{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T18:01:43Z","timestamp":1780596103913,"version":"3.54.1"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,8]],"date-time":"2025-06-08T00:00:00Z","timestamp":1749340800000},"content-version":"am","delay-in-days":311,"URL":"http:\/\/www.elsevier.com\/open-access\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,8,1]],"date-time":"2024-08-01T00:00:00Z","timestamp":1722470400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"content-domain":{"domain":["clinicalkey.fr","clinicalkey.jp","clinicalkey.com.au","clinicalkey.es","clinicalkey.com","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2024,8]]},"DOI":"10.1016\/j.leukres.2024.107530","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T15:47:02Z","timestamp":1717429622000},"page":"107530","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Impact of post-transplant cyclophosphamide and splenomegaly on primary graft failure and multi-lineage cytopenia after allogeneic hematopoietic cell transplantation"],"prefix":"10.1016","volume":"143","author":[{"given":"Emma","family":"Zulch","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshitaka","family":"Inoue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph","family":"Cioccio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin","family":"Rakszawski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natthapol","family":"Songdej","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myles","family":"Nickolich","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seema","family":"Naik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Witold","family":"Rybka","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher","family":"Ehmann","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey","family":"Sivik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jseph","family":"Mierski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brooke","family":"Silar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caitlin","family":"Vajdic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Greiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valerie","family":"Brown","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond","family":"Hohl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Claxton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroko","family":"Shike","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catharine I.","family":"Paules","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Mineishi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Minagawa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.leukres.2024.107530_bib1","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/sj.bmt.1704428","article-title":"Failure of trilineage blood cell reconstitution after initial neutrophil engraftment in patients undergoing allogeneic hematopoietic cell transplantation - frequency and outcomes","volume":"33","author":"Lee","year":"2004","journal-title":"Bone Marrow Transpl."},{"issue":"6","key":"10.1016\/j.leukres.2024.107530_bib2","doi-asserted-by":"crossref","first-page":"1947","DOI":"10.1182\/bloodadvances.2021004537","article-title":"Clinical features, pathophysiology, and therapy of poor graft function post-allogeneic stem cell transplantation","volume":"6","author":"Prabahran","year":"2022","journal-title":"Blood Adv."},{"issue":"8","key":"10.1016\/j.leukres.2024.107530_bib3","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.bbmt.2010.02.013","article-title":"Second unrelated donor hematopoietic cell transplantation for primary graft failure","volume":"16","author":"Schriber","year":"2010","journal-title":"Biol. Blood Marrow Transpl."},{"issue":"4","key":"10.1016\/j.leukres.2024.107530_bib4","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/bmt.2012.239","article-title":"Graft failure in the modern era of allogeneic hematopoietic SCT","volume":"48","author":"Olsson","year":"2013","journal-title":"Bone Marrow Transpl."},{"issue":"8","key":"10.1016\/j.leukres.2024.107530_bib5","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jtct.2021.04.007","volume":"27","author":"Kharfan-Dabaja","year":"2021","journal-title":"Transpl. Cell Ther."},{"issue":"8","key":"10.1016\/j.leukres.2024.107530_bib6","doi-asserted-by":"crossref","first-page":"1754","DOI":"10.1038\/leu.2015.75","article-title":"Primary graft failure after myeloablative allogeneic hematopoietic cell transplantation for hematologic malignancies","volume":"29","author":"Olsson","year":"2015","journal-title":"Leukemia"},{"issue":"9","key":"10.1016\/j.leukres.2024.107530_bib7","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1038\/bmt.2016.98","article-title":"Incidence and risk factors of poor graft function after allogeneic stem cell transplantation for myelofibrosis","volume":"51","author":"Alchalby","year":"2016","journal-title":"Bone Marrow Transpl."},{"issue":"5","key":"10.1016\/j.leukres.2024.107530_bib8","doi-asserted-by":"crossref","first-page":"1477","DOI":"10.1182\/blood.V74.5.1477.1477","article-title":"Antibody-mediated marrow failure after allogeneic bone marrow transplantation","volume":"74","author":"Barge","year":"1989","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.leukres.2024.107530_bib9","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.bbmt.2020.05.018","article-title":"Splenomegaly negatively impacts neutrophil engraftment in cord blood transplantation","volume":"26","author":"Yuasa","year":"2020","journal-title":"Biol. Blood Marrow Transpl."},{"key":"10.1016\/j.leukres.2024.107530_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.637512","article-title":"Allogeneic hemopoietic stem cell transplantation for myelofibrosis: 2021","volume":"12","author":"Bacigalupo","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.leukres.2024.107530_bib11","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1182\/blood.V76.1.245.245","article-title":"Use of recombinant human granulocyte-macrophage colony-stimulating factor in graft failure after bone marrow transplantation","volume":"76","author":"Nemunaitis","year":"1990","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.leukres.2024.107530_bib12","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1182\/blood.2021011975","article-title":"HLA still matters in allogeneic transplants","volume":"138","author":"Bacigalupo","year":"2021","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.leukres.2024.107530_bib13","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1182\/blood.2021011281","article-title":"HLA-haploidentical vs matched unrelated donor transplants with posttransplant cyclophosphamide-based prophylaxis","volume":"138","author":"Gooptu","year":"2021","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.leukres.2024.107530_bib14","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.bbmt.2015.05.001","article-title":"Complement-binding donor-specific anti-HLA antibodies and risk of primary graft failure in hematopoietic stem cell transplantation","volume":"21","author":"Ciurea","year":"2015","journal-title":"Biol. Blood Marrow Transpl."},{"issue":"6","key":"10.1016\/j.leukres.2024.107530_bib15","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1007\/s00277-023-05206-5","article-title":"Poor graft function after haploidentical stem cell transplantation with post-transplant cyclophosphamide","volume":"102","author":"Gomez-Centurion","year":"2023","journal-title":"Ann. Hematol."},{"issue":"3","key":"10.1016\/j.leukres.2024.107530_bib16","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1038\/s41409-018-0279-1","article-title":"Myeloablative and reduced-intensity conditioning in HLA-haploidentical peripheral blood stem cell transplantation using post-transplant cyclophosphamide","volume":"54","author":"Sugita","year":"2019","journal-title":"Bone Marrow Transpl."},{"issue":"1","key":"10.1016\/j.leukres.2024.107530_bib17","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1111\/ejh.13332","article-title":"Impact of CD34+ cell dose on reduced intensity conditioning regimen haploidentical hematopoietic stem cell transplantation","volume":"104","author":"Salas","year":"2020","journal-title":"Eur. J. Haematol."},{"issue":"8","key":"10.1016\/j.leukres.2024.107530_bib18","doi-asserted-by":"crossref","first-page":"892","DOI":"10.1002\/ajh.25826","volume":"95","author":"Maffini","year":"2020","journal-title":"Am. J. Hematol."},{"issue":"12","key":"10.1016\/j.leukres.2024.107530_bib19","doi-asserted-by":"crossref","first-page":"1628","DOI":"10.1016\/j.bbmt.2009.07.004","article-title":"Defining the intensity of conditioning regimens: working definitions","volume":"15","author":"Bacigalupo","year":"2009","journal-title":"Biol. Blood Marrow Transpl."},{"issue":"3","key":"10.1016\/j.leukres.2024.107530_bib20","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/j.bbmt.2008.12.497","article-title":"Reduced-intensity conditioning regimen workshop: defining the dose spectrum","volume":"15","author":"Giralt","year":"2009","journal-title":"Rep. a Workshop Conv. Cent. Int. Blood Marrow Transpl. Res.\u00a0Biol. Blood Marrow Transpl."},{"issue":"3","key":"10.1016\/j.leukres.2024.107530_bib21","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1016\/j.bbmt.2013.11.034","article-title":"CD34+-selected stem cell boost without further conditioning for poor graft function after allogeneic stem cell transplantation in patients with hematological malignancies","volume":"20","author":"Klyuchnikov","year":"2014","journal-title":"Biol. Blood Marrow Transplant."},{"issue":"3","key":"10.1016\/j.leukres.2024.107530_bib22","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1038\/bmt.2012.244","article-title":"Investigation of the freely available easy-to-use software 'EZR' for medical statistics","volume":"48","author":"Kanda","year":"2013","journal-title":"Bone Marrow Transpl."},{"issue":"10","key":"10.1016\/j.leukres.2024.107530_bib23","doi-asserted-by":"crossref","DOI":"10.1016\/j.jtct.2022.07.021","article-title":"Post-transplantation cyclophosphamide versus tacrolimus and methotrexate graft-versus-host disease prophylaxis for HLA-matched donor transplantation","volume":"28","author":"Mehta","year":"2022","journal-title":"Transpl. Cell Ther."},{"issue":"3","key":"10.1016\/j.leukres.2024.107530_bib24","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1007\/s00277-022-05077-2","article-title":"Donor HLA mismatch promotes full donor T-cell chimerism in the allogeneic stem cell transplant with reduced-intensity conditioning and post-transplant cyclophosphamide GVHD prophylaxis","volume":"102","author":"Cioccio","year":"2023","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.leukres.2024.107530_bib25","article-title":"LBA-4 post-transplant cyclophosphamide, tacrolimus, and mycophenolate mofetil as the new standard for graft-versus-host disease (GVHD) prophylaxis in reduced intensity conditioning: results from phase III BMT CTN 1703","author":"Holtan","year":"2022","journal-title":"64th ASH Anu. Meet. Abstr."},{"issue":"4","key":"10.1016\/j.leukres.2024.107530_bib26","doi-asserted-by":"crossref","first-page":"386","DOI":"10.1038\/s41409-022-01908-y","article-title":"Reduced post-transplant cyclophosphamide doses in haploidentical hematopoietic cell transplantation for elderly patients with hematological malignancies","volume":"58","author":"Dulery","year":"2023","journal-title":"Bone Marrow Transpl."},{"issue":"5","key":"10.1016\/j.leukres.2024.107530_bib27","doi-asserted-by":"crossref","first-page":"487","DOI":"10.1038\/sj.bmt.1701119","article-title":"Serial and quantitative analysis of mixed hematopoietic chimerism by PCR in patients with acute leukemias allows the prediction of relapse after allogeneic BMT","volume":"21","author":"Bader","year":"1998","journal-title":"Bone Marrow Transpl."},{"issue":"12","key":"10.1016\/j.leukres.2024.107530_bib28","doi-asserted-by":"crossref","first-page":"2201","DOI":"10.1016\/j.bbmt.2016.09.014","article-title":"Nonfluorodeoxyglucose-avid persistent splenomegaly at time of transplantation delays neutrophil and platelets engraftment without affecting survival in patients with lymphomas undergoing allogeneic hematopoietic cell transplantation","volume":"22","author":"Khimani","year":"2016","journal-title":"Biol. Blood Marrow Transpl."},{"issue":"6","key":"10.1016\/j.leukres.2024.107530_bib29","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1007\/s00277-018-3278-9","article-title":"Enlarged spleen is associated with low neutrophil and platelet engraftment rates and poor survival after allogeneic stem cell transplantation in patients with acute myeloid leukemia and myelodysplastic syndrome","volume":"97","author":"Shimomura","year":"2018","journal-title":"Ann. Hematol."},{"issue":"12","key":"10.1016\/j.leukres.2024.107530_bib30","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1038\/s41375-021-01276-4","volume":"35","author":"Kroger","year":"2021","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.leukres.2024.107530_bib31","doi-asserted-by":"crossref","first-page":"e59","DOI":"10.1016\/S2352-3026(22)00330-1","article-title":"Splenomegaly in patients with primary or secondary myelofibrosis who are candidates for allogeneic hematopoietic cell transplantation: a position paper on behalf of the chronic malignancies working party of the EBMT","volume":"10","author":"Polverelli","year":"2023","journal-title":"Lancet Haematol."},{"issue":"26","key":"10.1016\/j.leukres.2024.107530_bib32","doi-asserted-by":"crossref","first-page":"5264","DOI":"10.1182\/blood-2009-07-234880","article-title":"Allogeneic stem cell transplantation after reduced-intensity conditioning in patients with myelofibrosis: a prospective, multicenter study of the chronic leukemia working party of the european group for blood and marrow transplantation","volume":"114","author":"Kroger","year":"2009","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.leukres.2024.107530_bib33","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1002\/ajh.26020","volume":"96","author":"Polverelli","year":"2021","journal-title":"Am. J. Hematol."}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212624000961?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212624000961?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2024,8,6]],"date-time":"2024-08-06T23:45:44Z","timestamp":1722987944000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212624000961"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":33,"alternative-id":["S0145212624000961"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2024.107530","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2024,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Impact of post-transplant cyclophosphamide and splenomegaly on primary graft failure and multi-lineage cytopenia after allogeneic hematopoietic cell transplantation","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2024.107530","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107530"}}