{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:07:23Z","timestamp":1791086843507,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2010,8,1]],"date-time":"2010-08-01T00:00:00Z","timestamp":1280620800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"NIH","award":["R01 HL082983"],"award-info":[{"award-number":["R01 HL082983"]}]},{"name":"NIH","award":["U54 RR019391"],"award-info":[{"award-number":["U54 RR019391"]}]},{"name":"NIH","award":["K24 HL077522"],"award-info":[{"award-number":["K24 HL077522"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2010,8]]},"DOI":"10.1016\/j.leukres.2010.02.033","type":"journal-article","created":{"date-parts":[[2010,3,25]],"date-time":"2010-03-25T06:09:57Z","timestamp":1269497397000},"page":"969-973","source":"Crossref","is-referenced-by-count":36,"title":["Spectrum of mutations in RARS-T patients includes TET2 and ASXL1 mutations"],"prefix":"10.1016","volume":"34","author":[{"given":"Hadrian","family":"Szpurka","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna M.","family":"Jankowska","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Makishima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juraj","family":"Bodo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nelli","family":"Bejanyan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric D.","family":"Hsi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikkael A.","family":"Sekeres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaroslaw P.","family":"Maciejewski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"October (7)","key":"10.1016\/j.leukres.2010.02.033_bib1","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1182\/blood-2006-02-005751","article-title":"Refractory anemia with ringed sideroblasts associated with marked thrombocytosis (RARS-T), another myeloproliferative condition characterized by JAK2 V617F mutation","volume":"108","author":"Szpurka","year":"2006","journal-title":"Blood"},{"issue":"September (9)","key":"10.1016\/j.leukres.2010.02.033_bib2","doi-asserted-by":"crossref","first-page":"1641","DOI":"10.1038\/sj.leu.2404316","article-title":"Refractory anemia with ringed sideroblasts associated with marked thrombocytosis harbors JAK2 mutation and shows overlapping myeloproliferative and myelodysplastic features","volume":"20","author":"Wang","year":"2006","journal-title":"Leukemia"},{"issue":"September (5)","key":"10.1016\/j.leukres.2010.02.033_bib3","doi-asserted-by":"crossref","first-page":"1781","DOI":"10.1182\/blood-2006-03-008227","article-title":"The JAK2-V617F mutation and essential thrombocythemia features in a subset of patients with refractory anemia with ring sideroblasts (RARS)","volume":"108","author":"Boissinot","year":"2006","journal-title":"Blood"},{"issue":"November (11)","key":"10.1016\/j.leukres.2010.02.033_bib4","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1038\/sj.leu.2404373","article-title":"The JAK2 V617F mutation is rare in RARS but common in RARS-T","volume":"20","author":"Ceesay","year":"2006","journal-title":"Leukemia"},{"issue":"November (11)","key":"10.1016\/j.leukres.2010.02.033_bib5","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1038\/sj.leu.2404405","article-title":"High occurrence of JAK2 V617 mutation in refractory anemia with ringed sideroblasts associated with marked thrombocytosis","volume":"20","author":"Renneville","year":"2006","journal-title":"Leukemia"},{"issue":"February (3)","key":"10.1016\/j.leukres.2010.02.033_bib6","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1182\/blood-2006-05-022491","article-title":"High frequency of the JAK2 V617F mutation in patients with thrombocytosis (platelet count>600\u00d7109\/L) and ringed sideroblasts more than 15% considered as MDS\/MPD, unclassifiable","volume":"109","author":"Gattermann","year":"2007","journal-title":"Blood"},{"issue":"January (1)","key":"10.1016\/j.leukres.2010.02.033_bib7","doi-asserted-by":"crossref","first-page":"34","DOI":"10.3324\/haematol.11581","article-title":"JAK2V617F mutation status identifies subtypes of refractory anemia with ringed sideroblasts associated with marked thrombocytosis","volume":"93","author":"Schmitt-Graeff","year":"2008","journal-title":"Haematologica"},{"issue":"April (4)","key":"10.1016\/j.leukres.2010.02.033_bib8","first-page":"392","article-title":"Essential thrombocythemia with ringed sideroblasts: a heterogeneous spectrum of diseases, but not a distinct entity","volume":"87","author":"Schmitt-Graeff","year":"2002","journal-title":"Haematologica"},{"issue":"November (10)","key":"10.1016\/j.leukres.2010.02.033_bib9","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1182\/blood-2006-04-018879","article-title":"MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients","volume":"108","author":"Pardanani","year":"2006","journal-title":"Blood"},{"issue":"July (7)","key":"10.1016\/j.leukres.2010.02.033_bib10","doi-asserted-by":"crossref","first-page":"e270","DOI":"10.1371\/journal.pmed.0030270","article-title":"MPLW515L is a novel somatic activating mutation in myelofibrosis with myeloid metaplasia","volume":"3","author":"Pikman","year":"2006","journal-title":"PLoS Med"},{"issue":"March (3)","key":"10.1016\/j.leukres.2010.02.033_bib11","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/leu.2008.249","article-title":"UPD1p indicates the presence of MPL W515L mutation in RARS-T, a mechanism analogous to UPD9p and JAK2 V617F mutation","volume":"23","author":"Szpurka","year":"2009","journal-title":"Leukemia"},{"issue":"August (24)","key":"10.1016\/j.leukres.2010.02.033_bib12","doi-asserted-by":"crossref","first-page":"4002","DOI":"10.1200\/JCO.2009.22.6985","article-title":"Novel TET2 mutations associated with UPD4q24 in myelodysplastic syndrome","volume":"27","author":"Mohamedali","year":"2009","journal-title":"J Clin Oncol"},{"issue":"July (7)","key":"10.1016\/j.leukres.2010.02.033_bib13","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1038\/ng.391","article-title":"Acquired mutations in TET2 are common in myelodysplastic syndromes","volume":"41","author":"Langemeijer","year":"2009","journal-title":"Nat Genet"},{"issue":"May (22)","key":"10.1016\/j.leukres.2010.02.033_bib14","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1056\/NEJMoa0810069","article-title":"Mutation in TET2 in myeloid cancers","volume":"360","author":"Delhommeau","year":"2009","journal-title":"N Engl J Med"},{"issue":"June (25)","key":"10.1016\/j.leukres.2010.02.033_bib15","doi-asserted-by":"crossref","first-page":"6403","DOI":"10.1182\/blood-2009-02-205690","article-title":"Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic\/myeloproliferative neoplasms","volume":"113","author":"Jankowska","year":"2009","journal-title":"Blood"},{"issue":"July (7)","key":"10.1016\/j.leukres.2010.02.033_bib16","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1038\/leu.2009.59","article-title":"Detection of mutant TET2 in myeloid malignancies other than myeloproliferative neoplasms: CMML, MDS, MDS\/MPN and AML","volume":"23","author":"Tefferi","year":"2009","journal-title":"Leukemia"},{"issue":"July (1)","key":"10.1016\/j.leukres.2010.02.033_bib17","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1182\/blood-2009-03-210039","article-title":"Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies","volume":"114","author":"Abdel-Wahab","year":"2009","journal-title":"Blood"},{"issue":"November","key":"10.1016\/j.leukres.2010.02.033_bib18","article-title":"Mutations of JAK2 and TET2, but not CBL are detectable in a high portion of patients with refractory anemia with ring sideroblasts and thrombocytosis (RARS-T)","author":"Flach","year":"2009","journal-title":"Haematologica"},{"issue":"May (5)","key":"10.1016\/j.leukres.2010.02.033_bib19","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1038\/leu.2009.47","article-title":"TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis","volume":"23","author":"Tefferi","year":"2009","journal-title":"Leukemia"},{"issue":"June (6)","key":"10.1016\/j.leukres.2010.02.033_bib20","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1111\/j.1365-2141.2009.07697.x","article-title":"Mutations of polycomb-associated gene ASXL1 in myelodysplastic syndromes and chronic myelomonocytic leukaemia","volume":"145","author":"Gelsi-Boyer","year":"2009","journal-title":"Br J Haematol"},{"issue":"November (11)","key":"10.1016\/j.leukres.2010.02.033_bib21","doi-asserted-by":"crossref","first-page":"2183","DOI":"10.1038\/leu.2009.141","article-title":"Mutations of ASXL1 gene in myeloproliferative neoplasms","volume":"23","author":"Carbuccia","year":"2009","journal-title":"Leukemia"},{"issue":"11","key":"10.1016\/j.leukres.2010.02.033_bib22","doi-asserted-by":"crossref","first-page":"e1225","DOI":"10.1371\/journal.pone.0001225","article-title":"SNP array karyotyping allows for the detection of uniparental disomy and cryptic chromosomal abnormalities in MDS\/MPD-U and MPD","volume":"2","author":"Gondek","year":"2007","journal-title":"PLoS ONE"},{"issue":"March (3)","key":"10.1016\/j.leukres.2010.02.033_bib23","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1016\/S0301-472X(01)00789-5","article-title":"Acquired uniparental disomy of chromosome 9p is a frequent stem cell defect in polycythemia vera","volume":"30","author":"Kralovics","year":"2002","journal-title":"Exp Hematol"},{"issue":"July (7)","key":"10.1016\/j.leukres.2010.02.033_bib24","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1038\/leu.2008.113","article-title":"Clinical correlates of JAK2V617F presence or allele burden in myeloproliferative neoplasms: a critical reappraisal","volume":"22","author":"Vannucchi","year":"2008","journal-title":"Leukemia"},{"issue":"August (3)","key":"10.1016\/j.leukres.2010.02.033_bib25","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1182\/blood-2008-01-135897","article-title":"Characteristics and clinical correlates of MPL 515W>L\/K mutation in essential thrombocythemia","volume":"112","author":"Vannucchi","year":"2008","journal-title":"Blood"},{"issue":"July (14)","key":"10.1016\/j.leukres.2010.02.033_bib26","first-page":"4075","article-title":"LCX, leukemia-associated protein with a CXXC domain, is fused to MLL in acute myeloid leukemia with trilineage dysplasia having t(10;11)(q22;q23)","volume":"62","author":"Ono","year":"2002","journal-title":"Cancer Res"},{"issue":"March (3)","key":"10.1016\/j.leukres.2010.02.033_bib27","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1038\/sj.leu.2402834","article-title":"TET1, a member of a novel protein family, is fused to MLL in acute myeloid leukemia containing the t(10;11)(q22;q23)","volume":"17","author":"Lorsbach","year":"2003","journal-title":"Leukemia"},{"issue":"May (5929)","key":"10.1016\/j.leukres.2010.02.033_bib28","doi-asserted-by":"crossref","first-page":"930","DOI":"10.1126\/science.1170116","article-title":"Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1","volume":"324","author":"Tahiliani","year":"2009","journal-title":"Science"},{"key":"10.1016\/j.leukres.2010.02.033_bib29","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues","author":"Swerdlow","year":"2008"},{"issue":"May (5)","key":"10.1016\/j.leukres.2010.02.033_bib30","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1007\/s00277-007-0409-0","article-title":"Gattermann N. MPL 515 and JAK2 mutation analysis in MDS presenting with a platelet count of more than 500\u00d7109\/l","volume":"87","author":"Zipperer","year":"2008","journal-title":"Ann Hematol"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212610001165?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212610001165?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,6,3]],"date-time":"2020-06-03T08:15:57Z","timestamp":1591172157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212610001165"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":30,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2010,8]]}},"alternative-id":["S0145212610001165"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2010.02.033","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}