{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:10:31Z","timestamp":1758935431618,"version":"3.44.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"4","license":[{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T00:00:00Z","timestamp":1270080000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2010,7,24]],"date-time":"2010-07-24T00:00:00Z","timestamp":1279929600000},"content-version":"vor","delay-in-days":114,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2010,4]]},"DOI":"10.1016\/j.leukres.2009.06.026","type":"journal-article","created":{"date-parts":[[2009,7,25]],"date-time":"2009-07-25T06:10:56Z","timestamp":1248502256000},"page":"483-486","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":17,"title":["T-cell lymphoblastic leukemia in early childhood presents NOTCH1 mutations and MLL rearrangements"],"prefix":"10.1016","volume":"34","author":[{"given":"Marcela Braga","family":"Mansur","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Emerenciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessandra","family":"Splendore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian","family":"Brewer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rocio","family":"Hassan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Pombo-de-Oliveira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2009.06.026_bib1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1182\/blood.V96.1.24","article-title":"Biological and therapeutic aspects of infant leukemia","volume":"96","author":"Biondi","year":"2000","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.06.026_bib2","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/363358a0","article-title":"In utero rearrangements in the trithorax-related oncogene in infant leukaemias","volume":"363","author":"Ford","year":"1993","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2009.06.026_bib3","doi-asserted-by":"crossref","first-page":"3036","DOI":"10.1182\/blood-2007-03-077339","article-title":"Screening for leukemia- and clone-specific markers at birth in children with T-cell precursor ALL suggests a predominantly postnatal origin","volume":"110","author":"Fischer","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.06.026_bib4","doi-asserted-by":"crossref","first-page":"6964","DOI":"10.1158\/1078-0432.CCR-07-1474","article-title":"Notch-1 mutations are secondary events in some patients with T-cell acute lymphoblastic leukemia","volume":"13","author":"Mansour","year":"2007","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.leukres.2009.06.026_bib5","doi-asserted-by":"crossref","first-page":"13950","DOI":"10.1073\/pnas.94.25.13950","article-title":"Backtracking leukemia to birth: identification of clonotypic gene fusion sequences in neonatal blood spots","volume":"94","author":"Gale","year":"1997","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2009.06.026_bib6","doi-asserted-by":"crossref","first-page":"2321","DOI":"10.1182\/blood-2002-12-3817","article-title":"Leukemia in twins: lessons in natural history","volume":"102","author":"Greaves","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.06.026_bib7","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1182\/blood.V89.1.281","article-title":"Monoclonal origin of concordant T-cell malignancy in identical twins","volume":"89","author":"Ford","year":"1997","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.06.026_bib8","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1182\/blood-2007-02-074690","article-title":"NOTCH1 mutation can be an early, prenatal genetic event in T-ALL","volume":"111","author":"Eguchi-Ishimae","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.06.026_bib9","doi-asserted-by":"crossref","first-page":"2336","DOI":"10.1158\/1055-9965.EPI-06-0031","article-title":"Infant acute leukemia and maternal exposures during pregnancy","volume":"15","author":"Pombo-de-Oliveira","year":"2006","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"10.1016\/j.leukres.2009.06.026_bib10","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1002\/pbc.20654","article-title":"Molecular cytogenetic findings of acute leukemia included in the Brazilian Collaborative Study Group of Infant acute leukemia","volume":"47","author":"Emerenciano","year":"2006","journal-title":"Pediatr Blood Cancer"},{"key":"10.1016\/j.leukres.2009.06.026_bib11","doi-asserted-by":"crossref","first-page":"2291","DOI":"10.1080\/10428190802491698","article-title":"Clinical relevance of FLT3 gene abnormalities in Brazilian patients with infant leukemia","volume":"49","author":"Emerenciano","year":"2008","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.leukres.2009.06.026_bib12","first-page":"1783","article-title":"Proposals for the immunological classification of acute leukemias. European Group for the Immunological Characterization of Leukemias (EGIL)","volume":"9","author":"Bene","year":"1995","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.06.026_bib13","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1073\/pnas.0126614100","article-title":"Color and genomic ancestry in Brazilians","volume":"100","author":"Parra","year":"2003","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2009.06.026_bib14","doi-asserted-by":"crossref","first-page":"1901","DOI":"10.1038\/sj.leu.2401592","article-title":"Standardized RT-PCR analysis of fusion gene transcripts from chromosome aberrations in acute leukemia for detection of minimal residual disease. Report of the BIOMED-1 Concerted Action: investigation of minimal residual disease in acute leukemia","volume":"13","author":"van Dongen","year":"1999","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.06.026_bib15","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1038\/sj.leu.2402249","article-title":"A new recurrent and specific cryptic translocation, t(5;14)(q35;q32), is associated with expression of the Hox11L2 gene in T acute lymphoblastic leukemia","volume":"15","author":"Bernard","year":"2001","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.06.026_bib16","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1073\/pnas.0406994102","article-title":"Diagnostic tool for the identification of MLL rearrangements including unknown partner genes","volume":"102","author":"Meyer","year":"2005","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2009.06.026_bib17","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1093\/nar\/16.3.1215","article-title":"A simple salting out procedure for extracting DNA from human nucleated cells","volume":"16","author":"Miller","year":"1988","journal-title":"Nucleic Acids Res"},{"key":"10.1016\/j.leukres.2009.06.026_bib18","doi-asserted-by":"crossref","DOI":"10.1097\/00019606-200306000-00003","article-title":"Laboratory strategies for efficient handling of paraffin-embedded tissues for molecular detection of clonality in non-hodgkin lymphomas","author":"Stefanoff","year":"2003","journal-title":"Diagn Mol Pathol"},{"key":"10.1016\/j.leukres.2009.06.026_bib19","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 Concerted Action BMH4-CT98-3936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.06.026_bib20","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1126\/science.1102160","article-title":"Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia","volume":"306","author":"Weng","year":"2004","journal-title":"Science"},{"key":"10.1016\/j.leukres.2009.06.026_bib21","first-page":"1","article-title":"SIL-TAL1 fusion gene negative impact in T-cell acute lymphoblastic leukemia outcome","volume":"26","author":"Mansur","year":"2009","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.leukres.2009.06.026_bib22","first-page":"161","article-title":"Characteristics of pro-T ALL subgroups: comparison with late T-ALL. The Groupe d\u2019Etude Immunologique des Leucemies","volume":"7","author":"Garand","year":"1993","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.06.026_bib23","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1038\/sj.leu.2404957","article-title":"Prognostic significance of molecular-cytogenetic abnormalities in pediatric T-ALL is not explained by immunophenotypic differences","volume":"22","author":"van","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.06.026_bib24","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1182\/blood-2002-10-3221","article-title":"Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation","volume":"102","author":"Ferrando","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.06.026_bib25","first-page":"1116","article-title":"Genetic insights in the pathogenesis of T-cell acute lymphoblastic leukemia","volume":"90","author":"De","year":"2005","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2009.06.026_bib26","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1038\/nrc1880","article-title":"Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemia","volume":"6","author":"Grabher","year":"2006","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.leukres.2009.06.026_bib27","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1038\/sj.leu.2404546","article-title":"NOTCH1-induced T-cell leukemia in transgenic zebrafish","volume":"21","author":"Chen","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.06.026_bib28","doi-asserted-by":"crossref","first-page":"2283","DOI":"10.1084\/jem.183.5.2283","article-title":"Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles","volume":"183","author":"Pear","year":"1996","journal-title":"J Exp Med"},{"key":"10.1016\/j.leukres.2009.06.026_bib29","doi-asserted-by":"crossref","first-page":"758","DOI":"10.1038\/nature05690","article-title":"Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia","volume":"446","author":"Mullighan","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2009.06.026_bib30","doi-asserted-by":"crossref","first-page":"3043","DOI":"10.1158\/1078-0432.CCR-05-2832","article-title":"NOTCH1 mutations in T-cell acute lymphoblastic leukemia: prognostic significance and implication in multifactorial leukemogenesis","volume":"12","author":"Zhu","year":"2006","journal-title":"Clin Cancer Res"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212609003385?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212609003385?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:57:12Z","timestamp":1758934632000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212609003385"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2010,4]]}},"alternative-id":["S0145212609003385"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2009.06.026","relation":{},"ISSN":["0145-2126"],"issn-type":[{"type":"print","value":"0145-2126"}],"subject":[],"published":{"date-parts":[[2010,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"T-cell lymphoblastic leukemia in early childhood presents NOTCH1 mutations and MLL rearrangements","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2009.06.026","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2009 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}