{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T18:12:43Z","timestamp":1759342363175},"reference-count":33,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.leukres.2008.02.023","type":"journal-article","created":{"date-parts":[[2008,4,16]],"date-time":"2008-04-16T13:29:30Z","timestamp":1208352570000},"page":"1779-1783","source":"Crossref","is-referenced-by-count":9,"title":["Improvement of cardiac function, mitral regurgitation and pulmonary hypertension in a patient with chronic eosinophilic leukemia (CEL) after low dose imatinib therapy"],"prefix":"10.1016","volume":"32","author":[{"given":"Maria-Theresa","family":"Krauth","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Binder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leopold","family":"\u00d6hler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"J\u00e4ger","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Valent","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2008.02.023_bib1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.7326\/0003-4819-97-1-78","article-title":"NIH conference. The idiopathic hypereosinophilic syndrome. Clinical, pathophysiologic, and therapeutic considerations","volume":"97","author":"Fauci","year":"1982","journal-title":"Ann Intern Med"},{"key":"10.1016\/j.leukres.2008.02.023_bib2","first-page":"2","article-title":"Eosinophilic leukaemias and the idiopathic hypereosinophilic syndrome","volume":"95","author":"Bain","year":"1996","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2008.02.023_bib3","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1016\/j.jaci.2007.02.010","article-title":"Eosinophilic disorders","volume":"119","author":"Simon","year":"2007","journal-title":"Allergy Clin Immunol"},{"key":"10.1016\/j.leukres.2008.02.023_bib4","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1016\/j.beha.2005.07.013","article-title":"Eosinophilic disorders: molecular pathogenesis, new classification, and modern therapy","volume":"19","author":"Gotlib","year":"2006","journal-title":"Best Pract Res Clin Haematol"},{"key":"10.1016\/j.leukres.2008.02.023_bib5","series-title":"World Health Organization classification of tumours: pathology and genetics of tumours of haematopoietic and lymphoid tissues","first-page":"29","article-title":"Chronic eosinophilic leukaemia and the hypereosinophilic syndrome","author":"Bain","year":"2001"},{"key":"10.1016\/j.leukres.2008.02.023_bib6","doi-asserted-by":"crossref","first-page":"2879","DOI":"10.1182\/blood-2003-06-1824","article-title":"The FIP1L1-PDGFRalpha fusion tyrosine kinase in hypereosinophilic syndrome and chronic eosinophilic leukemia: implications for diagnosis, classification, and management","volume":"103","author":"Gotlib","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2008.02.023_bib7","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1159\/000085562","article-title":"Modern diagnosis and treatment of primary eosinophilia","volume":"114","author":"Tefferi","year":"2005","journal-title":"Acta Haematol"},{"key":"10.1016\/j.leukres.2008.02.023_bib8","first-page":"177","article-title":"Detection of the FIP1L1-PDGFRA fusion in idiopathic hypereosinophilic syndrome and chronic eosinophilic leukemia","volume":"125","author":"Cools","year":"2006","journal-title":"Methods Mol Med"},{"key":"10.1016\/j.leukres.2008.02.023_bib9","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1111\/j.1365-2141.2006.06038.x","article-title":"Eosinophilia: secondary, clonal and idiopathic","volume":"133","author":"Tefferi","year":"2006","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2008.02.023_bib10","doi-asserted-by":"crossref","first-page":"8078","DOI":"10.1073\/pnas.0601192103","article-title":"Activation of FIP1L1-PDGFRalpha requires disruption of the juxtamembrane domain of PDGFRalpha and is FIP1L1-independent","volume":"103","author":"Stover","year":"2006","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2008.02.023_bib11","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/j.1365-2141.2005.05863.x","article-title":"Multilineage involvement of the fusion gene in patients with FIP1L1\/PDGFRA-positive hypereosinophilic syndrome","volume":"132","author":"Robyn","year":"2006","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2008.02.023_bib12","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1056\/NEJMoa025217","article-title":"A tyrosine kinase created by fusion of the PDGFRA and FIP1L1 genes as a therapeutic target of imatinib in idiopathic hypereosinophilic syndrome","volume":"348","author":"Cools","year":"2003","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2008.02.023_bib13","first-page":"236","article-title":"Imatinib mesylate can induce complete molecular remission in FIP1L1-PDGFR-a positive idiopathic hypereosinophilic syndrome","volume":"89","author":"Martinelli","year":"2004","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2008.02.023_bib14","doi-asserted-by":"crossref","first-page":"4635","DOI":"10.1182\/blood-2006-10-050054","article-title":"Low-dose imatinib mesylate leads to rapid induction of major molecular responses and achievement of complete molecular remission in FIP1L1-PDGFRA-positive chronic eosinophilic leukemia","volume":"109","author":"Jovanovic","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2008.02.023_bib15","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.3324\/haematol.11420","article-title":"The efficacy of imatinib mesylate in patients with FIP1L1-PDGFRalpha-positive hypereosinophilic syndrome. Results of a multicenter prospective study","volume":"92","author":"Baccarani","year":"2007","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2008.02.023_bib16","first-page":"651","article-title":"AlphaIFN-induced hematologic and cytogenetic remission in chronic eosinophilic leukemia with t(1;5)","volume":"84","author":"Luciano","year":"1999","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2008.02.023_bib17","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1007\/s002770050018","article-title":"Complete haematological and cytogenetic response to interferon alpha-2a of a myeloproliferative disorder with eosinophilia associated with a unique t(4;7) aberration","volume":"79","author":"Sch\u00f6ffski","year":"2000","journal-title":"Ann Hematol"},{"key":"10.1016\/j.leukres.2008.02.023_bib18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.iac.2007.06.003","article-title":"Treatment of hypereosinophilic syndromes with prednisone, hydroxyurea, and interferon","volume":"27","author":"Butterfield","year":"2007","journal-title":"Immunol Allergy Clin N Am"},{"key":"10.1016\/j.leukres.2008.02.023_bib19","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1038\/nm1446","article-title":"Cardiotoxicity of the cancer therapeutic agent imatinib mesylate","volume":"12","author":"Kerkel\u00e4","year":"2006","journal-title":"Nat Med"},{"key":"10.1016\/j.leukres.2008.02.023_bib20","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/nm0107-15a","article-title":"In reply to cardiotoxicity of the cancer therapeutic agent imatinib mesylate","volume":"13","author":"Rosti","year":"2007","journal-title":"Nat Med"},{"key":"10.1016\/j.leukres.2008.02.023_bib21","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1182\/blood-2007-01-070144","article-title":"Congestive heart failure is a rare event in patients receiving imatinib therapy","volume":"110","author":"Atallah","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2008.02.023_bib22","doi-asserted-by":"crossref","first-page":"2828","DOI":"10.1182\/blood-2007-04-038943","article-title":"How I treat chronic myeloid leukemia in the imatinib era","volume":"110","author":"Goldman","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2008.02.023_bib23","unstructured":"Syed IS, Martinez MW, Feng DL, Glockner JF. Cardiac magnetic resonance imaging of eosinophilic endomyocardial disease. Int J Cardiol 2007; in press [Epub ahead of print]."},{"key":"10.1016\/j.leukres.2008.02.023_bib24","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.amjmed.2005.10.055","article-title":"Magnetic resonance imaging of the heart in a patient with hypereosinophilic syndrome","volume":"119","author":"Plastiras","year":"2006","journal-title":"Am J Med"},{"key":"10.1016\/j.leukres.2008.02.023_bib25","first-page":"726","article-title":"Unique presentation of hypereosinophilic syndrome: recurrent mitral prosthetic valve thrombosis without endomyocardial disease","volume":"15","author":"Janoskuti","year":"2006","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.leukres.2008.02.023_bib26","first-page":"721","article-title":"Obstructive prosthetic mitral valve thrombosis in idiopathic hypereosinophilic syndrome: a case report and review of the literature","volume":"15","author":"Hii","year":"2006","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.leukres.2008.02.023_bib27","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.0742-2822.2004.03061.x","article-title":"Rupture of chordae tendinae complicating mitral regurgitation in left-sided endomyocardial fibrosis: diagnosis by transesophageal echocardiography","volume":"21","author":"Campos","year":"2004","journal-title":"Echocardiography"},{"key":"10.1016\/j.leukres.2008.02.023_bib28","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1017\/S1047951102000136","article-title":"Multiple valvar replacements for hypereosinophilic syndrome","volume":"12","author":"Radford","year":"2002","journal-title":"Cardiol Young"},{"key":"10.1016\/j.leukres.2008.02.023_bib29","first-page":"447","article-title":"Recurrent thrombosis of prosthetic mitral valve in idiopathic hypereosinophilic syndrome","volume":"11","author":"Watanabe","year":"2002","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.leukres.2008.02.023_bib30","doi-asserted-by":"crossref","first-page":"1725","DOI":"10.1016\/S0003-4975(03)00689-1","article-title":"Hypereosinophilic thrombus causing aortic stenosis and myocardial infarction","volume":"76","author":"D'Souza","year":"2003","journal-title":"Ann Thorac Surg"},{"key":"10.1016\/j.leukres.2008.02.023_bib31","first-page":"529","article-title":"Mitral valve repair in idiopathic hypereosinophilic syndrome","volume":"13","author":"Fuzellier","year":"2004","journal-title":"J Heart Valve Dis"},{"key":"10.1016\/j.leukres.2008.02.023_bib32","first-page":"207","article-title":"Surgical treatment for L\u00f6ffler's endocarditis with left ventricular thrombus and severe mitral regurgitation: a case report","volume":"47","author":"Tanaka","year":"2006","journal-title":"J Cardiol"},{"key":"10.1016\/j.leukres.2008.02.023_bib33","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1097\/01.tp.0000251385.71296.27","article-title":"Heart transplantation in a patient with endomyocardial fibrosis due to hypereosinophilic syndrome","volume":"83","author":"Korczyk","year":"2007","journal-title":"Transplantation"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521260800101X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521260800101X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,30]],"date-time":"2018-12-30T02:29:02Z","timestamp":1546136942000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014521260800101X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":33,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S014521260800101X"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2008.02.023","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}