{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:41:13Z","timestamp":1792428073537,"version":"4.5.0"},"reference-count":21,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Leukemia Research"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.leukres.2026.108324","type":"journal-article","created":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T08:51:29Z","timestamp":1789721489000},"page":"108324","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Chronic myeloid leukemia is not a familial disease\u2026or maybe it is?"],"prefix":"10.1016","volume":"170","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7391-7168","authenticated-orcid":false,"given":"Jeffrey H.","family":"Lipton","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.leukres.2026.108324_bib1","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1038\/s41375-022-01613-1","article-title":"The 5th edition of the World Health Organization classification of hematolymphoid tumours: myeloid and histiocytic\/dedritric neoplasms","volume":"36","author":"Khoury","year":"2022","journal-title":"Leukemia"},{"issue":"18","key":"10.1016\/j.leukres.2026.108324_bib2","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1001\/jama.2025.0220","article-title":"Chronic myeloid leukemia: a review","volume":"333","author":"Jabbour","year":"2025","journal-title":"JAMA"},{"key":"10.1016\/j.leukres.2026.108324_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1159\/000551493","article-title":"Chronic myeloid leukemia (CML): historical perspective, pathophysiology, and treatment advances","volume":"13","author":"Tungjitviboonkun","year":"2026","journal-title":"Acta Haematol."},{"key":"10.1016\/j.leukres.2026.108324_bib4","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2025.1546813","article-title":"The biology of chronic myeloid leukemia: an overview of the new insight and biomarkers","volume":"15","author":"Sicuranza","year":"2025","journal-title":"Front. Oncol."},{"issue":"12","key":"10.1016\/j.leukres.2026.108324_bib5","article-title":"Four decades of molecular innovation in chronic myeloid leukemia: from antisense targetig to treatment-free remission","volume":"18","author":"De Propis","year":"2026","journal-title":"Cancers"},{"issue":"10","key":"10.1016\/j.leukres.2026.108324_bib6","article-title":"Global, regional and national burden of chronic myeloid leukemia, 1990-217","volume":"15","author":"Lin","year":"2020","journal-title":"Front. Oncol. Dec."},{"issue":"1","key":"10.1016\/j.leukres.2026.108324_bib7","first-page":"433","article-title":"Meeting the needs of CML patients in resource-poor countries","volume":"2019","author":"Malhotra","year":"2019","journal-title":"Hematol. ASH Educ. Prog."},{"issue":"3","key":"10.1016\/j.leukres.2026.108324_bib8","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1182\/blood-2013-05-501312","article-title":"No familial aggregation in chronic myeloid leukemia","volume":"122","author":"Bj\u00f6rkholm","year":"2013","journal-title":"Blood"},{"issue":"2","key":"10.1016\/j.leukres.2026.108324_bib9","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1182\/blood.V31.2.216.216","article-title":"Chronic myelocytic leukemia in identical twins and a sibling","volume":"31","author":"Tokuhata","year":"1968","journal-title":"Blood"},{"issue":"8404","key":"10.1016\/j.leukres.2026.108324_bib10","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1016\/S0140-6736(84)91260-1","article-title":"Familial chronic myeloid leukaemia","volume":"2","author":"Lillicrap","year":"1984","journal-title":"Lancet"},{"issue":"1","key":"10.1016\/j.leukres.2026.108324_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.cancergencyto.2004.11.013","article-title":"Chronic myelogenous leukemia occurring in two brothers diagnosed 26 years apart","volume":"160","author":"Lessen","year":"2005","journal-title":"Cancer Genet. Cytogenet."},{"issue":"5","key":"10.1016\/j.leukres.2026.108324_bib12","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1159\/000513925","article-title":"Two cases of possible familial chronic myeloid leukemia in a family with extensive history of cancer","volume":"144","author":"Aitken","year":"2021","journal-title":"Acta Haematol."},{"key":"10.1016\/j.leukres.2026.108324_bib13","article-title":"Chronic myelogenous leukemia occurring in two brothers: the opposite sides of the same coin?","volume":"16","author":"Verrou","year":"2021","journal-title":"Leuk. Res. Rep."},{"issue":"7","key":"10.1016\/j.leukres.2026.108324_bib14","first-page":"969","article-title":"Development of leukemia in donor cells after allogeneic stem cell transplantation\u2013a survey of the European Group for Blood and Marrow Transplantation (EBMT","volume":"90","author":"Hertenstein","year":"2005","journal-title":"Haematologica"},{"issue":"7","key":"10.1016\/j.leukres.2026.108324_bib15","first-page":"59","article-title":"Familial myeloproliferative syndrome (study of 4 families and review of the literature)","volume":"57","author":"Bondare","year":"1985","journal-title":"Ter. Arkh"},{"issue":"2","key":"10.1016\/j.leukres.2026.108324_bib16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1111\/cge.12044","article-title":"23094849 Inheritance of the chronic myeloproliferative neoplasms. a systematic review","volume":"83","author":"Ranjan","year":"2013","journal-title":"Clin. Genet."},{"issue":"6","key":"10.1016\/j.leukres.2026.108324_bib17","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1159\/000504740","article-title":"Avoiding the thorns of the gifted red rose: case report of late diagnosis of polycythemia rubra vera in a sibling bone marrow transplantation donor for a patient with chronic myeloid leukemia","volume":"143","author":"Amitai","year":"2020","journal-title":"Acta Haematol."},{"issue":"6","key":"10.1016\/j.leukres.2026.108324_bib18","first-page":"703","article-title":"BCR\/ABL1 transcripts in healthy individuals: a comparative analysis between first-degree relatives of patients with chronic myelogenous leukemia and subjects without antecedents of the disease","volume":"49","author":"Meza-Espinoza","year":"2019","journal-title":"Ann. Clin. Lab. Sci."},{"issue":"1","key":"10.1016\/j.leukres.2026.108324_bib19","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1186\/s12885-024-12102-2","article-title":"Higher prevalence of harbouring BCR::ABL1 in first-degree relatives of chronic myeloid leukaemia (CML) patients compared to normal population","volume":"24","author":"Kuan","year":"2024","journal-title":"BMC Cancer"},{"issue":"2","key":"10.1016\/j.leukres.2026.108324_bib20","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/leu.2010.197","article-title":"Do we have to kill the last CML cell?","volume":"25","author":"Ross","year":"1995","journal-title":"Leukemia"},{"key":"10.1016\/j.leukres.2026.108324_bib21","doi-asserted-by":"crossref","first-page":"3362","DOI":"10.1182\/blood.V92.9.3362","article-title":"The presence of typical and atypical BCR\/ABL fusion genes in leukocytes of normal individuals: biologic significance implications for the assessment of minimal residual disease","volume":"92","author":"Bose","year":"1998","journal-title":"Blood"}],"container-title":["Leukemia Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212626001682?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0145212626001682?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T16:07:07Z","timestamp":1792426027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0145212626001682"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":21,"alternative-id":["S0145212626001682"],"URL":"https:\/\/doi.org\/10.1016\/j.leukres.2026.108324","relation":{},"ISSN":["0145-2126"],"issn-type":[{"value":"0145-2126","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic myeloid leukemia is not a familial disease\u2026or maybe it is?","name":"articletitle","label":"Article Title"},{"value":"Leukemia Research","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.leukres.2026.108324","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"simple-article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Ltd. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"108324"}}