{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T02:01:31Z","timestamp":1778724091342,"version":"3.51.4"},"reference-count":19,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2016,5,1]],"date-time":"2016-05-01T00:00:00Z","timestamp":1462060800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100002701","name":"Ministry of Education","doi-asserted-by":"publisher","award":["NRF-2014R1A1A2A16049597"],"award-info":[{"award-number":["NRF-2014R1A1A2A16049597"]}],"id":[{"id":"10.13039\/501100002701","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003621","name":"Ministry of Science, ICT and Future Planning","doi-asserted-by":"publisher","award":["NRF-2014R1A2A1A10052286"],"award-info":[{"award-number":["NRF-2014R1A2A1A10052286"]}],"id":[{"id":"10.13039\/501100003621","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2016,5]]},"DOI":"10.1016\/j.leukres.2016.03.001","type":"journal-article","created":{"date-parts":[[2016,3,10]],"date-time":"2016-03-10T02:17:16Z","timestamp":1457576236000},"page":"45-52","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Burden of cytogenetically abnormal plasma cells in light chain amyloidosis and their prognostic relevance"],"prefix":"10.1016","volume":"44","author":[{"given":"Seon Young","family":"Kim","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyongok","family":"Im","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si Nae","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Ah","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Soo","family":"Yoon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Soon","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2016.03.001_bib0005","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1186\/1756-8722-4-47","article-title":"Light chain (AL) amyloidosis: update on diagnosis and management","volume":"4","author":"Rosenzweig","year":"2011","journal-title":"J. Hematol. Oncol."},{"key":"10.1016\/j.leukres.2016.03.001_bib0010","doi-asserted-by":"crossref","first-page":"6333","DOI":"10.1200\/JCO.2005.05.021","article-title":"Molecular pathogenesis and a consequent classification of multiple myeloma","volume":"23","author":"Bergsagel","year":"2005","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.leukres.2016.03.001_bib0015","doi-asserted-by":"crossref","first-page":"3809","DOI":"10.1182\/blood-2010-02-268987","article-title":"Hyperdiploidy is less frequent in AL amyloidosis compared with monoclonal gammopathy of undetermined significance and inversely associated with translocation t(11;14)","volume":"117","author":"Bochtler","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2016.03.001_bib0020","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1038\/nrc746","article-title":"Multiple myeloma: evolving genetic events and host interactions","volume":"2","author":"Kuehl","year":"2002","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.leukres.2016.03.001_bib0025","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/S0165-4608(97)00058-7","article-title":"A novel three-color, clone-specific fluorescence in situ hybridization procedure for monoclonal gammopathies","volume":"101","author":"Ahmann","year":"1998","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.leukres.2016.03.001_bib0030","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.cancergencyto.2006.11.015","article-title":"Interphase fluorescence in situ hybridization in multiple myeloma and monoclonal gammopathy of undetermined significance without and with positive plasma cell identification: analysis of 192 cases from the Region of Southern Denmark","volume":"174","author":"Christensen","year":"2007","journal-title":"Cancer Genet. Cytogenet."},{"key":"10.1016\/j.leukres.2016.03.001_bib0035","doi-asserted-by":"crossref","first-page":"2266","DOI":"10.1182\/blood.V98.7.2266","article-title":"Translocations involving the immunoglobulin heavy-chain locus are possible early genetic events in patients with primary systemic amyloidosis","volume":"98","author":"Hayman","year":"2001","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2016.03.001_bib0040","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1016\/S0002-9440(10)64115-6","article-title":"Translocation T(4;14)(p16.3;q32) is a recurrent genetic lesion in primary amyloidosis","volume":"158","author":"Perfetti","year":"2001","journal-title":"Am. J. Pathol."},{"key":"10.1016\/j.leukres.2016.03.001_bib0045","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1046\/j.1365-2141.2002.03438.x","article-title":"Translocations of 14q32 and deletions of 13q14 are common chromosomal abnormalities in systemic amyloidosis","volume":"117","author":"Harrison","year":"2002","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.leukres.2016.03.001_bib0050","doi-asserted-by":"crossref","first-page":"4700","DOI":"10.1182\/blood-2007-11-122101","article-title":"Evaluation of the cytogenetic aberration pattern in amyloid light chain amyloidosis as compared with monoclonal gammopathy of undetermined significance reveals common pathways of karyotypic instability","volume":"111","author":"Bochtler","year":"2008","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2016.03.001_bib0055","first-page":"2015","article-title":"Translocation t(11;14) is associated with adverse outcome in patients with newly diagnosed AL amyloidosis when treated with bortezomib-Based regimens","author":"Bochtler","year":"2016","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.leukres.2016.03.001_bib0060","doi-asserted-by":"crossref","first-page":"e310","DOI":"10.1038\/bcj.2015.34","article-title":"Abnormal FISH in patients with immunoglobulin light chain amyloidosis is a risk factor for cardiac involvement and for death","volume":"5","author":"Warsame","year":"2015","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.leukres.2016.03.001_bib0065","doi-asserted-by":"crossref","first-page":"85","DOI":"10.7326\/0003-4819-140-2-200401200-00008","article-title":"High-dose melphalan and autologous stem-cell transplantation in patients with AL amyloidosis: an 8-year study","volume":"140","author":"Skinner","year":"2004","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.leukres.2016.03.001_bib0070","unstructured":"Slovak ML, C. International System of Human Cytogenetic Nomenclature. ISCN. Basel : S Karger AG; 2009."},{"key":"10.1016\/j.leukres.2016.03.001_bib0075","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3109\/13506129.2013.854766","article-title":"Gain of chromosome 1q21 is an independent adverse prognostic factor in light chain amyloidosis patients treated with melphalan\/dexamethasone","volume":"21","author":"Bochtler","year":"2014","journal-title":"Amyloid"},{"key":"10.1016\/j.leukres.2016.03.001_bib0080","doi-asserted-by":"crossref","first-page":"279","DOI":"10.3324\/haematol.2011.060632","article-title":"Cytogenetic profiles in multiple myeloma and monoclonal gammopathy of undetermined significance: a study in highly purified aberrant plasma cells","volume":"98","author":"Schmidt-Hieber","year":"2013","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2016.03.001_bib0085","doi-asserted-by":"crossref","first-page":"5124","DOI":"10.1182\/blood-2013-01-453001","article-title":"Systemic light chain amyloidosis: an update for treating physicians","volume":"121","author":"Merlini","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2016.03.001_bib0090","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/bjh.12191","article-title":"Light chain amyloidosis 2012: a new era","volume":"160","author":"Gatt","year":"2013","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.leukres.2016.03.001_bib0095","doi-asserted-by":"crossref","first-page":"1131","DOI":"10.1016\/j.hoc.2014.08.013","article-title":"High Dose melphalan and autologous peripheral blood stem cell transplantation in AL amyloidosis","volume":"28","author":"Sanchorawala","year":"2014","journal-title":"Hematol. Oncol. Clin. North Am."}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212616300285?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212616300285?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2022,6,26]],"date-time":"2022-06-26T00:17:50Z","timestamp":1656202670000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212616300285"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,5]]},"references-count":19,"alternative-id":["S0145212616300285"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2016.03.001","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2016,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Burden of cytogenetically abnormal plasma cells in light chain amyloidosis and their prognostic relevance","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2016.03.001","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2016 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}