{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,29]],"date-time":"2025-10-29T12:52:55Z","timestamp":1761742375396},"reference-count":55,"publisher":"Elsevier BV","issue":"6","license":[{"start":{"date-parts":[[2004,6,1]],"date-time":"2004-06-01T00:00:00Z","timestamp":1086048000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2004,6]]},"DOI":"10.1016\/j.lfs.2004.01.017","type":"journal-article","created":{"date-parts":[[2004,5,11]],"date-time":"2004-05-11T11:49:26Z","timestamp":1084276166000},"page":"717-732","source":"Crossref","is-referenced-by-count":21,"title":["Sequential changes in redox status and nitric oxide synthases expression in the liver after bile duct ligation"],"prefix":"10.1016","volume":"75","author":[{"given":"M.Jos\u00e9","family":"V\u00e1zquez-Gil","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.Jos\u00e9","family":"Mesonero","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Flores","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Criado","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Froil\u00e1n","family":"Hidalgo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel A","family":"Ar\u00e9valo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angel","family":"S\u00e1nchez-Rodr\u0131\u0301guez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.Jes\u00fas","family":"Tu\u00f1\u00f3n","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jos\u00e9 M","family":"L\u00f3pez-Novoa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A","family":"Esteller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2004.01.017_BIB1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1006\/phrs.1997.0225","article-title":"Evidence for oxidative stress in the hepatic mitochondria of bile duct ligated rats","volume":"36","author":"Alptekin","year":"1997","journal-title":"Pharmacol Res"},{"key":"10.1016\/j.lfs.2004.01.017_BIB2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1111\/j.1600-0676.1988.tb00978.x","article-title":"Quantitative aspects of the parenchymal-stroma relationship in experimentally induced cholestasis","volume":"8","author":"Aronson","year":"1988","journal-title":"Liver"},{"key":"10.1016\/j.lfs.2004.01.017_BIB3","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1067\/msy.2001.110427","article-title":"Expression of inducible nitric oxide synthase in the liver of bile duct-ligated Wistar rats with modulation by lymphomononuclear cells","volume":"129","author":"Arriero","year":"2001","journal-title":"Surgery"},{"key":"10.1016\/j.lfs.2004.01.017_BIB4","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0168-8278(88)80472-0","article-title":"Reactive oxygen intermediates and liver injury","volume":"6","author":"Arthur","year":"1988","journal-title":"J Hepatol"},{"key":"10.1016\/j.lfs.2004.01.017_BIB5","first-page":"391","article-title":"Regulation of rat liver S-adenoylmethionine synthetase during septic shock: role of nitric oxide","volume":"25","author":"\u00c1vila","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB6","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1146\/annurev.iy.12.040194.001041","article-title":"Function and activation of NF-kappa B in the immune system","volume":"12","author":"Baeuerle","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"10.1016\/j.lfs.2004.01.017_BIB7","first-page":"243","article-title":"Nitric oxide and inducible nitric oxide synthase expression are downregulated in acute cholestasis in the rat accompanied by liver ischemia","volume":"127","author":"Baron","year":"2000","journal-title":"Comp Bioch Phys Tox Pharm"},{"key":"10.1016\/j.lfs.2004.01.017_BIB8","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0304-4165(99)00118-X","article-title":"Role of glutathione, lipid peroxidation and antioxidants on acute bile-duct obstruction in the rat","volume":"18","author":"Baron","year":"1999","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.lfs.2004.01.017_BIB9","series-title":"Cells of the Hepatic Sinusoid","first-page":"32","article-title":"Expression of iNOS during development of liver fibrosis in rats","author":"Beljaars","year":"1997"},{"key":"10.1016\/j.lfs.2004.01.017_BIB11","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0168-8278(90)90274-U","article-title":"Systemic hypotension and pressor responsiveness in cholestasis. A study in conscious 3-day bile duct ligated rats","volume":"11","author":"Bomzon","year":"1990","journal-title":"J Hepatol"},{"key":"10.1016\/j.lfs.2004.01.017_BIB12","first-page":"598","article-title":"Enhanced nitric oxide synthase activity in portal hypertensive rabbits","volume":"22","author":"Cahill","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB13","doi-asserted-by":"crossref","first-page":"2002","DOI":"10.1097\/00003246-200006000-00054","article-title":"Depletion of liver glutathione potentiates the oxidative stress and decreases nitric oxide synthesis in a rat endotoxin shock model","volume":"28","author":"Carbonell","year":"2000","journal-title":"Crit Care Med"},{"key":"10.1016\/j.lfs.2004.01.017_BIB14","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1016\/S0076-6879(55)02300-8","article-title":"Assays of catalases and peroxidases","volume":"2","author":"Chance","year":"1955","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.lfs.2004.01.017_BIB15","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1007\/BF03258359","article-title":"Impairment of methionine metabolism in liver disease","volume":"4","author":"Corrales","year":"1992","journal-title":"Drug Invest"},{"key":"10.1016\/j.lfs.2004.01.017_BIB16","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/S0168-8278(99)80291-8","article-title":"In vivo regulation by gluthatione of methionine adenosyltransferse S-nitrosylation in rat liver","volume":"31","author":"Corrales","year":"1999","journal-title":"J Hepatol"},{"key":"10.1016\/j.lfs.2004.01.017_BIB17","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1002\/hep.510260203","article-title":"Elevated glomerular and blood mononuclear lymphocyte nitric oxide production in rats with chronic bile duct ligation: role of inducible nitric oxide synthase activation","volume":"26","author":"Criado","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB18","doi-asserted-by":"crossref","first-page":"699","DOI":"10.1006\/abbi.1995.1093","article-title":"Regulation of hepatic nitric oxide synthase by reactive oxygen intermediates and glutathione","volume":"316","author":"Duval","year":"1995","journal-title":"Arch Biochem Biophys"},{"key":"10.1016\/j.lfs.2004.01.017_BIB19","first-page":"317","article-title":"Hemolytic anemia and susceptibility to hydrogen-peroxide hemolysis in children with vitamin E-deficiency and chronic liver disease","volume":"19","author":"Fern\u00e1ndez-Zamorano","year":"1988","journal-title":"J Med"},{"key":"10.1016\/j.lfs.2004.01.017_BIB20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1080\/003655298750026543","article-title":"Oxidative stress in the liver and biliary tract diseases","volume":"228","author":"Feher","year":"1998","journal-title":"Scand J Gastroenterol"},{"key":"10.1016\/j.lfs.2004.01.017_BIB21","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/S0076-6879(84)05015-1","article-title":"Assays of glutathione peroxidase","volume":"105","author":"Flohe","year":"1984","journal-title":"Methods Enzymol"},{"key":"10.1016\/j.lfs.2004.01.017_BIB23","doi-asserted-by":"crossref","first-page":"478","DOI":"10.1016\/0016-5085(90)90841-N","article-title":"Suppression of cellular immunity in obstructive jaundice is caused by endotoxins: a study with germ-free rats","volume":"98","author":"Greve","year":"1990","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB24","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/hep.1840070308","article-title":"The evolution of changes in quantitative liver function tests in rat model of biliary cirrhosis: correlation with morphometric measurement of hepatocyte mass","volume":"7","author":"Gross","year":"1987","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB25","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/0003-2697(76)90326-2","article-title":"A fluorometric method for determination of oxidized and reduced glutathione in tissues","volume":"74","author":"Hissin","year":"1976","journal-title":"Anal Biochem"},{"key":"10.1016\/j.lfs.2004.01.017_BIB26","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/0003-2697(81)90261-X","article-title":"A simple method to determine nanogram levels of 4-hydroxyproline in biological tissues","volume":"112","author":"Jamall","year":"1981","journal-title":"Anal Biochem"},{"key":"10.1016\/j.lfs.2004.01.017_BIB27","first-page":"607","article-title":"Reduced antioxidante capacity in liver mitochondria from bile duct ligated rats","volume":"22","author":"Kr\u00e4henb\u00fchl","year":"1995","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB28","doi-asserted-by":"crossref","first-page":"902","DOI":"10.1002\/hep.510240424","article-title":"Progressive decrease in tissue glycogen content in rats with long-term cholestasis","volume":"24","author":"Kr\u00e4henb\u00fchl","year":"1996","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB30","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1007\/BF01986184","article-title":"Intrasplenic infusion. A simple method for intraportal infusion in rats","volume":"37","author":"L\u00f3pez-Novoa","year":"1981","journal-title":"Experientia"},{"key":"10.1016\/j.lfs.2004.01.017_BIB31","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1002\/hep.1840080113","article-title":"S-adenosyl-L-methionine synthetase and phospholipid methyltransferase are inhibited in human cirrhosis","volume":"8","author":"Mart\u0131\u0301n-Duce","year":"1998","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB32","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1042\/CS19980250","article-title":"Effects of chronic nitric oxide activation or inhibition on early hepatic fibrosis in rats with bile duct ligation","volume":"96","author":"Mayoral","year":"1999","journal-title":"Clin Sci"},{"key":"10.1016\/j.lfs.2004.01.017_BIB33","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/aja.1001190307","article-title":"A dynamic and static study of hepatic arterioles and hepatic sphincters","volume":"119","author":"McCuskey","year":"1965","journal-title":"Am. J. Anat."},{"key":"10.1016\/j.lfs.2004.01.017_BIB34","doi-asserted-by":"crossref","first-page":"3170","DOI":"10.1016\/S0021-9258(19)45228-9","article-title":"The role of superoxide anion in the autooxidation of epinephrine and a simple assay for superoxide dismutase","volume":"247","author":"Misra","year":"1972","journal-title":"J Biol Chem"},{"key":"10.1016\/j.lfs.2004.01.017_BIB35","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1016\/0168-8278(92)90071-V","article-title":"Interleukin-6 production by peripheral blood monocites in patients with chronic liver disease and acute viral hepatitis","volume":"15","author":"M\u00fcller","year":"1992","journal-title":"J Hepatol"},{"key":"10.1016\/j.lfs.2004.01.017_BIB36","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1016\/S0742-8413(98)10018-X","article-title":"Liver damage induced by acute cholestasis in the rat is ameliorated partially by L-arginine","volume":"120","author":"Muriel","year":"1998","journal-title":"Comp Biochem Physiol C Pharmacol Toxicol Endocrinol"},{"key":"10.1016\/j.lfs.2004.01.017_BIB37","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/S0168-8278(94)80143-6","article-title":"Protective effect of S-adenosyl-L-methionine on liver damage induced by biliary obstruction in rats: a histological, ultrastructural and biochemical approach","volume":"21","author":"Muriel","year":"1994","journal-title":"J Hepatol"},{"key":"10.1016\/j.lfs.2004.01.017_BIB38","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1152\/ajplegacy.1960.199.6.1181","article-title":"Direct measurement of blood pressures in minute vessels of the liver","volume":"199","author":"Nakata","year":"1960","journal-title":"Am. J. Physiol."},{"key":"10.1016\/j.lfs.2004.01.017_BIB39","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1006\/jsre.1996.0290","article-title":"Cholestatic liver injury down-regulates hepatic glutathione synthesis","volume":"63","author":"Neuschwander-Tetri","year":"1996","journal-title":"J Surg Res"},{"key":"10.1016\/j.lfs.2004.01.017_BIB41","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/0003-2697(79)90738-3","article-title":"Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction","volume":"95","author":"Ohkawa","year":"1979","journal-title":"Anal Biochem"},{"key":"10.1016\/j.lfs.2004.01.017_BIB42","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1002\/hep.1840030118","article-title":"Is cirrhosis of the liver experimentally produced by CCl4 an adequate model of human cirrhosis?","volume":"3","author":"P\u00e9rez-Tamayo","year":"1983","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB43","doi-asserted-by":"crossref","first-page":"1909","DOI":"10.1016\/0016-5085(92)91451-9","article-title":"Modulation of the hyperdynamic circulation of cirrhotic rats by nitric oxide inhibition","volume":"103","author":"Pizcueta","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB44","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1007\/s004330050100","article-title":"Glutathione status in liver and plasma during development of biliary cirrhosis after bile duct ligation","volume":"198","author":"Purucker","year":"1998","journal-title":"Res Exp Med"},{"key":"10.1016\/j.lfs.2004.01.017_BIB45","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/BF01928168","article-title":"Abnormal lipid composition of microsomes from cirrhotic rat liver-does it contribute to decreased microsomal function?","volume":"15","author":"Reichen","year":"1992","journal-title":"Experientia"},{"key":"10.1016\/j.lfs.2004.01.017_BIB47","first-page":"G124","article-title":"Regulation of inducible nitric oxide synthase and nitric oxide during hepatic injury and fibrogenesis","volume":"273","author":"Rockey","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.lfs.2004.01.017_BIB48","doi-asserted-by":"crossref","first-page":"2923","DOI":"10.1172\/JCI119842","article-title":"Liver sinusoidal endothelial cells are responsible for nitric oxide modulation of resistance in the hepatic sinusoids","volume":"100","author":"Shah","year":"1997","journal-title":"J Clin Invest"},{"key":"10.1016\/j.lfs.2004.01.017_BIB49","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1006\/jsre.1998.5467","article-title":"Obstructive jaundice alters Kupffer cell function independent of bacterial translocation","volume":"80","author":"Sheen-Chen","year":"1998","journal-title":"J Surg Res"},{"key":"10.1016\/j.lfs.2004.01.017_BIB50","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1002\/hep.1840050421","article-title":"Localization of increased hepatic vascular resistance in liver cirrhosis","volume":"5","author":"Shibayama","year":"1985","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB51","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1016\/0304-4157(78)90010-2","article-title":"Fluidity parameters of lipid regions determined by fluorescence polarization","volume":"15","author":"Shinitzky","year":"1978","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.lfs.2004.01.017_BIB53","doi-asserted-by":"crossref","first-page":"1625","DOI":"10.1016\/0016-5085(92)91187-9","article-title":"Antioxidant defenses in the bile duct-ligated rat","volume":"103","author":"Singh","year":"1992","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB54","series-title":"Diseases of the liver","first-page":"1373","article-title":"The liver and its effect on endocrine function in health and disease","author":"Smanik","year":"1993"},{"key":"10.1016\/j.lfs.2004.01.017_BIB55","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1096\/fasebj.5.1.1703974","article-title":"Inhibition of macrophage and endothelial cell nitric oxide synthase by diphenyleneiodonium and its analogs","volume":"5","author":"Stuehr","year":"1991","journal-title":"FASEB J"},{"key":"10.1016\/j.lfs.2004.01.017_BIB56","doi-asserted-by":"crossref","first-page":"1500","DOI":"10.1016\/S0016-5085(03)00280-4","article-title":"The role of nitric oxide synthase isoforms in extrahepatic portal hypertension: studies in gene-knockout mice","volume":"124","author":"Theodorakis","year":"2003","journal-title":"Gastroenterology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB57","doi-asserted-by":"crossref","first-page":"1184","DOI":"10.1002\/hep.510250522","article-title":"Endotoxin impairs biliary glutathione and HCO3- excretion and blocks the choleretic effect of nitric oxide in rat liver","volume":"25","author":"Trauner","year":"1997","journal-title":"Hepatology"},{"key":"10.1016\/j.lfs.2004.01.017_BIB58","first-page":"265","article-title":"Proliferation and phenotypic modulation of portal fibroblasts in the early stages of cholestatic fibrosis in the rat","volume":"74","author":"Tuchweber","year":"1996","journal-title":"Lab Invest"},{"key":"10.1016\/j.lfs.2004.01.017_BIB59","doi-asserted-by":"crossref","first-page":"776","DOI":"10.1016\/0140-6736(91)91384-7","article-title":"Hyperdinamic circulation in cirrhosis: a role for nitric oxide?","volume":"337","author":"Vallance","year":"1991","journal-title":"Lancet"},{"key":"10.1016\/j.lfs.2004.01.017_BIB60","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1006\/abio.1995.1079","article-title":"Sample pretreatment with nitrate reductase and glucose-6-phosphate dehydrogenase quantitatively reduces nitrate while avoiding interference by NADP+ when the Griess reaction is used to assay for nitrite","volume":"20","author":"Verdon","year":"1995","journal-title":"Anal Biochem"},{"key":"10.1016\/j.lfs.2004.01.017_BIB61","first-page":"G624","article-title":"Endothelin-1 induces direct constriction of hepatic sinusoids","volume":"266","author":"Zhang","year":"1994","journal-title":"Am. J. Physiol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320504002930?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320504002930?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T13:07:57Z","timestamp":1623935277000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320504002930"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,6]]},"references-count":55,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["S0024320504002930"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2004.01.017","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2004,6]]}}}