{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T01:04:49Z","timestamp":1778893489479,"version":"3.51.4"},"reference-count":128,"publisher":"Elsevier BV","issue":"10","license":[{"start":{"date-parts":[[2014,10,1]],"date-time":"2014-10-01T00:00:00Z","timestamp":1412121600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":["lrjournal.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2014,10]]},"DOI":"10.1016\/j.leukres.2014.07.006","type":"journal-article","created":{"date-parts":[[2014,7,22]],"date-time":"2014-07-22T00:30:12Z","timestamp":1405989012000},"page":"1230-1236","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":28,"title":["The platelet\u2013cancer loop in myeloproliferative cancer. Is thrombocythemia an enhancer of cancer invasiveness and metastasis in essential thrombocythemia, polycythemia vera and myelofibrosis?"],"prefix":"10.1016","volume":"38","author":[{"given":"Hans Carl","family":"Hasselbalch","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2014.07.006_bib0005","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1056\/NEJMra063728","article-title":"The myeloproliferative disorders","volume":"55","author":"Campbell","year":"2006","journal-title":"N Engl J Med"},{"issue":"7","key":"10.1016\/j.leukres.2014.07.006_bib0010","doi-asserted-by":"crossref","first-page":"1216","DOI":"10.3324\/haematol.2009.020412","article-title":"Utoimmunity and the risk of myeloproliferative neoplasms","volume":"95","author":"Kristinsson","year":"2010","journal-title":"Haematologica"},{"issue":"14","key":"10.1016\/j.leukres.2014.07.006_bib0015","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1182\/blood-2011-11-394775","article-title":"Perspectives on chronic inflammation in essential thrombocythemia, polycythemia vera, and myelofibrosis: is chronic inflammation a trigger and driver of clonal evolution and development of accelerated atherosclerosis and second cancer?","volume":"119","author":"Hasselbalch","year":"2012","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.leukres.2014.07.006_bib0020","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.leukres.2012.10.020","article-title":"Chronic inflammation as a promoter of mutagenesis in essential thrombocythemia, polycythemia vera and myelofibrosis. A human inflammation model for cancer development?","volume":"37","author":"Hasselbalch","year":"2013","journal-title":"Leuk Res"},{"issue":"2","key":"10.1016\/j.leukres.2014.07.006_bib0025","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cytogfr.2013.01.004","article-title":"The role of cytokines in the initiation and progression of myelofibrosis","volume":"24","author":"Hasselbalch","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"issue":"7","key":"10.1016\/j.leukres.2014.07.006_bib0030","doi-asserted-by":"crossref","first-page":"2068","DOI":"10.1158\/1055-9965.EPI-09-0353","article-title":"Increased risk of lymphoid neoplasms in patients with Philadelphia chromosome-negative myeloproliferative neoplasms","volume":"18","author":"Vannucchi","year":"2009","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"issue":"9","key":"10.1016\/j.leukres.2014.07.006_bib0035","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1093\/aje\/kwq262","article-title":"Are chronic myeloid leukemia patients more at risk for second malignancies? A population-based study","volume":"172","author":"Rebora","year":"2010","journal-title":"Am J Epidemiol"},{"issue":"2","key":"10.1016\/j.leukres.2014.07.006_bib0040","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1365-2141.2010.08538.x","article-title":"Higher risk of primary cancers after polycythaemia vera and vice versa","volume":"153","author":"Fallah","year":"2011","journal-title":"Br J Haematol"},{"issue":"25","key":"10.1016\/j.leukres.2014.07.006_bib0045","doi-asserted-by":"crossref","first-page":"6515","DOI":"10.1182\/blood-2011-04-348755","article-title":"Chronic myeloproliferative neoplasms and subsequent cancer risk: a Danish population-based cohort study","volume":"118","author":"Frederiksen","year":"2011","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.leukres.2014.07.006_bib0050","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1200\/JCO.2010.31.8436","article-title":"European LeukemiaNet. Philadelphia-negative classical myeloproliferative neoplasms: critical concepts and management recommendations from European Leukemia","volume":"29","author":"Barbui","year":"2011","journal-title":"Net J Clin Oncol"},{"issue":"1","key":"10.1016\/j.leukres.2014.07.006_bib0055","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.leukres.2008.06.002","article-title":"Myelofibrosis with myeloid metaplasia: the advanced phase of an untreated disseminated hematological cancer. Time to change our therapeutic attitude with early upfront treatment?","volume":"33","author":"Hasselbalch","year":"2009","journal-title":"Leuk Res"},{"issue":"3","key":"10.1016\/j.leukres.2014.07.006_bib0060","doi-asserted-by":"crossref","first-page":"392","DOI":"10.2174\/138945011794815275","article-title":"Interferon-alpha in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms. Status and perspectives","volume":"12","author":"Hasselbalch","year":"2011","journal-title":"Curr Drug Targets"},{"issue":"6","key":"10.1016\/j.leukres.2014.07.006_bib0065","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1586\/ehm.11.63","article-title":"A new era of interferon-alpha2 in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms","volume":"4","author":"Hasselbalch","year":"2011","journal-title":"Expert Rev Hematol"},{"issue":"18","key":"10.1016\/j.leukres.2014.07.006_bib0070","doi-asserted-by":"crossref","first-page":"E564","DOI":"10.1200\/JCO.2011.35.6238","article-title":"Interferon alpha in the treatment of Philadelphia-negative chronic myeloproliferative neoplasms","volume":"29","author":"Hasselbalch","year":"2011","journal-title":"J Clin Oncol"},{"issue":"1","key":"10.1016\/j.leukres.2014.07.006_bib0075","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1586\/ehm.12.69","article-title":"Interferon in the treatment of essential thrombocythemia, polycythemia vera and myelofibrosis","volume":"6","author":"Silver","year":"2013","journal-title":"Expert Rev Hematol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0080","article-title":"A mechanistic rationale for the use of statins to enhance JAK2 inhibitor therapy in MPN [abstract]","volume":"118","author":"Griner","year":"2011","journal-title":"Blood (ASH Annual Meeting Abstracts)"},{"issue":"2","key":"10.1016\/j.leukres.2014.07.006_bib0085","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/bjh.12103","article-title":"JAK2-V617F-mediated signaling is dependent on the lipid rafts and statins inhibit JAK2-V617F-dependent cell growth","volume":"160","author":"Griner","year":"2013","journal-title":"Br J Haematol"},{"issue":"10","key":"10.1016\/j.leukres.2014.07.006_bib0090","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/j.leukres.2005.12.018","article-title":"Statins in the treatment of polycythaemia vera and allied disorders: an antithrombotic and cytoreductive potential?","volume":"30","author":"Hasselbalch","year":"2006","journal-title":"Leuk Res"},{"issue":"6","key":"10.1016\/j.leukres.2014.07.006_bib0095","first-page":"576","article-title":"Statin use and reduced cancer-related mortality","volume":"368","author":"Nielsen","year":"2013","journal-title":"N Engl J Med"},{"issue":"3","key":"10.1016\/j.leukres.2014.07.006_bib0100","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1034\/j.1600-0609.2001.00359.x","article-title":"Increased circulating platelet-leukocyte aggregates in myeloproliferative disorders is correlated to previous thrombosis, platelet activation and platelet count","volume":"66","author":"Jensen","year":"2001","journal-title":"Eur J Haematol"},{"issue":"3\u20134","key":"10.1016\/j.leukres.2014.07.006_bib0105","first-page":"148","article-title":"Leukocytosis,JAK2V617F mutation, and hemostasis in myeloproliferative disorders","volume":"36","author":"Marchetti","year":"2008","journal-title":"Pathophysiol Haemost Thromb"},{"issue":"5","key":"10.1016\/j.leukres.2014.07.006_bib0110","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1016\/j.exphem.2007.01.053","article-title":"V617F JAK-2mutation in patients with essential thrombocythemia: relation to platelet, granulocyte, and plasma hemostatic and inflammatory molecules","volume":"35","author":"Falanga","year":"2007","journal-title":"Exp Hematol"},{"issue":"1","key":"10.1016\/j.leukres.2014.07.006_bib0115","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1160\/TH09-09-0663","article-title":"Nitric oxide derivatives and soluble plasma selectins in patients with myeloproliferative neoplasms","volume":"104","author":"Cella","year":"2010","journal-title":"Thromb Haemost"},{"issue":"22","key":"10.1016\/j.leukres.2014.07.006_bib0120","doi-asserted-by":"crossref","first-page":"6830","DOI":"10.1158\/1078-0432.CCR-09-0371","article-title":"Tumor-derived tissue factor-bearing microparticles are associated with venous thromboembolic events in malignancy","volume":"15","author":"Zwicker","year":"2009","journal-title":"Clin Cancer Res"},{"issue":"13","key":"10.1016\/j.leukres.2014.07.006_bib0125","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1182\/blood-2013-03-460154","article-title":"Myeloproliferative neoplasms and thrombosis","volume":"122","author":"Barbui","year":"2013","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.leukres.2014.07.006_bib0130","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1007\/s10238-013-0230-0","article-title":"Cancer-related coagulopathy (Trousseau's syndrome): review of the literature and experience of a single center of internal medicine","volume":"13","author":"Dammacco","year":"2013","journal-title":"Clin Exp Med"},{"issue":"5","key":"10.1016\/j.leukres.2014.07.006_bib0135","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1097\/MOH.0b013e32836344d3","article-title":"Platelet function beyond hemostasis and thrombosis","volume":"20","author":"Ware","year":"2013","journal-title":"Curr Opin Hematol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0140","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1073\/pnas.61.1.46","article-title":"Antimetastatic effects associated with platelet reduction","volume":"61","author":"Gasic","year":"1968","journal-title":"Proc Nat Acad Sci USA"},{"key":"10.1016\/j.leukres.2014.07.006_bib0145","doi-asserted-by":"crossref","first-page":"1182","DOI":"10.1056\/NEJM197111182852108","article-title":"Tumor angiogenesis: therapeutic implications","volume":"285","author":"Folkman","year":"1971","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2014.07.006_bib0150","doi-asserted-by":"crossref","first-page":"646","DOI":"10.7326\/0003-4819-95-5-636","article-title":"Role of platelets in tumor cell metastases","volume":"95","author":"Karpatkin","year":"1981","journal-title":"Ann Intern Med"},{"issue":"4","key":"10.1016\/j.leukres.2014.07.006_bib0155","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1172\/JCI113411","article-title":"Role of adhesive proteins in platelet tumor interaction in vitro and metastasis formation in vivo","volume":"81","author":"Karpatkin","year":"1988","journal-title":"J Clin Invest"},{"key":"10.1016\/j.leukres.2014.07.006_bib0160","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1007\/BF01307186","article-title":"Platelets and cancer metastasis: a causal relationship","volume":"11","author":"Honn","year":"1992","journal-title":"Cancer Metastasis Rev"},{"issue":"3","key":"10.1016\/j.leukres.2014.07.006_bib0165","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/ijc.2910600324","article-title":"The effect of platelets on invasiveness and protease production of human mammary tumor cells","volume":"60","author":"Belloc","year":"1995","journal-title":"Int J Cancer"},{"issue":"9142","key":"10.1016\/j.leukres.2014.07.006_bib0170","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1016\/S0140-6736(98)05095-8","article-title":"Involvement of platelets in tumour angiogenesis?","volume":"352","author":"Pinedo","year":"1998","journal-title":"Lancet"},{"key":"10.1016\/j.leukres.2014.07.006_bib0175","first-page":"1696","article-title":"Platelets and metastasis: a novel fatty link","volume":"114","author":"Gupta","year":"2004","journal-title":"Eur J Clin Invest"},{"key":"10.1016\/j.leukres.2014.07.006_bib0180","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1055\/s-2004-822974","article-title":"Platelets and angiogenesis in malignancy","volume":"30","author":"Sierko","year":"2004","journal-title":"Semin Thromb Hemost"},{"issue":"1","key":"10.1016\/j.leukres.2014.07.006_bib0185","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1182\/blood-2004-06-2272","article-title":"Platelets and fibrin(ogen) increase metastatic potential by impeding natural killer cell-mediated elimination of tumor cells","volume":"105","author":"Palumbo","year":"2005","journal-title":"Blood"},{"issue":"43","key":"10.1016\/j.leukres.2014.07.006_bib0190","first-page":"237","article-title":"Role of platelet-derived microparticles in angiogenesis and tumor progression","author":"Varon","year":"2009","journal-title":"Discovery Med"},{"issue":"5","key":"10.1016\/j.leukres.2014.07.006_bib0195","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1182\/blood-2011-02-334524","article-title":"Release of angiogenesis regulatory proteins from platelet alpha granules: modulation of physiologic and pathologic angiogenesis","volume":"118","author":"Battinelli","year":"2011","journal-title":"Blood"},{"issue":"Suppl 1","key":"10.1016\/j.leukres.2014.07.006_bib0200","doi-asserted-by":"crossref","first-page":"S98","DOI":"10.1016\/j.thromres.2012.08.289","article-title":"Involvement of platelet derived microparticles in tumor metastasis and tissue regeneration","volume":"130","author":"Varon","year":"2012","journal-title":"Thromb Res"},{"issue":"24","key":"10.1016\/j.leukres.2014.07.006_bib0205","doi-asserted-by":"crossref","first-page":"4869","DOI":"10.1182\/blood-2012-06-438598","article-title":"Platelets increase the proliferation of ovarian cancer cells","volume":"120","author":"Cho","year":"2012","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.leukres.2014.07.006_bib0210","doi-asserted-by":"crossref","first-page":"2747","DOI":"10.1002\/ijc.27441","article-title":"Tumor-platelet interaction in solid tumors","volume":"130","author":"Buergy","year":"2012","journal-title":"Int J Cancer"},{"issue":"5","key":"10.1016\/j.leukres.2014.07.006_bib0215","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.ccr.2011.09.009","article-title":"Direct signaling between platelets and cancer cells induces an epithelial\u2013mesenchymal-like transition and promotes metastasis","volume":"20","author":"Labelle","year":"2011","journal-title":"Cancer Cell"},{"issue":"12","key":"10.1016\/j.leukres.2014.07.006_bib0220","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1158\/2159-8290.CD-12-0329","article-title":"The initial hours of metastasis: the importance of cooperative host-tumor cell interactions during hematogenous dissemination","volume":"2","author":"Labelle","year":"2012","journal-title":"Cancer Discovery"},{"issue":"5","key":"10.1016\/j.leukres.2014.07.006_bib0225","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.ejim.2013.01.017","article-title":"The platelet\u2013cancer loop","volume":"24","author":"Goubran","year":"2013","journal-title":"Eur J Intern Med"},{"issue":"3","key":"10.1016\/j.leukres.2014.07.006_bib0230","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1055\/s-0034-1370767","article-title":"Platelet\u2013cancer interactions","volume":"40","author":"Goubran","year":"2014","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.leukres.2014.07.006_bib0235","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1002\/jcp.24539","article-title":"Platelets in tumor progression: a host factor effect that offers multiple potential targets in the treatment of cancer","volume":"229","author":"Sharma","year":"2014","journal-title":"J Cell Physiol"},{"issue":"2","key":"10.1016\/j.leukres.2014.07.006_bib0240","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1182\/blood-2014-03-562538","article-title":"Paraneoplastic thrombocytosis\u2014the secret of tumor self-promotion","volume":"124","author":"Lin","year":"2014","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.leukres.2014.07.006_bib0245","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/S1470-2045(02)00789-1","article-title":"Platelets and cancer","volume":"3","author":"Nash","year":"2002","journal-title":"Lancet Oncol"},{"issue":"12","key":"10.1016\/j.leukres.2014.07.006_bib0250","doi-asserted-by":"crossref","first-page":"2362","DOI":"10.1161\/ATVBAHA.110.207514","article-title":"Platelets: linking hemostasis and cancer","volume":"30","author":"Jain","year":"2010","journal-title":"Arterioscler Thromb Vasc Biol"},{"issue":"10","key":"10.1016\/j.leukres.2014.07.006_bib0255","doi-asserted-by":"crossref","first-page":"e26125","DOI":"10.1371\/journal.pone.0026125","article-title":"Platelet adhesion and degranulation induce pro-survival and pro-angiogenic signalling in ovarian cancer cells","volume":"6","author":"Egan","year":"2011","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.leukres.2014.07.006_bib0260","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1517\/14712598.7.4.449","article-title":"Vascular endothelial growth factor and immunosuppression in cancer: current knowledge and potential for new therapy","volume":"7","author":"Johnson","year":"2007","journal-title":"Expert Opin Biol Ther"},{"issue":"12","key":"10.1016\/j.leukres.2014.07.006_bib0265","doi-asserted-by":"crossref","first-page":"4589","DOI":"10.1182\/blood-2005-10-4169","article-title":"Role of transforming growth factor-beta in hematologic malignancies","volume":"107","author":"Dong","year":"2006","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.leukres.2014.07.006_bib0270","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.it.2010.04.002","article-title":"TGF-beta and immune cells: an important regulatory axis in the tumor microenvironment and progression","volume":"31","author":"Yang","year":"2010","journal-title":"Trends Immunol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0275","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1111\/j.1538-7836.2010.04131.x","article-title":"The platelet contribution to cancer progression","volume":"9","author":"Bambace","year":"2011","journal-title":"J Thromb Haemost"},{"issue":"6","key":"10.1016\/j.leukres.2014.07.006_bib0280","first-page":"1295","article-title":"Lysis of tumor cells by natural killer cells in mice is impeded by platelets","volume":"59","author":"Nieswandt","year":"1999","journal-title":"Cancer Res"},{"issue":"5","key":"10.1016\/j.leukres.2014.07.006_bib0285","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1111\/j.1365-3083.1991.tb02522.x","article-title":"Inhibition of human natural killer cell activity by platelet-derived growth factor (PDGF). III. Membrane binding studies and differential biological effect of recombinant PDGF isoforms","volume":"33","author":"Gersuk","year":"1991","journal-title":"Scand J Immunol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0290","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1159\/000012095","article-title":"Thrombocytes are the major source for soluble vascular endothelial growth factor in peripheral blood","volume":"58","author":"Gunsilius","year":"2000","journal-title":"Oncology"},{"key":"10.1016\/j.leukres.2014.07.006_bib0295","doi-asserted-by":"crossref","first-page":"7775","DOI":"10.1158\/0008-5472.CAN-09-2123","article-title":"Platelet-derived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity","volume":"69","author":"Kopp","year":"2009","journal-title":"Cancer Res"},{"issue":"Suppl 1","key":"10.1016\/j.leukres.2014.07.006_bib0300","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1111\/j.1538-7836.2011.04317.x","article-title":"How platelets safeguard vascular integrity","volume":"9","author":"Ho-Tin-No\u00e9","year":"2011","journal-title":"J Thromb Haemost"},{"key":"10.1016\/j.leukres.2014.07.006_bib0305","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/nrc3004","article-title":"Contribution of platelets to tumour metastasis","volume":"11","author":"Gay","year":"2011","journal-title":"Nat Rev Cancer"},{"issue":"2","key":"10.1016\/j.leukres.2014.07.006_bib0310","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1073\/pnas.94.2.663","article-title":"Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets","volume":"94","author":"M\u00f6hle","year":"1997","journal-title":"Proc Nat Acad Sci USA"},{"issue":"1","key":"10.1016\/j.leukres.2014.07.006_bib0315","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1055\/s-0037-1615158","article-title":"Peripheral blood platelets express VEGF-C and VEGF which are released during platelet activation","volume":"80","author":"Wartiovaara","year":"1998","journal-title":"Thromb Haemost"},{"issue":"34","key":"10.1016\/j.leukres.2014.07.006_bib0320","doi-asserted-by":"crossref","first-page":"23969","DOI":"10.1074\/jbc.274.34.23969","article-title":"On the mechanism of thrombin-induced angiogenesis. Potentiation of vascular endothelial growth factor activity on endothelial cells by up-regulation of its receptors","volume":"274","author":"Tsopanoglou","year":"1999","journal-title":"J Biol Chem"},{"issue":"4","key":"10.1016\/j.leukres.2014.07.006_bib0325","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1073\/pnas.0510412103","article-title":"Platelets and platelet adhesion support angiogenesis while preventing excessive hemorrhage","volume":"103","author":"Kisucka","year":"2006","journal-title":"Proc Nat Acad Sci USA"},{"issue":"12","key":"10.1016\/j.leukres.2014.07.006_bib0330","doi-asserted-by":"crossref","first-page":"2835","DOI":"10.1182\/blood-2008-06-159541","article-title":"Platelets actively sequester angiogenesis regulators","volume":"113","author":"Klement","year":"2009","journal-title":"Blood"},{"issue":"16","key":"10.1016\/j.leukres.2014.07.006_bib0335","doi-asserted-by":"crossref","first-page":"9325","DOI":"10.1073\/pnas.95.16.9325","article-title":"P-selectin deficiency attenuates tumor growth and metastasis","volume":"95","author":"Kim","year":"1998","journal-title":"Proc Nat Acad Sci USA"},{"issue":"4","key":"10.1016\/j.leukres.2014.07.006_bib0340","doi-asserted-by":"crossref","first-page":"2193","DOI":"10.1073\/pnas.261704098","article-title":"Synergistic effects of L- and P-selectin in facilitating tumor metastasis can involve non-mucin ligands and implicate leukocytes as enhancers of metastasis","volume":"99","author":"Borsig","year":"2002","journal-title":"Proc Nat Acad Sci USA"},{"issue":"24","key":"10.1016\/j.leukres.2014.07.006_bib0345","doi-asserted-by":"crossref","first-page":"14205","DOI":"10.1073\/pnas.2234372100","article-title":"Platelet and osteoclast beta3 integrins are critical for bone metastasis","volume":"100","author":"Bakewell","year":"2003","journal-title":"Proc Nat Acad Sci USA"},{"issue":"21","key":"10.1016\/j.leukres.2014.07.006_bib0350","doi-asserted-by":"crossref","first-page":"9024","DOI":"10.1073\/pnas.0700625104","article-title":"Platelet glycoprotein Ib alpha supports experimental lung metastasis","volume":"104","author":"Jain","year":"2007","journal-title":"Proc Nat Acad Sci USA"},{"issue":"9","key":"10.1016\/j.leukres.2014.07.006_bib0355","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1183\/09031936.96.09091826","article-title":"Prognostic significance of thrombocytosis in patients with primary lung cancer","volume":"9","author":"Pedersen","year":"1996","journal-title":"Eur Respir J"},{"key":"10.1016\/j.leukres.2014.07.006_bib0360","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1006\/gyno.2000.5838","article-title":"The significance of thrombocytosis in patients with locally advanced cervical carcinoma: a Gynecologic Oncology Group study","volume":"78","author":"Hernandez","year":"2000","journal-title":"Gynecol Oncol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0365","first-page":"3983","article-title":"Preoperative thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer","volume":"20","author":"Scholz","year":"2000","journal-title":"Anticancer Res"},{"key":"10.1016\/j.leukres.2014.07.006_bib0370","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1007\/BF02573067","article-title":"Poor prognosis associated with thrombocytosis in patients with gastric cancer","volume":"9","author":"Ikeda","year":"2002","journal-title":"Ann Surg Oncol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0375","doi-asserted-by":"crossref","first-page":"1098","DOI":"10.1055\/s-0037-1613413","article-title":"Impact of pretreatment thrombocytosis on survival in primary breast cancer","volume":"89","author":"Menzel","year":"2003","journal-title":"Thromb Haemost"},{"key":"10.1016\/j.leukres.2014.07.006_bib0380","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jamcollsurg.2004.01.022","article-title":"Thrombocytosis associated with poor prognosis in patients with esophageal carcinoma","volume":"198","author":"Shimada","year":"2004","journal-title":"J Am Coll Surg"},{"key":"10.1016\/j.leukres.2014.07.006_bib0385","first-page":"2687","article-title":"Preoperative leukocytosis, anemia and thrombocytosis are associated with poor survival in non-small cell lung cancer","volume":"29","author":"Tomita","year":"2009","journal-title":"Anticancer Res"},{"key":"10.1016\/j.leukres.2014.07.006_bib0390","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1007\/s12032-009-9217-9","article-title":"Platelet count: association with prognosis in lung cancer","volume":"27","author":"Gonzalez Barcala","year":"2010","journal-title":"Med Oncol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0395","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1016\/j.ygyno.2011.04.012","article-title":"The impact of pretreatment thrombocytosis and persistent thrombocytosis after adjuvant chemotherapy in patients with advanced epithelial ovarian cancer","volume":"122","author":"Lee","year":"2011","journal-title":"Gynecol Oncol"},{"issue":"5","key":"10.1016\/j.leukres.2014.07.006_bib0400","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1097\/MOU.0b013e32834966fa","article-title":"The prognostic value of hematological and systemic inflammatory disorders in invasive bladder cancer","volume":"21","author":"Gakis","year":"2011","journal-title":"Curr Opin Urol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0405","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.ejso.2012.04.009","article-title":"Impact of pretreatment thrombocytosis on blood\u2013borne metastasis and prognosis of gastric cancer","volume":"38","author":"Hwang","year":"2012","journal-title":"Eur J Surg Oncol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0410","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.arcmed.2012.06.008","article-title":"Thrombocytosis as a predictor of distant recurrence in patients with rectal cancer","volume":"43","author":"Cravioto-Villanueva","year":"2012","journal-title":"Arch Med Res"},{"issue":"11 Pt B","key":"10.1016\/j.leukres.2014.07.006_bib0415","doi-asserted-by":"crossref","first-page":"E533","DOI":"10.1111\/j.1464-410X.2012.11231.x","article-title":"A new prognostic model for cancer-specific survival after radical cystectomy including pretreatment thrombocytosis and standard pathological risk factors","volume":"110","author":"Todenh\u00f6fer","year":"2012","journal-title":"BJU Int"},{"key":"10.1016\/j.leukres.2014.07.006_bib0420","doi-asserted-by":"crossref","first-page":"3176","DOI":"10.1007\/s12032-012-0247-3","article-title":"Swedish lung cancer radiation study group: the prognostic value of anaemia, thrombocytosis and leukocytosis at time of diagnosis in patients with non-small cell lung cancer","volume":"29","author":"Holgersson","year":"2012","journal-title":"Med Oncol"},{"issue":"7","key":"10.1016\/j.leukres.2014.07.006_bib0425","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1056\/NEJMoa1110352","article-title":"Paraneoplastic thrombocytosis in ovarian cancer","volume":"366","author":"Stone","year":"2012","journal-title":"N Engl J Med"},{"key":"10.1016\/j.leukres.2014.07.006_bib0430","doi-asserted-by":"crossref","first-page":"289563","DOI":"10.1155\/2013\/289563","article-title":"Pretreatment thrombocytosis as a prognostic factor in metastatic breast cancer","volume":"2013","author":"Stravodimou","year":"2013","journal-title":"Int J Breast Cancer"},{"key":"10.1016\/j.leukres.2014.07.006_bib0435","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1007\/s00384-012-1594-4","article-title":"Thrombocytosis before pre-operative chemoradiotherapy predicts poor response and shorter local recurrence-free survival in rectal cancer","volume":"28","author":"Kawai","year":"2013","journal-title":"Int J Colorectal Dis"},{"issue":"12","key":"10.1016\/j.leukres.2014.07.006_bib0440","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1186\/1477-7819-12-37","article-title":"Preoperative thrombocytosis is a significant unfavorable prognostic factor for patients with resectable non-small cell lung cancer","volume":"12","author":"Kim","year":"2014","journal-title":"World J Surg Oncol"},{"issue":"2","key":"10.1016\/j.leukres.2014.07.006_bib0445","doi-asserted-by":"crossref","first-page":"34","DOI":"10.4251\/wjgo.v6.i2.34","article-title":"Thrombocytosis as a prognostic marker in gastrointestinal cancers","volume":"6","author":"Voutsadakis","year":"2014","journal-title":"World J Gastrointest Oncol"},{"issue":"9826","key":"10.1016\/j.leukres.2014.07.006_bib0450","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1016\/S0140-6736(12)60209-8","article-title":"Effect of daily aspirin on risk of cancer metastasis: a study of incident cancers during randomised controlled trials","volume":"379","author":"Rothwell","year":"2012","journal-title":"Lancet"},{"issue":"9826","key":"10.1016\/j.leukres.2014.07.006_bib0455","doi-asserted-by":"crossref","first-page":"1602","DOI":"10.1016\/S0140-6736(11)61720-0","article-title":"Short-term effects of daily aspirin on cancer incidence, mortality, and non-vascular death: analysis of the time course of risks and benefits in 51 randomised controlled trials","volume":"379","author":"Rothwell","year":"2012","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.leukres.2014.07.006_bib0460","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1016\/S1470-2045(12)70112-2","article-title":"Effects of regular aspirin on long-term cancer incidence and metastasis: a systematic comparison of evidence from observational studies versus randomised trials","volume":"13","author":"Algra","year":"2012","journal-title":"Lancet Oncol"},{"issue":"4","key":"10.1016\/j.leukres.2014.07.006_bib0465","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.bpg.2012.10.001","article-title":"Mechanisms of the antitumoural effects of aspirin in the gastrointestinal tract","volume":"26","author":"Bruno","year":"2012","journal-title":"Best Pract Res Clin Gastroenterol"},{"issue":"6101","key":"10.1016\/j.leukres.2014.07.006_bib0470","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1126\/science.337.6101.1471","article-title":"Will an aspirin a day keep cancer away?","volume":"337","author":"Kaiser","year":"2012","journal-title":"Science"},{"issue":"6101","key":"10.1016\/j.leukres.2014.07.006_bib0475","doi-asserted-by":"crossref","first-page":"1472","DOI":"10.1126\/science.337.6101.1472","article-title":"Wondering how the wonder drug works","volume":"337","author":"Kaiser","year":"2012","journal-title":"Science"},{"key":"10.1016\/j.leukres.2014.07.006_bib0480","first-page":"615","article-title":"Thrombocytosis: platelet kinetics in neoplasia","volume":"84","author":"Tranum","year":"1974","journal-title":"J Lab Clin Med"},{"key":"10.1016\/j.leukres.2014.07.006_bib0485","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1055\/s-2004-822974","article-title":"Platelets and angiogenesis in malignancy","volume":"30","author":"Sierko","year":"2004","journal-title":"Semin Thromb Hemost"},{"key":"10.1016\/j.leukres.2014.07.006_bib0490","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1182\/blood.V80.8.2052.2052","article-title":"Thrombocytosis in patients with tumors producing colony-stimulating factor","volume":"80","author":"Suzuki","year":"1992","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2014.07.006_bib0495","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1111\/j.1365-2141.1993.tb04668.x","article-title":"High IL-6 levels in ascitic fluid correlate with reactive thrombocytosis in patients with epithelial ovarian cancer","volume":"83","author":"Gastl","year":"1993","journal-title":"Br J Haematol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0500","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1097\/00000421-200304000-00007","article-title":"Levels of serum cytokines and acute phase proteins in patients with essential and cancer-related thrombocytosis","volume":"26","author":"Alexandrakis","year":"2003","journal-title":"Am J Clin Oncol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0505","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1038\/bjc.1998.150","article-title":"Interleukin 6 and its relationship to clinical parameters in patients with malignant pleural mesothelioma","volume":"77","author":"Nakano","year":"1998","journal-title":"Br J Cancer"},{"key":"10.1016\/j.leukres.2014.07.006_bib0510","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.3748\/wjg.v10.i8.1115","article-title":"C-reactive protein, procalcitonin, interleukin-6, vascular endothelial growth factor and oxidative metabolites in diagnosis of infection and staging in patients with gastric cancer","volume":"10","author":"Ilhan","year":"2004","journal-title":"World J Gastroenterol"},{"key":"10.1016\/j.leukres.2014.07.006_bib0515","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.canlet.2013.05.033","article-title":"Profiles of circulating inflammatory cytokines in colorectal cancer (CRC), high cancer risk conditions, and health are distinct. Possible implications for CRC screening and surveillance","volume":"337","author":"Krzystek-Korpacka","year":"2013","journal-title":"Cancer Lett"},{"key":"10.1016\/j.leukres.2014.07.006_bib0520","doi-asserted-by":"crossref","first-page":"1079","DOI":"10.1007\/s00418-008-0527-3","article-title":"Tumor-host interactions: the role of inflammation","volume":"130","author":"Le Bitoux","year":"2008","journal-title":"Histochem Cell Biol"},{"issue":"4","key":"10.1016\/j.leukres.2014.07.006_bib0525","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00109-013-1021-5","article-title":"The metastasis-promoting roles of tumor-associated immune cells","volume":"91","author":"Smith","year":"2013","journal-title":"J Mol Med"},{"key":"10.1016\/j.leukres.2014.07.006_bib0530","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1158\/1078-0432.CCR-11-1591","article-title":"Molecular pathways: hypoxia response in immune cells fighting or promoting cancer","volume":"18","author":"Palaz\u00f3n","year":"2012","journal-title":"Clin Cancer Res"},{"issue":"9255","key":"10.1016\/j.leukres.2014.07.006_bib0535","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1016\/S0140-6736(00)04046-0","article-title":"Inflammation and cancer: back to Virchow?","volume":"357","author":"Balkwill","year":"2001","journal-title":"Lancet"},{"issue":"6917","key":"10.1016\/j.leukres.2014.07.006_bib0540","doi-asserted-by":"crossref","first-page":"860","DOI":"10.1038\/nature01322","article-title":"Inflammation and cancer","volume":"420","author":"Coussens","year":"2002","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.leukres.2014.07.006_bib0545","doi-asserted-by":"crossref","first-page":"749","DOI":"10.1038\/nri1703","article-title":"NF-kappaB: linking inflammation and immunity to cancer development and progression","volume":"5","author":"Karin","year":"2005","journal-title":"Nat Rev Immunol"},{"issue":"11","key":"10.1016\/j.leukres.2014.07.006_bib0550","doi-asserted-by":"crossref","first-page":"2373","DOI":"10.1002\/ijc.23173","article-title":"Inflammation and cancer: an ancient link with novel potentials","volume":"121","author":"Hussain","year":"2007","journal-title":"Int J Cancer"},{"issue":"3","key":"10.1016\/j.leukres.2014.07.006_bib0555","doi-asserted-by":"crossref","first-page":"161","DOI":"10.3109\/07853890903405753","article-title":"Molecular pathways and targets in cancer-related inflammation","volume":"42","author":"Mantovani","year":"2010","journal-title":"Ann Med"},{"issue":"4","key":"10.1016\/j.leukres.2014.07.006_bib0560","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1038\/nri2956","article-title":"Platelets and the immune continuum","volume":"11","author":"Semple","year":"2011","journal-title":"Nat Rev Immunol"},{"issue":"6","key":"10.1016\/j.leukres.2014.07.006_bib0565","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1007\/s00005-012-0193-y","article-title":"Platelets in inflammation and immune modulations: functions beyond hemostasis","volume":"60","author":"Huang","year":"2012","journal-title":"Arch Immunol Ther Exp"},{"issue":"3","key":"10.1016\/j.leukres.2014.07.006_bib0570","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.thromres.2012.11.028","article-title":"Platelet-leukocyte crosstalk: linking proinflammatory responses to procoagulant state","volume":"131","author":"Ghasemzadeh","year":"2013","journal-title":"Thromb Res"},{"issue":"4","key":"10.1016\/j.leukres.2014.07.006_bib0575","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1002\/ajh.2830340411","article-title":"Idiopathic myelofibrosis: a clinical study of 80 patients","volume":"34","author":"Hasselbalch","year":"1990","journal-title":"Am J Hematol"},{"issue":"3","key":"10.1016\/j.leukres.2014.07.006_bib0580","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1111\/j.1365-2141.2004.05277.x","article-title":"Thrombosis and haemorrhage in polycythaemia vera and essential thrombocythaemia","volume":"128","author":"Elliott","year":"2005","journal-title":"Br J Haematol"},{"issue":"4","key":"10.1016\/j.leukres.2014.07.006_bib0585","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1182\/blood-2009-02-206797","article-title":"Perspectives on thrombosis in essential thrombocythemia and polycythemia vera: is leukocytosis a causative factor?","volume":"114","author":"Barbui","year":"2009","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.leukres.2014.07.006_bib0590","doi-asserted-by":"crossref","first-page":"2224","DOI":"10.1200\/JCO.2005.07.062","article-title":"Vascular and neoplastic risk in a large cohort of patients with polycythemia vera","volume":"23","author":"Marchioli","year":"2005","journal-title":"J Clin Oncol"},{"issue":"2","key":"10.1016\/j.leukres.2014.07.006_bib0595","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1586\/17474086.2013.876356","article-title":"Perspectives on the impact of JAK-inhibitor therapy upon inflammation-mediated comorbidities in myelofibrosis and related neoplasms","volume":"7","author":"Hasselbalch","year":"2014","journal-title":"Expert Rev Hematol"},{"issue":"10","key":"10.1016\/j.leukres.2014.07.006_bib0600","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1038\/nri910","article-title":"NF-kappaB regulation in the immune system","volume":"2","author":"Li","year":"2002","journal-title":"Nat Rev Immunol"},{"issue":"5288","key":"10.1016\/j.leukres.2014.07.006_bib0605","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1126\/science.274.5288.782","article-title":"An essential role for NFkappaB in preventing TNF-alpha induced cell death","volume":"274","author":"Beg","year":"1996","journal-title":"Science"},{"issue":"7007","key":"10.1016\/j.leukres.2014.07.006_bib0610","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/nature02924","article-title":"NF-kappaB functions as a tumour promoter in inflammation associated cancer","volume":"431","author":"Pikarsky","year":"2004","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.leukres.2014.07.006_bib0615","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/S1359-6101(01)00020-X","article-title":"Tumor necrosis factor or tumor promoting factor?","volume":"13","author":"Balkwill","year":"2002","journal-title":"Cytokine Growth Factor Rev"},{"issue":"24","key":"10.1016\/j.leukres.2014.07.006_bib0620","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1182\/blood-2011-04-348144","article-title":"Tumor necrosis factor-alpha facilitates clonal expansion of JAK2V617F-positive cells in myeloproliferative neoplasms","volume":"118","author":"Fleischman","year":"2011","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.leukres.2014.07.006_bib0625","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1016\/j.leukres.2012.07.009","article-title":"Molecular profiling of peripheral blood cells from patients with polycythemia vera and related neoplasms: identification of deregulated genes of significance for inflammation and immune surveillance","volume":"36","author":"Skov","year":"2012","journal-title":"Leuk Res"},{"issue":"9","key":"10.1016\/j.leukres.2014.07.006_bib0630","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1016\/j.exphem.2012.05.011","article-title":"Gene expression profiling with principal component analysis depicts the biological continuum from essential thrombocythemia over polycythemia vera to myelofibrosis","volume":"40","author":"Skov","year":"2012","journal-title":"Exp Hematol"},{"issue":"10","key":"10.1016\/j.leukres.2014.07.006_bib0635","doi-asserted-by":"crossref","first-page":"2269","DOI":"10.3109\/10428194.2013.764417","article-title":"Whole blood transcriptional profiling reveals significant downregulation of HLA Class I and II genes in essential thrombocythemia, polycythemia vera and myelofibrosis","volume":"54","author":"Skov","year":"2013","journal-title":"Leuk Lymphoma"},{"key":"10.1016\/j.leukres.2014.07.006_bib0640","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1056\/NEJMoa035572","article-title":"Efficacy and safety of low-dose aspirin in polycythemia vera","volume":"350","author":"Landolfi","year":"2004","journal-title":"N Engl J Med"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212614002239?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212614002239?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2020,8,22]],"date-time":"2020-08-22T12:58:20Z","timestamp":1598101100000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212614002239"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,10]]},"references-count":128,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["S0145212614002239"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2014.07.006","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2014,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The platelet\u2013cancer loop in myeloproliferative cancer. Is thrombocythemia an enhancer of cancer invasiveness and metastasis in essential thrombocythemia, polycythemia vera and myelofibrosis?","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2014.07.006","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2014 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}