{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,28]],"date-time":"2025-10-28T18:41:38Z","timestamp":1761676898048,"version":"3.44.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.leukres.2020.106464","type":"journal-article","created":{"date-parts":[[2020,10,21]],"date-time":"2020-10-21T11:25:41Z","timestamp":1603279541000},"page":"106464","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Evidence that knock down of GSK-3\u03b2 in Chronic Myelogenous Leukemia cells augments IFN-\u03b3-induced apoptosis"],"prefix":"10.1016","volume":"99","author":[{"given":"Melissa R.","family":"Kauffman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saeed","family":"Nazemidashtarjandi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davoud","family":"Ghazanfari","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Abigail E.","family":"Allen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nathan M.","family":"Reynolds","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Faik","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monica M.","family":"Burdick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelly D.","family":"McCall","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3666-5373","authenticated-orcid":false,"given":"Douglas J.","family":"Goetz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2020.106464_bib0005","unstructured":"Leukemia - Chronic Myeloid - CML - Statistics, Cancer.Net. (2012). https:\/\/www.cancer.net\/cancer-types\/leukemia-chronic-myeloid-cml\/statistics (Accessed October 25, 2019)."},{"key":"10.1016\/j.leukres.2020.106464_bib0010","doi-asserted-by":"crossref","first-page":"1330","DOI":"10.1056\/NEJM199904293401706","article-title":"Chronic myeloid leukemia","volume":"340","author":"Sawyers","year":"1999","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.leukres.2020.106464_bib0015","article-title":"Interferon gamma modulates sensitivity of CML cells to tyrosine kinase inhibitors","volume":"5","author":"Held","year":"2015","journal-title":"Oncoimmunology"},{"key":"10.1016\/j.leukres.2020.106464_bib0020","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s11899-018-0449-7","article-title":"Tyrosine kinase inhibitors in the treatment of chronic-phase CML: strategies for frontline decision-making","volume":"13","author":"Kennedy","year":"2018","journal-title":"Curr. Hematol. Malig. Rep."},{"key":"10.1016\/j.leukres.2020.106464_bib0025","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1084\/jem.20121229","article-title":"Cytotoxic T cells induce proliferation of chronic myeloid leukemia stem cells by secreting interferon-\u03b3","volume":"210","author":"Schurch","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.leukres.2020.106464_bib0030","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1189\/jlb.0603252","article-title":"Interferon-\u03b3: an overview of signals, mechanisms and functions","volume":"75","author":"Schroder","year":"2004","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.leukres.2020.106464_bib0035","doi-asserted-by":"crossref","first-page":"13153","DOI":"10.1074\/jbc.M007646200","article-title":"Interferon \u03b3 (IFN\u03b3) and tumor necrosis factor \u03b1 synergism in ME-180 cervical cancer cell apoptosis and necrosis: IFN\u03b3 inhibits cytoprotective NF-\u03baB through STAT1\/IRF-1 pathways","volume":"276","author":"Suk","year":"2001","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.leukres.2020.106464_bib0040","doi-asserted-by":"crossref","first-page":"847","DOI":"10.3389\/fimmu.2018.00847","article-title":"Interferon-gamma at the crossroads of tumor immune surveillance or evasion","volume":"9","author":"Castro","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.leukres.2020.106464_bib0045","first-page":"2244","article-title":"Interferon-\u03b3 affects leukemia cell apoptosis through regulating Fas\/FasL signaling pathway","volume":"21","author":"Xia","year":"2017","journal-title":"Eur. Rev. Med. Pharmacol. Sci."},{"key":"10.1016\/j.leukres.2020.106464_bib0050","doi-asserted-by":"crossref","first-page":"C1289","DOI":"10.1152\/ajpcell.00061.2019","article-title":"Identification of a novel selective and potent inhibitor of glycogen synthase kinase-3","volume":"317","author":"Noori","year":"2019","journal-title":"Am. J. Physiol.-Cell Physiol."},{"key":"10.1016\/j.leukres.2020.106464_bib0055","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173340","article-title":"Modulation of LPS-Induced inflammatory cytokine production by a novel glycogen synthase kinase-3 inhibitor","volume":"883","author":"Noori","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.leukres.2020.106464_bib0060","doi-asserted-by":"crossref","first-page":"2431","DOI":"10.1002\/j.1460-2075.1990.tb07419.x","article-title":"Molecular cloning and expression of glycogen synthase kinase-3\/factor A","volume":"9","author":"Woodgett","year":"1990","journal-title":"EMBO J."},{"key":"10.1016\/j.leukres.2020.106464_bib0065","doi-asserted-by":"crossref","first-page":"2881","DOI":"10.18632\/oncotarget.2037","article-title":"GSK-3 as potential target for therapeutic intervention in cancer","volume":"5","author":"McCubrey","year":"2014","journal-title":"Oncotarget"},{"key":"10.1016\/j.leukres.2020.106464_bib0070","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1111\/j.1432-1033.1980.tb06059.x","article-title":"Glycogen synthase kinase-3 from rabbit skeletal muscle","volume":"107","author":"Embi","year":"1980","journal-title":"Eur. J. Biochem."},{"key":"10.1016\/j.leukres.2020.106464_bib0075","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1126\/science.1075762","article-title":"The protein kinase complement of the human genome","volume":"298","author":"Manning","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.leukres.2020.106464_bib0080","first-page":"1","article-title":"What are the bona fide GSK3 substrates?","volume":"2011","author":"Sutherland","year":"2011","journal-title":"Int. J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.leukres.2020.106464_bib0085","doi-asserted-by":"crossref","first-page":"1415","DOI":"10.1016\/j.cell.2007.05.052","article-title":"Systematic discovery of in vivo phosphorylation networks","volume":"129","author":"Linding","year":"2007","journal-title":"Cell"},{"key":"10.1016\/j.leukres.2020.106464_bib0090","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1007\/s11064-006-9128-5","article-title":"Glycogen synthase kinase-3 (GSK3): inflammation, diseases, and therapeutics","volume":"32","author":"Jope","year":"2007","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.leukres.2020.106464_bib0095","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2012\/930710","article-title":"GSK-3: a bifunctional role in cell death pathways","volume":"2012","author":"Jacobs","year":"2012","journal-title":"Int. J. Cell Biol."},{"key":"10.1016\/j.leukres.2020.106464_bib0100","doi-asserted-by":"crossref","first-page":"3499","DOI":"10.1101\/gad.12.22.3499","article-title":"Glycogen synthase kinase-3\u03b2 regulates cyclin D1 proteolysis and subcellular localization","volume":"12","author":"Diehl","year":"1998","journal-title":"Genes Dev."},{"key":"10.1016\/j.leukres.2020.106464_bib0105","doi-asserted-by":"crossref","first-page":"16989","DOI":"10.1074\/jbc.M700610200","article-title":"Resolution of the nuclear localization mechanism of glycogen synthase kinase-3: functional effects in apoptosis","volume":"282","author":"Meares","year":"2007","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.leukres.2020.106464_bib0110","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1016\/j.yexcr.2007.12.015","article-title":"Inhibition of GSK3 differentially modulates NF-\u03baB, CREB, AP-1 and \u03b2-catenin signaling in hepatocytes, but fails to promote TNF-\u03b1-induced apoptosis","volume":"314","author":"G\u00f6tschel","year":"2008","journal-title":"Exp. Cell Res."},{"key":"10.1016\/j.leukres.2020.106464_bib0115","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.pneurobio.2006.07.006","article-title":"The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways","volume":"79","author":"Beurel","year":"2006","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.leukres.2020.106464_bib0120","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1186\/1471-2202-5-20","article-title":"Lithium facilitates apoptotic signaling induced by activation of the Fas death domain-containing receptor","volume":"5","author":"Song","year":"2004","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.leukres.2020.106464_bib0125","doi-asserted-by":"crossref","first-page":"856","DOI":"10.4049\/jimmunol.0804033","article-title":"Glycogen synthase kinase-3\u03b2 facilitates IFN-\u03b3-Induced STAT1 activation by regulating src homology-2 domain-containing phosphatase 2","volume":"183","author":"Tsai","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.leukres.2020.106464_bib0130","unstructured":"KBM-7, (n.d.). https:\/\/www.ebi.ac.uk\/ols\/ontologies\/efo\/terms?short_form=EFO_0005903 (Accessed January 8, 2020)."},{"key":"10.1016\/j.leukres.2020.106464_bib0135","doi-asserted-by":"crossref","first-page":"340","DOI":"10.1038\/nature10348","article-title":"Ebola virus entry requires the cholesterol transporter Niemann-Pick C1","volume":"477","author":"Carette","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2020.106464_bib0140","doi-asserted-by":"crossref","first-page":"353","DOI":"10.4161\/cc.23200","article-title":"The involvement of a Nanog, Klf4 and c-Myc transcriptional circuitry in the intertwining between neoplastic progression and reprogramming","volume":"12","author":"Marzi","year":"2013","journal-title":"Cell Cycle"},{"year":"2020","series-title":"Horizon Product Information for GSK3B Knockout Cell Line","author":"Horizon","key":"10.1016\/j.leukres.2020.106464_bib0145"},{"key":"10.1016\/j.leukres.2020.106464_bib0150","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.jbiotec.2015.06.427","article-title":"Systematic analysis of CRISPR\u2013Cas9 mismatch tolerance reveals low levels of off-target activity","volume":"211","author":"Anderson","year":"2015","journal-title":"J. Biotechnol."},{"key":"10.1016\/j.leukres.2020.106464_bib0155","doi-asserted-by":"crossref","first-page":"26056","DOI":"10.1074\/jbc.272.41.26056","article-title":"Cleavage of focal adhesion kinase by caspases during apoptosis","volume":"272","author":"Wen","year":"1997","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.leukres.2020.106464_bib0160","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1084\/jem.20050678","article-title":"Aberrant T cell differentiation in the absence of Dicer","volume":"202","author":"Muljo","year":"2005","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.leukres.2020.106464_bib0165","doi-asserted-by":"crossref","first-page":"2295","DOI":"10.1038\/sj.onc.1205255","article-title":"IFN-\u03b3 sensitizes for apoptosis by upregulating caspase-8 expression through the Stat1 pathway","volume":"21","author":"Fulda","year":"2002","journal-title":"Oncogene"},{"key":"10.1016\/j.leukres.2020.106464_bib0170","doi-asserted-by":"crossref","first-page":"5328","DOI":"10.1128\/MCB.17.9.5328","article-title":"Activation of the STAT signaling pathway can cause expression of caspase 1 and apoptosis","volume":"17","author":"Chin","year":"1997","journal-title":"Mol. Cell. Biol."},{"key":"10.1016\/j.leukres.2020.106464_bib0175","first-page":"2832","article-title":"IFN-gamma induces cell growth inhibition by Fas-mediated apoptosis: requirement of STAT1 protein for up-regulation of Fas and FasL expression","volume":"58","author":"Xu","year":"1998","journal-title":"Cancer Res."},{"key":"10.1016\/j.leukres.2020.106464_bib0180","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1084\/jem.20011171","article-title":"Critical role for tumor necrosis factor-related apoptosis-inducing ligand in immune surveillance against tumor development","volume":"195","author":"Takeda","year":"2002","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.leukres.2020.106464_bib0185","doi-asserted-by":"crossref","first-page":"e16241","DOI":"10.1371\/journal.pone.0016241","article-title":"TNF-\u03b1 operates with IFN-\u03b3 to repress Bcl-xL expression to sen\u03b3sitize metastatic colon carcinoma cells to TRAIL-mediated apoptosis","volume":"6","author":"Liu","year":"2011","journal-title":"PLoS One"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212620301697?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212620301697?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:00:48Z","timestamp":1758934848000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212620301697"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":37,"alternative-id":["S0145212620301697"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2020.106464","relation":{},"ISSN":["0145-2126"],"issn-type":[{"type":"print","value":"0145-2126"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence that knock down of GSK-3\u03b2 in Chronic Myelogenous Leukemia cells augments IFN-\u03b3-induced apoptosis","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2020.106464","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106464"}}