{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T10:49:53Z","timestamp":1789901393701,"version":"4.0.1"},"reference-count":42,"publisher":"Elsevier BV","issue":"7","license":[{"start":{"date-parts":[[2015,7,1]],"date-time":"2015-07-01T00:00:00Z","timestamp":1435708800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2015,3,18]],"date-time":"2015-03-18T00:00:00Z","timestamp":1426636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100005036","name":"Universitetet i Bergen","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005036","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005029","name":"Helse Vest Regionalt Helsef\u00f8retak","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005029","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2015,7]]},"DOI":"10.1016\/j.leukres.2015.03.003","type":"journal-article","created":{"date-parts":[[2015,3,29]],"date-time":"2015-03-29T07:03:22Z","timestamp":1427612602000},"page":"702-708","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":14,"title":["IGHV gene usage and mutational status in follicular lymphoma: Correlations with prognosis and patient age"],"prefix":"10.1016","volume":"39","author":[{"given":"Ellen","family":"Berget","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anders","family":"Molven","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Turid","family":"L\u00f8keland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lars","family":"Helgeland","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olav Karsten","family":"Vintermyr","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.leukres.2015.03.003_bib0215","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1111\/j.1365-2559.2010.03696.x","article-title":"Epidemiology of lymphomas","volume":"58","author":"Roman","year":"2011","journal-title":"Histopathology"},{"issue":"5","key":"10.1016\/j.leukres.2015.03.003_bib0220","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1182\/blood-2003-12-4434","article-title":"Follicular lymphoma international prognostic index","volume":"104","author":"Solal-Celigny","year":"2004","journal-title":"Blood"},{"issue":"27","key":"10.1016\/j.leukres.2015.03.003_bib0225","doi-asserted-by":"crossref","first-page":"4555","DOI":"10.1200\/JCO.2008.21.3991","article-title":"Follicular lymphoma international prognostic index 2: a new prognostic index for follicular lymphoma developed by the international follicular lymphoma prognostic factor project","volume":"27","author":"Federico","year":"2009","journal-title":"J Clin Oncol"},{"issue":"19","key":"10.1016\/j.leukres.2015.03.003_bib0230","doi-asserted-by":"crossref","first-page":"8910","DOI":"10.1073\/pnas.91.19.8910","article-title":"BCL2 translocation frequency rises with age in humans","volume":"91","author":"Liu","year":"1994","journal-title":"Proc Natl Acad Sci USA"},{"issue":"9","key":"10.1016\/j.leukres.2015.03.003_bib0235","doi-asserted-by":"crossref","first-page":"2528","DOI":"10.1182\/blood.V85.9.2528.bloodjournal8592528","article-title":"Lymphoma-associated translocation t(14;18) in blood B cells of normal individuals","volume":"85","author":"Limpens","year":"1995","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.leukres.2015.03.003_bib0240","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1200\/JCO.1996.14.4.1333","article-title":"BCL-2\/J(H) rearrangements in circulating B cells of healthy blood donors and patients with nonmalignant diseases","volume":"14","author":"Dolken","year":"1996","journal-title":"J Clin Oncol"},{"key":"10.1016\/j.leukres.2015.03.003_bib0245","series-title":"WHO classification of tumours of haematopoietic and lymphoid tissues.","year":"2008"},{"issue":"6","key":"10.1016\/j.leukres.2015.03.003_bib0250","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1182\/blood.V78.6.1561.1561","article-title":"Ig VH gene expression among human follicular lymphoma","volume":"78","author":"Bahler","year":"1991","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.leukres.2015.03.003_bib0255","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1111\/j.1365-2141.1994.tb04780.x","article-title":"Clonal history of a human follicular lymphoma as revealed in the immunoglobulin variable region genes","volume":"86","author":"Zhu","year":"1994","journal-title":"Br J Haematol"},{"issue":"1","key":"10.1016\/j.leukres.2015.03.003_bib0260","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1046\/j.1365-2141.1997.8492477.x","article-title":"Follicular lymphoma immunoglobulin kappa light chains are affected by the antigen selection process, but to a lesser degree than their partner heavy chains","volume":"96","author":"Stamatopoulos","year":"1997","journal-title":"Br J Haematol"},{"issue":"11","key":"10.1016\/j.leukres.2015.03.003_bib0265","doi-asserted-by":"crossref","first-page":"4292","DOI":"10.1182\/blood.V91.11.4292","article-title":"Analysis of VH genes in follicular and diffuse lymphoma shows ongoing somatic mutation and multiple isotype transcripts in early diseases with changes during disease progression","volume":"91","author":"Ottensmeier","year":"1998","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.leukres.2015.03.003_bib0270","doi-asserted-by":"crossref","first-page":"2922","DOI":"10.1182\/blood.V95.9.2922.009k38_2922_2929","article-title":"Variable heavy chain gene analysis of follicular lymphomas: correlation between heavy chain isotype expression and somatic mutation load","volume":"95","author":"Aarts","year":"2000","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.leukres.2015.03.003_bib0275","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1084\/jem.180.1.329","article-title":"Analysis of somatic mutation in five B cell subsets of human tonsil","volume":"180","author":"Pascual","year":"1994","journal-title":"J Exp Med"},{"issue":"6","key":"10.1016\/j.leukres.2015.03.003_bib0280","doi-asserted-by":"crossref","first-page":"1840","DOI":"10.1182\/blood.V94.6.1840","article-title":"Ig V gene mutation status and CD38 expression as novel prognostic indicators in chronic lymphocytic leukemia","volume":"94","author":"Damle","year":"1999","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.leukres.2015.03.003_bib0285","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1182\/blood.V94.6.1848","article-title":"Unmutated Ig V(H) genes are associated with a more aggressive form of chronic lymphocytic leukemia","volume":"94","author":"Hamblin","year":"1999","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.leukres.2015.03.003_bib0290","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1182\/blood.V99.4.1299","article-title":"Analysis of the IgV(H) somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course","volume":"99","author":"Algara","year":"2002","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.leukres.2015.03.003_bib0295","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/S0002-9440(10)64159-4","article-title":"Splenic marginal zone lymphomas appear to originate from different B cell types","volume":"161","author":"Bahler","year":"2002","journal-title":"Am J Pathol"},{"issue":"10","key":"10.1016\/j.leukres.2015.03.003_bib0300","doi-asserted-by":"crossref","first-page":"4042","DOI":"10.1182\/blood-2002-11-3456","article-title":"Molecular heterogeneity in MCL defined by the use of specific VH genes and the frequency of somatic mutations","volume":"101","author":"Camacho","year":"2003","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.leukres.2015.03.003_bib0305","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/sj.leu.2404457","article-title":"ERIC recommendations on IGHV gene mutational status analysis in chronic lymphocytic leukemia","volume":"21","author":"Ghia","year":"2007","journal-title":"Leukemia"},{"issue":"6","key":"10.1016\/j.leukres.2015.03.003_bib0310","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1038\/leu.2011.49","article-title":"Immunoglobulin sequence analysis and prognostication in CLL: guidelines from the ERIC review board for reliable interpretation of problematic cases","volume":"25","author":"Langerak","year":"2011","journal-title":"Leukemia"},{"issue":"6","key":"10.1016\/j.leukres.2015.03.003_bib0315","doi-asserted-by":"crossref","first-page":"2262","DOI":"10.1182\/blood.V99.6.2262","article-title":"Somatically mutated Ig V(H)3\u201321 genes characterize a new subset of chronic lymphocytic leukemia","volume":"99","author":"Tobin","year":"2002","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.leukres.2015.03.003_bib0320","doi-asserted-by":"crossref","first-page":"2889","DOI":"10.1182\/blood-2005-06-2227","article-title":"Strikingly homologous immunoglobulin gene rearrangements and poor outcome in V(H)3\u201321-using chronic lymphocytic leukemia patients independent of geographic origin and mutational status","volume":"107","author":"Thorselius","year":"2006","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.leukres.2015.03.003_bib0325","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1111\/j.1365-2141.2008.07469.x","article-title":"Molecular and clinical features of chronic lymphocytic leukaemia with stereotyped B cell receptors: results from an Italian multicentre study","volume":"144","author":"Bomben","year":"2009","journal-title":"Br J Haematol"},{"issue":"10","key":"10.1016\/j.leukres.2015.03.003_bib0330","doi-asserted-by":"crossref","first-page":"1705","DOI":"10.3324\/haematol.2010.025338","article-title":"Prognostic factors identified three risk groups in the LRF CLL4 trial, independent of treatment allocation","volume":"95","author":"Oscier","year":"2010","journal-title":"Haematol Hematol J"},{"issue":"9","key":"10.1016\/j.leukres.2015.03.003_bib0335","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.3324\/haematol.2012.074252","article-title":"Somatic hypermutation analysis in follicular lymphoma provides evidence suggesting bidirectional cell migration between lymph node and bone marrow during disease progression and relapse","volume":"98","author":"Wartenberg","year":"2013","journal-title":"Haematologica"},{"issue":"8","key":"10.1016\/j.leukres.2015.03.003_bib0340","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1084\/jem.20050068","article-title":"Among B cell non-Hodgkin's lymphomas, MALT lymphomas express a unique antibody repertoire with frequent rheumatoid factor reactivity","volume":"201","author":"Bende","year":"2005","journal-title":"J Exp Med"},{"issue":"12","key":"10.1016\/j.leukres.2015.03.003_bib0345","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1136\/jclinpath-2014-202382","article-title":"Prognostic value of bone marrow involvement by clonal immunoglobulin gene rearrangements in follicular lymphoma","volume":"67","author":"Berget","year":"2014","journal-title":"J Clin Pathol"},{"issue":"12","key":"10.1016\/j.leukres.2015.03.003_bib0350","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1038\/sj.leu.2403202","article-title":"Design and standardization of PCR primers and protocols for detection of clonal immunoglobulin and T-cell receptor gene recombinations in suspect lymphoproliferations: report of the BIOMED-2 concerted action BMH4-CT98-3936","volume":"17","author":"van Dongen","year":"2003","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.leukres.2015.03.003_bib0355","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/jcp.2010.081109","article-title":"Detection of clonality in follicular lymphoma using formalin-fixed, paraffin-embedded tissue samples and BIOMED-2 immunoglobulin primers","volume":"64","author":"Berget","year":"2011","journal-title":"J Clin Pathol"},{"issue":"10","key":"10.1016\/j.leukres.2015.03.003_bib0360","doi-asserted-by":"crossref","first-page":"2488","DOI":"10.1172\/JCI119433","article-title":"Analysis of the human V-H gene repertoire\u2014differential effects of selection and somatic hypermutation on human peripheral CD5(+)\/IgM(+) and CD5(-)\/IgM(+) B cells","volume":"99","author":"Brezinschek","year":"1997","journal-title":"J Clin Invest"},{"issue":"2","key":"10.1016\/j.leukres.2015.03.003_bib0365","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1046\/j.1365-2141.1998.00787.x","article-title":"Similar characteristics of the CDR3 of V(H)1-69\/DP-10 rearrangements in normal human peripheral blood and chronic lymphocytic leukaemia B cells","volume":"102","author":"Brezinschek","year":"1998","journal-title":"Br J Haematol"},{"issue":"5","key":"10.1016\/j.leukres.2015.03.003_bib0370","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1136\/jcp.2006.038984","article-title":"Improved clonality assessment in germinal centre\/post-germinal centre non-Hodgkin's lymphomas with high rates of somatic hypermutation","volume":"60","author":"Catherwood","year":"2007","journal-title":"J Clin Pathol"},{"issue":"2","key":"10.1016\/j.leukres.2015.03.003_bib0375","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1111\/j.1600-0609.1999.tb01732.x","article-title":"V-H gene family utilization in different B cell lymphoma subgroups","volume":"62","author":"Rosenquist","year":"1999","journal-title":"Eur J Haematol"},{"issue":"15","key":"10.1016\/j.leukres.2015.03.003_bib0380","doi-asserted-by":"crossref","first-page":"6770","DOI":"10.1073\/pnas.89.15.6770","article-title":"Clonal evolution of a follicular lymphoma: evidence for antigen selection","volume":"89","author":"Bahler","year":"1992","journal-title":"Proc Natl Acad Sci USA"},{"issue":"3","key":"10.1016\/j.leukres.2015.03.003_bib0385","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1182\/blood.V80.3.738.738","article-title":"Absence of immunoglobulin variable region hypermutation in a large cell lymphoma after in vivo and in vitro propagation","volume":"80","author":"Stiernholm","year":"1992","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.leukres.2015.03.003_bib0390","doi-asserted-by":"crossref","first-page":"3072","DOI":"10.1182\/blood.V86.8.3072.3072","article-title":"Preferential use of the VH4 Ig gene family by diffuse large-cell lymphoma","volume":"86","author":"Hsu","year":"1995","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.leukres.2015.03.003_bib0395","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1002\/(SICI)1096-9896(199906)188:2<133::AID-PATH349>3.0.CO;2-Y","article-title":"Common and HIV-related diffuse large B cell lymphomas differ in their immunoglobulin gene mutation pattern","volume":"188","author":"Delecluse","year":"1999","journal-title":"J Pathol"},{"issue":"5","key":"10.1016\/j.leukres.2015.03.003_bib0400","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1182\/blood.V95.5.1797.005k30_1797_1803","article-title":"Molecular analysis of immunoglobulin genes in diffuse large B cell lymphomas","volume":"95","author":"Lossos","year":"2000","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.leukres.2015.03.003_bib0405","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1016\/j.leukres.2014.01.001","article-title":"Analysis of the IGHV region in Burkitt's lymphomas supports a germinal centre origin and a role for superantigens in lymphomagenesis","volume":"38","author":"Baptista","year":"2014","journal-title":"Leuk Res"},{"issue":"20","key":"10.1016\/j.leukres.2015.03.003_bib0410","doi-asserted-by":"crossref","first-page":"5307","DOI":"10.1158\/0008-5472.CAN-12-1615","article-title":"Molecular subsets of mantle cell lymphoma defined by the IGHV mutational status and SOX11 expression have distinct biologic and clinical features","volume":"72","author":"Navarro","year":"2012","journal-title":"Cancer Res"},{"issue":"4","key":"10.1016\/j.leukres.2015.03.003_bib0415","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/nrc1589","article-title":"Mechanisms of B cell lymphoma pathogenesis","volume":"5","author":"Kuppers","year":"2005","journal-title":"Nat Rev Cancer"},{"issue":"1","key":"10.1016\/j.leukres.2015.03.003_bib0420","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1038\/nrc2764","article-title":"From pathogenesis to treatment of chronic lymphocytic leukaemia","volume":"10","author":"Zenz","year":"2010","journal-title":"Nat Rev Cancer"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212615000727?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212615000727?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T08:07:48Z","timestamp":1620979668000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212615000727"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,7]]},"references-count":42,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2015,7]]}},"alternative-id":["S0145212615000727"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2015.03.003","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2015,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"IGHV gene usage and mutational status in follicular lymphoma: Correlations with prognosis and patient age","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2015.03.003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}]}}