{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T14:25:54Z","timestamp":1772893554193,"version":"3.50.1"},"reference-count":43,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2009,5,1]],"date-time":"2009-05-01T00:00:00Z","timestamp":1241136000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2009,5]]},"DOI":"10.1016\/j.leukres.2008.10.006","type":"journal-article","created":{"date-parts":[[2008,11,14]],"date-time":"2008-11-14T11:18:10Z","timestamp":1226661490000},"page":"717-727","source":"Crossref","is-referenced-by-count":31,"title":["Converting cell lines representing hematological malignancies from glucocorticoid-resistant to glucocorticoid-sensitive: Signaling pathway interactions"],"prefix":"10.1016","volume":"33","author":[{"given":"Anna S.","family":"Garza","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron L.","family":"Miller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Betty H.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E. Brad","family":"Thompson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2008.10.006_bib1","first-page":"1","article-title":"MAP kinases and the regulation of nuclear receptors","volume":"48","author":"Kyriakis","year":"2000","journal-title":"Sci STKE"},{"key":"10.1016\/j.leukres.2008.10.006_bib2","doi-asserted-by":"crossref","first-page":"6035","DOI":"10.1093\/emboj\/cdg590","article-title":"Glucocorticoid receptor-JNK interaction mediates inhibition of the JNK pathway by glucocorticoids","volume":"22","author":"Bruna","year":"2003","journal-title":"EMBO J"},{"key":"10.1016\/j.leukres.2008.10.006_bib3","doi-asserted-by":"crossref","first-page":"2050","DOI":"10.1073\/pnas.95.5.2050","article-title":"Antagonism of glucocorticoid receptor transcriptional activation by the c-Jun N-terminal kinase","volume":"95","author":"Rogatsky","year":"1998","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2008.10.006_bib4","first-page":"3684","article-title":"Resistance of human leukemic CEM-C1 cells is overcome by synergism between glucocorticoid and protein kinase A pathways: correlation with c-Myc suppression","volume":"58","author":"Medh","year":"1998","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2008.10.006_bib5","doi-asserted-by":"crossref","first-page":"2838","DOI":"10.1038\/sj.onc.1207556","article-title":"Mitogen-activated protein kinases in apoptosis regulation","volume":"23","author":"Wada","year":"2004","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2008.10.006_bib6","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1210\/me.2004-0528","article-title":"p38 MAP kinase is a key mediator in glucocorticoid-induced apoptosis of lymphoid cells: correlation between p38 MAPK activation and site-specific phosphorylation of the human glucocorticoid receptor at serine 211","volume":"19","author":"Miller","year":"2005","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.leukres.2008.10.006_bib7","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1475-2867-7-3","article-title":"Pathway interactions between MAPKs, mTOR, PKA, and the glucocorticoid receptor in lymphoid cells","author":"Miller","year":"2007","journal-title":"Cancer Cell Int"},{"key":"10.1016\/j.leukres.2008.10.006_bib8","doi-asserted-by":"crossref","first-page":"3138","DOI":"10.1182\/blood-2003-05-1543","article-title":"Rapamycin sensitizes multiple myeloma cells to apoptosis induced by dexamethasone","volume":"103","author":"Stromberg","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2008.10.006_bib9","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1210\/me.8.6.665","article-title":"Apoptosis and steroid hormones","volume":"8","author":"Thompson","year":"1994","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.leukres.2008.10.006_bib10","doi-asserted-by":"crossref","first-page":"543","DOI":"10.1016\/S0888-7543(03)00045-4","article-title":"Gene expression profile of human lymphoid CEM cells sensitive and resistant to glucocorticoid-evoked apoptosis","volume":"81","author":"Medh","year":"2003","journal-title":"Genomics"},{"key":"10.1016\/j.leukres.2008.10.006_bib11","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1210\/me.10.3.306","article-title":"Role of c-jun induction in the glucocorticoid-evoked apoptotic pathway in human leukemic lymphoblasts","volume":"10","author":"Zhou","year":"1996","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.leukres.2008.10.006_bib12","first-page":"4540","article-title":"Identification of human leukemic glucocorticoid receptors using affinity labeling and anti-human glucocorticoid receptor antibodies","volume":"44","author":"Harmon","year":"1984","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2008.10.006_bib13","first-page":"563","article-title":"Glucocorticoid sensitivity and receptors in cells of human myelogenous leukemia lines","volume":"40","author":"Koeffler","year":"1980","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2008.10.006_bib14","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1210\/me.7.5.631","article-title":"Identification of the activation-labile gene: a single point mutation in the human glucocorticoid receptor presents as two distinct receptor phenotypes","volume":"7","author":"Ashraf","year":"1993","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.leukres.2008.10.006_bib15","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.exphem.2006.06.018","article-title":"Modification of glucocorticoid sensitivity by MAP kinase signaling pathways in glucocorticoid-induced T-cell apoptosis","volume":"34","author":"Tanaka","year":"2006","journal-title":"Exp Hematol"},{"issue":"52","key":"10.1016\/j.leukres.2008.10.006_bib16","doi-asserted-by":"crossref","first-page":"37370","DOI":"10.1074\/jbc.M703697200","article-title":"PKA, not EPAC, suppresses hedgehog activity and regulates glucocorticoid sensitivity in acute lymphoblastic leukemia cells","volume":"282","author":"Ji","year":"2007","journal-title":"J Biol Chem"},{"issue":"34","key":"10.1016\/j.leukres.2008.10.006_bib17","doi-asserted-by":"crossref","first-page":"4629","DOI":"10.1038\/sj.onc.1204680","article-title":"Constitutive expression of ectopic c-Myc delays glucocorticoid-evoked apoptosis of human leukemic CEM-C7 cells","volume":"20","author":"Medh","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2008.10.006_bib18","first-page":"1378","article-title":"Glucocorticoid-induced cell death requires autoinduction of glucocorticoid receptor expression in human leukemic T cells","volume":"59","author":"Ramdas","year":"1999","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.leukres.2008.10.006_bib19","doi-asserted-by":"crossref","first-page":"693","DOI":"10.1096\/fj.00-0327com","article-title":"Gene expression profiles of proliferating vs. G1\/G0 arrested human leukemia cells suggest a mechanism for glucocorticoid-induced apoptosis","volume":"15","author":"Tonko","year":"2001","journal-title":"FASEB J"},{"issue":"2\u20135","key":"10.1016\/j.leukres.2008.10.006_bib20","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/S0960-0760(03)00194-8","article-title":"Gene networks in glucocorticoid-evoked apoptosis in leukemic cells","volume":"85","author":"Webb","year":"2003","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"26","key":"10.1016\/j.leukres.2008.10.006_bib21","doi-asserted-by":"crossref","first-page":"23861","DOI":"10.1074\/jbc.M301843200","article-title":"Microarray analysis uncovers the induction of the proapoptotic BH3-only protein Bim in multiple models of glucocorticoid-induced apoptosis","volume":"278","author":"Wang","year":"2003","journal-title":"J Biol Chem"},{"issue":"2","key":"10.1016\/j.leukres.2008.10.006_bib22","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1002\/ijc.2910360217","article-title":"Two distinct human myeloma cell lines originating from one patient with myeloma","volume":"36","author":"Katagiri","year":"1985","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.leukres.2008.10.006_bib23","doi-asserted-by":"crossref","first-page":"1246","DOI":"10.3181\/00379727-125-32327","article-title":"Production of free light chains of immunoglobulin by a hematopoietic cell line derived from a patient with multiple myeloma","volume":"125","author":"Matsuoka","year":"1967","journal-title":"Proc Soc Exp Biol Med"},{"issue":"3\u20138","key":"10.1016\/j.leukres.2008.10.006_bib24","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/0960-0760(92)90352-J","article-title":"Glucocorticoids in malignant lymphoid cells: gene regulation and the minimum receptor fragment for lysis","volume":"41","author":"Thompson","year":"1992","journal-title":"J Steroid Biochem Mol Biol"},{"issue":"3","key":"10.1016\/j.leukres.2008.10.006_bib25","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1002\/j.1460-2075.1995.tb07021.x","article-title":"Glucocorticoid-induced apoptosis of human leukemic cells is caused by the repressive function of the glucocorticoid receptor","volume":"14","author":"Helmberg","year":"1995","journal-title":"EMBO J"},{"issue":"11 Pt 2","key":"10.1016\/j.leukres.2008.10.006_bib26","first-page":"4861","article-title":"Glucocorticoid Receptors in lymphoid tumors","volume":"41","author":"Leventhal","year":"1981","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2008.10.006_bib27","first-page":"1873","article-title":"Glucocorticoid effects on myeloma cells in culture: correlation of growth inhibition with induction of glucocorticoid receptor messenger RNA","volume":"50","author":"Gomi","year":"1990","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2008.10.006_bib28","doi-asserted-by":"crossref","first-page":"89","DOI":"10.2169\/internalmedicine1962.21.89","article-title":"Effect of Dexamethasone on the growth of human lymphoblastoid cell lines","volume":"21","author":"Sasaki","year":"1982","journal-title":"Jpn J Med"},{"key":"10.1016\/j.leukres.2008.10.006_bib29","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1002\/ijc.2910300407","article-title":"Glucocorticoid receptors in hairy-cell leukemia","volume":"30","author":"Kontula","year":"1982","journal-title":"Int J Cancer"},{"key":"10.1016\/j.leukres.2008.10.006_bib30","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1182\/blood.V45.3.321.321","article-title":"Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome","volume":"45","author":"Lozzio","year":"1975","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2008.10.006_bib31","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/0014-5793(80)80354-1","article-title":"Glucocorticoid-receptor-mediated stimulation of 5\u2032 nucleotidase in human lyphoblastoid IM-9 cells","volume":"121","author":"Rousseau","year":"1980","journal-title":"FEBS Lett"},{"key":"10.1016\/j.leukres.2008.10.006_bib32","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1002\/1097-0142(19900215)65:4<920::AID-CNCR2820650417>3.0.CO;2-E","article-title":"Effects of natural \u03b2-interferon and recombinant \u03b1-2B-interferon on proliferation, glucocorticoid receptor content, and antigen expression in cultured HL-60 cells","volume":"65","author":"Sica","year":"1990","journal-title":"Cancer"},{"key":"10.1016\/j.leukres.2008.10.006_bib33","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1006\/viro.1994.1132","article-title":"Reduced signal transduction through glucocorticoid receptor in Burkitt's lymphoma cell lines","volume":"199","author":"Sinclair","year":"1994","journal-title":"Virology"},{"issue":"1","key":"10.1016\/j.leukres.2008.10.006_bib34","first-page":"14","article-title":"Progesterone receptor expression by human leukocyte cell lines: molecular mechanisms of cytokine suppression","volume":"34","author":"Srivastava","year":"2007","journal-title":"Clin Exp Obstet Gynecol"},{"key":"10.1016\/j.leukres.2008.10.006_bib35","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1182\/blood-2002-01-0189","article-title":"Rapamycin-induced G1 arrest in cycling B-CLL cells is associated with reduced expression of cyclin D3, cyclin E, cyclin A, and surviving","volume":"101","author":"Decker","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2008.10.006_bib36","doi-asserted-by":"crossref","first-page":"2119","DOI":"10.1210\/mend-3-12-2119","article-title":"Cyclic AMP-dependent protein kinase modulation of the glucocorticoid-induced cytolytic response in murine T-lymphoma cells","volume":"3","author":"Gruol","year":"1989","journal-title":"Mol Endocrinol"},{"issue":"10","key":"10.1016\/j.leukres.2008.10.006_bib37","doi-asserted-by":"crossref","first-page":"2382","DOI":"10.1210\/me.2002-0144","article-title":"Nuclear export of glucocorticoid receptor is enhanced by c-Jun N-terminal kinase-mediated phosphorylation","volume":"16","author":"Itoh","year":"2002","journal-title":"Mol Endocrinol"},{"key":"10.1016\/j.leukres.2008.10.006_bib38","doi-asserted-by":"crossref","first-page":"4920","DOI":"10.1158\/1078-0432.CCR-07-0276","article-title":"Receptor in B cell chronic lymphocytic leukemia but not in normal circulating hematopoietic cells phosphodiesterase 4 inhibitors augment levels of glucocorticoid","volume":"13","author":"Meyers","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"4","key":"10.1016\/j.leukres.2008.10.006_bib39","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.ccr.2006.09.006","article-title":"Gene expression-based chemical genomics identifies rapamycin as a modulator of MCL1 and glucocorticoid resistance","volume":"10","author":"Wei","year":"2006","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.leukres.2008.10.006_bib40","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2174\/156802606776173465","article-title":"How much is enough? Modulation of dose-response curve for steroid receptor-regulated gene expression by changing concentrations of transcription factor","volume":"6","author":"Simons","year":"2006","journal-title":"Curr Top Med Chem"},{"key":"10.1016\/j.leukres.2008.10.006_bib41","doi-asserted-by":"crossref","unstructured":"Leung KT, Li K, Sai-Ming Sun S, Sheung Chan PK, Eng-Choon Ooi V, Chi-Ming Chiu L. Activation of the JNK pathway promotes phosphorylation and degradation of BimEL a novel mechanism of chemoresistance in T-cell acute lymphoblastic leukemia. Carcinogenesis 2007;Epub. PMID: 18174237.","DOI":"10.1093\/carcin\/bgm294"},{"issue":"8","key":"10.1016\/j.leukres.2008.10.006_bib42","doi-asserted-by":"crossref","first-page":"2209","DOI":"10.1158\/1535-7163.MCT-07-0231","volume":"6","author":"Davies","year":"2007","journal-title":"Mol Cancer Ther"},{"issue":"3","key":"10.1016\/j.leukres.2008.10.006_bib43","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1200\/JCO.2007.12.0345","article-title":"Phase I trial of the novel mammalian target of rapamycin inhibitor deforolimus (AP23573; MK-8669) administered intravenously daily for 5 days every 2 weeks to patients with advanced malignancies","volume":"26","author":"Mita","year":"2008","journal-title":"J Clin Oncol"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212608004621?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212608004621?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,10]],"date-time":"2020-05-10T07:54:20Z","timestamp":1589097260000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212608004621"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":43,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2009,5]]}},"alternative-id":["S0145212608004621"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2008.10.006","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}