{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T20:55:33Z","timestamp":1790283333853,"version":"4.1.0"},"reference-count":41,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2012,11,1]],"date-time":"2012-11-01T00:00:00Z","timestamp":1351728000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Teamwork Project of Natural Science Foundation of Guangdong Province","award":["9351503102000001"],"award-info":[{"award-number":["9351503102000001"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2012,11]]},"DOI":"10.1016\/j.leukres.2012.07.017","type":"journal-article","created":{"date-parts":[[2012,8,29]],"date-time":"2012-08-29T21:15:48Z","timestamp":1346274948000},"page":"1417-1421","source":"Crossref","is-referenced-by-count":16,"title":["Pentamidine sensitizes chronic myelogenous leukemia K562 cells to TRAIL-induced apoptosis"],"prefix":"10.1016","volume":"36","author":[{"given":"Geng","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jikai","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-shan","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"November (11)","key":"10.1016\/j.leukres.2012.07.017_bib0005","first-page":"745","article-title":"BCR\u2013ABL and BCR proteins: biochemical characterization and localization","volume":"4","author":"Dhut","year":"1990","journal-title":"Leukemia"},{"issue":"January (1)","key":"10.1016\/j.leukres.2012.07.017_bib0010","doi-asserted-by":"crossref","first-page":"31","DOI":"10.2174\/156800911793743637","article-title":"Current treatment concepts of CML","volume":"11","author":"Leitner","year":"2011","journal-title":"Curr Cancer Drug Targets"},{"issue":"May (5)","key":"10.1016\/j.leukres.2012.07.017_bib0015","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1016\/S1471-4922(03)00069-2","article-title":"Pentamidine uptake and resistance in pathogenic protozoa: past, present and future","volume":"19","author":"Bray","year":"2003","journal-title":"Trends Parasitol"},{"issue":"October (1)","key":"10.1016\/j.leukres.2012.07.017_bib0020","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/0009-2797(93)03199-5","article-title":"Binding of Pt-pentamidine to nucleosomal DNA. Studies of the antiproliferative activity of the drug against human cancer cells","volume":"89","author":"Perez","year":"1993","journal-title":"Chem Biol Interact"},{"issue":"October (1)","key":"10.1016\/j.leukres.2012.07.017_bib0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0163-7258(99)00021-2","article-title":"Synthetic DNA minor groove-binding drugs","volume":"84","author":"Reddy","year":"1999","journal-title":"Pharmacol Ther"},{"issue":"December (14)","key":"10.1016\/j.leukres.2012.07.017_bib0030","first-page":"1255","article-title":"Pentamidine is an inhibitor of PRL phosphatases with anticancer activity","volume":"1","author":"Pathak","year":"2002","journal-title":"Mol Cancer Ther"},{"issue":"April 1 (1)","key":"10.1016\/j.leukres.2012.07.017_bib0035","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.canlet.2011.01.008","article-title":"Pentamidine reduces expression of hypoxia-inducible factor-1alpha in DU145 and MDA-MB-231 cancer cells","volume":"303","author":"Jung","year":"2011","journal-title":"Cancer Lett"},{"issue":"August (8)","key":"10.1016\/j.leukres.2012.07.017_bib0040","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1158\/1535-7163.911.3.8","article-title":"The DNA double-stranded break repair protein endo\u2013exonuclease as a therapeutic target for cancer","volume":"3","author":"Chow","year":"2004","journal-title":"Mol Cancer Ther"},{"issue":"February (2)","key":"10.1016\/j.leukres.2012.07.017_bib0045","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1097\/CAD.0b013e3283340cee","article-title":"The effect of pentamidine on melanoma ex vivo","volume":"21","author":"Smith","year":"2010","journal-title":"Anticancer Drugs"},{"issue":"December 1 (23)","key":"10.1016\/j.leukres.2012.07.017_bib0050","doi-asserted-by":"crossref","first-page":"11359","DOI":"10.1158\/0008-5472.CAN-07-2235","article-title":"The novel combination of chlorpromazine and pentamidine exerts synergistic antiproliferative effects through dual mitotic action","volume":"67","author":"Lee","year":"2007","journal-title":"Cancer Res"},{"issue":"December (6)","key":"10.1016\/j.leukres.2012.07.017_bib0055","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/1074-7613(95)90057-8","article-title":"Identification and characterization of a new member of the TNF family that induces apoptosis","volume":"3","author":"Wiley","year":"1995","journal-title":"Immunity"},{"issue":"September (9)","key":"10.1016\/j.leukres.2012.07.017_bib0060","doi-asserted-by":"crossref","first-page":"745","DOI":"10.1038\/nri1184","article-title":"Signalling pathways of the TNF superfamily: a double-edged sword","volume":"3","author":"Aggarwal","year":"2003","journal-title":"Nat Rev Immunol"},{"issue":"August 8 (5327)","key":"10.1016\/j.leukres.2012.07.017_bib0065","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1126\/science.277.5327.815","article-title":"An antagonist decoy receptor and a death domain-containing receptor for TRAIL","volume":"277","author":"Pan","year":"1997","journal-title":"Science"},{"issue":"August (4)","key":"10.1016\/j.leukres.2012.07.017_bib0070","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.cytogfr.2006.04.002","article-title":"The role of the TRAIL\/TRAIL receptors system in hematopoiesis and endothelial cell biology","volume":"17","author":"Zauli","year":"2006","journal-title":"Cytokine Growth Factor Rev"},{"issue":"February (2)","key":"10.1016\/j.leukres.2012.07.017_bib0075","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/5517","article-title":"Tumoricidal activity of tumor necrosis factor-related apoptosis-inducing ligand in vivo","volume":"5","author":"Walczak","year":"1999","journal-title":"Nat Med"},{"issue":"August 1 (3)","key":"10.1016\/j.leukres.2012.07.017_bib0080","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1002\/cncr.11524","article-title":"Clinical implications of the tumor necrosis factor family in benign and malignant hematologic disorders","volume":"98","author":"Younes","year":"2003","journal-title":"Cancer"},{"issue":"September 21 (40)","key":"10.1016\/j.leukres.2012.07.017_bib0085","doi-asserted-by":"crossref","first-page":"4604","DOI":"10.1038\/sj.onc.1203816","article-title":"Resistance to TRAIL-induced apoptosis in primitive neuroectodermal brain tumor cells correlates with a loss of caspase-8 expression","volume":"19","author":"Grotzer","year":"2000","journal-title":"Oncogene"},{"issue":"October (10)","key":"10.1016\/j.leukres.2012.07.017_bib0090","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/sj.cdd.4400727","article-title":"Potential mechanisms of resistance to TRAIL\/Apo2L-induced apoptosis in human promyelocytic leukemia HL-60 cells during granulocytic differentiation","volume":"7","author":"Shiiki","year":"2000","journal-title":"Cell Death Differ"},{"issue":"October (10)","key":"10.1016\/j.leukres.2012.07.017_bib0095","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1038\/nrc2465","article-title":"The TRAIL apoptotic pathway in cancer onset, progression and therapy","volume":"8","author":"Johnstone","year":"2008","journal-title":"Nat Rev Cancer"},{"issue":"October 20 (48)","key":"10.1016\/j.leukres.2012.07.017_bib0100","doi-asserted-by":"crossref","first-page":"6207","DOI":"10.1038\/onc.2008.298","article-title":"The promise of cancer therapeutics targeting the TNF-related apoptosis-inducing ligand and TRAIL receptor pathway","volume":"27","author":"Wang","year":"2008","journal-title":"Oncogene"},{"issue":"April (2)","key":"10.1016\/j.leukres.2012.07.017_bib0105","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.drup.2004.03.002","article-title":"Enhancement of therapeutic potential of TRAIL by cancer chemotherapy and irradiation: mechanisms and clinical implications","volume":"7","author":"Shankar","year":"2004","journal-title":"Drug Resist Updat"},{"issue":"May 1 (9)","key":"10.1016\/j.leukres.2012.07.017_bib0110","doi-asserted-by":"crossref","first-page":"2596","DOI":"10.1182\/blood.V97.9.2596","article-title":"Ionizing radiation sensitizes erythroleukemic cells but not normal erythroblasts to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated cytotoxicity by selective up-regulation of TRAIL-R1","volume":"97","author":"Di Pietro","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2012.07.017_bib0115","article-title":"Amurensin G, a novel SIRT1 inhibitor, sensitizes TRAIL-resistant human leukemic K562 cells to TRAIL-induced apoptosis","volume":"March 29","author":"Kim","year":"2012","journal-title":"Biochem Pharmacol"},{"issue":"September\u2013October (5)","key":"10.1016\/j.leukres.2012.07.017_bib0120","doi-asserted-by":"crossref","first-page":"608","DOI":"10.1016\/0035-9203(91)90364-5","article-title":"Pentamidine concentrations in plasma, whole blood and cerebrospinal fluid during treatment of Trypanosoma gambiense infection in Cote d\u2019Ivoire","volume":"85","author":"Bronner","year":"1991","journal-title":"Trans R Soc Trop Med Hyg"},{"issue":"July (7)","key":"10.1016\/j.leukres.2012.07.017_bib0125","doi-asserted-by":"crossref","first-page":"1362","DOI":"10.1038\/sj.leu.2402501","article-title":"The cholesterol lowering drug lovastatin induces cell death in myeloma plasma cells","volume":"16","author":"van de Donk","year":"2002","journal-title":"Leukemia"},{"issue":"February 8 (1)","key":"10.1016\/j.leukres.2012.07.017_bib0130","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.canlet.2008.08.029","article-title":"Lycorine induces apoptosis and down-regulation of Mcl-1 in human leukemia cells","volume":"274","author":"Liu","year":"2009","journal-title":"Cancer Lett"},{"issue":"September 15 (6)","key":"10.1016\/j.leukres.2012.07.017_bib0135","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bcp.2009.05.016","article-title":"Sensitization of human K562 leukemic cells to TRAIL-induced apoptosis by inhibiting the DNA-PKcs\/Akt-mediated cell survival pathway","volume":"78","author":"Kim","year":"2009","journal-title":"Biochem Pharmacol"},{"issue":"6","key":"10.1016\/j.leukres.2012.07.017_bib0140","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1159\/000164141","article-title":"Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction","volume":"65","author":"Wei","year":"1997","journal-title":"Pathobiology"},{"issue":"February (2)","key":"10.1016\/j.leukres.2012.07.017_bib0145","first-page":"481","article-title":"Regulation and function of Bcl-2 during differentiation-induced cell death in HL-60 promyelocytic cells","volume":"146","author":"Benito","year":"1995","journal-title":"Am J Pathol"},{"issue":"March 1 (5)","key":"10.1016\/j.leukres.2012.07.017_bib0150","doi-asserted-by":"crossref","first-page":"1883","DOI":"10.1158\/0008-5472.CAN-10-2252","article-title":"Distinct TRAIL resistance mechanisms can be overcome by proteasome inhibition but not generally by synergizing agents","volume":"71","author":"Menke","year":"2011","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2012.07.017_bib0155","article-title":"XIAP inhibition and generation of reactive oxygen species enhances TRAIL sensitivity in inflammatory breast cancer cells","volume":"April 16","author":"Allensworth","year":"2012","journal-title":"Mol Cancer Ther"},{"issue":"November (11)","key":"10.1016\/j.leukres.2012.07.017_bib0160","doi-asserted-by":"crossref","first-page":"2737","DOI":"10.1158\/1535-7163.MCT-06-0426","article-title":"Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites","volume":"5","author":"Lee","year":"2006","journal-title":"Mol Cancer Ther"},{"issue":"October 7 (21)","key":"10.1016\/j.leukres.2012.07.017_bib0165","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.1021\/jm0497038","article-title":"Identification and characterization of small molecule inhibitors of the calcium-dependent S100B-p53 tumor suppressor interaction","volume":"47","author":"Markowitz","year":"2004","journal-title":"J Med Chem"},{"issue":"May (4)","key":"10.1016\/j.leukres.2012.07.017_bib0170","doi-asserted-by":"crossref","first-page":"395","DOI":"10.2174\/138920007780655432","article-title":"Synergistic cytotoxic activity of recombinant TRAIL plus the non-genotoxic activator of the p53 pathway nutlin-3 in acute myeloid leukemia cells","volume":"8","author":"Secchiero","year":"2007","journal-title":"Curr Drug Metab"},{"issue":"August (8)","key":"10.1016\/j.leukres.2012.07.017_bib0175","first-page":"839","article-title":"p53 in chronic myeloid leukemia cell lines","volume":"6","author":"Bi","year":"1992","journal-title":"Leukemia"},{"issue":"January 8 (2)","key":"10.1016\/j.leukres.2012.07.017_bib0180","doi-asserted-by":"crossref","first-page":"1274","DOI":"10.1016\/j.bbrc.2009.12.058","article-title":"Hypoxia-induced decoy receptor 2 gene expression is regulated via a hypoxia-inducible factor 1alpha-mediated mechanism","volume":"391","author":"Pei","year":"2010","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.leukres.2012.07.017_bib0185","article-title":"Molecular mechanisms of the PRL phosphatases","volume":"March 13","author":"Rios","year":"2012","journal-title":"FEBS J"},{"issue":"November 9 (5545)","key":"10.1016\/j.leukres.2012.07.017_bib0190","doi-asserted-by":"crossref","first-page":"1343","DOI":"10.1126\/science.1065817","article-title":"A phosphatase associated with metastasis of colorectal cancer","volume":"294","author":"Saha","year":"2001","journal-title":"Science"},{"issue":"November (11)","key":"10.1016\/j.leukres.2012.07.017_bib0195","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1158\/1535-7163.MCT-05-0248","article-title":"PRL phosphatases as potential molecular targets in cancer","volume":"4","author":"Stephens","year":"2005","journal-title":"Mol Cancer Ther"},{"issue":"November 1 (21)","key":"10.1016\/j.leukres.2012.07.017_bib0200","doi-asserted-by":"crossref","first-page":"8959","DOI":"10.1158\/0008-5472.CAN-10-2041","article-title":"Overexpression of the protein tyrosine phosphatase PRL-2 correlates with breast tumor formation and progression","volume":"70","author":"Hardy","year":"2010","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.leukres.2012.07.017_bib0205","doi-asserted-by":"crossref","first-page":"e19798","DOI":"10.1371\/journal.pone.0019798","article-title":"PRL-3, a metastasis associated tyrosine phosphatase, is involved in FLT3-ITD signaling and implicated in anti-AML therapy","volume":"6","author":"Zhou","year":"2011","journal-title":"PLoS ONE"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521261200327X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521261200327X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,6,25]],"date-time":"2023-06-25T13:29:50Z","timestamp":1687699790000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014521261200327X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,11]]},"references-count":41,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["S014521261200327X"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2012.07.017","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2012,11]]}}}