{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T19:57:48Z","timestamp":1783799868078,"version":"3.55.0"},"reference-count":51,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["09\/006(0513)\/2019-EMR-I"],"award-info":[{"award-number":["09\/006(0513)\/2019-EMR-I"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001412","name":"Council of Scientific and Industrial Research, India","doi-asserted-by":"publisher","award":["11013\/16\/2021-GIA\/HR"],"award-info":[{"award-number":["11013\/16\/2021-GIA\/HR"]}],"id":[{"id":"10.13039\/501100001412","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009104","name":"Department of Health Research, India","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009104","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["55\/4\/10\/CARE-AML\/2018-NCD-II"],"award-info":[{"award-number":["55\/4\/10\/CARE-AML\/2018-NCD-II"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.leukres.2026.108170","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T15:56:03Z","timestamp":1769010963000},"page":"108170","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Single cell transcriptomics derived combinatorial markers distinguished leukemic stem cells from hematopoietic stem cells in acute myeloid leukemia"],"prefix":"10.1016","volume":"161","author":[{"given":"Aafreen","family":"Khan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1759-7857","authenticated-orcid":false,"given":"Smeeta","family":"Gajendra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivek Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepshi","family":"Thakral","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sameer","family":"Bakhshi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranjit Kumar","family":"Sahoo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachna","family":"Seth","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandeep","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5364-4086","authenticated-orcid":false,"given":"Ritu","family":"Gupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.leukres.2026.108170_bib1","doi-asserted-by":"crossref","DOI":"10.1038\/bcj.2016.50","article-title":"Acute myeloid leukemia: a comprehensive review and 2016 update","volume":"6","author":"De Kouchkovsky","year":"2016","journal-title":"Blood Cancer J."},{"key":"10.1016\/j.leukres.2026.108170_bib2","doi-asserted-by":"crossref","first-page":"1136","DOI":"10.1056\/NEJMra1406184","article-title":"Acute myeloid leukemia","volume":"373","author":"D\u00f6hner","year":"2015","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.leukres.2026.108170_bib3","doi-asserted-by":"crossref","first-page":"1894","DOI":"10.1016\/S0140-6736(06)69780-8","article-title":"Acute myeloid leukaemia","volume":"368","author":"Estey","year":"2006","journal-title":"Lancet"},{"key":"10.1016\/j.leukres.2026.108170_bib4","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1182\/blood-2016-10-696054","article-title":"Biology and relevance of human acute myeloid leukemia stem cells","volume":"129","author":"Thomas","year":"2017","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2026.108170_bib5","doi-asserted-by":"crossref","first-page":"1756","DOI":"10.1007\/s12015-022-10349-5","article-title":"Leukemic stem cell signatures in Acute myeloid leukemia- targeting the Guardians with novel approaches","volume":"18","author":"Thakral","year":"2022","journal-title":"Stem Cell Rev. Rep."},{"key":"10.1016\/j.leukres.2026.108170_bib6","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1038\/nm0797-730","article-title":"Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell","volume":"3","author":"Bonnet","year":"1997","journal-title":"Nat. Med"},{"key":"10.1016\/j.leukres.2026.108170_bib7","doi-asserted-by":"crossref","first-page":"473","DOI":"10.4252\/wjsc.v6.i4.473","article-title":"Identification and targeting leukemia stem cells: the path to the cure for acute myeloid leukemia","volume":"6","author":"Zhou","year":"2014","journal-title":"World J. Stem Cells"},{"key":"10.1016\/j.leukres.2026.108170_bib8","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/367645a0","article-title":"A cell initiating human acute myeloid leukaemia after transplantation into SCID mice","volume":"367","author":"Lapidot","year":"1994","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2026.108170_bib9","doi-asserted-by":"crossref","unstructured":"D.C. Taussig, F. Miraki-Moud, F. Anjos-Afonso, D.J. Pearce, K. Allen, C. Ridler, D. Lillington, H. Oakervee, J. Cavenagh, S.G. Agrawal, T.A. Lister, J.G. Gribben, D. Bonnet, 2008, Anti-CD38 antibody-mediated clearance of human repopulating cells masks the heterogeneity of leukemia-initiating cells, (2008). https:\/\/doi.org\/10.1182\/blood-2008-10-118331.","DOI":"10.1182\/blood-2007-10-118331"},{"key":"10.1016\/j.leukres.2026.108170_bib10","doi-asserted-by":"crossref","first-page":"1976","DOI":"10.1182\/blood-2009-02-206565","article-title":"Leukemia-initiating cells from some acute myeloid leukemia patients with mutated nucleophosmin reside in the CD34 fraction","volume":"115","author":"Taussig","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2026.108170_bib11","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1038\/s41375-018-0326-3","article-title":"CD34+CD38\u2212 leukemic stem cell frequency to predict outcome in acute myeloid leukemia","volume":"33","author":"Zeijlemaker","year":"2019","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2026.108170_bib12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0107587","article-title":"Leukemic stem cell frequency: a strong biomarker for clinical outcome in acute myeloid leukemia","volume":"9","author":"Terwijn","year":"2014","journal-title":"PLoS One"},{"key":"10.1016\/j.leukres.2026.108170_bib13","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1111\/bjh.13941","article-title":"CD45RA, a specific marker for leukaemia stem cell sub-populations in acute myeloid leukaemia","volume":"173","author":"Kersten","year":"2016","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.leukres.2026.108170_bib14","doi-asserted-by":"crossref","first-page":"4086","DOI":"10.1182\/blood-2005-03-1072","article-title":"D. Bonnet, Hematopoietic stem cells express multiple myeloid markers: implications for the origin and targeted therapy of acute myeloid leukemia","volume":"106","author":"Taussig","year":"2005","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2026.108170_bib15","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/leu.2015.252","article-title":"A simple one-tube assay for immunophenotypical quantification of leukemic stem cells in acute myeloid leukemia","volume":"30","author":"Zeijlemaker","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2026.108170_bib16","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/cyto.b.22201","article-title":"The role of the primitive marker CD133 in CD34-negative acute myeloid leukemia for the detection of leukemia stem cells","volume":"108","author":"Reuvekamp","year":"2025","journal-title":"Cytom. B Clin. Cytom."},{"key":"10.1016\/j.leukres.2026.108170_bib17","doi-asserted-by":"crossref","first-page":"1700","DOI":"10.1038\/sj.leu.2404754","article-title":"Aberrant marker expression patterns on the CD34+CD38- stem cell compartment in acute myeloid leukemia allows to distinguish the malignant from the normal stem cell compartment both at diagnosis and in remission","volume":"21","author":"van Rhenen","year":"2007","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2026.108170_bib18","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s00277-022-05021-4","article-title":"Integrated single-cell transcriptome analysis of CD34\u2009+\u2009enriched leukemic stem cells revealed intra- and inter-patient transcriptional heterogeneity in pediatric acute myeloid leukemia","volume":"102","author":"Thakral","year":"2023","journal-title":"Ann. Hematol."},{"key":"10.1016\/j.leukres.2026.108170_bib19","doi-asserted-by":"crossref","first-page":"D917","DOI":"10.1093\/nar\/gkv1101","article-title":"BloodSpot: a database of gene expression profiles and transcriptional programs for healthy and malignant haematopoiesis","volume":"44","author":"Bagger","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.leukres.2026.108170_bib20","doi-asserted-by":"crossref","first-page":"2059","DOI":"10.1056\/NEJMoa1301689","volume":"368","author":"Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.leukres.2026.108170_bib21","doi-asserted-by":"crossref","first-page":"802","DOI":"10.1111\/j.1365-2141.2008.07261.x","article-title":"An international standardization programme towards the application of gene expression profiling in routine leukaemia diagnostics: the Microarray Innovations in LEukemia study prephase","volume":"142","author":"Kohlmann","year":"2008","journal-title":"Br. J. Haematol."},{"key":"10.1016\/j.leukres.2026.108170_bib22","doi-asserted-by":"crossref","first-page":"2529","DOI":"10.1200\/JCO.2009.23.4732","article-title":"Clinical utility of microarray-based gene expression profiling in the diagnosis and subclassification of leukemia: report from the international microarray innovations in leukemia study group","volume":"28","author":"Haferlach","year":"2010","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.leukres.2026.108170_bib23","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1038\/nbt.4096","article-title":"Integrating single-cell transcriptomic data across different conditions, technologies, and species","volume":"36","author":"Butler","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.leukres.2026.108170_bib24","doi-asserted-by":"crossref","unstructured":"M.Gh Al-Asadi, G. Brindle, M. Castellanos, S.T. May, K.I. Mills, N.H. Russell, C.H. Seedhouse, M. Pallis, A molecular signature of dormancy in CD34 + CD38-acute myeloid leukaemia cells, 2017. \u3008www.impactjournals.com\/oncotarget\u3009.","DOI":"10.18632\/oncotarget.22808"},{"key":"10.1016\/j.leukres.2026.108170_bib25","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1038\/nature20598","article-title":"A 17-gene stemness score for rapid determination of risk in acute leukaemia","volume":"540","author":"Ng","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.leukres.2026.108170_bib26","doi-asserted-by":"crossref","unstructured":"G. Korotkevich, V. Sukhov, N. Budin, B. Shpak, M.N. Artyomov, A. Sergushichev, 2016, Fast gene set enrichment analysis. https:\/\/doi.org\/10.1101\/060012.","DOI":"10.1101\/060012"},{"key":"10.1016\/j.leukres.2026.108170_bib27","doi-asserted-by":"crossref","first-page":"1739","DOI":"10.1093\/bioinformatics\/btr260","article-title":"Molecular signatures database (MSigDB) 3.0","volume":"27","author":"Liberzon","year":"2011","journal-title":"Bioinformatics"},{"key":"10.1016\/j.leukres.2026.108170_bib28","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1038\/leu.2015.252","article-title":"A simple one-tube assay for immunophenotypical quantification of leukemic stem cells in acute myeloid leukemia","volume":"30","author":"Zeijlemaker","year":"2016","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2026.108170_bib29","doi-asserted-by":"crossref","DOI":"10.1111\/ijlh.14250","article-title":"Immunophenotypic characterization of leukemic stem cells in acute myeloid leukemia using single tube 10-colour panel by multiparametric flow cytometry: Deciphering the spectrum, complexity and immunophenotypic heterogeneity","author":"Das","year":"2024","journal-title":"Int J. Lab Hematol. N.\/a"},{"key":"10.1016\/j.leukres.2026.108170_bib30","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1002\/cyto.b.22068","article-title":"Relevance of polyclonal plasma cells and post-therapy immunomodulation in measurable residual disease assessment in multiple myeloma","volume":"102","author":"Das","year":"2022","journal-title":"Cytom. B Clin. Cytom."},{"key":"10.1016\/j.leukres.2026.108170_bib31","doi-asserted-by":"crossref","first-page":"480","DOI":"10.1038\/nri2580","article-title":"New insights into the regulation of T cells by \u03b3c family cytokines","volume":"9","author":"Rochman","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.leukres.2026.108170_bib32","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1002\/stem.1661","article-title":"Concise review: Evidence for CD34 as a common marker for diverse progenitors","volume":"32","author":"Sidney","year":"2014","journal-title":"Stem Cells"},{"key":"10.1016\/j.leukres.2026.108170_bib33","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1158\/0008-5472.CAN-18-2932","article-title":"Single-Cell Gene Expression Analyses Reveal Distinct Self-Renewing and Proliferating Subsets in the Leukemia Stem Cell Compartment in Acute Myeloid Leukemia","volume":"80","author":"Sachs","year":"2020","journal-title":"Cancer Res"},{"key":"10.1016\/j.leukres.2026.108170_bib34","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1186\/s13059-023-03031-7","article-title":"Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AML","volume":"24","author":"Zhang","year":"2023","journal-title":"Genome Biol."},{"key":"10.1016\/j.leukres.2026.108170_bib35","unstructured":"B. Moshaver, A. Kelder, G.J. Ossenkoppele, A.H. Westra, S. Zweegman, G.J. Schuurhuis, Leukemia stem cell diversity in CD34-negative versus CD34-positive acute myeloid leukemia. Combining CD34\/CD38-defined with SP-defined stem cell populations, n.d. \u3008http:\/\/www.invitrogen.com\u3009."},{"key":"10.1016\/j.leukres.2026.108170_bib36","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1002\/cyto.b.22201","article-title":"The role of the primitive marker CD133 in CD34-negative acute myeloid leukemia for the detection of leukemia stem cells","volume":"108","author":"Reuvekamp","year":"2025","journal-title":"Cytom. B Clin. Cytom."},{"key":"10.1016\/j.leukres.2026.108170_bib37","doi-asserted-by":"crossref","first-page":"5402","DOI":"10.1182\/bloodadvances.2020001802","article-title":"CD200 expression marks leukemia stem cells in human AML","volume":"4","author":"Ho","year":"2020","journal-title":"Blood Adv."},{"key":"10.1016\/j.leukres.2026.108170_bib38","doi-asserted-by":"crossref","first-page":"344","DOI":"10.20517\/cdr.2021.140","article-title":"Characteristics of leukemic stem cells in acute leukemia and potential targeted therapies for their specific eradication","volume":"5","author":"Hansen","year":"2022","journal-title":"Cancer Drug Resist."},{"key":"10.1016\/j.leukres.2026.108170_bib39","doi-asserted-by":"crossref","first-page":"698","DOI":"10.1111\/cas.16431","article-title":"TIM-3 marks measurable residual leukemic stem cells responsible for relapse after allogeneic stem cell transplantation","volume":"116","author":"Sakoda","year":"2025","journal-title":"Cancer Sci."},{"key":"10.1016\/j.leukres.2026.108170_bib40","doi-asserted-by":"crossref","first-page":"1777","DOI":"10.1038\/sj.leu.2401903","article-title":"The interleukin-3 receptor alpha chain is a unique marker for human acute myelogenous leukemia stem cells","volume":"14","author":"Jordan","year":"2000","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2026.108170_bib41","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s12185-013-1433-6","article-title":"TIM-3 as a novel therapeutic target for eradicating acute myelogenous leukemia stem cells","volume":"98","author":"Kikushige","year":"2013","journal-title":"Int J. Hematol."},{"key":"10.1016\/j.leukres.2026.108170_bib42","doi-asserted-by":"crossref","DOI":"10.21037\/sci.2017.02.10","article-title":"The biomarkers of leukemia stem cells in acute myeloid leukemia","author":"Ding","year":"2017","journal-title":"Stem Cell Invest. 2017"},{"key":"10.1016\/j.leukres.2026.108170_bib43","doi-asserted-by":"crossref","unstructured":"N. Hosen, C.Y. Park, N. Tatsumi, Y. Oji, H. Sugiyama, M. Gramatzki, A.M. Krensky, I.L. Weissman, CD96 is a leukemic stem cell-specific marker in human acute myeloid leukemia, 2007. \u3008www.pnas.org\/cgi\/content\/full\/\u3009.","DOI":"10.1073\/pnas.0704271104"},{"key":"10.1016\/j.leukres.2026.108170_bib44","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.cell.2009.05.045","article-title":"CD47 is an adverse prognostic factor and therapeutic antibody target on human acute myeloid leukemia stem cells","volume":"138","author":"Majeti","year":"2009","journal-title":"Cell"},{"key":"10.1016\/j.leukres.2026.108170_bib45","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3000349","article-title":"Identification of therapeutic targets for quiescent, chemotherapy-resistant human leukemia stem cells","volume":"2","author":"Saito","year":"2010","journal-title":"Sci. Transl. Med."},{"key":"10.1016\/j.leukres.2026.108170_bib46","doi-asserted-by":"crossref","DOI":"10.1038\/s41420-021-00446-8","article-title":"CD52 is a novel target for the treatment of FLT3-ITD-mutated myeloid leukemia","volume":"7","author":"Karnan","year":"2021","journal-title":"Cell Death Discov."},{"key":"10.1016\/j.leukres.2026.108170_bib47","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1038\/s41375-022-01789-6","article-title":"Single-cell analysis reveals the chemotherapy-induced cellular reprogramming and novel therapeutic targets in relapsed\/refractory acute myeloid leukemia","volume":"37","author":"Li","year":"2023","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2026.108170_bib48","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.2147\/IJGM.S431696","article-title":"A systematic immune and prognostic analysis of CD48 interaction with tumor microenvironment in pan-cancer","volume":"16","author":"He","year":"2023","journal-title":"Int. J. Gen. Med."},{"key":"10.1016\/j.leukres.2026.108170_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s12272-021-01365-z","article-title":"CD48-expressing non-small-cell lung cancer cells are susceptible to natural killer cell\u2013mediated cytotoxicity","volume":"45","author":"Park","year":"2022","journal-title":"Arch. Pharm. Res."},{"key":"10.1016\/j.leukres.2026.108170_bib50","doi-asserted-by":"crossref","first-page":"4181","DOI":"10.2147\/OTT.S198762","article-title":"CD48 is a key molecule of immunomodulation affecting prognosis in glioma","volume":"12","author":"Zou","year":"2019","journal-title":"Oncol. Targets Ther."},{"key":"10.1016\/j.leukres.2026.108170_bib51","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1042\/CS20191170","article-title":"Acute myeloid leukemia immune escape by epigenetic CD48 silencing","volume":"134","author":"Wang","year":"2020","journal-title":"Clin. Sci."}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212626000147?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212626000147?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T18:43:46Z","timestamp":1777488226000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212626000147"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":51,"alternative-id":["S0145212626000147"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2026.108170","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Single cell transcriptomics derived combinatorial markers distinguished leukemic stem cells from hematopoietic stem cells in acute myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2026.108170","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108170"}}