{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T18:31:47Z","timestamp":1759602707788},"reference-count":20,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2009,6,1]],"date-time":"2009-06-01T00:00:00Z","timestamp":1243814400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2009,6]]},"DOI":"10.1016\/j.leukres.2008.10.002","type":"journal-article","created":{"date-parts":[[2008,11,13]],"date-time":"2008-11-13T12:42:25Z","timestamp":1226580145000},"page":"750-751","source":"Crossref","is-referenced-by-count":3,"title":["Burkitt lymphoma translocation turns Notch over to the dark side"],"prefix":"10.1016","volume":"33","author":[{"given":"Leonardo","family":"Mirandola","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Basile","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paola","family":"Comi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaella","family":"Chiaramonte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2008.10.002_bib1","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T-cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.leukres.2008.10.002_bib2","doi-asserted-by":"crossref","first-page":"8022","DOI":"10.1128\/MCB.01091-06","article-title":"Notch1 contributes to mouse T-cell leukemia by directly inducing the expression of c-myc","volume":"26","author":"Sharma","year":"2006","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.leukres.2008.10.002_bib3","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1016\/j.leukres.2006.07.009","article-title":"Still puzzling Notch signaling in B-cell malignancies","volume":"30","author":"Chiaramonte","year":"2006","journal-title":"Leukemia Res"},{"key":"10.1016\/j.leukres.2008.10.002_bib4","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1016\/S1074-7613(02)00472-7","article-title":"Pax5 promotes B lymphopoiesis and blocks T-cell development by repressing Notch1","volume":"17","author":"Souabni","year":"2002","journal-title":"Immunity"},{"key":"10.1016\/j.leukres.2008.10.002_bib5","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1002\/jcb.10383","article-title":"Differential regulation of Notch signal transduction in leukemia and lymphoma cells in culture","volume":"88","author":"Chiaramonte","year":"2003","journal-title":"J Cell Biochem"},{"key":"10.1016\/j.leukres.2008.10.002_bib6","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.canlet.2004.07.022","article-title":"A wide role for NOTCH1 signaling in acute leukemia","volume":"219","author":"Chiaramonte","year":"2005","journal-title":"Cancer Lett"},{"key":"10.1016\/j.leukres.2008.10.002_bib7","doi-asserted-by":"crossref","first-page":"36523","DOI":"10.1074\/jbc.M006415200","article-title":"Cell cycle arrest and apoptosis induced by Notch1 in B cells","volume":"275","author":"Morimura","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2008.10.002_bib8","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1038\/sj.cdd.4401253","article-title":"Notch1 enhances B-cell receptor-induced apoptosis in mature activated B cells without affecting cell cycle progression and surface IgM expression","volume":"10","author":"Romer","year":"2003","journal-title":"Cell Death Differ"},{"key":"10.1016\/j.leukres.2008.10.002_bib9","doi-asserted-by":"crossref","first-page":"3398","DOI":"10.1182\/blood.V99.9.3398","article-title":"Activated Notch1 signaling promotes tumor cell proliferation and survival in Hodgkin and anaplastic large cell lymphoma","volume":"99","author":"Jundt","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2008.10.002_bib10","doi-asserted-by":"crossref","first-page":"3742","DOI":"10.1182\/blood.V99.10.3742","article-title":"Notch2 is involved in the overexpression of CD23 in B-cell chronic lymphocytic leukemia","volume":"99","author":"Hubmann","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2008.10.002_bib11","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.1016\/j.leukres.2006.05.003","article-title":"Establishment of a novel B-cell lymphoma cell line with suppressed growth by gamma-secretase inhibitors","volume":"30","author":"Tohda","year":"2006","journal-title":"Leuk Res"},{"key":"10.1016\/j.leukres.2008.10.002_bib12","unstructured":"He F, Wang L, Hu XB, Yin DD, Zhang P, Li GH, Wang YC, Huang SY, Liang YM, Han H. Notch and BCR signaling synergistically promote the proliferation of Raji B-lymphoma cells. Leukemia Res, this issue."},{"key":"10.1016\/j.leukres.2008.10.002_bib13","doi-asserted-by":"crossref","first-page":"2096","DOI":"10.1101\/gad.1450406","article-title":"c-Myc is an important direct target of Notch1 in T-cell acute lymphoblastic leukemia\/lymphoma","volume":"20","author":"Weng","year":"2006","journal-title":"Genes Dev"},{"key":"10.1016\/j.leukres.2008.10.002_bib14","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1002\/j.1460-2075.1996.tb00367.x","article-title":"Epstein-Barr virus nuclear antigen 2 is a transcriptional suppressor of the immunoglobulin mu gene: implications for the expression of the translocated c-myc gene in Burkitt's lymphoma cells","volume":"15","author":"Jochner","year":"1996","journal-title":"EMBO J"},{"key":"10.1016\/j.leukres.2008.10.002_bib15","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/S0171-2985(97)80050-2","article-title":"Both Epstein-Barr viral nuclear antigen 2 (EBNA2) and activated Notch1 transactivate genes by interacting with the cellular protein RBP-J kappa","volume":"198","author":"Strobl","year":"1997","journal-title":"Immunobiology"},{"key":"10.1016\/j.leukres.2008.10.002_bib16","doi-asserted-by":"crossref","first-page":"3307","DOI":"10.1002\/j.1460-2075.1992.tb05409.x","article-title":"Hold back of RNA polymerase II at the transcription start site mediates down-regulation of c-myc in vivo","volume":"11","author":"Strobl","year":"1992","journal-title":"EMBO J"},{"key":"10.1016\/j.leukres.2008.10.002_bib17","doi-asserted-by":"crossref","first-page":"3277","DOI":"10.4049\/jimmunol.166.5.3277","article-title":"Notch signaling suppresses IgH gene expression in chicken B cells: implication in spatially restricted expression of Serrate2\/Notch1 in the bursa of Fabricius","volume":"166","author":"Morimura","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.leukres.2008.10.002_bib18","doi-asserted-by":"crossref","first-page":"32338","DOI":"10.1074\/jbc.M004148200","article-title":"NF-kappa B activity is required for the deregulation of c-myc expression by the immunoglobulin heavy chain enhancer","volume":"275","author":"Kanda","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2008.10.002_bib19","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/sj.emboj.7600902","article-title":"Notch1 augments NF-kappaB activity by facilitating its nuclear retention","volume":"25","author":"Shin","year":"2006","journal-title":"EMBO J"},{"key":"10.1016\/j.leukres.2008.10.002_bib20","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1182\/blood-2006-09-046698","article-title":"Notch activity synergizes with B-cell-receptor and CD40 signaling to enhance B-cell activation","volume":"109","author":"Thomas","year":"2007","journal-title":"Blood"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212608004608?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212608004608?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,15]],"date-time":"2019-05-15T11:41:04Z","timestamp":1557920464000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212608004608"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,6]]},"references-count":20,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2009,6]]}},"alternative-id":["S0145212608004608"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2008.10.002","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2009,6]]}}}