{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:28:47Z","timestamp":1787624927511,"version":"build-2736575974"},"reference-count":16,"publisher":"Elsevier BV","issue":"5","license":[{"start":{"date-parts":[[2012,5,1]],"date-time":"2012-05-01T00:00:00Z","timestamp":1335830400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Federal District of Upper Austria"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2012,5]]},"DOI":"10.1016\/j.leukres.2012.01.008","type":"journal-article","created":{"date-parts":[[2012,2,10]],"date-time":"2012-02-10T04:19:23Z","timestamp":1328847563000},"page":"588-590","source":"Crossref","is-referenced-by-count":3,"title":["The clinical impact of DNA methylation frequencies of JAK2 negative regulators in patients with essential Thrombocythemia"],"prefix":"10.1016","volume":"36","author":[{"given":"Mathilde","family":"F\u00f6dermayr","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Zach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria","family":"Huber","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigrid","family":"Machherndl-Spandl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soraya","family":"W\u00f6lfl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hans-Christian","family":"B\u00f6sm\u00fcller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Hasenschwandtner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonja","family":"Burgstaller","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Otto","family":"Krieger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dieter","family":"Lutz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ansgar","family":"Weltermann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanns","family":"Hauser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.leukres.2012.01.008_bib0005","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.molmed.2005.10.003","article-title":"A JAK2 mutation in myeloproliferative disorders: pathogenesis and therapeutic and scientific prospects","volume":"11","author":"James","year":"2005","journal-title":"Trends Mol Med"},{"key":"10.1016\/j.leukres.2012.01.008_bib0010","doi-asserted-by":"crossref","first-page":"1054","DOI":"10.1016\/S0140-6736(05)74230-6","article-title":"Acquired mutation of the tyrosine kinase JAK2 in human myeloproliferative disorders","volume":"365","author":"Baxter","year":"2005","journal-title":"Lancet"},{"key":"10.1016\/j.leukres.2012.01.008_bib0015","doi-asserted-by":"crossref","first-page":"1779","DOI":"10.1056\/NEJMoa051113","article-title":"A gain-of-function mutation of JAK2 in myeloproliferative disorders","volume":"352","author":"Kralovics","year":"2005","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2012.01.008_bib0020","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/sj.leu.2403241","article-title":"JAK\/STAT, Raf\/MEK\/ERK PI3K\/Akt and BCR-ABL in cell cycle progression and leukemogenesis","volume":"18","author":"Steelman","year":"2004","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2012.01.008_bib0025","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.bcp.2005.12.017","article-title":"JAK\/STAT signal transduction: regulators and implication in hematological malignancies","volume":"71","author":"Valentino","year":"2006","journal-title":"Biochem Pharmacol"},{"issue":"8","key":"10.1016\/j.leukres.2012.01.008_bib0030","doi-asserted-by":"crossref","first-page":"2920","DOI":"10.1182\/blood-2005-05-2087","article-title":"The V617F JAK2 mutation is uncommon in cancers and in myeloid malignancies other than the classic myeloproliferative disorders","volume":"106","author":"Scott","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2012.01.008_bib0035","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1111\/j.1365-2141.2008.07072.x","article-title":"Epigenetic inactivation of suppressors of cytokine signalling in Philadelphia-negative chronic myeloproliferative disorders","volume":"141","author":"Capello","year":"2008","journal-title":"Br J Haematol"},{"issue":"3","key":"10.1016\/j.leukres.2012.01.008_bib0040","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1365-2141.2007.06806.x","article-title":"Prevalance of JAK2 V617F and exon 12 mutations in polycythaemia vera","volume":"139","author":"Scott","year":"2007","journal-title":"Br J Haematol"},{"issue":"10","key":"10.1016\/j.leukres.2012.01.008_bib0045","doi-asserted-by":"crossref","first-page":"3472","DOI":"10.1182\/blood-2006-04-018879","article-title":"MPL515 mutations in myeloproliferative and other myeloid disorders: a study of 1182 patients","volume":"108","author":"Pardanani","year":"2006","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2012.01.008_bib0050","doi-asserted-by":"crossref","first-page":"1638","DOI":"10.1016\/j.leukres.2008.03.014","article-title":"Methylation status of SOCS1 and SOCS3 in BCR-ABL negative and JAK2V617F negative chronic myeloproliferative neoplasms","volume":"10","author":"Fern\u00e1ndez-Mercado","year":"2008","journal-title":"Leuk Res"},{"issue":"3","key":"10.1016\/j.leukres.2012.01.008_bib0055","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1182\/blood-2006-08-039909","article-title":"Monitoring of the JAK2-V617F mutation by highly sensitive quantitative real-time PCR after allogeneic stem cell transplantation in patients with myelofibrosis","volume":"109","author":"Kr\u00f6ger","year":"2006","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.leukres.2012.01.008_bib0060","doi-asserted-by":"crossref","first-page":"4618","DOI":"10.1182\/blood.V99.12.4618","article-title":"Quantitative assessment of hematopoietic chimerism after bone marrow transplantation by real-time quantitative polymerase chain reaction","volume":"99","author":"Alizadeh","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2012.01.008_bib0065","doi-asserted-by":"crossref","first-page":"1586","DOI":"10.1002\/ijc.23694","article-title":"Epigenetic alteration of SOCS family members is a possible pathogenetic mechanism in JAK2 wild type myeloproliferative diseases","volume":"123","author":"Teofili","year":"2008","journal-title":"Int J Cancer"},{"issue":"11","key":"10.1016\/j.leukres.2012.01.008_bib0070","doi-asserted-by":"crossref","first-page":"1635","DOI":"10.3324\/haematol.13043","article-title":"Methylation of the suppressor of cytokine signaling 3 gene (SOCS3) in myeloproliferative disorders","volume":"93","author":"Fourouclas","year":"2008","journal-title":"Haematologica"},{"issue":"3","key":"10.1016\/j.leukres.2012.01.008_bib0075","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1038\/sj.leu.2404513","article-title":"Epigenetic alterations complement mutation of JAK2 tyrosine kinase in patients with BCR\/ABL-negative myeloproliferative disorders","volume":"21","author":"Jost","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2012.01.008_bib0080","doi-asserted-by":"crossref","first-page":"1010","DOI":"10.1136\/jclinpath-2011-200175","article-title":"Epigenomic profiling in polycythaemia vera and essential thrombocythaemia shows low levels of aberrant DNA methylation","volume":"64","author":"Barrio","year":"2011","journal-title":"J Clin Pathol"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212612000276?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212612000276?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,11,26]],"date-time":"2018-11-26T05:27:01Z","timestamp":1543210021000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212612000276"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,5]]},"references-count":16,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2012,5]]}},"alternative-id":["S0145212612000276"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2012.01.008","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2012,5]]}}}