{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T11:49:21Z","timestamp":1791287361104,"version":"4.1.0"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2024,9,1]],"date-time":"2024-09-01T00:00:00Z","timestamp":1725148800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007313","name":"University of Texas MD Anderson Cancer Center","doi-asserted-by":"publisher","award":["CA016672"],"award-info":[{"award-number":["CA016672"]}],"id":[{"id":"10.13039\/100007313","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2024,9]]},"DOI":"10.1016\/j.leukres.2024.107563","type":"journal-article","created":{"date-parts":[[2024,8,20]],"date-time":"2024-08-20T02:52:18Z","timestamp":1724122338000},"page":"107563","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Characteristics and outcomes of children, adolescent, and young adult patients with myelodysplastic neoplasms: A single-center retrospective analysis"],"prefix":"10.1016","volume":"144","author":[{"given":"David","family":"McCall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tareq","family":"Abuasab","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juan Jose","family":"Rodriguez-Sevilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shehab Fareed","family":"Mohamed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anish","family":"Patnaik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirthi","family":"Devireddy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naszrin","family":"Arani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irtiza","family":"Sheikh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raehannah","family":"Jamshidi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amber","family":"Gibson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Roth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar","family":"Nu\u00f1ez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly S.","family":"Chien","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanam","family":"Loghavi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sherry A.","family":"Pierce","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koji","family":"Sasaki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ghayas","family":"Issa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Branko","family":"Cuglievan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hagop","family":"Kantarjian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillermo","family":"Garcia-Manero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.leukres.2024.107563_bib1","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1053\/j.seminhematol.2007.10.006","article-title":"Myelodysplastic syndrome in children and adolescents","volume":"45","author":"Niemeyer","year":"2008","journal-title":"Semin. Hematol."},{"issue":"3","key":"10.1016\/j.leukres.2024.107563_bib2","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s12308-015-0253-4","article-title":"Pediatric myelodysplastic syndromes","volume":"8","author":"Hofmann","year":"2015","journal-title":"J. Hematop."},{"issue":"1","key":"10.1016\/j.leukres.2024.107563_bib3","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1093\/annonc\/mdp264","article-title":"Prognostic impact of age and gender in 897 untreated patients with primary myelodysplastic syndromes","volume":"21","author":"N\u00f6sslinger","year":"2010","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.leukres.2024.107563_bib4","first-page":"52","article-title":"Primary myelodysplastic syndromes: analysis of prognostic factors in 235 patients and proposals for an improved scoring system","volume":"6","author":"Aul","year":"1992","journal-title":"Leukemia"},{"issue":"9","key":"10.1016\/j.leukres.2024.107563_bib5","first-page":"1315","article-title":"Cytogenetic analysis has strong independent prognostic value in de novo myelodysplastic syndromes and can be incorporated in a new scoring system: a report on 408 cases","volume":"7","author":"Morel","year":"1993","journal-title":"Leukemia"},{"issue":"1","key":"10.1016\/j.leukres.2024.107563_bib6","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1182\/blood.V74.1.395.395","article-title":"Two regression models and a scoring system for predicting survival and planning treatment in myelodysplastic syndromes: a multivariate analysis of prognostic factors in 370 patients","volume":"74","author":"Sanz","year":"1989","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.leukres.2024.107563_bib7","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1038\/s41375-021-01137-0","article-title":"Germline variants drive myelodysplastic syndrome in young adults","volume":"35","author":"Feurstein","year":"2021","journal-title":"Leukemia"},{"issue":"2","key":"10.1016\/j.leukres.2024.107563_bib8","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1038\/sj.leu.2402765","article-title":"A pediatric approach to the WHO classification of myelodysplastic and myeloproliferative diseases","volume":"17","author":"Hasle","year":"2003","journal-title":"Leukemia"},{"issue":"3","key":"10.1016\/j.leukres.2024.107563_bib9","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1038\/leu.2016.342","article-title":"Mutational landscape in children with myelodysplastic syndromes is distinct from adults: specific somatic drivers and novel germline variants","volume":"31","author":"Pastor","year":"2017","journal-title":"Leukemia"},{"issue":"13","key":"10.1016\/j.leukres.2024.107563_bib10","doi-asserted-by":"crossref","first-page":"1406","DOI":"10.1182\/blood-2017-09-765214","article-title":"How I treat myelodysplastic syndromes of childhood","volume":"131","author":"Locatelli","year":"2018","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.leukres.2024.107563_bib11","doi-asserted-by":"crossref","first-page":"1307","DOI":"10.1002\/ajh.26984","article-title":"Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management","volume":"98","author":"Garcia-Manero","year":"2023","journal-title":"Am. J. Hematol."},{"issue":"11","key":"10.1016\/j.leukres.2024.107563_bib12","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1038\/sj.leu.2402271","article-title":"Myelodysplastic syndrome in childhood: a retrospective study of 189 patients in Japan","volume":"15","author":"Sasaki","year":"2001","journal-title":"Leukemia"},{"issue":"3","key":"10.1016\/j.leukres.2024.107563_bib13","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2017-2151","article-title":"Age limit of pediatrics","volume":"140","author":"Hardin","year":"2017","journal-title":"Pediatrics"},{"issue":"19","key":"10.1016\/j.leukres.2024.107563_bib14","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13194847","article-title":"Adolescent and young adult (AYA) cancer survivorship practices: an overview","volume":"13","author":"Janssen","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"7","key":"10.1016\/j.leukres.2024.107563_bib15","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the world health organization classification of haematolymphoid tumours: myeloid and histiocytic\/dendritic neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"issue":"4","key":"10.1016\/j.leukres.2024.107563_bib16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1007\/s11899-014-0224-3","article-title":"I walk the line: how to tell MDS from other bone marrow failure conditions","volume":"9","author":"Gondek","year":"2014","journal-title":"Curr. Hematol. Malig. Rep."},{"issue":"12","key":"10.1016\/j.leukres.2024.107563_bib17","doi-asserted-by":"crossref","first-page":"2454","DOI":"10.1182\/blood-2012-03-420489","article-title":"Revised international prognostic scoring system for myelodysplastic syndromes","volume":"120","author":"Greenberg","year":"2012","journal-title":"Blood"},{"issue":"7","key":"10.1016\/j.leukres.2024.107563_bib18","doi-asserted-by":"crossref","DOI":"10.1056\/EVIDoa2200008","article-title":"Molecular international prognostic scoring system for myelodysplastic syndromes","volume":"1","author":"Bernard","year":"2022","journal-title":"NEJM Evid."},{"issue":"2","key":"10.1016\/j.leukres.2024.107563_bib19","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1038\/leu.2014.186","article-title":"Early assessment of minimal residual disease in AML by flow cytometry during aplasia identifies patients at increased risk of relapse","volume":"29","author":"K\u00f6hnke","year":"2015","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2024.107563_bib20","first-page":"2679","article-title":"Endleukemia assay v1: enabling ngs-based comprehensive routine molecular profiling of leukemias in routine clinical care","volume":"130","author":"Ok","year":"2017","journal-title":"Blood"},{"issue":"5","key":"10.1016\/j.leukres.2024.107563_bib21","doi-asserted-by":"crossref","first-page":"1103","DOI":"10.1038\/s41375-023-01864-6","article-title":"Therapy-related MDS dissected based on primary disease and treatment\u2014a nationwide perspective","volume":"37","author":"Moreno Berggren","year":"2023","journal-title":"Leukemia"},{"issue":"24","key":"10.1016\/j.leukres.2024.107563_bib22","doi-asserted-by":"crossref","first-page":"4642","DOI":"10.1200\/JCO.2003.04.036","article-title":"Revised recommendations of the international working group for diagnosis, standardization of response criteria, treatment outcomes, and reporting standards for therapeutic trials in acute myeloid leukemia","volume":"21","author":"Cheson","year":"2003","journal-title":"J. Clin. Oncol."},{"issue":"13","key":"10.1016\/j.leukres.2024.107563_bib23","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1182\/blood.V98.13.3575","article-title":"Comparison of idarubicin + ara-C-, fludarabine + ara-C-, and topotecan + ara-C-based regimens in treatment of newly diagnosed acute myeloid leukemia, refractory anemia with excess blasts in transformation, or refractory anemia with excess blasts","volume":"98","author":"Estey","year":"2001","journal-title":"Blood"},{"issue":"22","key":"10.1016\/j.leukres.2024.107563_bib24","doi-asserted-by":"crossref","first-page":"5272","DOI":"10.1002\/cncr.25516","article-title":"Intensively timed combination chemotherapy for the induction of adult patients with acute myeloid leukemia: long-term follow-up of a phase 2 study","volume":"116","author":"Rytting","year":"2010","journal-title":"Cancer"},{"issue":"1","key":"10.1016\/j.leukres.2024.107563_bib25","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1002\/ajh.24246","article-title":"Acute myeloid leukemia--major progress over four decades and glimpses into the future.","volume":"91","author":"Kantarjian","year":"2016","journal-title":"Am. J. Hematol."},{"issue":"1","key":"10.1016\/j.leukres.2024.107563_bib26","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1016\/j.phoj.2019.03.001","article-title":"Outcome and factors affecting survival of childhood myelodysplastic syndrome; single centre experience","volume":"4","author":"Abdalla","year":"2019","journal-title":"Pediatr. Hematol. Oncol. J."},{"issue":"9","key":"10.1016\/j.leukres.2024.107563_bib27","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1001\/jama.2022.14578","article-title":"Diagnosis and treatment of myelodysplastic syndromes: a review","volume":"328","author":"Sekeres","year":"2022","journal-title":"Jama"},{"issue":"1","key":"10.1016\/j.leukres.2024.107563_bib28","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1038\/s41467-017-01590-5","article-title":"The genomic landscape of pediatric myelodysplastic syndromes","volume":"8","author":"Schwartz","year":"2017","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.leukres.2024.107563_bib29","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41408-024-01054-2","article-title":"RAS mutations in myeloid malignancies: revisiting old questions with novel insights and therapeutic perspectives","volume":"14","author":"Alawieh","year":"2024","journal-title":"Blood Cancer J."},{"issue":"11","key":"10.1016\/j.leukres.2024.107563_bib30","doi-asserted-by":"crossref","first-page":"4641","DOI":"10.1182\/blood-2006-10-051342","article-title":"Monosomy 7 and deletion 7q in children and adolescents with acute myeloid leukemia: an international retrospective study","volume":"109","author":"Hasle","year":"2007","journal-title":"Blood"},{"issue":"3","key":"10.1016\/j.leukres.2024.107563_bib31","first-page":"216","article-title":"Myelodysplastic syndromes in children: where are we today?","volume":"12","author":"Rau","year":"2012","journal-title":"Ochsner J."},{"issue":"11","key":"10.1016\/j.leukres.2024.107563_bib32","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1182\/blood-2015-09-669937","article-title":"Prevalence, clinical characteristics, and prognosis of GATA2-related myelodysplastic syndromes in children and adolescents","volume":"127","author":"Wlodarski","year":"2016","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.leukres.2024.107563_bib33","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/sj.bmt.1704753","article-title":"Monosomy 7 associated with pediatric acute myeloid leukemia (AML) and myelodysplastic syndrome (MDS): successful management by allogeneic hematopoietic stem cell transplant (HSCT)","volume":"35","author":"Trobaugh-Lotrario","year":"2005","journal-title":"Bone Marrow Transplant."},{"issue":"19","key":"10.1016\/j.leukres.2024.107563_bib34","doi-asserted-by":"crossref","first-page":"3766","DOI":"10.1182\/blood-2010-04-280313","article-title":"Complex karyotype newly defined: the strongest prognostic factor in advanced childhood myelodysplastic syndrome","volume":"116","author":"G\u00f6hring","year":"2010","journal-title":"Blood"},{"issue":"12","key":"10.1016\/j.leukres.2024.107563_bib35","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.3324\/haematol.2016.145821","article-title":"Response to treatment with azacitidine in children with advanced myelodysplastic syndrome prior to hematopoietic stem cell transplantation","volume":"101","author":"Nicolas","year":"2016","journal-title":"Haematologica"},{"issue":"5","key":"10.1016\/j.leukres.2024.107563_bib36","doi-asserted-by":"crossref","first-page":"e322","DOI":"10.1097\/MPH.0000000000000042","article-title":"Azacitidine in the treatment of pediatric therapy-related myelodysplastic syndrome after allogeneic hematopoietic stem cell transplantation","volume":"36","author":"Inoue","year":"2014","journal-title":"J. Pedia Hematol. Oncol."},{"issue":"15","key":"10.1016\/j.leukres.2024.107563_bib37","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1056\/NEJMoa1103283","article-title":"Somatic SF3B1 mutation in myelodysplasia with ring sideroblasts","volume":"365","author":"Papaemmanuil","year":"2011","journal-title":"N. Engl. J. Med"},{"issue":"2","key":"10.1016\/j.leukres.2024.107563_bib38","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1111\/bjh.13317","article-title":"Haematopoietic and immune defects associated with GATA2 mutation","volume":"169","author":"Collin","year":"2015","journal-title":"Br. J. Haematol."},{"issue":"3","key":"10.1016\/j.leukres.2024.107563_bib39","doi-asserted-by":"crossref","first-page":"S179","DOI":"10.1016\/j.bbmt.2019.12.739","article-title":"Maintenance 5-azactidine may improve outcomes after allogeneic stem-cell transplantation in high-risk AML and MDS patients","volume":"26","author":"Danylesko","year":"2020","journal-title":"Biol. Blood Marrow Transplant."}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212624001292?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212624001292?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T10:36:38Z","timestamp":1778668598000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212624001292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9]]},"references-count":39,"alternative-id":["S0145212624001292"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2024.107563","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2024,9]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Characteristics and outcomes of children, adolescent, and young adult patients with myelodysplastic neoplasms: A single-center retrospective analysis","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2024.107563","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107563"}}