{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T19:33:11Z","timestamp":1783625591214,"version":"3.55.0"},"reference-count":50,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2015,9,1]],"date-time":"2015-09-01T00:00:00Z","timestamp":1441065600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"name":"Katharina-Hardt-Stiftung"}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2015,9]]},"DOI":"10.1016\/j.leukres.2015.06.005","type":"journal-article","created":{"date-parts":[[2015,6,14]],"date-time":"2015-06-14T13:29:09Z","timestamp":1434288549000},"page":"990-1001","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":35,"title":["Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients"],"prefix":"10.1016","volume":"39","author":[{"given":"Cai","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Bartenhagen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Gombert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Okpanyi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Binder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silja","family":"R\u00f6ttgers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jutta","family":"Bradtke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Teigler-Schlegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jochen","family":"Harbott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sebastian","family":"Ginzel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralf","family":"Thiele","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Husemann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pina F.I.","family":"Krell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arndt","family":"Borkhardt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Dugas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianda","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ute","family":"Fischer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2015.06.005_bib0255","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/gcc.20671","article-title":"High hyperdiploid childhood acute lymphoblastic leukemia","volume":"48","author":"Paulsson","year":"2009","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.leukres.2015.06.005_bib0260","doi-asserted-by":"crossref","first-page":"2756","DOI":"10.1182\/blood-2003-04-1128","article-title":"Outcome heterogeneity in childhood high-hyperdiploid acute lymphoblastic leukemia","volume":"102","author":"Moorman","year":"2003","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2015.06.005_bib0265","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1182\/blood-2002-01-0144","article-title":"Nondisjunction of chromosomes leading to hyperdiploid childhood B-cell precursor acute lymphoblastic leukemia is an early event during leukemogenesis","volume":"100","author":"Panzer-Grumayer","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2015.06.005_bib0270","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1182\/blood.V99.8.2992","article-title":"High frequency of leukemic clones in newborn screening blood samples of children with B-precursor acute lymphoblastic leukemia","volume":"99","author":"Taub","year":"2002","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2015.06.005_bib0275","doi-asserted-by":"crossref","first-page":"2202","DOI":"10.1038\/sj.leu.2403101","article-title":"Prenatal origin of hyperdiploid acute lymphoblastic leukemia in identical twins","volume":"17","author":"Maia","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2015.06.005_bib0280","series-title":"Mitelman Database of Chromosome Aberrations in Cancer","author":"Mitelman","year":"2009"},{"key":"10.1016\/j.leukres.2015.06.005_bib0285","doi-asserted-by":"crossref","first-page":"974","DOI":"10.1038\/leu.2012.263","article-title":"Distinct patterns of gained chromosomes in high hyperdiploid acute lymphoblastic leukemia with t(1;19)(q23;p13), t(9;22)(q34;q22) or MLL rearrangements","volume":"27","author":"Paulsson","year":"2013","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2015.06.005_bib0290","doi-asserted-by":"crossref","first-page":"1797","DOI":"10.1038\/leu.2012.60","article-title":"CREBBP HAT domain mutations prevail in relapse cases of high hyperdiploid childhood acute lymphoblastic leukemia","volume":"26","author":"Inthal","year":"2012","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2015.06.005_bib0295","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1038\/nature09727","article-title":"CREBBP mutations in relapsed acute lymphoblastic leukaemia","volume":"471","author":"Mullighan","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2015.06.005_bib0300","doi-asserted-by":"crossref","first-page":"3189","DOI":"10.1182\/blood-2006-10-051912","article-title":"Karyotype is an independent prognostic factor in adult acute lymphoblastic leukemia (ALL): analysis of cytogenetic data from patients treated on the Medical Research Council (MRC) UKALLXII\/Eastern Cooperative Oncology Group (ECOG) 2993 trial","volume":"109","author":"Moorman","year":"2007","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2015.06.005_bib0305","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/S1470-2045(10)70066-8","article-title":"Prognostic effect of chromosomal abnormalities in childhood B-cell precursor acute lymphoblastic leukaemia: results from the UK Medical Research Council ALL97\/99 randomised trial","volume":"11","author":"Moorman","year":"2010","journal-title":"Lancet Oncol."},{"key":"10.1016\/j.leukres.2015.06.005_bib0310","doi-asserted-by":"crossref","first-page":"564","DOI":"10.1002\/gcc.22054","article-title":"Next-generation-sequencing-based risk stratification and identification of new genes involved in structural and sequence variations in near haploid lymphoblastic leukemia","volume":"52","author":"Chen","year":"2013","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.leukres.2015.06.005_bib0315","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1056\/NEJMoa0808253","article-title":"Deletion of IKZF1 and prognosis in acute lymphoblastic leukemia","volume":"360","author":"Mullighan","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.leukres.2015.06.005_bib0320","doi-asserted-by":"crossref","first-page":"1258","DOI":"10.1038\/leu.2010.87","article-title":"IKZF1 deletions predict relapse in uniformly treated pediatric precursor B-ALL","volume":"24","author":"Kuiper","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2015.06.005_bib0325","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1146\/annurev.immunol.18.1.495","article-title":"The RAG proteins and V(D)J recombination: complexes, ends, and transposition","volume":"18","author":"Fugmann","year":"2000","journal-title":"Annu. Rev. Immunol."},{"issue":"12","key":"10.1016\/j.leukres.2015.06.005_bib0330","doi-asserted-by":"crossref","DOI":"10.1186\/gb-2002-3-12-research0072","article-title":"Identification and utilization of arbitrary correlations in models of recombination signal sequences","volume":"3","author":"Cowell","year":"2002","journal-title":"Genome Biol."},{"key":"10.1016\/j.leukres.2015.06.005_bib0335","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/gcc.20613","article-title":"The complex genomic profile of ETV6-RUNX1 positive acute lymphoblastic leukemia highlights a recurrent deletion of TBL1XR1","volume":"47","author":"Parker","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.leukres.2015.06.005_bib0340","doi-asserted-by":"crossref","first-page":"R103","DOI":"10.1186\/gb-2011-12-10-r103","article-title":"Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer","volume":"12","author":"Kloosterman","year":"2011","journal-title":"Genome Biol."},{"key":"10.1016\/j.leukres.2015.06.005_bib0345","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1038\/sj.leu.2405022","article-title":"Small RNAs analysis in CLL reveals a deregulation of miRNA expression and novel miRNA candidates of putative relevance in CLL pathogenesis","volume":"22","author":"Marton","year":"2008","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2015.06.005_bib0350","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/jhg.2009.40","article-title":"Molecular cloning of t(2;7)(p24.3;p14.2), a novel chromosomal translocation in myelodysplastic syndrome-derived acute myeloid leukemia","volume":"54","author":"Fujita","year":"2009","journal-title":"J. Hum. Genet."},{"key":"10.1016\/j.leukres.2015.06.005_bib0355","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1038\/nrc1299","article-title":"A census of human cancer genes","volume":"4","author":"Futreal","year":"2004","journal-title":"Nat. Rev. Cancer"},{"issue":"Database issue","key":"10.1016\/j.leukres.2015.06.005_bib0360","doi-asserted-by":"crossref","first-page":"D652","DOI":"10.1093\/nar\/gkp995","article-title":"COSMIC (the Catalogue of Somatic Mutations in Cancer): a resource to investigate acquired mutations in human cancer","volume":"38","author":"Forbes","year":"2010","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.leukres.2015.06.005_bib0365","doi-asserted-by":"crossref","first-page":"2008","DOI":"10.1038\/sj.leu.2404374","article-title":"FLT3 K663Q is a novel AML-associated oncogenic kinase: determination of biochemical properties and sensitivity to Sunitinib (SU11248)","volume":"20","author":"Schittenhelm","year":"2006","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2015.06.005_bib0370","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1002\/humu.20495","article-title":"Impact of mutant p53 functional properties on TP53 mutation patterns and tumor phenotype: lessons from recent developments in the IARC TP53 database","volume":"28","author":"Petitjean","year":"2007","journal-title":"Hum. Mutat."},{"key":"10.1016\/j.leukres.2015.06.005_bib0375","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1126\/science.1978757","article-title":"Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms","volume":"250","author":"Malkin","year":"1990","journal-title":"Science"},{"key":"10.1016\/j.leukres.2015.06.005_bib0380","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1177\/1947601911411084","article-title":"Ras in cancer and developmental diseases","volume":"2","author":"Fernandez-Medarde","year":"2011","journal-title":"Genes Cancer"},{"key":"10.1016\/j.leukres.2015.06.005_bib0385","doi-asserted-by":"crossref","first-page":"3080","DOI":"10.1182\/blood-2011-03-341412","article-title":"Key pathways are frequently mutated in high-risk childhood acute lymphoblastic leukemia: a report from the Children's Oncology Group","volume":"118","author":"Zhang","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2015.06.005_bib0390","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/ng.2532","article-title":"The genomic landscape of hypodiploid acute lymphoblastic leukemia","volume":"45","author":"Holmfeldt","year":"2013","journal-title":"Nat. Genet."},{"key":"10.1016\/j.leukres.2015.06.005_bib0395","doi-asserted-by":"crossref","first-page":"3420","DOI":"10.1182\/blood-2014-04-531871","article-title":"Ras pathway mutations are prevalent in relapsed childhood acute lymphoblastic leukemia and confer sensitivity to MEK inhibition","volume":"124","author":"Irving","year":"2014","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2015.06.005_bib0400","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1002\/gcc.20502","article-title":"Mutations of FLT3, NRAS, KRAS, and PTPN11 are frequent and possibly mutually exclusive in high hyperdiploid childhood acute lymphoblastic leukemia","volume":"47","author":"Paulsson","year":"2008","journal-title":"Genes Chromosomes Cancer"},{"key":"10.1016\/j.leukres.2015.06.005_bib0405","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bcmd.2010.07.007","article-title":"Backtracking RAS mutations in high hyperdiploid childhood acute lymphoblastic leukemia","volume":"45","author":"Wiemels","year":"2010","journal-title":"Blood Cells Mol. Dis."},{"key":"10.1016\/j.leukres.2015.06.005_bib0410","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1038\/leu.2010.39","article-title":"Relapsed childhood high hyperdiploid acute lymphoblastic leukemia: presence of preleukemic ancestral clones and the secondary nature of microdeletions and RTK-RAS mutations","volume":"24","author":"Davidsson","year":"2010","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2015.06.005_bib0415","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1038\/nature09730","article-title":"Inactivating mutations of acetyltransferase genes in B-cell lymphoma","volume":"471","author":"Pasqualucci","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2015.06.005_bib0420","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1038\/nm.2651","article-title":"Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia","volume":"18","author":"Ntziachristos","year":"2012","journal-title":"Nat. Med."},{"key":"10.1016\/j.leukres.2015.06.005_bib0425","doi-asserted-by":"crossref","first-page":"3630","DOI":"10.1038\/ncomms4630","article-title":"The landscape of somatic mutations in epigenetic regulators across 1,000 paediatric cancer genomes","volume":"5","author":"Huether","year":"2014","journal-title":"Nat. Commun."},{"key":"10.1016\/j.leukres.2015.06.005_bib0430","doi-asserted-by":"crossref","first-page":"1247","DOI":"10.1093\/jnci\/djn253","article-title":"Identification of chromatin remodeling genes Arid4a and Arid4b as leukemia suppressor genes","volume":"100","author":"Wu","year":"2008","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.leukres.2015.06.005_bib0435","doi-asserted-by":"crossref","first-page":"21719","DOI":"10.1073\/pnas.1006981107","article-title":"Genetic landscape of high hyperdiploid childhood acute lymphoblastic leukemia","volume":"107","author":"Paulsson","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.leukres.2015.06.005_bib0440","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1038\/nature10106","article-title":"Direct reprogramming of somatic cells is promoted by maternal transcription factor Glis1","volume":"474","author":"Maekawa","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2015.06.005_bib0445","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/35066602","article-title":"Regulation of CD40 and CD40 ligand by the AT-hook transcription factor AKNA","volume":"410","author":"Siddiqa","year":"2001","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2015.06.005_bib0450","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1111\/j.1365-2141.2010.08312.x","article-title":"Application of genomics for risk stratification of childhood acute lymphoblastic leukaemia: from bench to bedside?","volume":"151","author":"Izraeli","year":"2010","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.leukres.2015.06.005_bib0455","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.cancergencyto.2008.10.001","article-title":"Marker chromosomes are a significant mechanism of high-level RUNX1 gene amplification in hematologic malignancies","volume":"189","author":"Moosavi","year":"2009","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.leukres.2015.06.005_bib0460","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/S0165-4608(01)00604-5","article-title":"Tetrasomy 21 as a sole chromosome abnormality in acute myeloid leukemia. fluorescence in situ hybridization and spectral karyotyping analyses","volume":"134","author":"Ohsaka","year":"2002","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.leukres.2015.06.005_bib0465","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1038\/sj.leu.2402849","article-title":"Amplification of AML1 on a duplicated chromosome 21 in acute lymphoblastic leukemia: a study of 20 cases","volume":"17","author":"Harewood","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2015.06.005_bib0470","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1038\/sj.leu.2403140","article-title":"Amplification of AML1 in acute lymphoblastic leukemia is associated with a poor outcome","volume":"17","author":"Robinson","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2015.06.005_bib0475","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1038\/sj.leu.2403000","article-title":"Amplification of band q22 of chromosome 21, including AML1, in older children with acute lymphoblastic leukemia: an emerging molecular cytogenetic subgroup","volume":"17","author":"Soulier","year":"2003","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2015.06.005_bib0480","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1182\/blood-2007-05-088310","article-title":"Molecular allelokaryotyping of pediatric acute lymphoblastic leukemias by high-resolution single nucleotide polymorphism oligonucleotide genomic microarray","volume":"111","author":"Kawamata","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2015.06.005_bib0485","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/CCO.0000000000000038","article-title":"Prevalence and clinical implications of chromothripsis in cancer genomes","volume":"26","author":"Kloosterman","year":"2014","journal-title":"Curr. Opin. Oncol."},{"key":"10.1016\/j.leukres.2015.06.005_bib0490","doi-asserted-by":"crossref","first-page":"2035","DOI":"10.1038\/sj.leu.2401940","article-title":"Dissecting the pathways to death","volume":"14","author":"Daniel","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2015.06.005_bib0495","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.cell.2011.12.013","article-title":"Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations","volume":"148","author":"Rausch","year":"2012","journal-title":"Cell"},{"key":"10.1016\/j.leukres.2015.06.005_bib0500","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.cell.2010.11.055","article-title":"Massive genomic rearrangement acquired in a single catastrophic event during cancer development","volume":"144","author":"Stephens","year":"2011","journal-title":"Cell"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212615303325?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212615303325?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,5,14]],"date-time":"2021-05-14T08:07:57Z","timestamp":1620979677000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212615303325"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,9]]},"references-count":50,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["S0145212615303325"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2015.06.005","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.725660194.793510861","asserted-by":"object"}]},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2015,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Next-generation-sequencing of recurrent childhood high hyperdiploid acute lymphoblastic leukemia reveals mutations typically associated with high risk patients","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2015.06.005","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2015 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}