{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T14:38:02Z","timestamp":1791038282945,"version":"4.1.0"},"reference-count":19,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2010,2,1]],"date-time":"2010-02-01T00:00:00Z","timestamp":1264982400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2010,2]]},"DOI":"10.1016\/j.leukres.2009.09.026","type":"journal-article","created":{"date-parts":[[2009,11,4]],"date-time":"2009-11-04T09:56:06Z","timestamp":1257328566000},"page":"254-257","source":"Crossref","is-referenced-by-count":28,"title":["A gene expression signature of primary resistance to imatinib in chronic myeloid leukemia"],"prefix":"10.1016","volume":"34","author":[{"given":"Hugues","family":"de Lavallade","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Finetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Carbuccia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jamshid S.","family":"Khorashad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aude","family":"Charbonnier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Letizia","family":"Foroni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane F.","family":"Apperley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Vey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fran\u00e7ois","family":"Bertucci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Birnbaum","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Jo\u00eblle","family":"Mozziconacci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2009.09.026_bib1","doi-asserted-by":"crossref","first-page":"2408","DOI":"10.1056\/NEJMoa062867","article-title":"Five-year follow-up of patients receiving imatinib for chronic myeloid leukemia","volume":"355","author":"Druker","year":"2006","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2009.09.026_bib2","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1200\/JCO.2007.15.8154","article-title":"Imatinib for newly diagnosed patients with chronic myeloid leukemia: incidence of sustained responses in an intention-to-treat analysis","volume":"26","author":"de Lavallade","year":"2008","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.leukres.2009.09.026_bib3","doi-asserted-by":"crossref","first-page":"1352","DOI":"10.1182\/blood.V66.6.1352.1352","article-title":"Prognostic discrimination among younger patients with chronic granulocytic leukemia: relevance to bone marrow transplantation","volume":"66","author":"Sokal","year":"1985","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.09.026_bib4","doi-asserted-by":"crossref","first-page":"4636","DOI":"10.1158\/0008-5472.CAN-06-0031","article-title":"Gene expression profiling shows medullary breast cancer is a subgroup of basal breast cancers","volume":"66","author":"Bertucci","year":"2006","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2009.09.026_bib5","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1038\/sj.leu.2404270","article-title":"Gene expression signature of primary imatinib-resistant chronic myeloid leukemia patients","volume":"20","author":"Frank","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.09.026_bib6","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1182\/blood-2005-05-2155","article-title":"Molecular profiling of CD34+ cells identifies low expression of CD7, along with high expression of proteinase 3 or elastase, as predictors of longer survival in patients with CML","volume":"107","author":"Yong","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.09.026_bib7","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1038\/nrc2147","article-title":"Chronic myeloid leukaemia as a model of disease evolution in human cancer","volume":"7","author":"Melo","year":"2007","journal-title":"Nat Rev Cancer"},{"key":"10.1016\/j.leukres.2009.09.026_bib8","doi-asserted-by":"crossref","first-page":"3746","DOI":"10.1182\/blood-2004-05-1941","article-title":"BCR\/ABL oncogenic kinase promotes unfaithful repair of the reactive oxygen species-dependent DNA double-strand breaks","volume":"104","author":"Nowicki","year":"2004","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.09.026_bib9","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1038\/sj.leu.2404197","article-title":"Identification of genes involved in imatininb resistance in CML: a gene-expression approach","volume":"20","author":"Villuendas","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.09.026_bib10","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1182\/blood-2005-07-2815","article-title":"BCR\/ABL kinase induces self-mutagenesis via reactive oxygen species to encode imatinib resistance","volume":"108","author":"Koptyra","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2009.09.026_bib11","doi-asserted-by":"crossref","first-page":"8762","DOI":"10.1158\/0008-5472.CAN-06-4807","article-title":"Reactive oxygen species, DNA damage, and error prone repair: a model for genomic instability with progression in myeloid leukemia?","volume":"67","author":"Rassool","year":"2007","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2009.09.026_bib12","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.dnarep.2005.10.005","article-title":"BCR\/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells","volume":"5","author":"Slupianek","year":"2006","journal-title":"DNA Repair"},{"key":"10.1016\/j.leukres.2009.09.026_bib13","doi-asserted-by":"crossref","first-page":"1975","DOI":"10.1038\/leu.2008.231","article-title":"BCR-ABL1-positive CML and BCR-ABL1-negative chronic myeloproliferative disorders: some common and contrasting features","volume":"22","author":"Cross","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2009.09.026_bib14","unstructured":"Ochs MF, Rink L, Tarn C, Mburu S, Taguchi T, Eisenberg B et al. Detection of treatment-induced changes in signaling pathways in gastrointestinal stromal tumors using transcriptomic data. Cancer Res; in press."},{"key":"10.1016\/j.leukres.2009.09.026_bib15","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1593\/neo.05472","article-title":"The polycomb group protein EZH2 impairs DNA repair in breast epithelial cells","volume":"7","author":"Zeidler","year":"2005","journal-title":"Neoplasia"},{"key":"10.1016\/j.leukres.2009.09.026_bib16","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1016\/j.ccr.2007.08.030","article-title":"A functional genetic approach identifies the PI3K pathway as a major determinant of trastuzumab resistance in breast cancer","volume":"12","author":"Berns","year":"2007","journal-title":"Cancer Cell"},{"key":"10.1016\/j.leukres.2009.09.026_bib17","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1158\/0008-5472.CAN-07-5659","article-title":"PIK3CA mutation\/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab","volume":"68","author":"Jhawer","year":"2008","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2009.09.026_bib18","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.cell.2006.11.042","article-title":"Essential role for nuclear PTEN in maintaining chromosomal integrity","volume":"128","author":"Shen","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.leukres.2009.09.026_bib19","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1476-4598-8-69","article-title":"MicroRNA expression profiling in imatinib-resistant chronic myeloid leukemia patients without clinically significant ABL1 mutations","volume":"8","author":"San Jose-Eneriz","year":"2009","journal-title":"Mol Cancer"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521260900486X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521260900486X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,5,23]],"date-time":"2020-05-23T12:02:14Z","timestamp":1590235334000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014521260900486X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,2]]},"references-count":19,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2010,2]]}},"alternative-id":["S014521260900486X"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2009.09.026","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2010,2]]}}}