{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:10:40Z","timestamp":1790917840422,"version":"4.1.0"},"reference-count":23,"publisher":"Elsevier BV","issue":"2","license":[{"start":{"date-parts":[[2014,2,1]],"date-time":"2014-02-01T00:00:00Z","timestamp":1391212800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["lrjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2014,2]]},"DOI":"10.1016\/j.leukres.2013.07.002","type":"journal-article","created":{"date-parts":[[2013,8,9]],"date-time":"2013-08-09T22:49:57Z","timestamp":1376088597000},"page":"263-266","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"title":["A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis?"],"prefix":"10.1016","volume":"38","author":[{"given":"Hans C.","family":"Hasselbalch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"14","key":"10.1016\/j.leukres.2013.07.002_bib0005","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1182\/blood-2011-11-394775","article-title":"Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?","volume":"119","author":"Hasselbalch","year":"2012","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.leukres.2013.07.002_bib0010","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.leukres.2012.10.020","article-title":"Chromic inflammation as a promoter of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?","volume":"37","author":"Hasselbalch","year":"2013","journal-title":"Leuk Res"},{"key":"10.1016\/j.leukres.2013.07.002_bib0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.cytogfr.2013.01.004","article-title":"The role of cytokines in the initiation and progression of myelofibrosis","author":"Hasselbalch","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"issue":"1","key":"10.1016\/j.leukres.2013.07.002_bib0020","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20110540","article-title":"A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2","volume":"209","author":"Kaufmann","year":"2012","journal-title":"J Exp Med"},{"issue":"2","key":"10.1016\/j.leukres.2013.07.002_bib0025","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.lab.2003.09.006","article-title":"Interleukin-1beta up-regulates the expression of thrombopoietin and transcription factors c-Jun, c-Fos, GATA-1, and NF-E2 in megakaryocytic cells","volume":"143","author":"Chuen","year":"2004","journal-title":"J Lab Clin Med"},{"issue":"1","key":"10.1016\/j.leukres.2013.07.002_bib0030","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/j.1365-2141.2005.05416.x","article-title":"Gene expression profiling in polycythaemia vera: overexpression of transcription factor NF-E2","volume":"129","author":"Goerttler","year":"2005","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2013.07.002_bib0035","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1111\/j.1365-2141.2009.07742.x","article-title":"NF-E2 overexpression delays erythroid maturation and increases erythrocyte production","volume":"146","author":"Mutschler","year":"2009","journal-title":"Br J Haematol"},{"issue":"1\u20132","key":"10.1016\/j.leukres.2013.07.002_bib0040","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.mrfmmm.2009.09.007","article-title":"A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders","volume":"690","author":"Kim","year":"2010","journal-title":"Mutat Res"},{"key":"10.1016\/j.leukres.2013.07.002_bib0045","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.mrfmmm.2010.03.007","article-title":"Chronic inflammation and mutagenesis","volume":"690","author":"Ferguson","year":"2010","journal-title":"Mutat Res"},{"key":"10.1016\/j.leukres.2013.07.002_bib0050","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.cell.2010.01.025","article-title":"Immunity, inflammation, and cancer","volume":"140","author":"Grivennikov","year":"2010","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.leukres.2013.07.002_bib0055","doi-asserted-by":"crossref","first-page":"315","DOI":"10.3324\/haematol.2010.031070","article-title":"Inflammation and thrombosis in essential thrombocythemia and polycythemia vera: different role of C-reactive protein and pentraxin 3","volume":"96","author":"Barbui","year":"2011","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.leukres.2013.07.002_bib0060","doi-asserted-by":"crossref","first-page":"183","DOI":"10.3324\/haematol.2010.038299","article-title":"Pathophysiology of thrombosis in myeloproliferative neoplasms","volume":"96","author":"Landolfi","year":"2011","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2013.07.002_bib0065","doi-asserted-by":"crossref","DOI":"10.1182\/blood-2012-11-463257","article-title":"Subcellular mislocalization of the transcription factor NF-E2 in erythroid cells discriminates pre-fibrotic primary myelofibrosis from essential thrombocythemia","author":"Aumann","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2013.07.002_bib0070","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1182\/blood-2009-05-223107","article-title":"NF-E2 domination over Nrf2 promotes ROS accumulation and megakaryocytic maturation","volume":"115","author":"Motohashi","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2013.07.002_bib0075","doi-asserted-by":"crossref","DOI":"10.1038\/leu.2013.102","article-title":"A role for reactive oxygen species in JAK2(V617F) myeloproliferative neoplasm progression","author":"Marty","year":"2013","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.leukres.2013.07.002_bib0080","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1038\/leu.2010.31","article-title":"Deregulated gene expression pathways in myelodysplastic syndrome hematopoietic stem cells","volume":"24","author":"Pellagatti","year":"2010","journal-title":"Leukemia"},{"issue":"9","key":"10.1016\/j.leukres.2013.07.002_bib0085","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.exphem.2012.05.011","article-title":"Gene expression profiling with principal component analysis depicts the biological continuum from essential thrombocythemia over polycythemia vera to myelofibrosis","volume":"40","author":"Skov","year":"2012","journal-title":"Exp Hematol"},{"issue":"11","key":"10.1016\/j.leukres.2013.07.002_bib0090","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.leukres.2012.07.009","article-title":"Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: identification of deregulated genes of significance for inflammation and immune surveillance","volume":"36","author":"Skov","year":"2012","journal-title":"Leuk Res"},{"issue":"3","key":"10.1016\/j.leukres.2013.07.002_bib0095","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/ncb2699","article-title":"Nrf2 regulates haematopoietic stem cell function","volume":"15","author":"Tsai","year":"2013","journal-title":"Nat Cell Biol"},{"key":"10.1016\/j.leukres.2013.07.002_bib0100","doi-asserted-by":"crossref","DOI":"10.3324\/haematol.2012.071183","article-title":"Transcription factor Nuclear Factor Erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative neoplasms","author":"Wehrle","year":"2013","journal-title":"Haematologica"},{"issue":"2","key":"10.1016\/j.leukres.2013.07.002_bib0105","doi-asserted-by":"crossref","first-page":"112","DOI":"10.5966\/sctm.2012-0046","article-title":"Elevated nuclear factor erythroid-2 levels promote epo-independent erythroid maturation and recapitulate the hematopoietic stem cell and common myeloid progenitor expansion observed in polycythemia vera patients","volume":"2","author":"Bogeska","year":"2013","journal-title":"Stem Cells Transl Med"},{"issue":"22","key":"10.1016\/j.leukres.2013.07.002_bib0110","doi-asserted-by":"crossref","first-page":"5816","DOI":"10.1182\/blood-2011-01-326025","article-title":"Do reactive oxygen species play a role in myeloid leukemias?","volume":"117","author":"Hole","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2013.07.002_bib0115","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20120521","article-title":"MPN patients harbor recurrent truncating mutations in transcription factor NF-E2","author":"Jutzi","year":"2013","journal-title":"J Exp Med"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212613002294?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212613002294?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2018,10,14]],"date-time":"2018-10-14T02:24:18Z","timestamp":1539483858000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212613002294"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2014,2]]}},"alternative-id":["S0145212613002294"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2013.07.002","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2014,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A role of NF-E2 in chronic inflammation and clonal evolution in essential thrombocythemia, polycythemia vera and myelofibrosis?","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2013.07.002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2013 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}