{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T13:08:03Z","timestamp":1773752883112,"version":"3.50.1"},"reference-count":30,"publisher":"Elsevier BV","issue":"23","license":[{"start":{"date-parts":[[2004,4,1]],"date-time":"2004-04-01T00:00:00Z","timestamp":1080777600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2004,4]]},"DOI":"10.1016\/j.lfs.2003.11.003","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T17:09:07Z","timestamp":1079802547000},"page":"2897-2908","source":"Crossref","is-referenced-by-count":64,"title":["The anti-hyperglycemic activity of the fruiting body of Cordyceps in diabetic rats induced by nicotinamide and streptozotocin"],"prefix":"10.1016","volume":"74","author":[{"given":"Hui-Chen","family":"Lo","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shih-Te","family":"Tu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kwo-Chuan","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Chen","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2003.11.003_BIB1","first-page":"145","article-title":"Healthcare use by veterans for diabetes mellitus in the Veterans Affairs medical care system","volume":"9","author":"Ashton","year":"2003","journal-title":"The American Journal of Managed Care"},{"key":"10.1016\/j.lfs.2003.11.003_BIB2","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1089\/10755530260128005","article-title":"A fermentation product of Cordyceps sinensis increases whole-body insulin sensitivity in rats","volume":"8","author":"Balon","year":"2002","journal-title":"Journal of Alternative and Complementary Medicine"},{"key":"10.1016\/j.lfs.2003.11.003_BIB3","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.2337\/diacare.26.5.1333","article-title":"The significance of impaired fasting glucose versus impaired glucose tolerance: importance of insulin secretion and resistance","volume":"26","author":"Carnevale Schianca","year":"2003","journal-title":"Diabetes Care"},{"key":"10.1016\/j.lfs.2003.11.003_BIB4","series-title":"Cordyceps: China's healing mushroom","first-page":"1","author":"Halpern","year":"1999"},{"key":"10.1016\/j.lfs.2003.11.003_BIB5","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0300-2977(99)00092-3","article-title":"Diabetes in the next century: challenges and opportunities","volume":"55","author":"Heine","year":"1999","journal-title":"The Netherlands Journal of Medicine"},{"key":"10.1016\/j.lfs.2003.11.003_BIB6","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/0009-8981(83)90078-5","article-title":"Fructosamine: a new approach to the estimation of serum glycosylprotein. An index of diabetic control","volume":"127","author":"Johnson","year":"1983","journal-title":"Clinica Chimica Acta"},{"key":"10.1016\/j.lfs.2003.11.003_BIB7","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1007\/s00125-002-0858-x","article-title":"Revealing the cost of type II diabetes in Europe","volume":"45","author":"Jonsson","year":"2002","journal-title":"Diabetologia"},{"key":"10.1016\/j.lfs.2003.11.003_BIB8","doi-asserted-by":"crossref","first-page":"2129","DOI":"10.1172\/JCI106180","article-title":"Diabetogenic action of streptozotocin: relationship of dose to metabolic response","volume":"48","author":"Junod","year":"1969","journal-title":"The Journal of Clinical Investigation"},{"key":"10.1016\/j.lfs.2003.11.003_BIB9","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0378-8741(97)00159-1","article-title":"Protective role of Anacardium occidentale extract against streptozotocin-induced diabetes in rats","volume":"62","author":"Kamtchouing","year":"1998","journal-title":"Journal of ethnopharmacology"},{"key":"10.1016\/j.lfs.2003.11.003_BIB10","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.1248\/bpb.16.1291","article-title":"Polysaccharides in fungi. XXXII. Hypoglycemic activity and Chemical properties of a polysaccharides from the cultural mycelium of Cordyceps sinenesis","volume":"16","author":"Kiho","year":"1993","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.lfs.2003.11.003_BIB11","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1248\/bpb.20.118","article-title":"Polysaccharides in fungi. XXXVIII. Anti-diabetic activity and structural feature of a galactomannan elaborated by Pestalotiopsis species","volume":"20","author":"Kiho","year":"1997","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.lfs.2003.11.003_BIB12","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1248\/bpb.18.1627","article-title":"Polysaccharides in fungi. XXXV. Anti diabetic activity of an acidic polysaccharide from the fruiting bodies of Tremella aurantia","volume":"18","author":"Kiho","year":"1995","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.lfs.2003.11.003_BIB13","doi-asserted-by":"crossref","first-page":"966","DOI":"10.1248\/bpb.22.966","article-title":"Structural features and hypoglycemic activity of a polysaccharide (CS-F10) from the cultured mycelium of Cordyceps sinensis","volume":"22","author":"Kiho","year":"1999","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.lfs.2003.11.003_BIB14","doi-asserted-by":"crossref","first-page":"2110","DOI":"10.1248\/cpb.40.2110","article-title":"Polysaccharides in fungi. XXX. Antitumor and immunomodulating activities of two polysaccharides from the fruiting bodies of Armillariella tabescens","volume":"40","author":"Kiho","year":"1992","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"10.1016\/j.lfs.2003.11.003_BIB15","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1248\/bpb.19.294","article-title":"Polysaccharide in fungi. XXXVI. Hypoglycemic activity of a polysaccharide (CS-F30) from the cultural mycelium of Cordyceps sinensis and its effects on glucose metabolism in mouse liver","volume":"19","author":"Kiho","year":"1996","journal-title":"Biological and Pharmaceutical Bulletin"},{"key":"10.1016\/j.lfs.2003.11.003_BIB16","doi-asserted-by":"crossref","first-page":"611","DOI":"10.3109\/07357909409023046","article-title":"Growth inhibitors against tumor cells in Cordyceps sinensis other than cordycepin and polysaccharides","volume":"12","author":"Kuo","year":"1994","journal-title":"Cancer Investigation"},{"key":"10.1016\/j.lfs.2003.11.003_BIB17","first-page":"313","article-title":"Combined traditional Chinese and western medicine. Effect of Cordyceps sinensis on erythropoiesis in mouse bone marrow","volume":"106","author":"Li","year":"1993","journal-title":"Chinese Medical Journal"},{"key":"10.1016\/j.lfs.2003.11.003_BIB18","doi-asserted-by":"crossref","first-page":"224","DOI":"10.2337\/diabetes.47.2.224","article-title":"Experimental NIDDM: Development of a new model in adult rats administered streptozotocin and nicotinamide","volume":"47","author":"Masiello","year":"1998","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2003.11.003_BIB19","first-page":"865","article-title":"Diabetes mellitus and cardiovascular complications: pathophysiological peculiarities and therapeutic implications","volume":"44","author":"Modena","year":"1999","journal-title":"Cardiologia"},{"key":"10.1016\/j.lfs.2003.11.003_BIB20","doi-asserted-by":"crossref","first-page":"2027","DOI":"10.1021\/bi00222a004","article-title":"Cordycepin analogues of 2\u2032, 5\u2032-olito-adenylate inhibit human immunodeficiency virus infection via inhibition of reverse transcriptase","volume":"30","author":"Muller","year":"1991","journal-title":"Biochemistry"},{"key":"10.1016\/j.lfs.2003.11.003_BIB21","doi-asserted-by":"crossref","first-page":"1337","DOI":"10.1248\/cpb.37.1337","article-title":"The correlation between molecular weight and antitumor activity of galactosaminoglycan (CO-N) from Cordyceps ophioglossoides","volume":"37","author":"Ohmori","year":"1989","journal-title":"Chemical and Pharmaceutical Bulletin"},{"key":"10.1016\/j.lfs.2003.11.003_BIB22","first-page":"382","article-title":"Natural products in Cordyceps","volume":"13","author":"Shiao","year":"1989","journal-title":"Proceedings of the National Science Council, Republic of China"},{"key":"10.1016\/j.lfs.2003.11.003_BIB23","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1016\/S0002-8223(21)03766-4","article-title":"Adherence to high-carbohydrate, high-fiber diets: long-term studies of non-obese diabetic men","volume":"85","author":"Story","year":"1985","journal-title":"Journal of the American Dietetic Association"},{"key":"10.1016\/j.lfs.2003.11.003_BIB24","series-title":"Science and Cultivation of Edible Fungi","first-page":"425","article-title":"Pharmacological effects of the mycelial extract of cultured Cordyceps sinensis on airways and aortal of the rat","author":"Tsunoo","year":"1995"},{"key":"10.1016\/j.lfs.2003.11.003_BIB25","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1046\/j.1464-5491.2002.00835.x","article-title":"Impaired glucose tolerance and impaired fasting glycaemia: the current status on definition and intervention","volume":"19","author":"Unwin","year":"2002","journal-title":"Diabetic Medicine"},{"key":"10.1016\/j.lfs.2003.11.003_BIB26","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1002\/(SICI)1097-4644(19980615)69:4<483::AID-JCB9>3.0.CO;2-J","article-title":"Effects of a water-soluble extract of Cordyceps sinensis on steroidogenesis and capsular morphology of lipid droplets in cultured rat adrenocortical cells","volume":"69","author":"Wang","year":"1998","journal-title":"Journal of Cellular Biochemistry"},{"key":"10.1016\/j.lfs.2003.11.003_BIB27","first-page":"E690","article-title":"Anabolic effects of IGF-I coinfused with total parenteral nutrition in dexamethasone-treated rats","volume":"266","author":"Yang","year":"1994","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.lfs.2003.11.003_BIB28","first-page":"157","article-title":"Antitumor activity of an extract of Ccordyceps sinensis (Berk.) Sacc. against murine tumor cell lines","volume":"59","author":"Yoshida","year":"1989","journal-title":"Japanese Journal of Experimental Medicine"},{"key":"10.1016\/j.lfs.2003.11.003_BIB29","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1126\/science.285.5435.1853","article-title":"Regulation of \u201cnutraceuticals\u201d","volume":"285","author":"Zeisel","year":"1999","journal-title":"Science"},{"key":"10.1016\/j.lfs.2003.11.003_BIB30","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1089\/10755530260127998","article-title":"CordyMax\u2122 Cs-4 improves glucose metabolism and increased insulin sensitivity in normal rats","volume":"8","author":"Zhao","year":"2002","journal-title":"Journal of Alternative and Complementary Medicine"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320504001134?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320504001134?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T04:46:02Z","timestamp":1682657162000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320504001134"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,4]]},"references-count":30,"journal-issue":{"issue":"23","published-print":{"date-parts":[[2004,4]]}},"alternative-id":["S0024320504001134"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2003.11.003","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2004,4]]}}}