{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T14:15:27Z","timestamp":1783606527855,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017594","name":"Medical Science and Technology Project of Zhejiang Province","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017594","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004731","name":"Zhejiang Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004731","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007194","name":"Wenzhou Municipal Science and Technology Bureau","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007194","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.leukres.2026.108270","type":"journal-article","created":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T07:17:45Z","timestamp":1782199065000},"page":"108270","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["CD244 modulates bone marrow infiltrating CD8+ T cells and serves as a prognostic and immunotherapeutic target in acute myeloid leukemia"],"prefix":"10.1016","volume":"167","author":[{"given":"Qiang","family":"Zhuang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaqian","family":"Pan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yisha","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanyin","family":"Zhou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shenghui","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixiang","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kang","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songfu","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3994-7563","authenticated-orcid":false,"given":"Fanfan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10147","key":"10.1016\/j.leukres.2026.108270_bib1","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1016\/S0140-6736(18)31041-9","article-title":"Acute myeloid leukaemia","volume":"392","author":"Short","year":"2018","journal-title":"Lancet"},{"issue":"2","key":"10.1016\/j.leukres.2026.108270_bib2","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1182\/bloodadvances.2019000792","article-title":"Immune profiles in acute myeloid leukemia bone marrow associate with patient age, T-cell receptor clonality, and survival","volume":"4","author":"Bruck","year":"2020","journal-title":"Blood Adv."},{"issue":"25","key":"10.1016\/j.leukres.2026.108270_bib3","doi-asserted-by":"crossref","first-page":"14331","DOI":"10.1073\/pnas.1916206117","article-title":"Reversible suppression of T cell function in the bone marrow microenvironment of acute myeloid leukemia","volume":"117","author":"Lamble","year":"2020","journal-title":"Proc. Natl. Acad. Sci. USA"},{"key":"10.1016\/j.leukres.2026.108270_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.blre.2022.100991","article-title":"Blasts in context: the impact of the immune environment on acute myeloid leukemia prognosis and treatment","volume":"57","author":"Serroukh","year":"2023","journal-title":"Blood Rev."},{"issue":"4","key":"10.1016\/j.leukres.2026.108270_bib5","doi-asserted-by":"crossref","first-page":"1552","DOI":"10.1172\/JCI129204","article-title":"Immune escape and immunotherapy of acute myeloid leukemia","volume":"130","author":"Vago","year":"2020","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.leukres.2026.108270_bib6","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/j.clim.2018.10.014","article-title":"2B4 and CD48: A powerful couple of the immune system","volume":"204","author":"Pahima","year":"2019","journal-title":"Clin. Immunol."},{"issue":"12","key":"10.1016\/j.leukres.2026.108270_bib7","doi-asserted-by":"crossref","first-page":"8159","DOI":"10.4049\/jimmunol.180.12.8159","article-title":"Molecular basis of the dual functions of 2B4 (CD244)","volume":"180","author":"Chlewicki","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.leukres.2026.108270_bib8","article-title":"Advances in Understanding the Roles of CD244 (SLAMF4) in Immune Regulation and Associated Diseases","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.leukres.2026.108270_bib9","doi-asserted-by":"crossref","first-page":"463","DOI":"10.21147\/j.issn.1000-9604.2017.05.11","article-title":"Higher PD-1 expression concurrent with exhausted CD8+ T cells in patients with de novo acute myeloid leukemia","volume":"29","author":"Tan","year":"2017","journal-title":"Chin. J. Cancer Res."},{"key":"10.1016\/j.leukres.2026.108270_bib10","doi-asserted-by":"crossref","first-page":"2612","DOI":"10.1038\/ncomms3612","article-title":"Inferring tumour purity and stromal and immune cell admixture from expression data","volume":"4","author":"Yoshihara","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.leukres.2026.108270_bib11","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.26476","article-title":"Simultaneous enumeration of cancer and immune cell types from bulk tumor gene expression data","volume":"6","author":"Racle","year":"2017","journal-title":"Elife"},{"issue":"4","key":"10.1016\/j.leukres.2026.108270_bib12","doi-asserted-by":"crossref","first-page":"812","DOI":"10.1016\/j.immuni.2018.03.023","article-title":"The Immune Landscape of Cancer","volume":"48","author":"Thorsson","year":"2018","journal-title":"Immunity"},{"issue":"7","key":"10.1016\/j.leukres.2026.108270_bib13","doi-asserted-by":"crossref","first-page":"3089","DOI":"10.7150\/thno.53649","article-title":"Siglec15 shapes a non-inflamed tumor microenvironment and predicts the molecular subtype in bladder cancer","volume":"11","author":"Hu","year":"2021","journal-title":"Theranostics"},{"issue":"6","key":"10.1016\/j.leukres.2026.108270_bib14","doi-asserted-by":"crossref","first-page":"1934","DOI":"10.1002\/hep.23936","article-title":"The immunoregulatory role of CD244 in chronic hepatitis B infection and its inhibitory potential on virus-specific CD8+ T-cell function","volume":"52","author":"Raziorrouh","year":"2010","journal-title":"Hepatology"},{"issue":"1","key":"10.1016\/j.leukres.2026.108270_bib15","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1186\/s13071-024-06573-2","article-title":"Upregulation of CD244 promotes CD8(+) T cell exhaustion in patients with alveolar echinococcosis and a murine model","volume":"17","author":"Wang","year":"2024","journal-title":"Parasit. Vectors"},{"issue":"16","key":"10.1016\/j.leukres.2026.108270_bib16","doi-asserted-by":"crossref","first-page":"1617","DOI":"10.1056\/NEJMoa040465","article-title":"Prognostically useful gene-expression profiles in acute myeloid leukemia","volume":"350","author":"Valk","year":"2004","journal-title":"N. Engl. J. Med."},{"issue":"10","key":"10.1016\/j.leukres.2026.108270_bib17","doi-asserted-by":"crossref","first-page":"3706","DOI":"10.1182\/blood-2007-02-073486","article-title":"Distinct gene expression profiles of acute myeloid\/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1","volume":"110","author":"Wouters","year":"2007","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.leukres.2026.108270_bib18","doi-asserted-by":"crossref","first-page":"1282","DOI":"10.1182\/blood-2011-11-394395","article-title":"Mutated regions of nucleophosmin 1 elicit both CD4(+) and CD8(+) T-cell responses in patients with acute myeloid leukemia","volume":"120","author":"Greiner","year":"2012","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.leukres.2026.108270_bib19","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1182\/blood-2013-04-496844","article-title":"Immune responses against the mutated region of cytoplasmatic NPM1 might contribute to the favorable clinical outcome of AML patients with NPM1 mutations (NPM1mut)","volume":"122","author":"Greiner","year":"2013","journal-title":"Blood"},{"key":"10.1016\/j.leukres.2026.108270_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.724436","article-title":"AKT Hyperphosphorylation and T Cell Exhaustion in Down Syndrome","volume":"13","author":"Peeters","year":"2022","journal-title":"Front. Immunol."},{"issue":"4","key":"10.1016\/j.leukres.2026.108270_bib21","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000515305","article-title":"Exploring Markers of Exhausted CD8 T Cells to Predict Response to Immune Checkpoint Inhibitor Therapy for Hepatocellular Carcinoma","volume":"10","author":"Hsu","year":"2021","journal-title":"Liver Cancer"},{"issue":"1","key":"10.1016\/j.leukres.2026.108270_bib22","doi-asserted-by":"crossref","DOI":"10.7448\/IAS.19.1.20697","article-title":"Elevation and persistence of CD8 T-cells in HIV infection: the Achilles heel in the ART era","volume":"19","author":"Cao","year":"2016","journal-title":"J. Int. AIDS Soc."},{"issue":"2","key":"10.1016\/j.leukres.2026.108270_bib23","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1038\/nm.3445","article-title":"HIV-1 persistence in CD4+ T cells with stem cell-like properties","volume":"20","author":"Buzon","year":"2014","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.leukres.2026.108270_bib24","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1038\/ni.1679","article-title":"Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection","volume":"10","author":"Blackburn","year":"2009","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.leukres.2026.108270_bib25","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1146\/annurev-immunol-101921-044122","article-title":"Designing Cancer Immunotherapies That Engage T Cells and NK Cells","volume":"41","author":"Kyrysyuk","year":"2023","journal-title":"Annu. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.leukres.2026.108270_bib26","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1016\/j.cell.2021.01.022","article-title":"Inhibitory CD161 receptor identified in glioma-infiltrating T cells by single-cell analysis","volume":"184","author":"Mathewson","year":"2021","journal-title":"Cell"},{"issue":"4","key":"10.1016\/j.leukres.2026.108270_bib27","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s00262-016-1803-z","article-title":"CD57 in human natural killer cells and T-lymphocytes","volume":"65","author":"Kared","year":"2016","journal-title":"Cancer Immunol. Immunother."},{"issue":"3","key":"10.1016\/j.leukres.2026.108270_bib28","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1111\/cei.13070","article-title":"Co-inhibitory profile and cytotoxicity of CD57(+) PD-1(-) T cells in end-stage renal disease patients","volume":"191","author":"Kraaijeveld","year":"2018","journal-title":"Clin. Exp. Immunol."},{"issue":"9","key":"10.1016\/j.leukres.2026.108270_bib29","doi-asserted-by":"crossref","first-page":"1407","DOI":"10.1084\/jem.186.9.1407","article-title":"Phenotypic and functional separation of memory and effector human CD8+ T cells","volume":"186","author":"Hamann","year":"1997","journal-title":"J. Exp. Med."},{"issue":"2","key":"10.1016\/j.leukres.2026.108270_bib30","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.immuni.2024.01.011","article-title":"Signaling via a CD27-TRAF2-SHP-1 axis during naive T cell activation promotes memory-associated gene regulatory networks","volume":"57","author":"Jaeger-Ruckstuhl","year":"2024","journal-title":"Immunity"},{"issue":"22","key":"10.1016\/j.leukres.2026.108270_bib31","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.127867","article-title":"2B4 but not PD-1 blockade improves mortality in septic animals with preexisting malignancy","volume":"4","author":"Chen","year":"2019","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.leukres.2026.108270_bib32","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1002\/hep.26192","article-title":"Monocyte\/macrophage-elicited natural killer cell dysfunction in hepatocellular carcinoma is mediated by CD48\/2B4 interactions","volume":"57","author":"Wu","year":"2013","journal-title":"Hepatology"},{"issue":"8","key":"10.1016\/j.leukres.2026.108270_bib33","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1038\/nri3862","article-title":"Molecular and cellular insights into T cell exhaustion","volume":"15","author":"Wherry","year":"2015","journal-title":"Nat. Rev. Immunol."},{"issue":"2","key":"10.1016\/j.leukres.2026.108270_bib34","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.jss.2015.02.004","article-title":"Murine lung cancer induces generalized T-cell exhaustion","volume":"195","author":"Mittal","year":"2015","journal-title":"J. Surg. Res."},{"issue":"5","key":"10.1016\/j.leukres.2026.108270_bib35","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1016\/j.ccell.2019.09.006","article-title":"Combination Immunotherapy with CAR T Cells and Checkpoint Blockade for the Treatment of Solid Tumors","volume":"36","author":"Grosser","year":"2019","journal-title":"Cancer Cell."},{"issue":"1","key":"10.1016\/j.leukres.2026.108270_bib36","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1186\/s13045-021-01164-5","article-title":"Combination strategies to maximize the benefits of cancer immunotherapy","volume":"14","author":"Zhu","year":"2021","journal-title":"J. Hematol. Oncol."},{"issue":"1","key":"10.1016\/j.leukres.2026.108270_bib37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1186\/s12943-024-01936-w","article-title":"Targeted deletion of CD244 on monocytes promotes differentiation into anti-tumorigenic macrophages and potentiates PD-L1 blockade in melanoma","volume":"23","author":"Kim","year":"2024","journal-title":"Mol. Cancer"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212626001141?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212626001141?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,9]],"date-time":"2026-07-09T13:21:51Z","timestamp":1783603311000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212626001141"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":37,"alternative-id":["S0145212626001141"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2026.108270","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"CD244 modulates bone marrow infiltrating CD8+ T cells and serves as a prognostic and immunotherapeutic target in acute myeloid leukemia","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2026.108270","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Ltd.","name":"copyright","label":"Copyright"}],"article-number":"108270"}}