{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:10:26Z","timestamp":1758935426732,"version":"3.44.0"},"reference-count":33,"publisher":"Elsevier BV","issue":"8","license":[{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2012,8,1]],"date-time":"2012-08-01T00:00:00Z","timestamp":1343779200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Ministry of Education, Culture, Sports, Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2012,8]]},"DOI":"10.1016\/j.leukres.2012.04.028","type":"journal-article","created":{"date-parts":[[2012,5,26]],"date-time":"2012-05-26T21:48:32Z","timestamp":1338068912000},"page":"1035-1040","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"title":["Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis"],"prefix":"10.1016","volume":"36","author":[{"given":"Rieka","family":"Go","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazuyoshi","family":"Takizawa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoshi","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yoshinori","family":"Katsuragi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Aoyagi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukio","family":"Mishima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryo","family":"Kominami","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2012.04.028_bib0005","doi-asserted-by":"crossref","first-page":"6306","DOI":"10.1200\/JCO.2005.05.047","article-title":"Molecular genetics of acute lymphoblastic leukemia","volume":"23","author":"Armstrong","year":"2005","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.leukres.2012.04.028_bib0010","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.blre.2010.09.004","article-title":"Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia","volume":"25","author":"Paganin","year":"2011","journal-title":"Blood Rev"},{"key":"10.1016\/j.leukres.2012.04.028_bib0015","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/j.1365-2141.2008.07314.x","article-title":"Molecular-genetic insights in paediatric T-cell acute lymphoblastic leukaemia","volume":"143","author":"Van Vlierberghe","year":"2008","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2012.04.028_bib0020","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1016\/S0006-291X(02)03069-3","article-title":"Homozygous deletions and point mutations of the Rit1\/Bcl11b gene in gamma-ray induced mouse thymic lymphomas","volume":"301","author":"Wakabayashi","year":"2003","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.leukres.2012.04.028_bib0025","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1038\/ni927","article-title":"Bcl11b is required for differentiation and survival of alphabeta T lymphocytes","volume":"4","author":"Wakabayashi","year":"2003","journal-title":"Nat Immunol"},{"key":"10.1016\/j.leukres.2012.04.028_bib0030","doi-asserted-by":"crossref","first-page":"10315","DOI":"10.1074\/jbc.275.14.10315","article-title":"Isolation of a novel family of C(2)H(2) zinc finger proteins implicated in transcriptional repression mediated by chicken ovalbumin upstream promoter transcription factor (COUP-TF) orphan nuclear receptors","volume":"275","author":"Avram","year":"2000","journal-title":"J Biol Chem"},{"key":"10.1016\/j.leukres.2012.04.028_bib0035","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1600-065X.2010.00953.x","article-title":"Critical roles of Bcl11b in T-cell development and maintenance of T-cell identity","volume":"238","author":"Liu","year":"2010","journal-title":"Immunol Rev"},{"key":"10.1016\/j.leukres.2012.04.028_bib0040","doi-asserted-by":"crossref","first-page":"3003","DOI":"10.1084\/jem.20070863","article-title":"BCL11B is required for positive selection and survival of double-positive thymocytes","volume":"204","author":"Albu","year":"2007","journal-title":"J Exp Med"},{"key":"10.1016\/j.leukres.2012.04.028_bib0045","doi-asserted-by":"crossref","first-page":"6211","DOI":"10.1073\/pnas.1014304108","article-title":"Transcription factor Bcl11b controls selection of invariant natural killer T-cells by regulating glycolipid presentation in double-positive thymocytes","volume":"108","author":"Albu","year":"2011","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2012.04.028_bib0050","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.1002\/eji.200940258","article-title":"Bcl11b represses a mature T-cell gene expression program in immature CD4(+)CD8(+) thymocytes","volume":"40","author":"Kastner","year":"2010","journal-title":"Eur J Immunol"},{"key":"10.1016\/j.leukres.2012.04.028_bib0055","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1126\/science.1188063","article-title":"Reprogramming of T cells to natural killer-like cells upon Bcl11b deletion","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.leukres.2012.04.028_bib0060","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.1188989","article-title":"An early T cell lineage commitment checkpoint dependent on the transcription factor Bcl11b","volume":"329","author":"Li","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.leukres.2012.04.028_bib0065","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1126\/science.1188995","article-title":"An essential developmental checkpoint for production of the T cell lineage","volume":"329","author":"Ikawa","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.leukres.2012.04.028_bib0070","doi-asserted-by":"crossref","first-page":"4131","DOI":"10.1038\/sj.onc.1202767","article-title":"Allelic loss mapping and physical delineation of a region harboring a putative thymic lymphoma suppressor gene on mouse chromosome 12","volume":"18","author":"Shinbo","year":"1999","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2012.04.028_bib0075","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1111\/j.1349-7006.2006.00218.x","article-title":"Radiation carcinogenesis in mouse thymic lymphomas","volume":"97","author":"Kominami","year":"2006","journal-title":"Cancer Sci"},{"key":"10.1016\/j.leukres.2012.04.028_bib0080","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1016\/j.bbrc.2007.02.003","article-title":"Haploinsufficiency of Bcl11b for suppression of lymphomagenesis and thymocyte development","volume":"355","author":"Kamimura","year":"2007","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.leukres.2012.04.028_bib0085","doi-asserted-by":"crossref","first-page":"5280","DOI":"10.1038\/sj.onc.1210325","article-title":"Multi-step lymphomagenesis deduced from DNA changes in thymic lymphomas and atrophic thymuses at various times after \u03b3-irradiation","volume":"26","author":"Ohi","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2012.04.028_bib0090","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1038\/sj.leu.2403619","article-title":"Disruption of the BCL11B gene through inv(14)(q11.2q32.31) results in the expression of BCL11B-TRDC fusion transcripts and is associated with the absence of wild-type BCL11B transcripts in T-ALL","volume":"19","author":"Przybylski","year":"2005","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2012.04.028_bib0095","doi-asserted-by":"crossref","first-page":"1321","DOI":"10.1038\/nm.2246","article-title":"The TLX1 oncogene drives aneuploidy in T cell transformation","volume":"16","author":"Keersmaecker","year":"2010","journal-title":"Nat Med"},{"key":"10.1016\/j.leukres.2012.04.028_bib0100","doi-asserted-by":"crossref","first-page":"4169","DOI":"10.1182\/blood-2010-11-318873","article-title":"The BCL11B tumor suppressor is mutated across the major molecular subtypes of T-cell acute lymphoblastic leukemia","volume":"118","author":"Gutierrez","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2012.04.028_bib0105","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/j.neuron.2004.12.036","article-title":"Neuronal subtype-specific genes that control corticospinal motor neuron development in vivo","volume":"45","author":"Arlotta","year":"2005","journal-title":"Neuron"},{"key":"10.1016\/j.leukres.2012.04.028_bib0110","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1016\/j.bbrc.2005.01.013","article-title":"p53 prevents maturation of T cell development to the immature CD4\u2212CD8+ stage in Bcl11b\u2212\/\u2212 mice","volume":"328","author":"Okazuka","year":"2005","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.leukres.2012.04.028_bib0115","doi-asserted-by":"crossref","first-page":"1347","DOI":"10.1111\/j.1349-7006.2010.01546.x","article-title":"Bcl11b heterozygosity promotes clonal expansion and differentiation arrest of thymocytes in gamma-irradiated mice","volume":"101","author":"Go","year":"2010","journal-title":"Cancer Sci"},{"key":"10.1016\/j.leukres.2012.04.028_bib0120","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1038\/nri2232","article-title":"Launching the T-cell-lineage developmental programme","volume":"8","author":"Rothenberg","year":"2008","journal-title":"Nat Rev Immunol"},{"key":"10.1016\/j.leukres.2012.04.028_bib0125","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1073\/pnas.0712059105","article-title":"Normal development is an integral part of tumorigenesis in T cell-specific PTEN-deficient mice","volume":"105","author":"Xue","year":"2008","journal-title":"Proc Natl Acad Sci USA"},{"key":"10.1016\/j.leukres.2012.04.028_bib0130","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1126\/science.1182378","article-title":"The Lmo2 oncogene initiates leukemia in mice by inducing thymocyte self-renewal","volume":"327","author":"McCormack","year":"2010","journal-title":"Science"},{"key":"10.1016\/j.leukres.2012.04.028_bib0135","first-page":"6382","article-title":"scid Thymocytes with TCRbeta gene rearrangements are targets for the oncogenic effect of SCL and LMO1 transgenes","volume":"61","author":"Chervinsky","year":"2001","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2012.04.028_bib0140","doi-asserted-by":"crossref","first-page":"2851","DOI":"10.1084\/jem.20081561","article-title":"Oncogenesis of T-ALL and malignant consequences of overexpressing intracellular NOTCH1","volume":"205","author":"Li","year":"2008","journal-title":"J Exp Med"},{"key":"10.1016\/j.leukres.2012.04.028_bib0145","doi-asserted-by":"crossref","first-page":"5840","DOI":"10.1038\/sj.onc.1210388","article-title":"Lack of Bcl11b tumor suppressor results in vulnerability to DNA replication stress and damages","volume":"26","author":"Kamimura","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2012.04.028_bib0150","doi-asserted-by":"crossref","first-page":"3797","DOI":"10.1038\/sj.onc.1210152","article-title":"Inhibition of BCL11B expression leads to apoptosis of malignant but not normal mature T cells","volume":"26","author":"Grabarczyk","year":"2007","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2012.04.028_bib0155","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/S1535-6108(02)00018-1","article-title":"Gene expression signatures define novel oncogenic pathways in T cell acute lymphoblastic leukemia","volume":"1","author":"Ferrando","year":"2002","journal-title":"Cancer Cell"},{"key":"10.1016\/j.leukres.2012.04.028_bib0160","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1182\/blood-2004-10-3900","article-title":"HOXA genes are included in genetic and biologic networks defining human acute T-cell leukemia (T-ALL)","volume":"106","author":"Soulier","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2012.04.028_bib0165","doi-asserted-by":"crossref","first-page":"4668","DOI":"10.1182\/blood-2007-09-111872","article-title":"The recurrent SET-NUP214 fusion as a new HOXA activation mechanism in pediatric T-cell acute lymphoblastic leukemia","volume":"111","author":"Van Vlierberghe","year":"2008","journal-title":"Blood"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212612002032?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212612002032?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T00:57:38Z","timestamp":1758934658000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212612002032"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,8]]},"references-count":33,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2012,8]]}},"alternative-id":["S0145212612002032"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2012.04.028","relation":{},"ISSN":["0145-2126"],"issn-type":[{"type":"print","value":"0145-2126"}],"subject":[],"published":{"date-parts":[[2012,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impairment in differentiation and cell cycle of thymocytes by loss of a Bcl11b tumor suppressor allele that contributes to leukemogenesis","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2012.04.028","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2012 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}