{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T12:31:27Z","timestamp":1793017887043,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2008,11,1]],"date-time":"2008-11-01T00:00:00Z","timestamp":1225497600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2008,11]]},"DOI":"10.1016\/j.leukres.2008.03.040","type":"journal-article","created":{"date-parts":[[2008,5,16]],"date-time":"2008-05-16T16:51:26Z","timestamp":1210956686000},"page":"1751-1755","source":"Crossref","is-referenced-by-count":32,"title":["FBXW7 mutation in adult T-cell and B-cell acute lymphocytic leukemias"],"prefix":"10.1016","volume":"32","author":[{"given":"Jee Hoon","family":"Song","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nikolai","family":"Schnittke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"April","family":"Zaat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine S.","family":"Walsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carl W.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2008.03.040_bib1","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1038\/35095068","article-title":"Archipelago regulates cyclin E levels in Drosophila and is mutated in human cancer cell lines","volume":"413","author":"Moberg","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2008.03.040_bib2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1126\/science.1065203","article-title":"Phosphorylation-dependent ubiquitination of cyclin E by the SCFFbw7 ubiquitin ligase","volume":"294","author":"Koepp","year":"2001","journal-title":"Science"},{"key":"10.1016\/j.leukres.2008.03.040_bib3","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1038\/35095076","article-title":"Human F-box protein hCdc4 targets cyclin E for proteolysis and is mutated in a breast cancer cell line","volume":"413","author":"Strohmaier","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2008.03.040_bib4","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.1038\/sj.emboj.7600217","article-title":"Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7","volume":"23","author":"Yada","year":"2004","journal-title":"EMBO J"},{"key":"10.1016\/j.leukres.2008.03.040_bib5","doi-asserted-by":"crossref","first-page":"1374","DOI":"10.1126\/science.1092880","article-title":"The ubiquitin ligase SCFFbw7 antagonizes apoptotic JNK signaling","volume":"303","author":"Nateri","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.leukres.2008.03.040_bib6","doi-asserted-by":"crossref","first-page":"7403","DOI":"10.1128\/MCB.21.21.7403-7415.2001","article-title":"SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation","volume":"21","author":"Wu","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.leukres.2008.03.040_bib7","doi-asserted-by":"crossref","first-page":"34371","DOI":"10.1074\/jbc.M101343200","article-title":"Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor","volume":"276","author":"Gupta-Rossi","year":"2001","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2008.03.040_bib8","first-page":"4535","article-title":"hCDC4 gene mutations in endometrial cancer","volume":"62","author":"Spruck","year":"2002","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2008.03.040_bib9","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1101\/gr.229102. Article published online before print in May 2002","article-title":"The human genome browser at UCSC","volume":"12","author":"Kent","year":"2002","journal-title":"Genome Res"},{"key":"10.1016\/j.leukres.2008.03.040_bib10","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.molcel.2006.05.020","article-title":"Ubiquitylation of cyclin E requires the sequential function of SCF complexes containing distinct hCdc4 isoforms","volume":"23","author":"van Drogen","year":"2006","journal-title":"Mol Cell"},{"key":"10.1016\/j.leukres.2008.03.040_bib11","doi-asserted-by":"crossref","first-page":"1923","DOI":"10.4161\/cc.5.17.3198","article-title":"Cooperation between different Cdc4\/Fbw7 isoforms may be associated with 2-step inactivation of SCF(Cdc4) targets","volume":"5","author":"Reed","year":"2006","journal-title":"Cell Cycle"},{"key":"10.1016\/j.leukres.2008.03.040_bib12","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/nature02313","article-title":"Inactivation of hCDC4 can cause chromosomal instability","volume":"428","author":"Rajagopalan","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2008.03.040_bib13","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nature03155","article-title":"Fbxw7\/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene","volume":"432","author":"Mao","year":"2004","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2008.03.040_bib14","doi-asserted-by":"crossref","first-page":"2369","DOI":"10.1016\/j.ejca.2005.10.034","article-title":"Mutational analysis of the hCDC4 gene in gastric carcinomas","volume":"42","author":"Lee","year":"2006","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.leukres.2008.03.040_bib15","doi-asserted-by":"crossref","first-page":"9006","DOI":"10.1158\/0008-5472.CAN-07-1320","article-title":"FBXW7\/hCDC4 is a general tumor suppressor in human cancer","volume":"67","author":"Akhoondi","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2008.03.040_bib16","doi-asserted-by":"crossref","first-page":"5611","DOI":"10.1158\/0008-5472.CAN-06-4381","article-title":"The tumor suppressor gene hCDC4 is frequently mutated in human T-cell acute lymphoblastic leukemia with functional consequences for Notch signaling","volume":"67","author":"Malyukova","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2008.03.040_bib17","doi-asserted-by":"crossref","first-page":"1813","DOI":"10.1084\/jem.20070876","article-title":"FBW7 mutations in leukemic cells mediate NOTCH pathway activation and resistance to {gamma}-secretase inhibitors","volume":"204","author":"O\u2019Neil","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.leukres.2008.03.040_bib18","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1084\/jem.20070872","article-title":"The SCFFBW7 ubiquitin ligase complex as a tumor suppressor in T cell leukemia","volume":"204","author":"Thompson","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.leukres.2008.03.040_bib19","first-page":"4449","article-title":"Status of the p53, Rb and MDM2 genes in canine osteosarcoma","volume":"18","author":"Mendoza","year":"1998","journal-title":"Anticancer Res"},{"key":"10.1016\/j.leukres.2008.03.040_bib20","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/S0022-2836(05)80360-2","article-title":"Basic local alignment search tool","volume":"215","author":"Altschul","year":"1990","journal-title":"J Mol Biol"},{"key":"10.1016\/j.leukres.2008.03.040_bib21","doi-asserted-by":"crossref","first-page":"148","DOI":"10.7150\/ijms.3.148","article-title":"Mutation analysis of hCDC4 in AML cells identifies a new intronic polymorphism","volume":"3","author":"Nowak","year":"2006","journal-title":"Int J Med Sci"},{"key":"10.1016\/j.leukres.2008.03.040_bib22","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.leukres.2008.03.040_bib23","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1038\/sj.bjc.6602928","article-title":"Cosmic 2005","volume":"94","author":"Forbes","year":"2006","journal-title":"Br J Cancer"},{"key":"10.1016\/j.leukres.2008.03.040_bib24","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.molcel.2007.02.022","article-title":"Structure of a Fbw7-Skp1-cyclin E complex: multisite-phosphorylated substrate recognition by SCF ubiquitin ligases","volume":"26","author":"Hao","year":"2007","journal-title":"Mol Cell"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212608001720?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212608001720?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,12,28]],"date-time":"2018-12-28T18:26:00Z","timestamp":1546021560000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212608001720"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,11]]},"references-count":24,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2008,11]]}},"alternative-id":["S0145212608001720"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2008.03.040","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2008,11]]}}}