{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,23]],"date-time":"2026-02-23T11:17:03Z","timestamp":1771845423035,"version":"3.50.1"},"reference-count":18,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,3,1]],"date-time":"2024-03-01T00:00:00Z","timestamp":1709251200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"funder":[{"DOI":"10.13039\/100001422","name":"American Society of Hematology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001422","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004328","name":"Genentech","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004328","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA252883"],"award-info":[{"award-number":["K08CA252883"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100031245","name":"Syros Pharmaceuticals","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100031245","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006293","name":"American Society of Clinical Oncology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006293","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2024,3]]},"DOI":"10.1016\/j.leukres.2024.107466","type":"journal-article","created":{"date-parts":[[2024,2,22]],"date-time":"2024-02-22T14:40:12Z","timestamp":1708612812000},"page":"107466","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["KRAS mutations, autoimmunity and female sex in chronic myelomonocytic leukemia"],"prefix":"10.1016","volume":"138","author":[{"given":"Afaf E.G.","family":"Osman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anton","family":"Rets","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ami B.","family":"Patel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.leukres.2024.107466_bib1","doi-asserted-by":"crossref","first-page":"824","DOI":"10.1002\/ajh.25104","article-title":"Chronic myelomonocytic leukemia: 2018 update on diagnosis, risk stratification and management","volume":"93","author":"Patnaik","year":"2018","journal-title":"Am. J. Hematol."},{"issue":"6","key":"10.1016\/j.leukres.2024.107466_bib2","doi-asserted-by":"crossref","first-page":"1488","DOI":"10.1080\/10428194.2016.1243681","article-title":"Spectrum of autoimmune diseases and systemic inflammatory syndromes in patients with chronic myelomonocytic leukemia","volume":"58","author":"Zahid","year":"2017","journal-title":"Leuk. Lymphoma"},{"issue":"2","key":"10.1016\/j.leukres.2024.107466_bib3","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1159\/000365877","article-title":"A close association of autoimmune-mediated processes and autoimmune disorders with chronic myelomonocytic leukemia: observation from a single institution","volume":"133","author":"Peker","year":"2015","journal-title":"Acta Haematol."},{"issue":"18","key":"10.1016\/j.leukres.2024.107466_bib4","doi-asserted-by":"crossref","first-page":"2753","DOI":"10.1182\/blood-2014-11-567917","article-title":"JMML and RALD (Ras-associated autoimmune leukoproliferative disorder): common genetic etiology yet clinically distinct entities","volume":"125","author":"Calvo","year":"2015","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.leukres.2024.107466_bib5","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1182\/blood-2016-05-714030","article-title":"Integrating clinical features and genetic lesions in the risk assessment of patients with chronic myelomonocytic leukemia","volume":"128","author":"Elena","year":"2016","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.leukres.2024.107466_bib6","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.1158\/1078-0432.CCR-09-2112","article-title":"RAS mutations contribute to evolution of chronic myelomonocytic leukemia to the proliferative variant","volume":"16","author":"Ricci","year":"2010","journal-title":"Clin. Cancer Res"},{"issue":"1","key":"10.1016\/j.leukres.2024.107466_bib7","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/sj.leu.2401240","article-title":"RAS mutations and clonality analysis in children with juvenile myelomonocytic leukemia (JMML)","volume":"13","author":"Flotho","year":"1999","journal-title":"Leukemia"},{"issue":"10","key":"10.1016\/j.leukres.2024.107466_bib8","first-page":"3534","article-title":"Chronic myelomonocytic leukemia in childhood: a retrospective analysis of 110 cases. European Working Group on Myelodysplastic Syndromes in Childhood (EWOG-MDS)","volume":"89","author":"Niemeyer","year":"1997","journal-title":"Blood"},{"issue":"21","key":"10.1016\/j.leukres.2024.107466_bib9","doi-asserted-by":"crossref","first-page":"8953","DOI":"10.1073\/pnas.0702975104","article-title":"NRAS mutation causes a human autoimmune lymphoproliferative syndrome","volume":"104","author":"Oliveira","year":"2007","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"10","key":"10.1016\/j.leukres.2024.107466_bib10","doi-asserted-by":"crossref","first-page":"2883","DOI":"10.1182\/blood-2010-07-295501","article-title":"Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis","volume":"117","author":"Niemela","year":"2011","journal-title":"Blood"},{"issue":"10","key":"10.1016\/j.leukres.2024.107466_bib11","doi-asserted-by":"crossref","first-page":"2887","DOI":"10.1182\/blood-2010-08-301515","article-title":"Autoimmune lymphoproliferative syndrome-like disease with somatic KRAS mutation","volume":"117","author":"Takagi","year":"2011","journal-title":"Blood"},{"issue":"11","key":"10.1016\/j.leukres.2024.107466_bib12","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2023.103442","article-title":"Autoimmune lymphoproliferative syndrome: a disorder of immune dysregulation","volume":"22","author":"Paskiewicz","year":"2023","journal-title":"Autoimmun. Rev."},{"issue":"5","key":"10.1016\/j.leukres.2024.107466_bib13","doi-asserted-by":"crossref","first-page":"E280","DOI":"10.1002\/ajh.24333","article-title":"Autoimmune diseases and myelodysplastic syndromes","volume":"91","author":"Komrokji","year":"2016","journal-title":"Am. J. Hematol."},{"issue":"7","key":"10.1016\/j.leukres.2024.107466_bib14","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/j.tig.2019.04.008","article-title":"The pregnancy pickle: evolved immune compensation due to pregnancy underlies sex differences in human diseases","volume":"35","author":"Natri","year":"2019","journal-title":"Trends Genet"},{"issue":"1","key":"10.1016\/j.leukres.2024.107466_bib15","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1007\/s10875-020-00883-7","article-title":"Clinical spectrum of ras-associated autoimmune leukoproliferative disorder (RALD)","volume":"41","author":"Neven","year":"2021","journal-title":"J. Clin. Immunol."},{"issue":"2","key":"10.1016\/j.leukres.2024.107466_bib16","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1056\/NEJMc2030638","article-title":"Distribution of KRAS (G12C) somatic mutations across race, sex, and cancer type","volume":"384","author":"Nassar","year":"2021","journal-title":"N. Engl. J. Med"},{"issue":"3","key":"10.1016\/j.leukres.2024.107466_bib17","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1016\/j.ygyno.2006.05.029","article-title":"KRAS and BRAF mutations in ovarian tumors: a comprehensive study of invasive carcinomas, borderline tumors and extraovarian implants","volume":"103","author":"Mayr","year":"2006","journal-title":"Gynecol. Oncol."},{"issue":"Supplement 1","key":"10.1016\/j.leukres.2024.107466_bib18","doi-asserted-by":"crossref","first-page":"4060","DOI":"10.1182\/blood-2022-163570","article-title":"Concerto (NCT04409639): a phase 2 trial of cobimetinib in newly diagnosed and HMA-treated CMML patients with RAS pathway mutations","volume":"140","author":"Patel","year":"2022","journal-title":"Blood"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212624000328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212624000328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,27]],"date-time":"2025-09-27T01:04:55Z","timestamp":1758935095000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212624000328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":18,"alternative-id":["S0145212624000328"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2024.107466","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"KRAS mutations, autoimmunity and female sex in chronic myelomonocytic leukemia","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2024.107466","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights reserved.","name":"copyright","label":"Copyright"}],"article-number":"107466"}}