{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T23:37:06Z","timestamp":1793144226969,"version":"4.5.0"},"reference-count":24,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2021,8,1]],"date-time":"2021-08-01T00:00:00Z","timestamp":1627776000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2021,8]]},"DOI":"10.1016\/j.leukres.2021.106586","type":"journal-article","created":{"date-parts":[[2021,4,24]],"date-time":"2021-04-24T00:08:57Z","timestamp":1619222937000},"page":"106586","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Easier and more explanatory indices by integrating leukocyte lymphocyte ratio (LLR) and prognostic nutritional index (PNI) to IPS systems in cases with classical Hodgkin lymphoma"],"prefix":"10.1016","volume":"107","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4642-3693","authenticated-orcid":false,"given":"Semra","family":"Paydas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8770-9842","authenticated-orcid":false,"given":"Sahin","family":"Lacin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mutlu","family":"Dogan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-439X","authenticated-orcid":false,"given":"Ibrahim","family":"Barista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Birol","family":"Yildiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulsah","family":"Seydaoglu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuri","family":"Karadurmus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sinem","family":"Civriz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed Ali","family":"Kaplan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Munci","family":"Yagci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin Derya","family":"Dincyurek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vehbi","family":"Ercolak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2021.106586_bib0005","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1056\/NEJM199811193392104","article-title":"A prognostic score for advanced Hodgkin\u2019s Disease. International prognostic factors Project on advanced Hodgkin\u2019s disease","volume":"339","author":"Hasenclever","year":"1998","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.leukres.2021.106586_bib0010","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1200\/JCO.2011.41.0910","article-title":"International prognostic score in advanced-stage Hodgkin\u2019s lymphoma: altered utility in the modern era","volume":"30","author":"Moccia","year":"2012","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.leukres.2021.106586_bib0015","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1111\/bjh.13634","article-title":"Evaluation of the International Prognostic Score (IPS-7) and a simpler score (IPS-3) for advanced Hodgkin lymphoma in the modern era","volume":"171","author":"Diefenbach","year":"2015","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.leukres.2021.106586_bib0020","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/ajh.23361","article-title":"Baseline serum TARC levels, predict therapy outcome in patients with Hodgkin lymphoma","volume":"88","author":"Sauer","year":"2013","journal-title":"Am. J. Hematol."},{"key":"10.1016\/j.leukres.2021.106586_bib0025","doi-asserted-by":"crossref","first-page":"692","DOI":"10.1200\/JCO.2012.43.4589","article-title":"Gascoyne RD.GEne expression-based model using formalin-embedded biopsies predict overall survival in advanced-stage classical Hodgkin lymphoma","volume":"31","author":"Scott","year":"2013","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.leukres.2021.106586_bib0030","doi-asserted-by":"crossref","first-page":"332","DOI":"10.3109\/10428194.2014.917636","article-title":"CD68-positive tumor associated macrophages predict unfavorable treatment outcomes in classical Hodgkin lymphoma in correlation with interim fluorodeoxyglucose-positron emission tomography assesment","volume":"56","author":"Touati","year":"2015","journal-title":"Leuk. Lymphoma"},{"key":"10.1016\/j.leukres.2021.106586_bib0035","first-page":"376","article-title":"Risk-adapted treatment of advanced Hodgkin lymphoma with PET-CT","author":"Lynch","year":"2016","journal-title":"ASCO Ed Book"},{"key":"10.1016\/j.leukres.2021.106586_bib0040","doi-asserted-by":"crossref","first-page":"1009","DOI":"10.1007\/s00277-018-3276-y","article-title":"Prognostic meaning of neutrophil to lymphocyte ratio (NLR) and lymphocyte to monocyte ration (LMR) in newly diagnosed Hodgkin lymphoma patients treated upfront with a PET-2 based strategy","volume":"97","author":"Romano","year":"2018","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.leukres.2021.106586_bib0045","doi-asserted-by":"crossref","first-page":"4343","DOI":"10.21873\/anticanres.13602","article-title":"Pretreatment neutrophil-to-lymphocyte ratio predicts survival after TAS-102 treatment of patients with metastatic colorectal cancer","volume":"39","author":"Matsuda","year":"2019","journal-title":"Anticancer Res."},{"key":"10.1016\/j.leukres.2021.106586_bib0050","doi-asserted-by":"crossref","first-page":"16717","DOI":"10.1038\/s41598-017-16955-5","article-title":"The role of the systemic inflammatory response in predicting outcomes in patients with operable cancer: systematic review and meta-analysis","volume":"7","author":"Dolan","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.leukres.2021.106586_bib0055","doi-asserted-by":"crossref","first-page":"871","DOI":"10.1634\/theoncologist.2012-0034","article-title":"The ratio of the absolute lymphocyte count to the absolute monocyte count is associated with prognosis in Hodgkin\u2019s lymphoma: correlation with tumor-associated macrophages","volume":"17","author":"Koh","year":"2012","journal-title":"Oncologist."},{"key":"10.1016\/j.leukres.2021.106586_bib0060","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.1245\/s10434-014-4097-4","article-title":"High neutrophil-to-lymphocyte ratio persistent during first-line chemotherapy predicts poor clinical outcome in patients with advanced urothelial cancer","volume":"22","author":"Rossi","year":"2015","journal-title":"Ann. Surg. Oncol."},{"key":"10.1016\/j.leukres.2021.106586_bib0065","doi-asserted-by":"crossref","first-page":"1537","DOI":"10.1007\/s00432-014-1714-3","article-title":"The prognostic significance of the prognostic nutritional index in cancer: a systematic review and meta-analysis","volume":"140","author":"Sun","year":"2014","journal-title":"J. Cancer Res. Clin. Oncol."},{"key":"10.1016\/j.leukres.2021.106586_bib0070","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00277-018-3540-1","article-title":"Clinical impact of prognostic nutritional index in diffuse large B cell lymphoma","volume":"98","author":"Go","year":"2019","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.leukres.2021.106586_bib0075","doi-asserted-by":"crossref","first-page":"1153","DOI":"10.1007\/s00277-020-04012-7","article-title":"Clinical significance of the prognostic nutritional index in very elderly patients with morbidity and mortality and its prognostic significance","volume":"99","author":"Hamada","year":"2020","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.leukres.2021.106586_bib0080","doi-asserted-by":"crossref","DOI":"10.1093\/jnci\/dju124","article-title":"Prognostic role of neutrophil-to-lymphocyte ratio in solid tumors: a systematic review and meta-analysis","volume":"106","author":"Templeton","year":"2014","journal-title":"J. Natl. Cancer Inst."},{"key":"10.1016\/j.leukres.2021.106586_bib0085","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000014834","article-title":"Prognostic significance of blood inflammatory biomarkers NLR, PLR, and LMR in cancer: a protocol for systematic review and meta-analysis","volume":"98","author":"-Kumarasamy","year":"2019","journal-title":"Medicine."},{"key":"10.1016\/j.leukres.2021.106586_bib0090","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1002\/hon.2359","article-title":"Neutrophil-lymphocyte ratio at diagnosis is an independent prognostic factor in patients with nodular sclerosis Hodgkin lymphoma: results of a large multicenter study involving 990 patients","volume":"35","author":"Marcheselli","year":"2017","journal-title":"Hematol. Oncol."},{"key":"10.1016\/j.leukres.2021.106586_bib0095","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/bjh.15054","article-title":"Pre-treatment neutrophil\/lymphocyte ratio and platelet\/lymphocyte ratio are prognostic of progression in early stage classical Hodgkin lymphoma","volume":"180","author":"Reddy","year":"2018","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.leukres.2021.106586_bib0100","doi-asserted-by":"crossref","first-page":"1565","DOI":"10.2217\/bmm-2019-0303","article-title":"Systemic Immune Inflammation Index predicting survival outcome in patients with classical Hodgkin lymphoma","volume":"13","author":"Mirili","year":"2019","journal-title":"Biomark. Med."},{"key":"10.1016\/j.leukres.2021.106586_bib0105","doi-asserted-by":"crossref","first-page":"877","DOI":"10.3389\/fonc.2020.00877","article-title":"Prognostic nutritional index, another prognostic factor for extranodal natural killer\/T cell lymphoma, nasal type","volume":"10","author":"Yao","year":"2020","journal-title":"Fronit. Oncol."},{"key":"10.1016\/j.leukres.2021.106586_bib0110","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1007\/s00508-016-1077-7","article-title":"Prognostic nutritional index as a predictor of prognosis in patients with diffuse large B cell Lymphoma","volume":"129","author":"Perisa","year":"2017","journal-title":"Wien Klin Wochencshr."},{"key":"10.1016\/j.leukres.2021.106586_bib0115","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1007\/s00277-018-3540-1","article-title":"Clinical impact of prognostic nutritional index in patients with diffuse large B cell Lymphoma","volume":"98","author":"Go","year":"2019","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.leukres.2021.106586_bib0120","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1097\/COC.0000000000000493","article-title":"The value of prognostic nutritional index in follicular lymphoma","volume":"42","author":"Lee","year":"2019","journal-title":"Am. J. Clin. Oncol."}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212621000874?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212621000874?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:01:21Z","timestamp":1758934881000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212621000874"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8]]},"references-count":24,"alternative-id":["S0145212621000874"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2021.106586","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2021,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Easier and more explanatory indices by integrating leukocyte lymphocyte ratio (LLR) and prognostic nutritional index (PNI) to IPS systems in cases with classical Hodgkin lymphoma","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2021.106586","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"106586"}}