{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T17:35:01Z","timestamp":1791048901843,"version":"4.1.0"},"reference-count":35,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2011,10,1]],"date-time":"2011-10-01T00:00:00Z","timestamp":1317427200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2011,10]]},"DOI":"10.1016\/j.leukres.2011.06.018","type":"journal-article","created":{"date-parts":[[2011,7,9]],"date-time":"2011-07-09T03:29:48Z","timestamp":1310182188000},"page":"1402-1408","source":"Crossref","is-referenced-by-count":40,"title":["Plumbagin treatment leads to apoptosis in human K562 leukemia cells through increased ROS and elevated TRAIL receptor expression"],"prefix":"10.1016","volume":"35","author":[{"given":"Jingping","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"McKallip","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"22 (May 31)","key":"10.1016\/j.leukres.2011.06.018_bib0005","doi-asserted-by":"crossref","first-page":"12687","DOI":"10.1074\/jbc.271.22.12687","article-title":"Induction of apoptosis by Apo-2 ligand, a new member of the tumor necrosis factor cytokine family","volume":"271","author":"Pitti","year":"1996","journal-title":"J Biol Chem"},{"issue":"6 (December)","key":"10.1016\/j.leukres.2011.06.018_bib0010","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/1074-7613(95)90057-8","article-title":"Identification and characterization of a new member of the TNF family that induces apoptosis","volume":"3","author":"Wiley","year":"1995","journal-title":"Immunity"},{"issue":"11 (November)","key":"10.1016\/j.leukres.2011.06.018_bib0015","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1038\/sj.cdd.4400943","article-title":"Insights into cancer therapeutic design based on p53 and TRAIL receptor signaling","volume":"8","author":"El-Deiry","year":"2001","journal-title":"Cell Death Differ"},{"issue":"6 (September 24)","key":"10.1016\/j.leukres.2011.06.018_bib0020","doi-asserted-by":"crossref","first-page":"957","DOI":"10.1016\/0092-8674(93)90719-7","article-title":"p53-dependent apoptosis modulates the cytotoxicity of anticancer agents","volume":"74","author":"Lowe","year":"1993","journal-title":"Cell"},{"issue":"6423 (April 29)","key":"10.1016\/j.leukres.2011.06.018_bib0025","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1038\/362847a0","article-title":"p53 is required for radiation-induced apoptosis in mouse thymocytes","volume":"362","author":"Lowe","year":"1993","journal-title":"Nature"},{"issue":"4 (April)","key":"10.1016\/j.leukres.2011.06.018_bib0030","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1101\/gad.7.4.535","article-title":"Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis","volume":"7","author":"Lowe","year":"1993","journal-title":"Genes Dev"},{"issue":"5186 (November 4)","key":"10.1016\/j.leukres.2011.06.018_bib0035","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1126\/science.7973635","article-title":"p53 status and the efficacy of cancer therapy in vivo","volume":"266","author":"Lowe","year":"1994","journal-title":"Science"},{"issue":"2 (February)","key":"10.1016\/j.leukres.2011.06.018_bib0040","first-page":"139","article-title":"Overview of cell death signaling pathways","volume":"4","author":"Jin","year":"2005","journal-title":"Cancer Biol Ther"},{"issue":"7 (July)","key":"10.1016\/j.leukres.2011.06.018_bib0045","doi-asserted-by":"crossref","first-page":"1844","DOI":"10.1158\/1535-7163.MCT-06-0050","article-title":"Multiple mechanisms underlie resistance of leukemia cells to Apo2 Ligand\/TRAIL","volume":"5","author":"Cheng","year":"2006","journal-title":"Mol Cancer Ther"},{"issue":"6 (September 15)","key":"10.1016\/j.leukres.2011.06.018_bib0050","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bcp.2009.05.016","article-title":"Sensitization of human K562 leukemic cells to TRAIL-induced apoptosis by inhibiting the DNA-PKcs\/Akt-mediated cell survival pathway","volume":"78","author":"Kim","year":"2009","journal-title":"Biochem Pharmacol"},{"issue":"44 (October 3)","key":"10.1016\/j.leukres.2011.06.018_bib0055","doi-asserted-by":"crossref","first-page":"6809","DOI":"10.1038\/sj.onc.1205853","article-title":"Mechanisms of resistance to TRAIL-induced apoptosis in primary B cell chronic lymphocytic leukaemia","volume":"21","author":"MacFarlane","year":"2002","journal-title":"Oncogene"},{"issue":"5 (May)","key":"10.1016\/j.leukres.2011.06.018_bib0060","first-page":"612","article-title":"TRAIL decoy receptors mediate resistance of acute myeloid leukemia cells to TRAIL","volume":"90","author":"Riccioni","year":"2005","journal-title":"Haematologica"},{"issue":"6 (December)","key":"10.1016\/j.leukres.2011.06.018_bib0065","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1023\/A:1026131425204","article-title":"Potential mechanisms of leukemia cell resistance to TRAIL-induced apopotosis","volume":"8","author":"Hao","year":"2003","journal-title":"Apoptosis"},{"issue":"1 (May)","key":"10.1016\/j.leukres.2011.06.018_bib0070","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1002\/jcb.22549","article-title":"TRAIL\/TRAIL-R in hematologic malignancies","volume":"110","author":"Testa","year":"2010","journal-title":"J Cell Biochem"},{"issue":"9 (May 12)","key":"10.1016\/j.leukres.2011.06.018_bib0075","doi-asserted-by":"crossref","first-page":"5604","DOI":"10.1021\/jf904260b","article-title":"6-Dehydrogingerdione sensitizes human hepatoblastoma Hep G2 cells to TRAIL-induced apoptosis via reactive oxygen species-mediated increase of DR5","volume":"58","author":"Chen","year":"2010","journal-title":"J Agric Food Chem"},{"issue":"4 (August 8)","key":"10.1016\/j.leukres.2011.06.018_bib0080","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/j.bbrc.2008.05.148","article-title":"Hydrogen peroxide enhances TRAIL-induced cell death through up-regulation of DR5 in human astrocytic cells","volume":"372","author":"Kwon","year":"2008","journal-title":"Biochem Biophys Res Commun"},{"issue":"15 (April 9)","key":"10.1016\/j.leukres.2011.06.018_bib0085","doi-asserted-by":"crossref","first-page":"11498","DOI":"10.1074\/jbc.M109.090209","article-title":"Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors","volume":"285","author":"Sung","year":"2010","journal-title":"J Biol Chem"},{"issue":"1 (January)","key":"10.1016\/j.leukres.2011.06.018_bib0090","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1021\/tx034132s","article-title":"Cytotoxic action of juglone and plumbagin: a mechanistic study using HaCaT keratinocytes","volume":"17","author":"Inbaraj","year":"2004","journal-title":"Chem Res Toxicol"},{"key":"10.1016\/j.leukres.2011.06.018_bib0095","doi-asserted-by":"crossref","DOI":"10.1124\/jpet.105.098863","article-title":"Plumbagin induces apoptosis and cell cycle arrest in A549 cells through p53 accumulation via JNK-mediated phosphorylation at Serine 15 in vitro and in vivo","author":"Hsu","year":"2006","journal-title":"J Pharmacol Exp Ther"},{"issue":"38 (August 29)","key":"10.1016\/j.leukres.2011.06.018_bib0100","doi-asserted-by":"crossref","first-page":"5912","DOI":"10.1038\/sj.onc.1205789","article-title":"Long-patch base excision repair of apurinic\/apyrimidinic site DNA is decreased in mouse embryonic fibroblast cell lines treated with plumbagin: involvement of cyclin-dependent kinase inhibitor p21Waf-1\/Cip-1","volume":"21","author":"Jaiswal","year":"2002","journal-title":"Oncogene"},{"issue":"4 (August)","key":"10.1016\/j.leukres.2011.06.018_bib0105","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1002\/mc.20031","article-title":"Plumbagin induces reactive oxygen species, which mediate apoptosis in human cervical cancer cells","volume":"40","author":"Srinivas","year":"2004","journal-title":"Mol Carcinog"},{"issue":"1 (August 15)","key":"10.1016\/j.leukres.2011.06.018_bib0110","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.taap.2010.05.013","article-title":"Plumbagin-induced apoptosis in lymphocytes is mediated through increased reactive oxygen species production, upregulation of Fas, and activation of the caspase cascade","volume":"247","author":"McKallip","year":"2010","journal-title":"Toxicol Appl Pharmacol"},{"issue":"9 (September)","key":"10.1016\/j.leukres.2011.06.018_bib0115","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s11095-008-9533-3","article-title":"Plumbagin-induced apoptosis in human prostate cancer cells is associated with modulation of cellular redox status and generation of reactive oxygen species","volume":"25","author":"Powolny","year":"2008","journal-title":"Pharm Res"},{"issue":"1 (January 18)","key":"10.1016\/j.leukres.2011.06.018_bib0120","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.canlet.2007.10.005","article-title":"Plumbagin induces cell cycle arrest and apoptosis through reactive oxygen species\/c-Jun N-terminal kinase pathways in human melanoma A375.S2 cells","volume":"259","author":"Wang","year":"2008","journal-title":"Cancer Lett"},{"issue":"5 (May)","key":"10.1016\/j.leukres.2011.06.018_bib0125","first-page":"658","article-title":"Plumbagin induces ROS-mediated apoptosis in human promyelocytic leukemia cells in vivo","volume":"34","author":"Xu","year":"2009","journal-title":"Leuk Res"},{"issue":"1\u20132 (May 15)","key":"10.1016\/j.leukres.2011.06.018_bib0130","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/S0304-3835(98)00035-4","article-title":"Inhibitory effects of plumbagin and juglone on azoxymethane-induced intestinal carcinogenesis in rats","volume":"127","author":"Sugie","year":"1998","journal-title":"Cancer Lett"},{"issue":"1 (August 11)","key":"10.1016\/j.leukres.2011.06.018_bib0135","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1007\/BF00926835","article-title":"Effect of plumbagin on some glucose metabolising enzymes studied in rats in experimental hepatoma","volume":"125","author":"Parimala","year":"1993","journal-title":"Mol Cell Biochem"},{"issue":"11 (November)","key":"10.1016\/j.leukres.2011.06.018_bib0140","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1111\/j.2042-7158.1996.tb03907.x","article-title":"Niosomal plumbagin with reduced toxicity and improved anticancer activity in BALB\/C mice","volume":"48","author":"Naresh","year":"1996","journal-title":"J Pharm Pharmacol"},{"key":"10.1016\/j.leukres.2011.06.018_bib0145","doi-asserted-by":"crossref","DOI":"10.1002\/med.20235","article-title":"Perspectives on medicinal properties of plumbagin and its analogs","author":"Padhye","year":"2010","journal-title":"Med Res Rev"},{"issue":"3 (September 15)","key":"10.1016\/j.leukres.2011.06.018_bib0150","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.taap.2007.05.018","article-title":"Induction of apoptosis by plumbagin through reactive oxygen species-mediated inhibition of topoisomerase II","volume":"223","author":"Kawiak","year":"2007","journal-title":"Toxicol Appl Pharmacol"},{"issue":"25 (June 23)","key":"10.1016\/j.leukres.2011.06.018_bib0155","doi-asserted-by":"crossref","first-page":"17023","DOI":"10.1074\/jbc.M601595200","volume":"281","author":"Sandur","year":"2006","journal-title":"J Biol Chem"},{"issue":"4 (April)","key":"10.1016\/j.leukres.2011.06.018_bib0160","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1038\/leu.2008.27","article-title":"Targeting survival cascades induced by activation of Ras\/Raf\/MEK\/ERK. PI3K\/PTEN\/Akt\/mTOR and Jak\/STAT pathways for effective leukemia therapy","volume":"22","author":"McCubrey","year":"2008","journal-title":"Leukemia"},{"issue":"4 (April)","key":"10.1016\/j.leukres.2011.06.018_bib0165","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/leu.2008.26","article-title":"Contributions of the Raf\/MEK\/ERK. PI3K\/PTEN\/Akt\/mTOR and Jak\/STAT pathways to leukemia","volume":"22","author":"Steelman","year":"2008","journal-title":"Leukemia"},{"issue":"4 (August)","key":"10.1016\/j.leukres.2011.06.018_bib0170","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1007\/s11596-010-0449-x","article-title":"Plumbagin enhances TRAIL-mediated apoptosis through up-regulation of death receptor in human melanoma A375 cells","volume":"30","author":"Li","year":"2010","journal-title":"J Huazhong Univ Sci Technol Med Sci"},{"issue":"16 (August 15)","key":"10.1016\/j.leukres.2011.06.018_bib0175","doi-asserted-by":"crossref","first-page":"6581","DOI":"10.1158\/0008-5472.CAN-09-1161","article-title":"Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: evidence for an essential role of reactive oxygen species","volume":"69","author":"Yodkeeree","year":"2009","journal-title":"Cancer Res"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212611003031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212611003031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T11:54:27Z","timestamp":1712577267000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212611003031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":35,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2011,10]]}},"alternative-id":["S0145212611003031"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2011.06.018","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}