{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T14:15:47Z","timestamp":1790777747250,"version":"4.1.0"},"reference-count":30,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001700","name":"Government of Japan Ministry of Education Culture Sports Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001700","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2021,6]]},"DOI":"10.1016\/j.leukres.2021.106570","type":"journal-article","created":{"date-parts":[[2021,3,31]],"date-time":"2021-03-31T21:57:51Z","timestamp":1617227871000},"page":"106570","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The in vitro effects of hepatoblastoma cells on the growth and differentiation of blasts in transient abnormal myelopoiesis associated with Down syndrome"],"prefix":"10.1016","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5215-5088","authenticated-orcid":false,"given":"Jun","family":"Miyauchi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6499-9285","authenticated-orcid":false,"given":"Hiroyuki","family":"Kawaguchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2021.106570_bib0005","series-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","first-page":"169","article-title":"Myeloid proliferations associated with Down syndrome","author":"Arber","year":"2017"},{"issue":"1","key":"10.1016\/j.leukres.2021.106570_bib0010","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1038\/nrc1525","article-title":"Origins of leukaemia in children with Down syndrome","volume":"5","author":"Hitzler","year":"2005","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.leukres.2021.106570_bib0015","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1365-2141.2009.07789.x","article-title":"Acute megakaryoblastic leukaemia (AMKL) and transient myeloproliferative disorder (TMD) in Down syndrome: a multi-step model of myeloid leukaemogenesis","volume":"147","author":"Roy","year":"2009","journal-title":"Br. J. Haematol."},{"issue":"3","key":"10.1016\/j.leukres.2021.106570_bib0020","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1111\/ped.13776","article-title":"Recent advances in the understanding of transient abnormal myelopoiesis in Down syndrome","volume":"61","author":"Watanabe","year":"2019","journal-title":"Pediatr. Int."},{"issue":"2","key":"10.1016\/j.leukres.2021.106570_bib0025","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1111\/bjh.15390","article-title":"Guidelines for the investigation and management of transient leukaemia of Down syndrome","volume":"182","author":"Tunstall","year":"2018","journal-title":"Br. J. Haematol."},{"issue":"5","key":"10.1016\/j.leukres.2021.106570_bib0030","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s11899-016-0338-x","article-title":"Transient abnormal myelopoiesis and AML in down syndrome: an update","volume":"11","author":"Bhatnagar","year":"2016","journal-title":"Curr. Hematol. Malig. Rep."},{"issue":"4","key":"10.1016\/j.leukres.2021.106570_bib0035","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1016\/j.siny.2012.02.010","article-title":"Biology and management of transient abnormal myelopoiesis (TAM) in children with Down syndrome","volume":"17","author":"Roy","year":"2012","journal-title":"Semin. Fetal Neonatal Med."},{"issue":"12","key":"10.1016\/j.leukres.2021.106570_bib0040","doi-asserted-by":"crossref","first-page":"2619","DOI":"10.1182\/blood-2008-11-163501","article-title":"Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndrome","volume":"113","author":"Malinge","year":"2009","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.leukres.2021.106570_bib0045","doi-asserted-by":"crossref","first-page":"4301","DOI":"10.1182\/blood-2003-01-0013","article-title":"GATA1 mutations in transient leukemia and acute megakaryoblastic leukemia of Down syndrome","volume":"101","author":"Hitzler","year":"2003","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.leukres.2021.106570_bib0050","doi-asserted-by":"crossref","first-page":"4298","DOI":"10.1182\/blood-2002-12-3904","article-title":"Mutagenesis of GATA1 is an initiating event in Down syndrome leukemogenesis","volume":"101","author":"Mundschau","year":"2003","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.leukres.2021.106570_bib0055","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1038\/ng955","article-title":"Acquired mutations in GATA1 in the megakaryoblastic leukemia of Down syndrome","volume":"32","author":"Wechsler","year":"2002","journal-title":"Nat. Genet."},{"issue":"10","key":"10.1016\/j.leukres.2021.106570_bib0060","doi-asserted-by":"crossref","first-page":"696","DOI":"10.1097\/01.mph.0000212997.02554.f6","article-title":"Development of acute megakaryoblastic leukemia from a minor clone in a Down syndrome patient with clinically overt transient myeloproliferative disorder","volume":"28","author":"Xu","year":"2006","journal-title":"J. Pediatr. Hematol. Oncol."},{"issue":"7","key":"10.1016\/j.leukres.2021.106570_bib0065","doi-asserted-by":"crossref","first-page":"2480","DOI":"10.1182\/blood-2003-10-3383","article-title":"Natural history of GATA1 mutations in Down syndrome","volume":"103","author":"Ahmed","year":"2004","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.leukres.2021.106570_bib0070","doi-asserted-by":"crossref","first-page":"1293","DOI":"10.1038\/ng.2759","article-title":"The landscape of somatic mutations in Down syndrome-related myeloid disorders","volume":"45","author":"Yoshida","year":"2013","journal-title":"Nat. Genet."},{"issue":"7","key":"10.1016\/j.leukres.2021.106570_bib0075","doi-asserted-by":"crossref","first-page":"1540","DOI":"10.1182\/blood.V75.7.1540.1540","article-title":"The production of transforming growth factor-\u03b2 in acute megakaryoblastic leukemia and its possible implications in myelofibrosis","volume":"75","author":"Terui","year":"1990","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.leukres.2021.106570_bib0080","doi-asserted-by":"crossref","first-page":"1521","DOI":"10.1182\/blood.V80.6.1521.1521","article-title":"Unusual diffuse liver fibrosis accompanying transient myeloproliferative disorder in Down\u2019s syndrome: a report of four autopsy cases and proposal of a hypothesis","volume":"80","author":"Miyauchi","year":"1992","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.leukres.2021.106570_bib0085","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1002\/(SICI)1096-911X(199809)31:3<159::AID-MPO6>3.0.CO;2-A","article-title":"Down syndrome, transient myeloproliferative disorder, and infantile liver fibrosis","volume":"31","author":"Schwab","year":"1998","journal-title":"Med. Pediatr. Oncol."},{"issue":"5","key":"10.1016\/j.leukres.2021.106570_bib0090","doi-asserted-by":"crossref","first-page":"587","DOI":"10.1111\/bjh.13096","article-title":"Haematopoietic development and leukaemia in Down syndrome","volume":"167","author":"Roberts","year":"2014","journal-title":"Br. J. Haematol."},{"issue":"6","key":"10.1016\/j.leukres.2021.106570_bib0095","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/ng1566","article-title":"Developmental stage-selective effect of somatically mutated leukemogenic transcription factor GATA1","volume":"37","author":"Li","year":"2005","journal-title":"Nat. Genet."},{"issue":"2","key":"10.1016\/j.leukres.2021.106570_bib0100","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1111\/bjh.15246","article-title":"Neonatal leukaemia","volume":"182","author":"Roberts","year":"2018","journal-title":"Br. J. Haematol."},{"issue":"6","key":"10.1016\/j.leukres.2021.106570_bib0105","doi-asserted-by":"crossref","first-page":"1176","DOI":"10.1002\/jcb.24764","article-title":"Fetal liver stromal cells support blast growth in transient abnormal myelopoiesis in Down syndrome through GM-CSF","volume":"115","author":"Miyauchi","year":"2014","journal-title":"J. Cell. Biochem."},{"issue":"6","key":"10.1016\/j.leukres.2021.106570_bib0110","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1111\/j.1365-2141.2009.08038.x","article-title":"Blasts in transient leukaemia in neonates with Down syndrome differentiate into basophil\/mast-cell and megakaryocyte lineages in vitro in association with down-regulation of truncated form of GATA1","volume":"148","author":"Miyauchi","year":"2010","journal-title":"Br. J. Haematol."},{"issue":"6","key":"10.1016\/j.leukres.2021.106570_bib0115","doi-asserted-by":"crossref","first-page":"2189","DOI":"10.1182\/blood.V92.6.2189","article-title":"Primary role of the liver in thrombopoietin production shown by tissue-specific knockout","volume":"92","author":"Qian","year":"1998","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.leukres.2021.106570_bib0120","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1182\/blood.V94.1.97.413k20_97_105","article-title":"Expression of the thrombopoietin gene in human fetal and neonatal tissues","volume":"94","author":"Wolber","year":"1999","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.leukres.2021.106570_bib0125","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1097\/00042737-200107000-00006","article-title":"The role of the liver in the production of thrombopoietin compared with erythropoietin","volume":"13","author":"Jelkmann","year":"2001","journal-title":"Eur. J. Gastroenterol. Hepatol."},{"issue":"17","key":"10.1016\/j.leukres.2021.106570_bib0130","doi-asserted-by":"crossref","first-page":"7799","DOI":"10.1073\/pnas.1003586107","article-title":"Fetal liver hepatic progenitors are supportive stromal cells for hematopoietic stem cells","volume":"107","author":"Chou","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.leukres.2021.106570_bib0135","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/j.bbrc.2011.05.137","article-title":"Hepatoblasts comprise a niche for fetal liver erythropoiesis through cytokine production","volume":"410","author":"Sugiyama","year":"2011","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"12","key":"10.1016\/j.leukres.2021.106570_bib0140","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1038\/nrc2536","article-title":"Insulin and insulin-like growth factor signalling in neoplasia","volume":"8","author":"Pollak","year":"2008","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.leukres.2021.106570_bib0145","doi-asserted-by":"crossref","first-page":"10","DOI":"10.5045\/br.2017.52.1.10","article-title":"Regulation of the embryonic erythropoietic niche: a future perspective","volume":"52","author":"Yumine","year":"2017","journal-title":"Blood Res."},{"issue":"2\u20133","key":"10.1016\/j.leukres.2021.106570_bib0150","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1159\/000343368","article-title":"Hepatic stellate cells support hematopoiesis and are liver-resident mesenchymal stem cells","volume":"31","author":"Kordes","year":"2013","journal-title":"Cell. Physiol. Biochem."}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212621000710?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212621000710?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:00:52Z","timestamp":1758934852000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212621000710"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,6]]},"references-count":30,"alternative-id":["S0145212621000710"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2021.106570","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2021,6]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The in vitro effects of hepatoblastoma cells on the growth and differentiation of blasts in transient abnormal myelopoiesis associated with Down syndrome","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2021.106570","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106570"}}