{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:49:13Z","timestamp":1791362953868,"version":"4.3.1"},"reference-count":26,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T00:00:00Z","timestamp":1617235200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2021,4]]},"DOI":"10.1016\/j.leukres.2021.106534","type":"journal-article","created":{"date-parts":[[2021,2,15]],"date-time":"2021-02-15T23:37:58Z","timestamp":1613432278000},"page":"106534","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Low serum cholesterol levels predict inferior prognosis and improve prognostic index scoring for peripheral T-cell lymphoma, unspecified"],"prefix":"10.1016","volume":"103","author":[{"given":"Jing","family":"Tang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia-Zhu","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-Hua","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-Ze","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua-Yuan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lei","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Yong","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4208-7477","authenticated-orcid":false,"given":"Wei","family":"Xu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2021.106534_bib0005","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-3-319-99716-2_4","article-title":"Peripheral T-cell lymphoma, not otherwise specified (PTCL-NOS)","volume":"176","author":"Oluwasanjo","year":"2019","journal-title":"Cancer Treat. Res."},{"issue":"8","key":"10.1016\/j.leukres.2021.106534_bib0010","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/ajh.25513","article-title":"Aggressive T-cell lymphomas: 2019 updates on diagnosis, risk stratification, and Management","volume":"94","author":"Zain","year":"2019","journal-title":"Am. J. Hematol."},{"issue":"7","key":"10.1016\/j.leukres.2021.106534_bib0015","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/ajh.24791","article-title":"The aggressive peripheral T-cell lymphomas: 2017","volume":"92","author":"Armitage","year":"2017","journal-title":"Am. J. Hematol."},{"issue":"12","key":"10.1016\/j.leukres.2021.106534_bib0020","doi-asserted-by":"crossref","first-page":"3402","DOI":"10.1182\/blood-2010-09-310342","article-title":"Peripheral T-cell lymphoma, not otherwise specified: a report of 340 cases from the International Peripheral T-cell Lymphoma Project","volume":"117","author":"Weisenburger","year":"2011","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.leukres.2021.106534_bib0025","doi-asserted-by":"crossref","first-page":"2474","DOI":"10.1182\/blood-2003-09-3080","article-title":"Peripheral T-cell lymphoma unspecified (PTCL-U): a new prognostic model from a retrospective multicentric clinical study","volume":"103","author":"Gallamini","year":"2004","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.leukres.2021.106534_bib0030","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/s00277-014-2188-8","article-title":"Analysis of prognostic factors and comparison of prognostic scores in peripheral T cell lymphoma, not otherwise specified: a single-institution study of 105 Chinese patients","volume":"94","author":"Xu","year":"2015","journal-title":"Ann. Hematol."},{"issue":"2","key":"10.1016\/j.leukres.2021.106534_bib0035","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016957","article-title":"The human serum metabolome","volume":"6","author":"Psychogios","year":"2011","journal-title":"PLoS One"},{"issue":"8","key":"10.1016\/j.leukres.2021.106534_bib0040","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.1002\/ijc.31590","article-title":"Low serum cholesterol levels predict inferior prognosis and improve NCCN-IPI scoring in diffuse large B cell lymphoma","volume":"143","author":"Gao","year":"2018","journal-title":"Int. J. Cancer"},{"key":"10.1016\/j.leukres.2021.106534_bib0045","doi-asserted-by":"crossref","first-page":"2387","DOI":"10.12659\/MSM.893442","article-title":"Metabolic syndrome components are associated with increased prostate Cancer risk","volume":"21","author":"Zhang","year":"2015","journal-title":"Med. Sci. Monit."},{"issue":"15","key":"10.1016\/j.leukres.2021.106534_bib0050","doi-asserted-by":"crossref","first-page":"1152","DOI":"10.1093\/jnci\/djh216","article-title":"Serum high-density lipoprotein cholesterol, metabolic profile, and breast cancer risk","volume":"96","author":"Furberg","year":"2004","journal-title":"J. Natl. Cancer Inst."},{"issue":"7","key":"10.1016\/j.leukres.2021.106534_bib0055","doi-asserted-by":"crossref","first-page":"1645","DOI":"10.1002\/ijc.30581","article-title":"Pretreatment direct bilirubin and total cholesterol are significant predictors of overall survival in advanced non-small-cell lung cancer patients with EGFR mutations","volume":"140","author":"Zhang","year":"2017","journal-title":"Int. J. Cancer"},{"issue":"3","key":"10.1016\/j.leukres.2021.106534_bib0060","doi-asserted-by":"crossref","first-page":"1209","DOI":"10.1002\/cam4.1987","article-title":"Correlation between immune signature and high-density lipoprotein cholesterol level in stage II\/III colorectal cancer","volume":"8","author":"Wang","year":"2019","journal-title":"Cancer Med."},{"issue":"11","key":"10.1016\/j.leukres.2021.106534_bib0065","first-page":"839","article-title":"Prognostic value of serum high-density lipoprotein cholesterol in patients with gallbladder cancer","volume":"111","author":"Yuan","year":"2019","journal-title":"Rev. Esp. Enferm. Dig."},{"issue":"4","key":"10.1016\/j.leukres.2021.106534_bib0070","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1080\/01635581.2019.1577983","article-title":"Systematic review and meta-analysis of the prognostic value of serum high-density lipoprotein cholesterol levels for solid tumors","volume":"71","author":"Hao","year":"2019","journal-title":"Nutr. Cancer"},{"issue":"3","key":"10.1016\/j.leukres.2021.106534_bib0075","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1620\/tjem.229.203","article-title":"Low serum LDL cholesterol levels are associated with elevated mortality from liver cancer in Japan: the Ibaraki Prefectural health study","volume":"229","author":"Saito","year":"2013","journal-title":"Tohoku J. Exp. Med."},{"issue":"5","key":"10.1016\/j.leukres.2021.106534_bib0080","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1016\/0002-9343(82)90543-5","article-title":"Plasma lipid alterations in leukemia and lymphoma","volume":"72","author":"Spiegel","year":"1982","journal-title":"Am. J. Med."},{"issue":"1","key":"10.1016\/j.leukres.2021.106534_bib0085","first-page":"23","article-title":"Cholesterol levels in patients with chronic lymphocytic leukemia","volume":"109","author":"Yavasoglu","year":"2017","journal-title":"J. Med. Assoc."},{"issue":"4","key":"10.1016\/j.leukres.2021.106534_bib0090","article-title":"Cholesterol levels provide prognostic information in patients with multiple myeloma","volume":"66","author":"Liu","year":"2020","journal-title":"Clin. Lab."},{"key":"10.1016\/j.leukres.2021.106534_bib0095","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.cyto.2018.02.005","article-title":"Low level of serum HDL-cholesterol with increased sIL-2R predicts a poor clinical outcome for patients with malignant lymphoma and adult T-cell leukemia-lymphoma","volume":"105","author":"Komiya","year":"2018","journal-title":"Cytokine"},{"issue":"3","key":"10.1016\/j.leukres.2021.106534_bib0100","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1007\/s13277-013-1284-z","article-title":"Low level of high-density lipoprotein cholesterol correlates with poor prognosis in extranodal natural killer\/T cell lymphoma","volume":"35","author":"Wang","year":"2014","journal-title":"Tumour Biol."},{"key":"10.1016\/j.leukres.2021.106534_bib0105","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1093\/jnci\/djr008","article-title":"Low\u2010density lipoprotein cholesterol and the risk of cancer: a Mendelian randomization study","volume":"103","author":"Benn","year":"2011","journal-title":"J. Natl. Cancer Inst."},{"issue":"5","key":"10.1016\/j.leukres.2021.106534_bib0110","doi-asserted-by":"crossref","first-page":"3522","DOI":"10.1007\/s12032-012-0244-6","article-title":"High numbers of tumor-associated macrophages correlate with poor prognosis in patients with mature T- and natural killer cell lymphomas","volume":"29","author":"Lin","year":"2012","journal-title":"Med. Oncol."},{"issue":"1","key":"10.1016\/j.leukres.2021.106534_bib0115","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3109\/10428194.2010.529204","article-title":"Expression of tumor-associated macrophages and vascular endothelial growth factor correlates with poor prognosis of peripheral T-cell lymphoma, not otherwise specified","volume":"52","author":"Zhang","year":"2011","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.leukres.2021.106534_bib0120","doi-asserted-by":"crossref","first-page":"E403","DOI":"10.1152\/ajpendo.00576.2002","article-title":"Acute inflammation increases selective uptake of HDL cholesteryl esters into adrenals of mice overexpressing human sPLA2","volume":"285","author":"Tietge","year":"2003","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"10.1016\/j.leukres.2021.106534_bib0125","doi-asserted-by":"crossref","first-page":"2169","DOI":"10.1016\/S0006-2952(02)01018-3","article-title":"Elevated uptake of low density lipoprotein by drug resistant human leukemic cell lines","volume":"63","author":"Tatidis","year":"2002","journal-title":"Biochem. Pharmacol."},{"issue":"1","key":"10.1016\/j.leukres.2021.106534_bib0130","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jacl.2014.09.014","article-title":"Elevated interleukin-10: a new cause of dyslipidemia leading to severe HDL deficiency","volume":"9","author":"Moraitis","year":"2015","journal-title":"J. Clin. Lipidol."}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212621000357?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212621000357?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:01:07Z","timestamp":1758934867000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212621000357"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,4]]},"references-count":26,"alternative-id":["S0145212621000357"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2021.106534","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2021,4]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Low serum cholesterol levels predict inferior prognosis and improve prognostic index scoring for peripheral T-cell lymphoma, unspecified","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2021.106534","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"106534"}}