOI":"10.1128\/JVI.71.9.6641-6649.1997","article-title":"Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector","volume":"71","author":"Blomer","year":"1997","journal-title":"J Virol"},{"key":"10.1016\/j.leukres.2008.02.012_bib20","doi-asserted-by":"crossref","first-page":"394","DOI":"10.4161\/cc.1.6.263","article-title":"Understanding p27Kip1 deregulation in cancer: down-regulation or mislocalization","volume":"1","author":"Viglietto","year":"2002","journal-title":"Cell Cycle"},{"key":"10.1016\/j.leukres.2008.02.012_bib21","doi-asserted-by":"crossref","first-page":"1074","DOI":"10.4161\/cc.3.8.1073","article-title":"Akt-dependent T198 phosphorylation of cyclin-dependent kinase inhibitor p27Kip1 in breast cancer","volume":"3","author":"Motti","year":"2004","journal-title":"Cell Cycle"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521260800091X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521260800091X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,3]],"date-time":"2020-05-03T18:43:35Z","timestamp":1588531415000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014521260800091X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,9]]},"references-count":21,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2008,9]]}},"alternative-id":["S014521260800091X"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2008.02.012","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2008,9]]}}}