{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T19:12:18Z","timestamp":1792005138709,"version":"4.4.0"},"reference-count":29,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2010,5,1]],"date-time":"2010-05-01T00:00:00Z","timestamp":1272672000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2010,5]]},"DOI":"10.1016\/j.leukres.2009.09.014","type":"journal-article","created":{"date-parts":[[2009,10,2]],"date-time":"2009-10-02T04:53:55Z","timestamp":1254459235000},"page":"605-609","source":"Crossref","is-referenced-by-count":38,"title":["Clinical correlation of circulating heat shock protein 70 in acute leukemia"],"prefix":"10.1016","volume":"34","author":[{"given":"Chen-Hsiung","family":"Yeh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Tseng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alison","family":"Hannah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeev","family":"Estrov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elihu","family":"Estey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagop","family":"Kantarjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maher","family":"Albitar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2009.09.014_bib1","doi-asserted-by":"crossref","first-page":"1852","DOI":"10.1126\/science.1068408","article-title":"Molecular chaperones in the cytosol: from nascent chain to folded protein","volume":"295","author":"Hartl","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.leukres.2009.09.014_bib2","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1093\/jnci\/92.19.1564","article-title":"Role of the heat shock response and molecular chaperones in oncogenesis and cell death","volume":"92","author":"Jolly","year":"2000","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.leukres.2009.09.014_bib3","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1038\/sj.leu.2401841","article-title":"Heat shock proteins: modulators of apoptosis in tumour cells","volume":"14","author":"Creagh","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.09.014_bib4","doi-asserted-by":"crossref","first-page":"7478","DOI":"10.1038\/sj.onc.1204948","article-title":"Selective depletion of inducible HSP70 enhances immunogenicity of rat colon cancer cells","volume":"20","author":"Gurbuxani","year":"2001","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2009.09.014_bib5","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1189\/jlb.0306167","article-title":"Intracellular and extracellular functions of heat shock proteins: repercussions in cancer therapy","volume":"81","author":"Schmitt","year":"2007","journal-title":"J Leukocyte Biol"},{"key":"10.1016\/j.leukres.2009.09.014_bib6","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1002\/ijc.2910610222","article-title":"A stress-inducible 72-kDa heat-shock protein (HSP72) is expressed on the surface of human tumor cells, but not on normal cells","volume":"61","author":"Multhoff","year":"1995","journal-title":"Int J Cancer"},{"key":"10.1016\/j.leukres.2009.09.014_bib7","first-page":"474","article-title":"Membrane-bound heat shock protein 70 (Hsp70) in acute myeloid leukemia: a tumor specific recognition structure for the cytolytic activity of autologous NK cells","volume":"88","author":"Gehrmann","year":"2003","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2009.09.014_bib8","doi-asserted-by":"crossref","first-page":"3354","DOI":"10.1158\/1078-0432.CCR-03-0382","article-title":"Differential up-regulation of cytosolic and membrane-bound heat shock protein 70 in tumor cells by anti-inflammatory drugs","volume":"10","author":"Gehrmann","year":"2004","journal-title":"Clin Cancer Res"},{"key":"10.1016\/j.leukres.2009.09.014_bib9","doi-asserted-by":"crossref","first-page":"e1925","DOI":"10.1371\/journal.pone.0001925","article-title":"Tumor-specific Hsp70 plasma membrane localization is enabled by the glycosphingolipid Gb3","volume":"3","author":"Gehrmann","year":"2008","journal-title":"PLoS ONE"},{"key":"10.1016\/j.leukres.2009.09.014_bib10","doi-asserted-by":"crossref","first-page":"3689","DOI":"10.1016\/j.febslet.2007.04.044","article-title":"Extracellular heat shock proteins in cell signaling","volume":"581","author":"Calderwood","year":"2007","journal-title":"FEBS Lett"},{"key":"10.1016\/j.leukres.2009.09.014_bib11","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/S0008-8749(03)00115-1","article-title":"Stress-induced release of HSC70 from human tumors","volume":"222","author":"Barreto","year":"2003","journal-title":"Cell Immunol"},{"key":"10.1016\/j.leukres.2009.09.014_bib12","doi-asserted-by":"crossref","first-page":"21601","DOI":"10.1074\/jbc.M302326200","article-title":"Expression of the molecular chaperone Hsp70 in detergent-resistant microdomains correlates with its membrane delivery and release","volume":"278","author":"Broquet","year":"2003","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2009.09.014_bib13","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/j.yexcr.2005.07.014","article-title":"Enhanced expression of heat shock proteins in gradually dying cells and their release from necrotically dead cells","volume":"310","author":"Saito","year":"2005","journal-title":"Exp Cell Res"},{"key":"10.1016\/j.leukres.2009.09.014_bib14","doi-asserted-by":"crossref","first-page":"23349","DOI":"10.1074\/jbc.M502017200","article-title":"Exosome-dependent trafficking of HSP70. A novel secretory pathway for cellular stress proteins","volume":"280","author":"Lancaster","year":"2005","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2009.09.014_bib15","doi-asserted-by":"crossref","first-page":"5238","DOI":"10.1158\/0008-5472.CAN-04-3804","article-title":"Heat shock protein 70 surface-positive tumor exosomes stimulate migratory and cytolytic activity of natural killer cells","volume":"65","author":"Gastpar","year":"2005","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2009.09.014_bib16","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.tibtech.2004.12.011","article-title":"Chaperones and slow death: a recipe for tumor immunotherapy","volume":"23","author":"Calderwood","year":"2005","journal-title":"Trends Biotechnol"},{"key":"10.1016\/j.leukres.2009.09.014_bib17","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S0959-8049(97)00002-6","article-title":"Expression of heat shock protein 72 in renal cell carcinoma: possible role and prognostic implications in cancer patients","volume":"33","author":"Santarosa","year":"1997","journal-title":"Eur J Cancer"},{"key":"10.1016\/j.leukres.2009.09.014_bib18","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1046\/j.1525-1500.1998.00069.x","article-title":"Prognostic significance of heat shock proteins HSP70 and HSP90 in endometrial carcinomas","volume":"22","author":"Nanbu","year":"1998","journal-title":"Cancer Detect Prev"},{"key":"10.1016\/j.leukres.2009.09.014_bib19","doi-asserted-by":"crossref","first-page":"35604","DOI":"10.1074\/jbc.M401851200","article-title":"Genomic mechanisms of p210BCR-ABL signaling: induction of heat shock protein 70 through the GATA response element confers resistance to paclitaxel-induced apoptosis","volume":"279","author":"Ray","year":"2004","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2009.09.014_bib20","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1002\/(SICI)1097-0215(19981023)79:5<468::AID-IJC4>3.0.CO;2-Z","article-title":"Heat shock protein expression and drug resistance in breast cancer patients treated with induction chemotherapy","volume":"79","author":"Vargas-Roig","year":"1998","journal-title":"Int J Cancer"},{"key":"10.1016\/j.leukres.2009.09.014_bib21","first-page":"777","article-title":"Radioresistance is associated to increased Hsp70 content in human glioblastoma cell lines","volume":"25","author":"Brondani Da Rocha","year":"2004","journal-title":"Int J Oncol"},{"key":"10.1016\/j.leukres.2009.09.014_bib22","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0167-5699(99)01558-3","article-title":"Heat shock proteins, tumor immunogenicity and antigen presentation: an integrated view","volume":"21","author":"Wells","year":"2000","journal-title":"Immunol Today"},{"key":"10.1016\/j.leukres.2009.09.014_bib23","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1158\/0008-5472.CAN-03-2936","article-title":"Enhanced efficacy of tumor cell vaccines transfected with secretable HSP70","volume":"64","author":"Massa","year":"2004","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2009.09.014_bib24","doi-asserted-by":"crossref","first-page":"49","DOI":"10.3816\/CGC.2004.n.013","article-title":"Plasma levels of heat shock protein 70 in patients with prostate cancer: a potential biomarker for prostate cancer","volume":"3","author":"Abe","year":"2004","journal-title":"Clin Prostate Cancer"},{"key":"10.1016\/j.leukres.2009.09.014_bib25","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1097\/01.PCC.0000161075.97355.2E","article-title":"Extracellular HSP70 levels in children with septic shock","volume":"6","author":"Wheeler","year":"2005","journal-title":"Pediatr Crit Care Med"},{"key":"10.1016\/j.leukres.2009.09.014_bib26","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.amjsurg.2003.08.029","article-title":"Circulating heat-shock protein 70 is associated with postoperative infection and organ dysfunction after liver resection","volume":"187","author":"Kimura","year":"2004","journal-title":"Am J Surg"},{"key":"10.1016\/j.leukres.2009.09.014_bib27","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1023\/B:BGEN.0000017684.15626.29","article-title":"Inflammatory status as an important determinant of heat shock protein 70 serum concentrations during aging","volume":"5","author":"Njemini","year":"2004","journal-title":"Biogerontology"},{"key":"10.1016\/j.leukres.2009.09.014_bib28","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1177\/107327480100800111","article-title":"Therapy of acute myeloid leukemia","volume":"8","author":"Tallman","year":"2001","journal-title":"Cancer Control"},{"key":"10.1016\/j.leukres.2009.09.014_bib29","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.1038\/sj.leu.2404391","article-title":"High HSP70-membrane expression on leukemic cells from patients with acute myeloid leukemia is associated with a worse prognosis","volume":"20","author":"Steiner","year":"2006","journal-title":"Leukemia"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212609004743?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212609004743?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,5,22]],"date-time":"2019-05-22T20:20:02Z","timestamp":1558556402000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212609004743"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":29,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2010,5]]}},"alternative-id":["S0145212609004743"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2009.09.014","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}