{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T20:18:56Z","timestamp":1775765936329,"version":"3.50.1"},"reference-count":45,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,8,1]],"date-time":"2020-08-01T00:00:00Z","timestamp":1596240000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100007637","name":"Departamento Administrativo de Ciencia, Tecnolog\u00eda e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007637","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2020,8]]},"DOI":"10.1016\/j.leukres.2020.106389","type":"journal-article","created":{"date-parts":[[2020,5,26]],"date-time":"2020-05-26T20:25:23Z","timestamp":1590524723000},"page":"106389","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":31,"special_numbering":"C","title":["Cannabinoid CP55940 selectively induces apoptosis in Jurkat cells and in ex vivo T-cell acute lymphoblastic leukemia through H2O2 signaling mechanism"],"prefix":"10.1016","volume":"95","author":[{"given":"Viviana","family":"Soto-Mercado","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Mendivil-Perez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3477-2386","authenticated-orcid":false,"given":"Marlene","family":"Jimenez-Del-Rio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Javier E","family":"Fox","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0557-0411","authenticated-orcid":false,"given":"Carlos","family":"Velez-Pardo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.leukres.2020.106389_bib0005","first-page":"83","article-title":"WHO classification of tumours of haematopoietic and lymphoid tissues in 2008: an overview","volume":"102","author":"Sabattini","year":"2010","journal-title":"Pathologica"},{"issue":"4 Suppl 2","key":"10.1016\/j.leukres.2020.106389_bib0010","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1053\/j.seminoncol.2009.05.002","article-title":"Central nervous system disease in hematological malignancies: historical perspective and practical applications","volume":"36","author":"Pui","year":"2009","journal-title":"Semin. Oncol."},{"issue":"3","key":"10.1016\/j.leukres.2020.106389_bib0015","doi-asserted-by":"crossref","first-page":"e142","DOI":"10.1016\/S1470-2045(19)30031-2","article-title":"Comparative features and outcomes between paediatric T-cell and B-cell acute lymphoblastic leukaemia","volume":"20","author":"Teachey","year":"2019","journal-title":"Lancet Oncol."},{"issue":"3","key":"10.1016\/j.leukres.2020.106389_bib0020","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1053\/j.seminhematol.2013.06.007","article-title":"A 50-year journey to cure childhood acute lymphoblastic leukemia","volume":"50","author":"Pui","year":"2013","journal-title":"Semin. Hematol."},{"key":"10.1016\/j.leukres.2020.106389_bib0025","doi-asserted-by":"crossref","first-page":"e314","DOI":"10.1200\/EDBK_156628","article-title":"Advances in the genetics and therapy of acute lymphoblastic leukemia","volume":"35","author":"Chiaretti","year":"2016","journal-title":"Am. Soc. Clin. Oncol. Educ. Book"},{"issue":"20","key":"10.1016\/j.leukres.2020.106389_bib0030","doi-asserted-by":"crossref","first-page":"3577","DOI":"10.1002\/cncr.29573","article-title":"Childhood acute lymphoblastic leukemia: integrating genomics into therapy","volume":"121","author":"Tasian","year":"2015","journal-title":"Cancer"},{"key":"10.1016\/j.leukres.2020.106389_bib0035","doi-asserted-by":"crossref","DOI":"10.1007\/s10495-017-1375-1","article-title":"Overcoming chemotherapy drug resistance by targeting inhibitors of apoptosis proteins (IAPs)","author":"Rathore","year":"2017","journal-title":"Apoptosis"},{"issue":"11-12","key":"10.1016\/j.leukres.2020.106389_bib0040","doi-asserted-by":"crossref","first-page":"2405","DOI":"10.1007\/s00018-016-2209-y","article-title":"Regulated cell death and adaptive stress responses","volume":"73","author":"Galluzzi","year":"2016","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.leukres.2020.106389_bib0045","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.jep.2018.09.004","article-title":"Cannabis sativa: a comprehensive ethnopharmacological review of a medicinal plant with a long history","volume":"227","author":"Bonini","year":"2018","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.leukres.2020.106389_bib0050","first-page":"1","article-title":"Phytochemistry of Cannabis sativa l","volume":"103","author":"ElSohly","year":"2017","journal-title":"Prog. Chem. Org. Nat. Prod."},{"issue":"2","key":"10.1016\/j.leukres.2020.106389_bib0055","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1124\/pr.54.2.161","article-title":"International union of pharmacology. XXVII. Classification of cannabinoid receptors","volume":"54","author":"Howlett","year":"2002","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.leukres.2020.106389_bib0060","doi-asserted-by":"crossref","first-page":"361","DOI":"10.3389\/fphar.2016.00361","article-title":"Preclinical and clinical assessment of cannabinoids as anti-cancer agents","volume":"7","author":"Ladin","year":"2016","journal-title":"Front. Pharmacol."},{"issue":"3","key":"10.1016\/j.leukres.2020.106389_bib0065","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1002\/cam4.1312","article-title":"The current state and future perspectives of cannabinoids in cancer biology","volume":"7","author":"Sledzinski","year":"2018","journal-title":"Cancer Med."},{"key":"10.1016\/j.leukres.2020.106389_bib0070","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1159\/000356446","article-title":"Cannabis extract treatment for terminal acute lymphoblastic leukemia with a Philadelphia chromosome mutation","volume":"6","author":"Singh","year":"2013","journal-title":"Case Rep Oncol"},{"issue":"2","key":"10.1016\/j.leukres.2020.106389_bib0075","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1182\/blood-2002-01-0098","article-title":"Targeting CB2 cannabinoid receptors as a novel therapy to treat malignant lymphoblastic disease","volume":"100","author":"McKallip","year":"2002","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.leukres.2020.106389_bib0080","doi-asserted-by":"crossref","first-page":"1214","DOI":"10.1182\/blood-2004-03-1182","article-title":"Cannabis-induced cytotoxicity in leukemic cell lines: the role of the cannabinoid receptors and the MAPK pathway","volume":"105","author":"Powles","year":"2005","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.leukres.2020.106389_bib0085","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1016\/j.yexcr.2006.03.009","article-title":"The CB2 cannabinoid receptor signals apoptosis via ceramide-dependent activation of the mitochondrial intrinsic pathway","volume":"312","author":"Herrera","year":"2006","journal-title":"Exp. Cell Res."},{"issue":"8","key":"10.1016\/j.leukres.2020.106389_bib0090","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1158\/1541-7786.MCR-05-0193","article-title":"Delta9-tetrahydrocannabinol-induced apoptosis in Jurkat leukemia T cells is regulated by translocation of Bad to mitochondria","volume":"4","author":"Jia","year":"2006","journal-title":"Mol. Cancer Res."},{"key":"10.1016\/j.leukres.2020.106389_bib0095","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1186\/s12885-015-2029-8","article-title":"Dronabinol has preferential antileukemic activity in acute lymphoblastic and myeloid leukemia with lymphoid differentiation patterns","volume":"16","author":"Kampa-Schittenhelm","year":"2016","journal-title":"BMC Cancer"},{"issue":"1","key":"10.1016\/j.leukres.2020.106389_bib0100","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3892\/ijo.2017.4022","article-title":"Anticancer effects of phytocannabinoids used with chemotherapy in leukaemia cells can be improved by altering the sequence of their administration","volume":"51","author":"Scott","year":"2017","journal-title":"Int. J. Oncol."},{"key":"10.1016\/j.leukres.2020.106389_bib0105","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1007\/112_2017_3","article-title":"Cannabinoids as modulators of cell death: clinical applications and future directions","volume":"173","author":"Fonseca","year":"2017","journal-title":"Rev. Physiol. Biochem. Pharmacol."},{"key":"10.1016\/j.leukres.2020.106389_bib0110","series-title":"Cannabinoid Receptor Ligands","author":"Perwee","year":"2010"},{"issue":"7","key":"10.1016\/j.leukres.2020.106389_bib0115","doi-asserted-by":"crossref","first-page":"1941","DOI":"10.1016\/j.tiv.2015.08.003","article-title":"On the effects of CP 55-940 and other cannabinoid receptor agonists in C6 and U373 cell lines","volume":"29","author":"Ortega","year":"2015","journal-title":"Toxicol. In Vitro"},{"key":"10.1016\/j.leukres.2020.106389_bib0120","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.lfs.2016.09.010","article-title":"Comparing the effects of endogenous and synthetic cannabinoid receptor agonists on survival of gastric cancer cells","volume":"165","author":"Ortega","year":"2016","journal-title":"Life Sci."},{"issue":"5","key":"10.1016\/j.leukres.2020.106389_bib0125","doi-asserted-by":"crossref","first-page":"558","DOI":"10.1007\/s10517-005-0344-9","article-title":"Cannabinoid receptor antagonists SR141716 and SR144528 exhibit properties of partial agonists in experiments on isolated perfused rat heart","volume":"139","author":"Krylatov","year":"2005","journal-title":"Bull. Exp. Biol. Med."},{"issue":"3","key":"10.1016\/j.leukres.2020.106389_bib0130","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1016\/S1097-2765(01)00214-3","article-title":"PUMA, a novel proapoptotic gene, is induced by p53","volume":"7","author":"Nakano","year":"2001","journal-title":"Mol. Cell"},{"issue":"5","key":"10.1016\/j.leukres.2020.106389_bib0135","doi-asserted-by":"crossref","first-page":"1606","DOI":"10.3892\/mmr.2014.1981","article-title":"c-Jun transactivates Puma gene expression to promote osteoarthritis","volume":"9","author":"Lu","year":"2014","journal-title":"Mol. Med. Rep."},{"issue":"3","key":"10.1016\/j.leukres.2020.106389_bib0140","doi-asserted-by":"crossref","first-page":"138","DOI":"10.3164\/jcbn.13-108","article-title":"Oxidized DJ-1 as a possible biomarker of Parkinson\u2019s disease","volume":"54","author":"Saito","year":"2014","journal-title":"J. Clin. Biochem. Nutr."},{"issue":"3","key":"10.1016\/j.leukres.2020.106389_bib0145","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1016\/j.bbrc.2004.03.110","article-title":"Cysteine-106 of DJ-1 is the most sensitive cysteine residue to hydrogen peroxide-mediated oxidation in vivo in human umbilical vein endothelial cells","volume":"317","author":"Kinumi","year":"2004","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.leukres.2020.106389_bib0150","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1007\/978-981-10-6583-5_6","article-title":"The multifaceted roles of DJ-1 as an antioxidant","volume":"1037","author":"Raninga","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.leukres.2020.106389_bib0155","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12964-015-0118-6","article-title":"Hydrogen peroxide - production, fate and role in redox signaling of tumor cells","volume":"13","author":"Lennicke","year":"2015","journal-title":"Cell Commun. Signal"},{"key":"10.1016\/j.leukres.2020.106389_bib0160","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/439587","article-title":"Oxidative stress-induced diseases via the ASK1 signaling pathway","volume":"2012","author":"Soga","year":"2012","journal-title":"Int. J. Cell Biol."},{"issue":"6","key":"10.1016\/j.leukres.2020.106389_bib0165","doi-asserted-by":"crossref","first-page":"1091","DOI":"10.1111\/jnc.13128","article-title":"The regulation of p53 up-regulated modulator of apoptosis by JNK\/c-Jun pathway in beta-amyloid-induced neuron death","volume":"134","author":"Akhter","year":"2015","journal-title":"J. Neurochem."},{"issue":"8","key":"10.1016\/j.leukres.2020.106389_bib0170","doi-asserted-by":"crossref","first-page":"2743","DOI":"10.1128\/MCB.21.8.2743-2754.2001","article-title":"Jun NH2-terminal kinase phosphorylation of p53 on Thr-81 is important for p53 stabilization and transcriptional activities in response to stress","volume":"21","author":"Buschmann","year":"2001","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.leukres.2020.106389_bib0175","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1016\/j.chemosphere.2017.02.144","article-title":"PM2.5 induced apoptosis in endothelial cell through the activation of the p53-bax-caspase pathway","volume":"177","author":"Wang","year":"2017","journal-title":"Chemosphere"},{"issue":"7","key":"10.1016\/j.leukres.2020.106389_bib0180","first-page":"3674","article-title":"KDM4B\/JMJD2B is a p53 target gene that modulates the amplitude of p53 response after DNA damage","volume":"45","author":"Castellini","year":"2017","journal-title":"Nucl. Acids Res."},{"key":"10.1016\/j.leukres.2020.106389_bib0185","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cophys.2018.03.005","article-title":"BH3-dependent and independent activation of BAX and BAK in mitochondrial apoptosis","volume":"3","author":"Jeng","year":"2018","journal-title":"Curr Opin Physiol"},{"issue":"16","key":"10.1016\/j.leukres.2020.106389_bib0190","doi-asserted-by":"crossref","first-page":"9357","DOI":"10.1074\/jbc.273.16.9357","article-title":"Caspase-3 is required for DNA fragmentation and morphological changes associated with apoptosis","volume":"273","author":"Janicke","year":"1998","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.leukres.2020.106389_bib0195","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/j.brainresbull.2016.12.004","article-title":"Parkin and PINK1 functions in oxidative stress and neurodegeneration","volume":"133","author":"Barodia","year":"2017","journal-title":"Brain Res. Bull."},{"issue":"6","key":"10.1016\/j.leukres.2020.106389_bib0200","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1097\/CAD.0000000000000223","article-title":"Doxorubicin induces apoptosis in Jurkat cells by mitochondria-dependent and mitochondria-independent mechanisms under normoxic and hypoxic conditions","volume":"26","author":"Mendivil-Perez","year":"2015","journal-title":"Anticancer Drugs"},{"key":"10.1016\/j.leukres.2020.106389_bib0205","doi-asserted-by":"crossref","DOI":"10.1155\/2014\/457154","article-title":"Response to rotenone is glucose-sensitive in a model of human acute lymphoblastic leukemia: involvement of oxidative stress mechanism, DJ-1, Parkin, and PINK-1 proteins","volume":"2014","author":"Mendivil-Perez","year":"2014","journal-title":"Oxid. Med. Cell. Longev."},{"key":"10.1016\/j.leukres.2020.106389_bib0210","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.tiv.2018.03.012","article-title":"Minocycline induces apoptosis in acute lymphoblastic leukemia Jurkat cells","volume":"50","author":"Ruiz-Moreno","year":"2018","journal-title":"Toxicol. In Vitro"},{"issue":"5","key":"10.1016\/j.leukres.2020.106389_bib0215","doi-asserted-by":"crossref","DOI":"10.1098\/rsob.120080","article-title":"PINK1 is activated by mitochondrial membrane potential depolarization and stimulates Parkin E3 ligase activity by phosphorylating Serine 65","volume":"2","author":"Kondapalli","year":"2012","journal-title":"Open Biol."},{"issue":"1","key":"10.1016\/j.leukres.2020.106389_bib0220","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1042\/BJ20140334","article-title":"Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65","volume":"460","author":"Kazlauskaite","year":"2014","journal-title":"Biochem. J."},{"issue":"2","key":"10.1016\/j.leukres.2020.106389_bib0225","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1083\/jcb.200910140","article-title":"PINK1 stabilized by mitochondrial depolarization recruits Parkin to damaged mitochondria and activates latent Parkin for mitophagy","volume":"189","author":"Matsuda","year":"2010","journal-title":"J. Cell Biol."}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212620300941?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212620300941?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:00:30Z","timestamp":1758934830000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212620300941"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8]]},"references-count":45,"alternative-id":["S0145212620300941"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2020.106389","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2020,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Cannabinoid CP55940 selectively induces apoptosis in Jurkat cells and in ex vivo T-cell acute lymphoblastic leukemia through H2O2 signaling mechanism","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2020.106389","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106389"}}