{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:51:24Z","timestamp":1790373084001,"version":"4.1.0"},"reference-count":107,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2018,9,1]],"date-time":"2018-09-01T00:00:00Z","timestamp":1535760000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"funder":[{"DOI":"10.13039\/501100005851","name":"Shahid Beheshti University of medical sciences","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100005851","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["clinicalkey.jp","clinicalkey.com","lrjournal.com","clinicalkey.es","clinicalkey.com.au","clinicalkey.fr","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2018,9]]},"DOI":"10.1016\/j.leukres.2018.07.021","type":"journal-article","created":{"date-parts":[[2018,7,29]],"date-time":"2018-07-29T11:41:53Z","timestamp":1532864513000},"page":"45-51","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["The clinical significance of CDX2 in leukemia: A new perspective for leukemia research"],"prefix":"10.1016","volume":"72","author":[{"given":"Mina","family":"Darvishi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pargol","family":"Mashati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5213-106X","authenticated-orcid":false,"given":"Abbas","family":"Khosravi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0005","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1196\/annals.1349.014","article-title":"Hox genes: from leukemia to hematopoietic stem cell expansion","volume":"1044","author":"Abramovich","year":"2005","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"9","key":"10.1016\/j.leukres.2018.07.021_bib0010","doi-asserted-by":"crossref","first-page":"2181","DOI":"10.1242\/dev.129.9.2181","article-title":"Cdx1 and Cdx2 have overlapping functions in anteroposterior patterning and posterior axis elongation","volume":"129","author":"van den Akker","year":"2002","journal-title":"Development"},{"issue":"6679","key":"10.1016\/j.leukres.2018.07.021_bib0015","doi-asserted-by":"crossref","first-page":"920","DOI":"10.1038\/31933","article-title":"The ParaHox gene cluster is an evolutionary sister of the Hox gene cluster","volume":"392","author":"Brooke","year":"1998","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.leukres.2018.07.021_bib0020","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1172\/JCI30182","article-title":"The homeobox gene CDX2 is aberrantly expressed in most cases of acute myeloid leukemia and promotes leukemogenesis","volume":"117","author":"Scholl","year":"2007","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.leukres.2018.07.021_bib0025","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1007\/s00412-015-0543-8","article-title":"Homeodomain proteins: an update","volume":"125","author":"B\u00fcrglin","year":"2016","journal-title":"Chromosoma"},{"issue":"14","key":"10.1016\/j.leukres.2018.07.021_bib0030","doi-asserted-by":"crossref","first-page":"4665","DOI":"10.1158\/1078-0432.CCR-09-0401","article-title":"Relationship of CDX2 loss with molecular features and prognosis in colorectal cancer","volume":"15","author":"Baba","year":"2009","journal-title":"Clin. Cancer Res."},{"issue":"8","key":"10.1016\/j.leukres.2018.07.021_bib0035","first-page":"15955","article-title":"The prognostic value of CDX2 in colorectal cancer: a meta-analysis","volume":"9","author":"Yu","year":"2016","journal-title":"Int. J. Clin. Exp. Med."},{"issue":"17","key":"10.1016\/j.leukres.2018.07.021_bib0040","doi-asserted-by":"crossref","first-page":"4049","DOI":"10.1182\/blood-2008-12-196634","article-title":"Aberrant expression of the homeobox gene CDX2 in pediatric acute lymphoblastic leukemia","volume":"113","author":"Riedt","year":"2009","journal-title":"Blood"},{"issue":"47","key":"10.1016\/j.leukres.2018.07.021_bib0045","doi-asserted-by":"crossref","first-page":"6766","DOI":"10.1038\/sj.onc.1210760","article-title":"Hox genes in hematopoiesis and leukemogenesis","volume":"26","author":"Argiropoulos","year":"2007","journal-title":"Oncogene"},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0050","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1128\/MCB.21.1.224-234.2001","article-title":"Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia","volume":"21","author":"Thorsteinsdottir","year":"2001","journal-title":"Mol. Cell. Biol."},{"issue":"12","key":"10.1016\/j.leukres.2018.07.021_bib0055","doi-asserted-by":"crossref","first-page":"2293","DOI":"10.1093\/nar\/25.12.2293","article-title":"Activation of enhancer elements by the homeobox gene Cdx2 is cell line specific","volume":"25","author":"Taylor","year":"1997","journal-title":"Nucleic Acids Res."},{"issue":"20","key":"10.1016\/j.leukres.2018.07.021_bib0060","doi-asserted-by":"crossref","first-page":"7641","DOI":"10.1073\/pnas.0401654101","article-title":"Cdx2 is essential for axial elongation in mouse development","volume":"101","author":"Chawengsaksophak","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"6620","key":"10.1016\/j.leukres.2018.07.021_bib0065","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1038\/386084a0","article-title":"Homeosis and intestinal tumours in Cdx2 mutant mice","volume":"386","author":"Chawengsaksophak","year":"1997","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.leukres.2018.07.021_bib0070","first-page":"2965","article-title":"Colonic hamartoma development by anomalous duplication in Cdx2Knockout mice","volume":"59","author":"Tamai","year":"1999","journal-title":"Cancer Res."},{"issue":"3","key":"10.1016\/j.leukres.2018.07.021_bib0075","doi-asserted-by":"crossref","first-page":"419","DOI":"10.1242\/dev.02216","article-title":"The Cdx4 mutation affects axial development and reveals an essential role of Cdx genes in the ontogenesis of the placental labyrinth in mice","volume":"133","author":"van Nes","year":"2006","journal-title":"Development"},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0080","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0092-8674(92)90471-N","article-title":"Homeobox genes and axial patterning","volume":"68","author":"McGinnis","year":"1992","journal-title":"Cell"},{"issue":"D1","key":"10.1016\/j.leukres.2018.07.021_bib0085","doi-asserted-by":"crossref","first-page":"D917","DOI":"10.1093\/nar\/gkv1101","article-title":"BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis","volume":"44","author":"Bagger","year":"2016","journal-title":"Nucleic Acids Res."},{"issue":"6955","key":"10.1016\/j.leukres.2018.07.021_bib0090","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1038\/nature01973","article-title":"cdx4 mutants fail to specify blood progenitors and can be rescued by multiple hox genes","volume":"425","author":"Davidson","year":"2003","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0095","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0301-472X(01)00757-3","article-title":"Differential expression of Hox, Meis1, and Pbx1 genes in primitive cells throughout murine hematopoietic ontogeny","volume":"30","author":"Pineault","year":"2002","journal-title":"Exp. Hematol."},{"issue":"22","key":"10.1016\/j.leukres.2018.07.021_bib0100","doi-asserted-by":"crossref","first-page":"12355","DOI":"10.1073\/pnas.93.22.12355","article-title":"Arrested development of embryonic red cell precursors in mouse embryos lacking transcription factor GATA-1","volume":"93","author":"Fujiwara","year":"1996","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0105","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1016\/j.ydbio.2006.01.003","article-title":"The caudal-related homeobox genes cdx1a and cdx4 act redundantly to regulate hox gene expression and the formation of putative hematopoietic stem cells during zebrafish embryogenesis","volume":"292","author":"Davidson","year":"2006","journal-title":"Dev. Biol."},{"issue":"6","key":"10.1016\/j.leukres.2018.07.021_bib0110","doi-asserted-by":"crossref","first-page":"720","DOI":"10.4161\/cc.3.6.951","article-title":"Runx1\/AML-1 ranks as a master regulator of adult hematopoiesis","volume":"3","author":"Ichikawa","year":"2004","journal-title":"Cell Cycle"},{"issue":"22","key":"10.1016\/j.leukres.2018.07.021_bib0115","doi-asserted-by":"crossref","first-page":"5456","DOI":"10.1182\/blood-2009-01-200048","article-title":"The transcriptional program controlled by the stem cell leukemia gene Scl\/Tal1 during early embryonic hematopoietic development","volume":"113","author":"Wilson","year":"2009","journal-title":"Blood"},{"issue":"52","key":"10.1016\/j.leukres.2018.07.021_bib0120","doi-asserted-by":"crossref","first-page":"19081","DOI":"10.1073\/pnas.0506127102","article-title":"Embryonic stem cell-derived hematopoietic stem cells","volume":"102","author":"Wang","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.leukres.2018.07.021_bib0125","doi-asserted-by":"crossref","first-page":"1642","DOI":"10.3324\/haematol.2010.023168","article-title":"Cdx4 is dispensable for murine adult hematopoietic stem cells but promotes MLL-AF9-mediated leukemogenesis","volume":"95","author":"Koo","year":"2010","journal-title":"Haematologica"},{"issue":"22","key":"10.1016\/j.leukres.2018.07.021_bib0130","doi-asserted-by":"crossref","first-page":"7756","DOI":"10.1073\/pnas.0708951105","article-title":"Cdx gene deficiency compromises embryonic hematopoiesis in the mouse","volume":"105","author":"Wang","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"4","key":"10.1016\/j.leukres.2018.07.021_bib0135","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/0092-8674(95)90104-3","article-title":"Disruption of the murine homeobox gene Cdx1 affects axial skeletal identities by altering the mesodermal expression domains of Hox genes","volume":"83","author":"Subramanian","year":"1995","journal-title":"Cell"},{"issue":"8","key":"10.1016\/j.leukres.2018.07.021_bib0140","doi-asserted-by":"crossref","first-page":"1035","DOI":"10.1634\/stemcells.2005-0080","article-title":"Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages","volume":"23","author":"Hyslop","year":"2005","journal-title":"Stem Cells"},{"issue":"42","key":"10.1016\/j.leukres.2018.07.021_bib0145","doi-asserted-by":"crossref","first-page":"28729","DOI":"10.1074\/jbc.M109.016840","article-title":"GATA3 is selectively expressed in the trophectoderm of peri-implantation embryo and directly regulates Cdx2 gene expression","volume":"284","author":"Home","year":"2009","journal-title":"J. Biol. Chem."},{"issue":"12","key":"10.1016\/j.leukres.2018.07.021_bib0150","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1089\/dna.1997.16.1419","article-title":"Comparison of intestinal phospholipase A\/lysophospholipase and sucrase-isomaltase genes suggests a common structure for enterocyte-specific promoters","volume":"16","author":"Taylor","year":"1997","journal-title":"DNA Cell Biol."},{"issue":"11","key":"10.1016\/j.leukres.2018.07.021_bib0155","doi-asserted-by":"crossref","first-page":"2165","DOI":"10.1101\/gad.6.11.2165","article-title":"Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex","volume":"6","author":"German","year":"1992","journal-title":"Genes Dev."},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0160","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1128\/MCB.16.1.19","article-title":"Activation of proglucagon gene transcription through a novel promoter element by the caudal-related homeodomain protein cdx-2\/3","volume":"16","author":"Jin","year":"1996","journal-title":"Mol. Cell. Biol."},{"issue":"11","key":"10.1016\/j.leukres.2018.07.021_bib0165","doi-asserted-by":"crossref","first-page":"7340","DOI":"10.1128\/MCB.14.11.7340","article-title":"A homeodomain protein related to caudal regulates intestine-specific gene transcription","volume":"14","author":"Suh","year":"1994","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0170","first-page":"670","article-title":"The caudal\u2010type homeobox protein Cdx\u20102 binds to the colon promoter of the carbonic anhydrase 1 gene","volume":"236","author":"Drummond","year":"1996","journal-title":"FEBS J."},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0175","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/S0014-5793(01)02952-0","article-title":"Nucleotide requirements for CDX2 binding to the cis promoter element mediating intestine\u2010specific expression of guanylyl cyclase C","volume":"507","author":"Di Guglielmo","year":"2001","journal-title":"FEBS Lett."},{"issue":"3","key":"10.1016\/j.leukres.2018.07.021_bib0180","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.jmb.2004.01.061","article-title":"Identifying target genes regulated downstream of Cdx2 by microarray analysis","volume":"337","author":"Uesaka","year":"2004","journal-title":"J. Mol. Biol."},{"issue":"41","key":"10.1016\/j.leukres.2018.07.021_bib0185","doi-asserted-by":"crossref","first-page":"28950","DOI":"10.1074\/jbc.274.41.28950","article-title":"Glucagon gene transcription activation mediated by synergistic interactions of pax-6 and cdx-2 with the p300 co-activator","volume":"274","author":"Hussain","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"6","key":"10.1016\/j.leukres.2018.07.021_bib0190","doi-asserted-by":"crossref","first-page":"1437","DOI":"10.1053\/gast.2001.29618","article-title":"Phosphorylation of the serine 60 residue within the Cdx2 activation domain mediates its transactivation capacity","volume":"121","author":"Rings","year":"2001","journal-title":"Gastroenterology"},{"issue":"4","key":"10.1016\/j.leukres.2018.07.021_bib0195","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1016\/S0006-291X(02)02697-9","article-title":"Novel interaction at the Cdx-2 binding sites of the lactase\u2013phlorizin hydrolase promoter","volume":"299","author":"van Wering","year":"2002","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.leukres.2018.07.021_bib0200","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.1053\/gast.2002.36598","article-title":"CDX2 regulates liver intestine\u2013cadherin expression in normal and malignant colon epithelium and intestinal metaplasia","volume":"123","author":"Hinoi","year":"2002","journal-title":"Gastroenterology"},{"issue":"18","key":"10.1016\/j.leukres.2018.07.021_bib0205","doi-asserted-by":"crossref","first-page":"14752","DOI":"10.1074\/jbc.M008277200","article-title":"Pou homeodomain protein OCT1 is implicated in the expression of the caudal-related homeobox gene Cdx-2","volume":"276","author":"Jin","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"4","key":"10.1016\/j.leukres.2018.07.021_bib0210","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1053\/gast.2002.36043","article-title":"PTEN and TNF-\u03b1 regulation of the intestinal-specific Cdx-2 homeobox gene through a PI3K, PKB\/Akt, and NF-\u03baB\u2013dependent pathway","volume":"123","author":"Kim","year":"2002","journal-title":"Gastroenterology"},{"issue":"48","key":"10.1016\/j.leukres.2018.07.021_bib0215","doi-asserted-by":"crossref","first-page":"34310","DOI":"10.1074\/jbc.274.48.34310","article-title":"Cell type-specific autoregulation of theCaudal-related homeobox gene Cdx-2\/3","volume":"274","author":"Xu","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"24","key":"10.1016\/j.leukres.2018.07.021_bib0220","doi-asserted-by":"crossref","first-page":"21885","DOI":"10.1074\/jbc.M100236200","article-title":"Intestinal epithelial cell differentiation involves activation of p38 mitogen-activated protein kinase that regulates the homeobox transcription factor CDX2","volume":"276","author":"Houde","year":"2001","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.leukres.2018.07.021_bib0225","doi-asserted-by":"crossref","first-page":"6499","DOI":"10.1074\/jbc.275.9.6499","article-title":"A-Myb up-regulates Bcl-2 through a Cdx binding site in t (14; 18) lymphoma cells","volume":"275","author":"Heckman","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"13","key":"10.1016\/j.leukres.2018.07.021_bib0230","first-page":"5202","article-title":"Molecular mechanisms of transcriptional control of bcl-2 and c-myc in follicular and transformed lymphoma","volume":"61","author":"Arcinas","year":"2001","journal-title":"Cancer Res."},{"issue":"39","key":"10.1016\/j.leukres.2018.07.021_bib0235","doi-asserted-by":"crossref","first-page":"7891","DOI":"10.1038\/sj.onc.1206639","article-title":"Regulation of Bcl-2 expression by C\/EBP in t (14; 18) lymphoma cells","volume":"22","author":"Heckman","year":"2003","journal-title":"Oncogene"},{"issue":"18","key":"10.1016\/j.leukres.2018.07.021_bib0240","doi-asserted-by":"crossref","first-page":"2241","DOI":"10.4161\/cc.6.18.4656","article-title":"HOX gene regulation in acute myeloid leukemia: CDX marks the spot?","volume":"6","author":"Frohling","year":"2007","journal-title":"Cell Cycle"},{"issue":"3","key":"10.1016\/j.leukres.2018.07.021_bib0245","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1182\/blood-2012-02-385898","article-title":"Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis","volume":"120","author":"Rawat","year":"2012","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0250","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1196\/annals.1392.006","article-title":"The Cdx\u2010Hox pathway in hematopoietic stem cell formation from embryonic stem cells","volume":"1106","author":"Lengerke","year":"2007","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0255","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.stem.2007.10.022","article-title":"BMP and Wnt specify hematopoietic fate by activation of the Cdx-Hox pathway","volume":"2","author":"Lengerke","year":"2008","journal-title":"Cell Stem Cell"},{"issue":"10","key":"10.1016\/j.leukres.2018.07.021_bib0260","doi-asserted-by":"crossref","first-page":"4944","DOI":"10.1182\/blood-2007-11-124644","article-title":"Modulation of murine embryonic stem cell\u2013derived CD41+ c-kit+ hematopoietic progenitors by ectopic expression of Cdx genes","volume":"111","author":"McKinney-Freeman","year":"2008","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0265","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/MOH.0b013e3282f3ded0","article-title":"New molecular concepts and targets in acute myeloid leukemia","volume":"15","author":"Buzzai","year":"2008","journal-title":"Curr. Opin. Hematol."},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0270","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1182\/blood-2007-04-085407","article-title":"Overexpression of CDX2 perturbs HOX gene expression in murine progenitors depending on its N-terminal domain and is closely correlated with deregulated HOX gene expression in human acute myeloid leukemia","volume":"111","author":"Rawat","year":"2008","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.leukres.2018.07.021_bib0275","first-page":"1585","article-title":"Significance of PAX (CDX2) gene expression in adult acute Myeloid leukemia","volume":"3","author":"Labib","year":"2015","journal-title":"Int. J."},{"issue":"10","key":"10.1016\/j.leukres.2018.07.021_bib0280","first-page":"835","article-title":"Expression level of CDX2 gene in acute myeloid leukemia and its clinical significance","volume":"33","author":"Lu","year":"2012","journal-title":"Zhonghua xue ye xue za zhi= Zhonghua xueyexue zazhi"},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0285","doi-asserted-by":"crossref","first-page":"174","DOI":"10.18632\/oncotarget.896","article-title":"Deregulation of the CDX2-KLF4 axis in acute myeloid leukemia and colon cancer","volume":"4","author":"Rouhi","year":"2013","journal-title":"Oncotarget"},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0290","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc1780","article-title":"KLF4, p21 and context-dependent opposing forces in cancer","volume":"6","author":"Rowland","year":"2006","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0295","doi-asserted-by":"crossref","DOI":"10.1172\/JCI64745","article-title":"CDX2-driven leukemogenesis involves KLF4 repression and deregulated PPAR\u03b3 signaling","volume":"123","author":"Faber","year":"2012","journal-title":"J. Clin. Invest."},{"issue":"3","key":"10.1016\/j.leukres.2018.07.021_bib0300","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1182\/blood.V93.3.1025","article-title":"Fusion of ETV6 to the caudal-related homeobox gene CDX2 in acute myeloid leukemia with the t (12; 13)(p13; q12)","volume":"93","author":"Chase","year":"1999","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.leukres.2018.07.021_bib0305","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1073\/pnas.0305555101","article-title":"Ectopic expression of the homeobox gene Cdx2 is the transforming event in a mouse model of t (12; 13)(p13; q12) acute myeloid leukemia","volume":"101","author":"Rawat","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.leukres.2018.07.021_bib0310","first-page":"728","article-title":"Expressions of CDX2 and \u03b2-catenin and their correlation in acute myeloid leukemia","volume":"35","author":"Wang","year":"2015","journal-title":"J. South. Med. Univ."},{"issue":"44","key":"10.1016\/j.leukres.2018.07.021_bib0315","doi-asserted-by":"crossref","first-page":"38253","DOI":"10.1074\/jbc.M111.269670","article-title":"miR-125b, a target of CDX2, regulates cell differentiation through repression of the core binding factor in hematopoietic malignancies","volume":"286","author":"Lin","year":"2011","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0320","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jnci.2013.12.002","article-title":"CDX2 gene expression in acute lymphoblastic leukemia","volume":"26","author":"Arnaoaut","year":"2014","journal-title":"J. Egypt. Natl. Cancer Inst."},{"issue":"4","key":"10.1016\/j.leukres.2018.07.021_bib0325","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1038\/leu.2008.355","article-title":"The homeobox gene CDX2 is aberrantly expressed and associated with an inferior prognosis in patients with acute lymphoblastic leukemia","volume":"23","author":"Thoene","year":"2009","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0330","doi-asserted-by":"crossref","DOI":"10.4081\/oncol.2018.348","article-title":"The impact of Mir-9 regulation in normal and malignant hematopoiesis","volume":"12","author":"Khosravi","year":"2018","journal-title":"Oncol. Rev."},{"issue":"45","key":"10.1016\/j.leukres.2018.07.021_bib0335","doi-asserted-by":"crossref","first-page":"16924","DOI":"10.1073\/pnas.0604579103","article-title":"Cdx4 dysregulates Hox gene expression and generates acute myeloid leukemia alone and in cooperation with Meis1a in a murine model","volume":"103","author":"Bansal","year":"2006","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.leukres.2018.07.021_bib0340","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1038\/leusup.2012.5","article-title":"Minimal residual disease","volume":"1","author":"Campana","year":"2012","journal-title":"Leuk. Suppl."},{"issue":"6","key":"10.1016\/j.leukres.2018.07.021_bib0345","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1111\/j.1365-2141.2005.05401.x","article-title":"Concurrent detection of minimal residual disease (MRD) in childhood acute lymphoblastic leukaemia by flow cytometry and real\u2010time PCR","volume":"128","author":"Kerst","year":"2005","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.leukres.2018.07.021_bib0350","series-title":"ASH Education Program Book","first-page":"98","article-title":"Acute myeloid leukemia","author":"Stone","year":"2004"},{"key":"10.1016\/j.leukres.2018.07.021_bib0355","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.jbior.2018.03.001","article-title":"Dual inhibition of PI3K\/mTOR signaling in chemoresistant AML primary cells","volume":"68","author":"Bertacchini","year":"2018","journal-title":"Adv. Biol. Regul."},{"issue":"17","key":"10.1016\/j.leukres.2018.07.021_bib0360","doi-asserted-by":"crossref","first-page":"6767","DOI":"10.1158\/0008-5472.CAN-09-4701","article-title":"CDX2 regulates multidrug resistance 1 gene expression in malignant intestinal epithelium","volume":"70","author":"Takakura","year":"2010","journal-title":"Cancer Res."},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0365","first-page":"321","article-title":"Overexpression of CDX2 in gastric cancer cells promotes the development of multidrug resistance","volume":"5","author":"Yan","year":"2015","journal-title":"Am. J. Cancer Res."},{"issue":"26","key":"10.1016\/j.leukres.2018.07.021_bib0370","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.3748\/wjg.v19.i26.4155","article-title":"Reversal of multidrug resistance in gastric cancer cells by CDX2 downregulation","volume":"19","author":"Yan","year":"2013","journal-title":"World J. Gastroenterol.: WJG"},{"issue":"4","key":"10.1016\/j.leukres.2018.07.021_bib0375","doi-asserted-by":"crossref","first-page":"953","DOI":"10.1124\/mol.65.4.953","article-title":"Coordinate regulation of the human UDP-glucuronosyltransferase 1A8, 1A9, and 1A10 genes by hepatocyte nuclear factor 1\u03b1 and the caudal-related homeodomain protein 2","volume":"65","author":"Gregory","year":"2004","journal-title":"Mol. Pharmacol."},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0380","doi-asserted-by":"crossref","first-page":"99","DOI":"10.3109\/03602530903209544","article-title":"The regulation of UDP-glucuronosyltransferase genes by tissue-specific and ligand-activated transcription factors","volume":"42","author":"Mackenzie","year":"2010","journal-title":"Drug Metab. Rev."},{"key":"10.1016\/j.leukres.2018.07.021_bib0385","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.pharmthera.2016.01.009","article-title":"The role of glucuronidation in drug resistance","volume":"159","author":"Mazerska","year":"2016","journal-title":"Pharmacol. Ther."},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0390","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1053\/j.gastro.2010.11.033","article-title":"Cdx2 levels modulate intestinal epithelium maturity and Paneth cell development","volume":"140","author":"Crissey","year":"2011","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0395","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1093\/carcin\/bgh304","article-title":"Relationship between CDX2 gene methylation and dietary factors in gastric cancer patients","volume":"26","author":"Yuasa","year":"2005","journal-title":"Carcinogenesis"},{"issue":"18","key":"10.1016\/j.leukres.2018.07.021_bib0400","doi-asserted-by":"crossref","first-page":"2298","DOI":"10.1101\/gad.1111603","article-title":"Transformation of myeloid progenitors by MLL oncoproteins is dependent on Hoxa7 and Hoxa9","volume":"17","author":"Ayton","year":"2003","journal-title":"Genes Dev."},{"issue":"11","key":"10.1016\/j.leukres.2018.07.021_bib0405","doi-asserted-by":"crossref","first-page":"4529","DOI":"10.1182\/blood-2002-08-2484","article-title":"Induction of acute myeloid leukemia in mice by the human leukemia-specific fusion gene NUP98-HOXD13 in concert with Meis1","volume":"101","author":"Pineault","year":"2003","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0410","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1128\/MCB.24.2.617-628.2004","article-title":"Hoxa9 and Meis1 are key targets for MLL-ENL-mediated cellular immortalization","volume":"24","author":"Zeisig","year":"2004","journal-title":"Mol. Cell. Biol."},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0415","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/gcc.10198","article-title":"Genome\u2010wide analysis of acute myeloid leukemia with normal karyotype reveals a unique pattern of homeobox gene expression distinct from those with translocation\u2010mediated fusion events","volume":"37","author":"Debernardi","year":"2003","journal-title":"Genes Chromosomes Cancer"},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0420","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1038\/sj.leu.2402354","article-title":"Quantitative HOX expression in chromosomally defined subsets of acute myelogenous leukemia","volume":"16","author":"Drabkin","year":"2002","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.leukres.2018.07.021_bib0425","first-page":"301","article-title":"Homeobox genes in leukemogenesis","volume":"71","author":"Buske","year":"2000","journal-title":"Int. J. Hematol."},{"issue":"4","key":"10.1016\/j.leukres.2018.07.021_bib0430","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1128\/MCB.25.4.1389-1401.2005","article-title":"Cdx protein interaction with Hoxa5 regulatory sequences contributes to Hoxa5 regional expression along the axial skeleton","volume":"25","author":"Tabari\u00e8s","year":"2005","journal-title":"Mol. Cell. Biol."},{"issue":"8","key":"10.1016\/j.leukres.2018.07.021_bib0435","doi-asserted-by":"crossref","first-page":"2286","DOI":"10.1182\/blood.V97.8.2286","article-title":"Overexpression of HOXA10 perturbs human lymphomyelopoiesis in vitro and in vivo","volume":"97","author":"Buske","year":"2001","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0440","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1159\/000046639","article-title":"The 8p11 myeloproliferative syndrome: a distinct clinical entity caused by constitutive activation of FGFR1","volume":"107","author":"Macdonald","year":"2002","journal-title":"Acta Haematol."},{"issue":"14","key":"10.1016\/j.leukres.2018.07.021_bib0445","doi-asserted-by":"crossref","first-page":"2410","DOI":"10.1038\/sj.onc.1208431","article-title":"Constitutive activation of the Wnt\/\u03b2-catenin signalling pathway in acute myeloid leukaemia","volume":"24","author":"Simon","year":"2005","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.leukres.2018.07.021_bib0450","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1042\/BJ20051417","article-title":"Human acyl-CoA: cholesterol acyltransferase 2 gene expression in intestinal Caco-2 cells and in hepatocellular carcinoma","volume":"394","author":"Song","year":"2006","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.leukres.2018.07.021_bib0455","doi-asserted-by":"crossref","first-page":"1361","DOI":"10.1093\/carcin\/bgt037","article-title":"Regulation of APC and AXIN2 expression by intestinal tumor suppressor CDX2 in colon cancer cells","volume":"34","author":"Olsen","year":"2013","journal-title":"Carcinogenesis"},{"issue":"3","key":"10.1016\/j.leukres.2018.07.021_bib0460","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1002\/jcb.22742","article-title":"HNF1\u03b1 and CDX2 transcriptional factors bind to cadherin\u201017 (CDH17) gene promoter and modulate its expression in hepatocellular carcinoma","volume":"111","author":"Zhu","year":"2010","journal-title":"J. Cell. Biochem."},{"issue":"39","key":"10.1016\/j.leukres.2018.07.021_bib0465","doi-asserted-by":"crossref","first-page":"7942","DOI":"10.1038\/sj.onc.1206634","article-title":"CDX2, a homeobox transcription factor, upregulates transcription of the p21\/WAF1\/CIP1 gene","volume":"22","author":"Bai","year":"2003","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0470","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1042\/BJ20120693","article-title":"Transcriptional networks driving enhancer function in the CFTR gene","volume":"446","author":"Kerschner","year":"2012","journal-title":"Biochem. J."},{"issue":"6","key":"10.1016\/j.leukres.2018.07.021_bib0475","doi-asserted-by":"crossref","first-page":"1118","DOI":"10.1002\/jcb.22490","article-title":"Control of intestinal promoter activity of the cellular migratory regulator gene ELMO3 by CDX2 and SP1","volume":"109","author":"Coskun","year":"2010","journal-title":"J. Cell. Biochem."},{"issue":"20","key":"10.1016\/j.leukres.2018.07.021_bib0480","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.1073\/pnas.1111135109","article-title":"Transcription factors c-Myc and CDX2 mediate E-selectin ligand expression in colon cancer cells undergoing EGF\/bFGF-induced epithelial\u2013mesenchymal transition","volume":"109","author":"Sakuma","year":"2012","journal-title":"PNAS"},{"issue":"4","key":"10.1016\/j.leukres.2018.07.021_bib0485","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1053\/j.gastro.2005.01.003","article-title":"CDX2-regulated expression of iron transport protein hephaestin in intestinal and colonic epithelium","volume":"128","author":"Hinoi","year":"2005","journal-title":"Gastroenterology"},{"issue":"32","key":"10.1016\/j.leukres.2018.07.021_bib0490","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1038\/sj.onc.1210258","article-title":"CDX2 promotes anchorage-independent growth by transcriptional repression of IGFBP-3","volume":"26","author":"Chun","year":"2007","journal-title":"Oncogene"},{"issue":"35","key":"10.1016\/j.leukres.2018.07.021_bib0495","doi-asserted-by":"crossref","first-page":"4884","DOI":"10.1038\/sj.onc.1204645","article-title":"Expression of the gut-enriched Kr\u00fcppel-like factor (Kr\u00fcppel-like factor 4) gene in the human colon cancer cell line RKO is dependent on CDX2","volume":"20","author":"Dang","year":"2001","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.leukres.2018.07.021_bib0500","doi-asserted-by":"crossref","first-page":"833","DOI":"10.1042\/bj3220833","article-title":"Regulation of lactase?phlorizin hydrolase gene expression by the caudal-related homoeodomain protein Cdx-2","volume":"322","author":"Troelsen","year":"1997","journal-title":"Biochem. J."},{"key":"10.1016\/j.leukres.2018.07.021_bib0505","first-page":"843","article-title":"TNF-\u03b1-induced down-regulation of CDX2 suppresses MEP1A expression in colitis","volume":"6","author":"Coskun","year":"1822","journal-title":"Biochim. Biophys. Acta, Mol. Basis Dis."},{"issue":"4","key":"10.1016\/j.leukres.2018.07.021_bib0510","doi-asserted-by":"crossref","first-page":"813","DOI":"10.1016\/S0006-291X(02)02935-2","article-title":"Homeodomain protein CDX2 regulates goblet-specific MUC2 gene expression","volume":"300","author":"Yamamoto","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.leukres.2018.07.021_bib0515","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.bbrc.2004.01.020","article-title":"Homeodomain protein CDX2 regulates COX-2 expression in colorectal cancer","volume":"315","author":"Kim","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"11","key":"10.1016\/j.leukres.2018.07.021_bib0520","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1016\/j.bcp.2006.03.001","article-title":"The transcription factor Cdx2 regulates the intestine-specific expression of human peptide transporter 1 through functional interaction with Sp1","volume":"71","author":"Shimakura","year":"2006","journal-title":"Biochem. Pharmacol."},{"issue":"1-2","key":"10.1016\/j.leukres.2018.07.021_bib0525","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.regpep.2006.11.014","article-title":"Regulation of TFF3 expression by homeodomain protein CDX2","volume":"140","author":"Shimada","year":"2007","journal-title":"Regul. Pept."},{"issue":"5","key":"10.1016\/j.leukres.2018.07.021_bib0530","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1093\/carcin\/bgu037","article-title":"Involvement of CDX2 in the cross talk between TNF-\u03b1 and Wnt signaling pathway in the colon cancer cell line Caco-2","volume":"35","author":"Coskun","year":"2014","journal-title":"Carcinogenesis"},{"issue":"2","key":"10.1016\/j.leukres.2018.07.021_bib0535","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.freeradbiomed.2012.04.032","article-title":"Constitutive expression of an antioxidant enzyme, glutathione S-transferase P1, during differentiation of human intestinal Caco-2 cells","volume":"53","author":"Kusano","year":"2012","journal-title":"Free Radical Biol. Med."}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212618301656?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212618301656?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,7,8]],"date-time":"2024-07-08T19:19:16Z","timestamp":1720466356000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212618301656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9]]},"references-count":107,"alternative-id":["S0145212618301656"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2018.07.021","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2018,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The clinical significance of CDX2 in leukemia: A new perspective for leukemia research","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2018.07.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2018 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}]}}