{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T20:16:11Z","timestamp":1773260171636,"version":"3.50.1"},"reference-count":41,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2009,11,1]],"date-time":"2009-11-01T00:00:00Z","timestamp":1257033600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2009,11]]},"DOI":"10.1016\/j.leukres.2009.04.007","type":"journal-article","created":{"date-parts":[[2009,5,8]],"date-time":"2009-05-08T03:50:29Z","timestamp":1241754629000},"page":"1454-1458","source":"Crossref","is-referenced-by-count":33,"title":["Risk of MDM2 SNP309 alone or in combination with the p53 codon 72 polymorphism in acute myeloid leukemia"],"prefix":"10.1016","volume":"33","author":[{"given":"Xiujuan","family":"Xiong","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiazhuo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zheng","family":"Tian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianxiang","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5340","key":"10.1016\/j.leukres.2009.04.007_bib1","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1126\/science.278.5340.1059","article-title":"Oncogenic transcription factors in the human acute leukemias","volume":"278","author":"Look","year":"1997","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.leukres.2009.04.007_bib2","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/S0092-8674(00)81871-1","article-title":"p53, the cellular gatekeeper for growth and division","volume":"88","author":"Levine","year":"1997","journal-title":"Cell"},{"issue":"7","key":"10.1016\/j.leukres.2009.04.007_bib3","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/BF03401691","article-title":"Differential regulation of the p21\/WAF-1 and mdm2 genes after high-dose UV irradiation p53-dependent and p53-independent regulation of the mdm2 gene","volume":"3","author":"Wu","year":"1997","journal-title":"Mol Med"},{"issue":"1","key":"10.1016\/j.leukres.2009.04.007_bib4","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/S0959-437X(01)00264-7","article-title":"The p53 and Mdm2 families in cancer","volume":"12","author":"Michael","year":"2002","journal-title":"Curr Opin Genet Dev"},{"issue":"4","key":"10.1016\/j.leukres.2009.04.007_bib5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1111\/j.1365-2141.1992.tb02979.x","article-title":"P53 gene mutations in acute myelogenous leukaemia","volume":"81","author":"Hu","year":"1992","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1016\/j.leukres.2009.04.007_bib6","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1034\/j.1600-0609.2000.90138.x","article-title":"Prognostic value of p53 gene mutations and the product expression in de novo acute myeloid leukemia","volume":"65","author":"Nakano","year":"2000","journal-title":"Eur J Haematol"},{"issue":"3","key":"10.1016\/j.leukres.2009.04.007_bib7","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1182\/blood.V91.3.1008","article-title":"17p Deletion in acute myeloid leukemia and myelodysplastic syndrome. Analysis of breakpoints and deleted segments by fluorescence in situ","volume":"91","author":"Soenen","year":"1998","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.leukres.2009.04.007_bib8","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1038\/35023507","article-title":"The MDM2 RING-finger domain is required to promote p53 nuclear export","volume":"2","author":"Geyer","year":"2000","journal-title":"Nat Cell Biol"},{"issue":"2","key":"10.1016\/j.leukres.2009.04.007_bib9","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1093\/emboj\/17.2.554","article-title":"Nucleo-cytoplasmic shuttling of the hdm2 oncoprotein regulates the levels of the p53 protein via a pathway used by the human immunodeficiency virus rev protein","volume":"17","author":"Roth","year":"1998","journal-title":"EMBO J"},{"issue":"6","key":"10.1016\/j.leukres.2009.04.007_bib10","doi-asserted-by":"crossref","first-page":"3077","DOI":"10.1073\/pnas.96.6.3077","article-title":"Nucleocytoplasmic shuttling of oncoprotein Hdm2 is required for Hdm2-mediated degradation of p53","volume":"96","author":"Tao","year":"1999","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"1","key":"10.1016\/j.leukres.2009.04.007_bib11","doi-asserted-by":"crossref","first-page":"27","DOI":"10.2174\/1568009053332636","article-title":"MDM2 and human malignancies: expression, clinical pathology, prognostic markers, and implications for chemotherapy","volume":"5","author":"Rayburn","year":"2005","journal-title":"Curr Cancer Drug Targets"},{"issue":"3","key":"10.1016\/j.leukres.2009.04.007_bib12","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1038\/ng1093","article-title":"The codon 72 polymorphic variants of p53 have markedly different apoptotic potential","volume":"33","author":"Dumont","year":"2003","journal-title":"Nat Genet"},{"issue":"2","key":"10.1016\/j.leukres.2009.04.007_bib13","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1128\/MCB.19.2.1092","article-title":"Two polymorphic variants of wild-type p53 differ biochemically and biologically","volume":"19","author":"Thomas","year":"1999","journal-title":"Mol Cell Biol"},{"issue":"4","key":"10.1016\/j.leukres.2009.04.007_bib14","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1093\/mutage\/geg008","article-title":"TP53 polymorphisms and lung cancer risk: a systematic review and meta-analysis","volume":"18","author":"Matakidou","year":"2003","journal-title":"Mutagenesis"},{"issue":"Suppl. 4","key":"10.1016\/j.leukres.2009.04.007_bib15","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1289\/ehp.97105s4919","article-title":"Polymorphisms of H-ras-1 and p53 in breast cancer and lung cancer: a meta-analysis","volume":"105","author":"Weston","year":"1997","journal-title":"Environ Health Perspect"},{"issue":"3","key":"10.1016\/j.leukres.2009.04.007_bib16","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1182\/blood-2007-11-126508","article-title":"MDM2 SNP309 and TP53 Arg72Pro interact to alter therapy-related acute myeloid leukemia susceptibility","volume":"112","author":"Ellis","year":"2008","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.leukres.2009.04.007_bib17","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/j.ejca.2008.02.007","article-title":"MDM2 SNP309 G allele decreases risk but does not affect onset age or survival of Chinese leukaemia patients","volume":"44","author":"Phang","year":"2008","journal-title":"Eur J Cancer"},{"issue":"5","key":"10.1016\/j.leukres.2009.04.007_bib18","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.cell.2004.11.022","article-title":"A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans","volume":"119","author":"Bond","year":"2004","journal-title":"Cell"},{"issue":"13","key":"10.1016\/j.leukres.2009.04.007_bib19","doi-asserted-by":"crossref","first-page":"5481","DOI":"10.1158\/0008-5472.CAN-05-0825","article-title":"A single nucleotide polymorphism in the MDM2 gene: from a molecular and cellular explanation to clinical effect","volume":"65","author":"Bond","year":"2005","journal-title":"Cancer Res"},{"issue":"3","key":"10.1016\/j.leukres.2009.04.007_bib20","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1002\/gepi.10261","article-title":"Polygenic inheritance of breast cancer: implications for design of association studies","volume":"25","author":"Antoniou","year":"2003","journal-title":"Genet Epidemiol"},{"issue":"4","key":"10.1016\/j.leukres.2009.04.007_bib21","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s00439-002-0902-4","article-title":"The future of association studies of common cancers","volume":"112","author":"Houlston","year":"2003","journal-title":"Hum Genet"},{"issue":"9","key":"10.1016\/j.leukres.2009.04.007_bib22","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.1038\/sj.onc.1210199","article-title":"A single nucleotide polymorphism in the p53 pathway interacts with gender, environmental stresses and tumor genetics to influence cancer in humans","volume":"26","author":"Bond","year":"2007","journal-title":"Oncogene"},{"issue":"14","key":"10.1016\/j.leukres.2009.04.007_bib23","doi-asserted-by":"crossref","first-page":"4123","DOI":"10.1158\/1078-0432.CCR-07-0609","article-title":"MDM2 SNP309 polymorphism as risk factor for susceptibility and poor prognosis in renal cell carcinoma","volume":"13","author":"Hirata","year":"2007","journal-title":"Clin Cancer Res"},{"issue":"11","key":"10.1016\/j.leukres.2009.04.007_bib24","doi-asserted-by":"crossref","first-page":"1996","DOI":"10.1038\/sj.leu.2403941","article-title":"MDM2 promoter variation and age of diagnosis of acute lymphoblastic leukemia","volume":"19","author":"Swinney","year":"2005","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.leukres.2009.04.007_bib25","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1111\/j.1365-2141.1976.tb03563.x","article-title":"Proposals for the classification of the acute leukaemias French\u2013American\u2013British (FAB) co-operative group","volume":"33","author":"Bennett","year":"1976","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1016\/j.leukres.2009.04.007_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1600-0609.1995.tb00225.x","article-title":"Diagnostic and prognostic advances in the immunophenotypic and genetic characterization of acute leukaemia","volume":"55","author":"Lo Coco","year":"1995","journal-title":"Eur J Haematol"},{"issue":"3","key":"10.1016\/j.leukres.2009.04.007_bib27","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1182\/blood.V87.3.1162.bloodjournal8731162","article-title":"Leukemia-associated changes identified by quantitative flow cytometry IV. CD34 overexpression in acute myelogenous leukemia M2 with t(8;21)","volume":"87","author":"Porwit-MacDonald","year":"1996","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.leukres.2009.04.007_bib28","doi-asserted-by":"crossref","first-page":"1232","DOI":"10.1182\/blood-2002-12-3714","article-title":"Allogeneic compared with autologous stem cell transplantation in the treatment of patients younger than 46 years with acute myeloid leukemia (AML) in first complete remission (CR1): an intention-to-treat analysis of the EORTC\/GIMEMAAML-10 trial","volume":"102","author":"Suciu","year":"2003","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.leukres.2009.04.007_bib29","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1093\/nar\/3.9.2303","article-title":"A general method for isolation of high molecular weight DNA from eukaryotes","volume":"3","author":"Blin","year":"1976","journal-title":"Nucleic Acids Res"},{"issue":"6","key":"10.1016\/j.leukres.2009.04.007_bib30","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1093\/carcin\/14.6.1085","article-title":"Germ line polymorphisms of p53 and CYP1A1 genes involved in human lung cancer","volume":"14","author":"Kawajiri","year":"1993","journal-title":"Carcinogenesis"},{"issue":"4","key":"10.1016\/j.leukres.2009.04.007_bib31","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1093\/jnci\/djj054","article-title":"Association between MDM2-SNP309 and age at colorectal cancer diagnosis according to p53 mutation status","volume":"98","author":"Menin","year":"2006","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.leukres.2009.04.007_bib32","first-page":"5","article-title":"Statistical methods in cancer research. Volume I\u2014the analysis of case\u2013control studies","volume":"32","author":"Breslow","year":"1980","journal-title":"IARC Sci Publ"},{"issue":"3","key":"10.1016\/j.leukres.2009.04.007_bib33","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1093\/carcin\/23.3.381","article-title":"Gene\u2013environment interaction and aetiology of cancer: what does it mean and how can we measure it?","volume":"23","author":"Brennan","year":"2002","journal-title":"Carcinogenesis"},{"issue":"12","key":"10.1016\/j.leukres.2009.04.007_bib34","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1158\/1055-9965.EPI-07-0634","article-title":"MDM2 promoter polymorphism SNP309 contributes to tumor susceptibility: evidence from 21 case-control studies","volume":"16","author":"Hu","year":"2007","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"10","key":"10.1016\/j.leukres.2009.04.007_bib35","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.1158\/0008-5472.CAN-06-0180","article-title":"MDM2 SNP309 accelerates tumor formation in a gender-specific and hormone-dependent manner","volume":"66","author":"Bond","year":"2006","journal-title":"Cancer Res"},{"issue":"45","key":"10.1016\/j.leukres.2009.04.007_bib36","doi-asserted-by":"crossref","first-page":"16297","DOI":"10.1073\/pnas.0508390102","article-title":"Detection of functional single-nucleotide polymorphisms that affect apoptosis","volume":"102","author":"Harris","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"12","key":"10.1016\/j.leukres.2009.04.007_bib37","first-page":"1075","article-title":"Susceptibility to lung cancer in light smokers associated with CYP1A1 polymorphisms in Mexican- and African-Americans","volume":"6","author":"Ishibe","year":"1997","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"1","key":"10.1016\/j.leukres.2009.04.007_bib38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/ijc.20537","article-title":"CYP1A1 variants and smoking-related lung cancer in San Francisco Bay area Latinos and African Americans","volume":"113","author":"Wrensch","year":"2005","journal-title":"Int J Cancer"},{"issue":"4","key":"10.1016\/j.leukres.2009.04.007_bib39","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1016\/S0145-2126(99)00187-3","article-title":"Poor clinical significance of p53 gene polymorphism in acute myeloid leukemia","volume":"24","author":"Nakano","year":"2000","journal-title":"Leuk Res"},{"issue":"19 Pt 1","key":"10.1016\/j.leukres.2009.04.007_bib40","doi-asserted-by":"crossref","first-page":"6840","DOI":"10.1158\/1078-0432.CCR-05-1139","article-title":"p53 codon 72 and MDM2 SNP309 polymorphisms and age of colorectal cancer onset in Lynch syndrome","volume":"11","author":"Sotamaa","year":"2005","journal-title":"Clin Cancer Res"},{"issue":"2","key":"10.1016\/j.leukres.2009.04.007_bib41","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/S0165-4608(00)00414-3","article-title":"Karyotype and age in acute myeloid leukemia. Are they linked?","volume":"126","author":"Moorman","year":"2001","journal-title":"Cancer Genet Cytogenet"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212609001799?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212609001799?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,18]],"date-time":"2020-05-18T00:49:44Z","timestamp":1589762984000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212609001799"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2009,11]]}},"alternative-id":["S0145212609001799"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2009.04.007","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}