{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:03:14Z","timestamp":1773820994037,"version":"3.50.1"},"reference-count":61,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T00:00:00Z","timestamp":1762905600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100016866","name":"Henry J Predolin Foundation for Research in Leukemia","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100016866","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000871","name":"Mayo Clinic","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000871","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014535","name":"Mayo Clinic Center for Individualized Medicine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014535","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2026,1]]},"DOI":"10.1016\/j.leukres.2025.108133","type":"journal-article","created":{"date-parts":[[2025,11,13]],"date-time":"2025-11-13T11:43:30Z","timestamp":1763034210000},"page":"108133","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Genomic profiling reveals molecular heterogeneity in patients with Richter transformation (RT) and chronic lymphocytic leukemia (CLL)"],"prefix":"10.1016","volume":"160","author":[{"given":"Shulan","family":"Tian","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hanyin","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sameer A.","family":"Parikh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanhang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Jin-Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erik","family":"Jessen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eric W.","family":"Klee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yucai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fan","family":"Leng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cinthya","family":"Zepeda-Mendoza","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6116-8163","authenticated-orcid":false,"given":"Rong","family":"He","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Saad J.","family":"Kenderian","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Linda B.","family":"Baughn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel L.","family":"Van Dyke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Paul J.","family":"Hampel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Neil E.","family":"Kay","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esteban","family":"Braggio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan L.","family":"Slager","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huihuang","family":"Yan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Ding","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2025.108133_bib1","doi-asserted-by":"crossref","first-page":"1016","DOI":"10.1111\/bjh.18352","article-title":"Clonally unrelated Richter syndrome are truly de novo diffuse large B-cell lymphomas with a mutational profile reminiscent of clonally related Richter syndrome","volume":"198","author":"Favini","year":"2022","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.leukres.2025.108133_bib2","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1038\/s41408-021-00477-5","article-title":"Distinct immune signatures in chronic lymphocytic leukemia and Richter syndrome","volume":"11","author":"Wang","year":"2021","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.leukres.2025.108133_bib3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/s41467-022-34642-6","article-title":"Molecular characterization of Richter syndrome identifies de novo diffuse large B-cell lymphomas with poor prognosis","volume":"14","author":"Bros\u00e9us","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.leukres.2025.108133_bib4","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1038\/s41591-022-02113-6","article-title":"Evolutionary history of transformation from chronic lymphocytic leukemia to Richter syndrome","volume":"29","author":"Parry","year":"2023","journal-title":"Nat. Med."},{"key":"10.1016\/j.leukres.2025.108133_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.829983","article-title":"Biology and treatment of richter transformation","volume":"12","author":"Condoluci","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.leukres.2025.108133_bib6","doi-asserted-by":"crossref","first-page":"3419","DOI":"10.1182\/blood-2017-02-765685","article-title":"Pembrolizumab in patients with CLL and Richter transformation or with relapsed CLL","volume":"129","author":"Ding","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2025.108133_bib7","doi-asserted-by":"crossref","first-page":"1662","DOI":"10.1038\/s41591-022-01927-8","article-title":"Detection of early seeding of Richter transformation in chronic lymphocytic leukemia","volume":"28","author":"Nadeu","year":"2022","journal-title":"Nat. Med."},{"key":"10.1016\/j.leukres.2025.108133_bib8","doi-asserted-by":"crossref","first-page":"2800","DOI":"10.1182\/blood.2020005650","article-title":"Genomic and transcriptomic correlates of Richter transformation in chronic lymphocytic leukemia","volume":"137","author":"Klintman","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2025.108133_bib9","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1084\/jem.20131448","article-title":"Genetic lesions associated with chronic lymphocytic leukemia transformation to Richter syndrome","volume":"210","author":"Fabbri","year":"2013","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.leukres.2025.108133_bib10","doi-asserted-by":"crossref","first-page":"2673","DOI":"10.1182\/blood-2013-03-489518","article-title":"Two main genetic pathways lead to the transformation of chronic lymphocytic leukemia to Richter syndrome","volume":"122","author":"Chigrinova","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2025.108133_bib11","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1182\/blood.2020008276","article-title":"B-cell receptor signaling and genetic lesions in TP53 and CDKN2A\/CDKN2B cooperate in Richter transformation","volume":"138","author":"Chakraborty","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2025.108133_bib12","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1182\/bloodadvances.2016003632","article-title":"Clonal evolution underlying leukemia progression and Richter transformation in patients with ibrutinib-relapsed CLL","volume":"1","author":"Kadri","year":"2017","journal-title":"Blood Adv."},{"key":"10.1016\/j.leukres.2025.108133_bib13","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1038\/s41467-022-35778-1","article-title":"Dysregulation of PRMT5 in chronic lymphocytic leukemia promotes progression with high risk of Richter's transformation","volume":"14","author":"Hing","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.leukres.2025.108133_bib14","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1182\/bloodadvances.2017007302","article-title":"Near-tetraploidy is associated with Richter transformation in chronic lymphocytic leukemia patients receiving ibrutinib","volume":"1","author":"Miller","year":"2017","journal-title":"Blood Adv."},{"key":"10.1016\/j.leukres.2025.108133_bib15","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1111\/bjh.13933","article-title":"The Dohner fluorescence in situ hybridization prognostic classification of chronic lymphocytic leukaemia (CLL): the CLL research consortium experience","volume":"173","author":"Van Dyke","year":"2016","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.leukres.2025.108133_bib16","doi-asserted-by":"crossref","first-page":"e208","DOI":"10.3324\/haematol.2018.198820","article-title":"Long-term real-world results of ibrutinib therapy in patients with relapsed or refractory chronic lymphocytic leukemia: 30-month follow up of the Swedish compassionate use cohort","volume":"104","author":"Winqvist","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2025.108133_bib17","doi-asserted-by":"crossref","first-page":"25826","DOI":"10.18632\/oncotarget.25381","article-title":"Clinical validation of the Tempus xO assay","volume":"9","author":"Beaubier","year":"2018","journal-title":"Oncotarget"},{"key":"10.1016\/j.leukres.2025.108133_bib18","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/nbt.2514","article-title":"Sensitive detection of somatic point mutations in impure and heterogeneous cancer samples","volume":"31","author":"Cibulskis","year":"2013","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.leukres.2025.108133_bib19","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1093\/bioinformatics\/btu137","article-title":"The biological reference repository (BioR): a rapid and flexible system for genomics annotation","volume":"30","author":"Kocher","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.leukres.2025.108133_bib20","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1038\/nature15393","article-title":"A global reference for human genetic variation","volume":"526","author":"Auton","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2025.108133_bib21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/nature19057","article-title":"Analysis of protein-coding genetic variation in 60,706 humans","volume":"536","author":"Lek","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2025.108133_bib22","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1038\/s41586-020-2308-7","article-title":"The mutational constraint spectrum quantified from variation in 141,456 humans","volume":"581","author":"Karczewski","year":"2020","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2025.108133_bib23","doi-asserted-by":"crossref","DOI":"10.1093\/nar\/gkx1153","article-title":"ClinVar: improving access to variant interpretations and supporting evidence","volume":"46","author":"Landrum","year":"2018","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.leukres.2025.108133_bib24","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1007\/s00439-020-02199-3","article-title":"The human gene mutation database (HGMD(\u00ae)): optimizing its use in a clinical diagnostic or research setting","volume":"139","author":"Stenson","year":"2020","journal-title":"Hum. Genet."},{"key":"10.1016\/j.leukres.2025.108133_bib25","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s13073-015-0195-6","article-title":"CSN and CAVA: variant annotation tools for rapid, robust next-generation sequencing analysis in the clinical setting","volume":"7","author":"Munz","year":"2015","journal-title":"Genome Med."},{"key":"10.1016\/j.leukres.2025.108133_bib26","doi-asserted-by":"crossref","first-page":"1713","DOI":"10.1093\/bioinformatics\/bty010","article-title":"Sensitive and specific post-call filtering of genetic variants in xenograft and primary tumors","volume":"34","author":"Mannakee","year":"2018","journal-title":"Bioinformatics"},{"key":"10.1016\/j.leukres.2025.108133_bib27","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1093\/bioinformatics\/btu356","article-title":"Toward better understanding of artifacts in variant calling from high-coverage samples","volume":"30","author":"Li","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.leukres.2025.108133_bib28","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1038\/nature14666","article-title":"Non-coding recurrent mutations in chronic lymphocytic leukaemia","volume":"526","author":"Puente","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2025.108133_bib29","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1038\/nature15395","article-title":"Mutations driving CLL and their evolution in progression and relapse","volume":"526","author":"Landau","year":"2015","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2025.108133_bib30","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1182\/blood-2015-02-585042","article-title":"Genomic and epigenomic heterogeneity in chronic lymphocytic leukemia","volume":"126","author":"Guieze","year":"2015","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2025.108133_bib31","article-title":"Chronic lymphocytic leukaemia","volume":"3","author":"Kipps","year":"2017","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.leukres.2025.108133_bib32","doi-asserted-by":"crossref","first-page":"2678","DOI":"10.1093\/bioinformatics\/btu363","article-title":"PatternCNV: a versatile tool for detecting copy number changes from exome sequencing data","volume":"30","author":"Wang","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.leukres.2025.108133_bib33","doi-asserted-by":"crossref","first-page":"1351","DOI":"10.1038\/s41587-019-0259-z","article-title":"Integrated genomic profiling expands clinical options for patients with cancer","volume":"37","author":"Beaubier","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.leukres.2025.108133_bib34","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1186\/1471-2105-15-224","article-title":"MAP-RSeq: Mayo Analysis Pipeline for RNA sequencing","volume":"15","author":"Kalari","year":"2014","journal-title":"BMC Bioinforma."},{"key":"10.1016\/j.leukres.2025.108133_bib35","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"10.1016\/j.leukres.2025.108133_bib36","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1093\/bioinformatics\/btt656","article-title":"featureCounts: an efficient general purpose program for assigning sequence reads to genomic features","volume":"30","author":"Liao","year":"2014","journal-title":"Bioinformatics"},{"key":"10.1016\/j.leukres.2025.108133_bib37","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1093\/bioinformatics\/btp616","article-title":"edgeR: a Bioconductor package for differential expression analysis of digital gene expression data","volume":"26","author":"Robinson","year":"2010","journal-title":"Bioinformatics"},{"key":"10.1016\/j.leukres.2025.108133_bib38","doi-asserted-by":"crossref","first-page":"W90","DOI":"10.1093\/nar\/gkw377","article-title":"Enrichr: a comprehensive gene set enrichment analysis web server 2016 update","volume":"44","author":"Kuleshov","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.leukres.2025.108133_bib39","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1038\/s41587-019-0114-2","article-title":"Determining cell type abundance and expression from bulk tissues with digital cytometry","volume":"37","author":"Newman","year":"2019","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.leukres.2025.108133_bib40","doi-asserted-by":"crossref","first-page":"563","DOI":"10.1182\/blood-2010-05-284984","article-title":"The lymph node microenvironment promotes B-cell receptor signaling, NF-kappaB activation, and tumor proliferation in chronic lymphocytic leukemia","volume":"117","author":"Herishanu","year":"2011","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2025.108133_bib41","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1182\/bloodadvances.2021006941","article-title":"The immune microenvironment shapes transcriptional and genetic heterogeneity in chronic lymphocytic leukemia","volume":"7","author":"Sun","year":"2023","journal-title":"Blood Adv."},{"key":"10.1016\/j.leukres.2025.108133_bib42","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1038\/nature07968","article-title":"Mutations of multiple genes cause deregulation of NF-kappaB in diffuse large B-cell lymphoma","volume":"459","author":"Compagno","year":"2009","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2025.108133_bib43","doi-asserted-by":"crossref","first-page":"3839","DOI":"10.1038\/s41467-018-06069-5","article-title":"Notch2 controls non-autonomous Wnt-signalling in chronic lymphocytic leukaemia","volume":"9","author":"Mangolini","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.leukres.2025.108133_bib44","doi-asserted-by":"crossref","first-page":"4701","DOI":"10.1111\/bph.13949","article-title":"Wnt signalling pathways in chronic lymphocytic leukaemia and B-cell lymphomas","volume":"174","author":"Janovska","year":"2017","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.leukres.2025.108133_bib45","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1007\/s00011-013-0633-0","article-title":"TNF-\u03b1 signalling and inflammation: interactions between old acquaintances","volume":"62","author":"Zelov\u00e1","year":"2013","journal-title":"Inflamm. Res."},{"key":"10.1016\/j.leukres.2025.108133_bib46","doi-asserted-by":"crossref","first-page":"784","DOI":"10.3389\/fimmu.2018.00784","article-title":"Role of TNF-TNF receptor 2 signal in regulatory T cells and its therapeutic implications","volume":"9","author":"Yang","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.leukres.2025.108133_bib47","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1038\/nrclinonc.2018.8","article-title":"Targeting the IL-6\/JAK\/STAT3 signalling axis in cancer","volume":"15","author":"Johnson","year":"2018","journal-title":"Nat. Rev. Clin. Oncol."},{"key":"10.1016\/j.leukres.2025.108133_bib48","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/nri.2016.153","article-title":"Programmed cell death and the immune system","volume":"17","author":"Nagata","year":"2017","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.leukres.2025.108133_bib49","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1182\/blood.2020005734","article-title":"Active Akt signaling triggers CLL toward Richter transformation via overactivation of Notch1","volume":"137","author":"Kohlhaas","year":"2021","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2025.108133_bib50","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1084\/jem.20110921","article-title":"Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation","volume":"208","author":"Fabbri","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.leukres.2025.108133_bib51","doi-asserted-by":"crossref","first-page":"576","DOI":"10.3324\/haematol.2018.196931","article-title":"Mutations in the RAS-BRAF-MAPK-ERK pathway define a specific subgroup of patients with adverse clinical features and provide new therapeutic options in chronic lymphocytic leukemia","volume":"104","author":"Gim\u00e9nez","year":"2019","journal-title":"Haematologica"},{"key":"10.1016\/j.leukres.2025.108133_bib52","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1111\/bjh.18952","article-title":"Clonal architecture and single-cell transcriptome landscape in Richter's syndrome","volume":"202","author":"Li","year":"2023","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.leukres.2025.108133_bib53","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1038\/leu.2017.177","article-title":"Whole-genome sequencing of chronic lymphocytic leukaemia reveals distinct differences in the mutational landscape between IgHV(mut) and IgHV(unmut) subgroups","volume":"32","author":"Burns","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2025.108133_bib54","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1200\/JCO.2016.71.0822","article-title":"Clinical implications of novel genomic discoveries in chronic lymphocytic leukemia","volume":"35","author":"Lazarian","year":"2017","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.leukres.2025.108133_bib55","doi-asserted-by":"crossref","first-page":"2122","DOI":"10.1182\/blood-2015-07-659144","article-title":"Clinical impact of clonal and subclonal TP53, SF3B1, BIRC3, NOTCH1, and ATM mutations in chronic lymphocytic leukemia","volume":"127","author":"Nadeu","year":"2016","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2025.108133_bib56","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/leu.2017.291","article-title":"Clinical impact of the subclonal architecture and mutational complexity in chronic lymphocytic leukemia","volume":"32","author":"Nadeu","year":"2018","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2025.108133_bib57","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/s41588-022-01140-w","article-title":"Molecular map of chronic lymphocytic leukemia and its impact on outcome","volume":"54","author":"Knisbacher","year":"2022","journal-title":"Nat. Genet"},{"key":"10.1016\/j.leukres.2025.108133_bib58","doi-asserted-by":"crossref","first-page":"854","DOI":"10.3389\/fgene.2019.00854","article-title":"New recurrent structural aberrations in the genome of chronic lymphocytic leukemia based on exome-sequencing data","volume":"10","author":"Mosquera Orgueira","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.leukres.2025.108133_bib59","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.808886","article-title":"Landscape of TP53 alterations in chronic lymphocytic leukemia via data mining mutation databases","volume":"12","author":"Soussi","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.leukres.2025.108133_bib60","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.ccell.2021.02.003","article-title":"A hotspot mutation in transcription factor IKZF3 drives B cell neoplasia via transcriptional dysregulation","volume":"39","author":"Lazarian","year":"2021","journal-title":"Cancer Cell"},{"key":"10.1016\/j.leukres.2025.108133_bib61","doi-asserted-by":"crossref","first-page":"2455","DOI":"10.1182\/blood.2021010958","article-title":"BCOR gene alterations in hematologic diseases","volume":"138","author":"Sportoletti","year":"2021","journal-title":"Blood"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521262500623X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S014521262500623X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T07:01:36Z","timestamp":1773817296000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S014521262500623X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1]]},"references-count":61,"alternative-id":["S014521262500623X"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2025.108133","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2026,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Genomic profiling reveals molecular heterogeneity in patients with Richter transformation (RT) and chronic lymphocytic leukemia (CLL)","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2025.108133","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108133"}}