{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T12:36:43Z","timestamp":1790858203428,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.leukres.2009.07.012","type":"journal-article","created":{"date-parts":[[2009,7,30]],"date-time":"2009-07-30T14:56:36Z","timestamp":1248965796000},"page":"641-648","source":"Crossref","is-referenced-by-count":23,"title":["mTOR inhibitor RAD001 (Everolimus) enhances the effects of imatinib in chronic myeloid leukemia by raising the nuclear expression of c-ABL protein"],"prefix":"10.1016","volume":"34","author":[{"given":"Manuela","family":"Mancini","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Corradi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Petta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Martinelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enza","family":"Barbieri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Alessandra","family":"Santucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2009.07.012_bib1","doi-asserted-by":"crossref","first-page":"7587","DOI":"10.1128\/MCB.13.12.7587","article-title":"A coiled-coil oligomerization domain of Bcr is essential for the transforming function of Bcr-Abl oncoproteins","volume":"13","author":"McWhirther","year":"1993","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.leukres.2009.07.012_bib2","doi-asserted-by":"crossref","first-page":"1619","DOI":"10.1182\/blood-2008-03-144790","article-title":"Molecular biology of BCR-ABL1-positive chronic myeloid leukemia","volume":"113","author":"Quint\u00e1s-Cardama","year":"2009","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.07.012_bib3","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/387516a0","article-title":"Ataxia teleangectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiations","volume":"387","author":"Baskaran","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2009.07.012_bib4","doi-asserted-by":"crossref","first-page":"5869","DOI":"10.1128\/MCB.21.17.5869-5878.2001","article-title":"c-Abl regulates p53 levels under normal and stress conditions by preventing its nuclear export and ubiquitination","volume":"21","author":"Sionov","year":"2001","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.leukres.2009.07.012_bib5","doi-asserted-by":"crossref","first-page":"6079","DOI":"10.1128\/MCB.22.17.6079-6088.2002","article-title":"Inactivation of NF-kB-dependent cell survival, a novel mechanism for the proapototic function of c-Abl","volume":"22","author":"Kawai","year":"2002","journal-title":"Mol Cell Biol"},{"key":"10.1016\/j.leukres.2009.07.012_bib6","doi-asserted-by":"crossref","first-page":"621","DOI":"10.1093\/jb\/mvm068","article-title":"c-Abl tyrosine kinase activates p21 via interaction with p53","volume":"141","author":"Jing","year":"2007","journal-title":"J Biochem"},{"key":"10.1016\/j.leukres.2009.07.012_bib7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.molcel.2007.12.022","article-title":"Yap1 phosphorylation by c-Abl is a critical step in selective activation of prospototic genes in response to DNA damage","volume":"29","author":"Levy","year":"2008","journal-title":"Mol Cell"},{"key":"10.1016\/j.leukres.2009.07.012_bib8","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1038\/ncb1228","article-title":"JNK phosphorylation of 14-3-3 proteins regulates nuclear targeting of c-Abl in the apoptotic response to DNA damage","volume":"7","author":"Yoshida","year":"2005","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.leukres.2009.07.012_bib9","doi-asserted-by":"crossref","DOI":"10.1111\/j.1600-0854.2009.00897.x","article-title":"Binding to 14-3-3 scaffolding protein prevents the pro-apoptotic activity of c-ABL in chronic myeloid leukemia","author":"Mancini","year":"2009","journal-title":"Traffic"},{"key":"10.1016\/j.leukres.2009.07.012_bib10","doi-asserted-by":"crossref","first-page":"6347","DOI":"10.1038\/sj.onc.1209885","article-title":"Upstream of the mammalian target of rapamycin: do all roads pass through mTOR?","volume":"25","author":"Corradetti","year":"2006","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2009.07.012_bib11","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.cub.2005.02.053","article-title":"Rheb binds and regulates the mTOR kinase","volume":"15","author":"Long","year":"2005","journal-title":"Curr Biol"},{"key":"10.1016\/j.leukres.2009.07.012_bib12","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.cell.2006.01.016","article-title":"TOR signalling in growth and metabolism","volume":"124","author":"Wullschleger","year":"2006","journal-title":"Cell"},{"key":"10.1016\/j.leukres.2009.07.012_bib13","doi-asserted-by":"crossref","first-page":"1932","DOI":"10.1038\/emboj.2008.120","article-title":"The mammalian target of rapamycin complex 2 controls folding and stability of Akt and protein kinase C","volume":"27","author":"Facchinetti","year":"2008","journal-title":"EMBO J"},{"key":"10.1016\/j.leukres.2009.07.012_bib14","doi-asserted-by":"crossref","first-page":"3767","DOI":"10.1182\/blood-2002-01-0109","article-title":"BCR\/ABL induces expression of vascular endothelial growth factor and its transcriptional activator, hypoxia inducible factor-1\u03b1, through a pathway involving phosphoinositide 3-kinase and the mammalian target of rapamycin","volume":"100","author":"Mayerholfer","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.07.012_bib15","first-page":"5716","article-title":"Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukaemia cells via the mammalian target of rapamycin","volume":"63","author":"Ly","year":"2003","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2009.07.012_bib16","doi-asserted-by":"crossref","first-page":"1717","DOI":"10.1182\/blood-2004-03-0849","article-title":"Activation of the PI3K\/mTOR pathway by BCR-ABL contributes to increased production of reactive oxygen species","volume":"105","author":"Kim","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.07.012_bib17","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1038\/sj.onc.1209901","article-title":"A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation","volume":"26","author":"Prabhu","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2009.07.012_bib18","doi-asserted-by":"crossref","first-page":"8601","DOI":"10.1074\/jbc.M707934200","article-title":"Suppression of programmed cell death 4 (PDCD4) protein expression by BCR-ABL-regulated engagement of the mTOR\/p70S6 kinase pathway","volume":"283","author":"Carayol","year":"2008","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2009.07.012_bib19","doi-asserted-by":"crossref","first-page":"1774","DOI":"10.1038\/sj.leu.2403898","article-title":"Compensatory PI3-kinase\/Akt\/mTOR activation regulates imatinib resistance development","volume":"19","author":"Burchert","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.07.012_bib20","doi-asserted-by":"crossref","first-page":"10779","DOI":"10.1074\/jbc.275.15.10779","article-title":"Regulation of the rapamycin and FKBP-target 1\/mammalian target of rapamycin and cap-dependent initiation of translation by the c-Abl protein-tyrosine kinase","volume":"275","author":"Kumar","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2009.07.012_bib21","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/S1097-2765(03)00180-1","article-title":"Sustained activation of JNK cascade and rapamycin-induced apoptosis are suppressed by p53\/p21Cip1","volume":"11","author":"Huang","year":"2003","journal-title":"Mol Cell"},{"key":"10.1016\/j.leukres.2009.07.012_bib22","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1038\/sj.thj.6200365","article-title":"Chk2 drives late G1\/early S phase arrest of clonal myeloid progenitors expressing the p210 BCR-ABL tyrosine kinase in response to STI571","volume":"5","author":"Mazzacurati","year":"2004","journal-title":"Hematol J"},{"key":"10.1016\/j.leukres.2009.07.012_bib23","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1111\/j.1365-2141.2005.05873.x","article-title":"P210 Bcr-abl tyrosine kinase interaction with histone deacetylase 1 modifies histone H4 acetylation and chromatin structure of chronic myeloid leukaemia haematopoietic progenitors","volume":"132","author":"Brusa","year":"2006","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2009.07.012_bib24","doi-asserted-by":"crossref","first-page":"2934","DOI":"10.1158\/0008-5472.CAN-07-6487","article-title":"A new pharmacological action of CCI-779 involves FKBP12-independent inhibition of mTOR kinase activity and profound repression of global protein synthesis","volume":"68","author":"Shor","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2009.07.012_bib25","doi-asserted-by":"crossref","first-page":"25485","DOI":"10.1074\/jbc.M501707200","article-title":"Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase","volume":"280","author":"Chiang","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2009.07.012_bib26","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1158\/0008-5472.CAN-08-3014","article-title":"TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phosphor-Ser2481 is a marker for intact mTOR signalling complex 2","volume":"69","author":"Copp","year":"2009","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2009.07.012_bib27","doi-asserted-by":"crossref","unstructured":"Rosner M, Siegel N, Valli A, Fuchs C, Hengstchl\u00e4ger M. mTOR phosphorylated at S2448 binds to raptor and rictor. Amino Acids 2009 [Epub ahead of print].","DOI":"10.1007\/s00726-008-0230-7"},{"key":"10.1016\/j.leukres.2009.07.012_bib28","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1016\/S0092-8674(00)81067-3","article-title":"Interaction of 14-3-3 with signalling proteins is mediated by the recognition of phosphoserine","volume":"84","author":"Muslin","year":"1996","journal-title":"Cell"},{"key":"10.1016\/j.leukres.2009.07.012_bib29","doi-asserted-by":"crossref","first-page":"7285","DOI":"10.1038\/onc.2008.334","article-title":"TTK\/Mps1 controls nuclear targeting of c-Abl by 14-3-3 coupled phosphorylation in response to oxidative stress","volume":"27","author":"Nihira","year":"2008","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2009.07.012_bib30","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1038\/84683","article-title":"Induction of apoptosis in chronic myelogenous leukemia through nuclear entrapment of BCR-ABL tyrosine kinase","volume":"7","author":"Vigneri","year":"2001","journal-title":"Nat Med"},{"key":"10.1016\/j.leukres.2009.07.012_bib31","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1091\/mbc.E06-07-0593","article-title":"Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase\/Akt regulation of Glut1 activity and trafficking","volume":"18","author":"Wieman","year":"2007","journal-title":"Mol Biol Cell"},{"key":"10.1016\/j.leukres.2009.07.012_bib32","doi-asserted-by":"crossref","first-page":"2527","DOI":"10.1182\/blood-2004-06-2494","article-title":"Antileukemic activity of rapamycin in acute myeloid leukemia","volume":"105","author":"R\u00e9cher","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.07.012_bib33","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1038\/387520a0","article-title":"Interaction between ATM protein and c-Abl in response to DNA damage","volume":"387","author":"Shafman","year":"1997","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2009.07.012_bib34","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1038\/nature01368","article-title":"DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation","volume":"421","author":"Bakkenist","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2009.07.012_bib35","doi-asserted-by":"crossref","first-page":"653","DOI":"10.2174\/156652405774641034","article-title":"Mammalian target of rapamycin as a therapeutic target in leukemia","volume":"5","author":"Giles","year":"2005","journal-title":"Curr Mol Med"},{"key":"10.1016\/j.leukres.2009.07.012_bib36","doi-asserted-by":"crossref","first-page":"703","DOI":"10.1016\/S0898-6568(00)00131-5","article-title":"14-3-3 proteins: regulation of subcellular localization by molecular interference","volume":"12","author":"Muslin","year":"2000","journal-title":"Cell Signal"},{"key":"10.1016\/j.leukres.2009.07.012_bib37","doi-asserted-by":"crossref","first-page":"16158","DOI":"10.1073\/pnas.0702596104","article-title":"Activation of PTEN\/mTOR\/STAT3 pathway in breast cancer stem-like cells is required for viability and maintenance","volume":"104","author":"Zhou","year":"2007","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2009.07.012_bib38","doi-asserted-by":"crossref","first-page":"10519","DOI":"10.1073\/pnas.0800939105","article-title":"ATF6\u03b1-Rheb-mTOR signalling promotes survival of dormant tumor cells in vivo","volume":"105","author":"Schewe","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2009.07.012_bib39","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1038\/nature04703","article-title":"Pten dependence distinguishes haematopoietic stem cells from leukaemia-initiating cells","volume":"441","author":"Yilmaz","year":"2006","journal-title":"Nature"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212609003518?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212609003518?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,21]],"date-time":"2019-05-21T19:56:39Z","timestamp":1558468599000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212609003518"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":39,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0145212609003518"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2009.07.012","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}