{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T04:23:31Z","timestamp":1791087811454,"version":"4.1.0"},"reference-count":26,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2004,7,1]],"date-time":"2004-07-01T00:00:00Z","timestamp":1088640000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2004,7]]},"DOI":"10.1016\/j.lfs.2004.01.028","type":"journal-article","created":{"date-parts":[[2004,5,29]],"date-time":"2004-05-29T14:09:10Z","timestamp":1085839750000},"page":"1123-1134","source":"Crossref","is-referenced-by-count":42,"title":["High concentrations of \u03b1-defensins in plasma and bronchoalveolar lavage fluid of patients with acute respiratory distress syndrome"],"prefix":"10.1016","volume":"75","author":[{"given":"Jun-ichi","family":"Ashitani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Mukae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuji","family":"Arimura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arisa","family":"Sano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masatoshi","family":"Tokojima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamitsu","family":"Nakazato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2004.01.028_BIB1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1189\/jlb.72.1.167","article-title":"Human neutrophil defensins induce lung epithelial cell proliferation in vitro","volume":"72","author":"Aarbiou","year":"2002","journal-title":"J Leukoc Biol"},{"key":"10.1016\/j.lfs.2004.01.028_BIB2","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1034\/j.1399-3003.2000.15e14.x","article-title":"G-CSF and IL-8 but not GM-CSF correlate with severity of pulmonary neutrophilia in acute respiratory distress syndrome","volume":"15","author":"Aggarwal","year":"2000","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lfs.2004.01.028_BIB3","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1378\/chest.121.2.519","article-title":"Elevated levels of alpha-defensins in plasma and BAL fluid of patients with active pulmonary tuberculosis","volume":"121","author":"Ashitani","year":"2002","journal-title":"Chest"},{"key":"10.1016\/j.lfs.2004.01.028_BIB4","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1136\/thx.54.11.1015","article-title":"Granulocyte-colony stimulating factor levels in bronchoalveolar lavage fluid from patients with idiopathic pulmonary fibrosis","volume":"54","author":"Ashitani","year":"1999","journal-title":"Thorax"},{"key":"10.1016\/j.lfs.2004.01.028_BIB5","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1183\/09031936.98.11010104","article-title":"Elevated concentrations of defensins in bronchoalveolar lavage fluid in diffuse panbronchiolitis","volume":"11","author":"Ashitani","year":"1998","journal-title":"Eur Respir J"},{"key":"10.1016\/j.lfs.2004.01.028_BIB6","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1378\/chest.113.3.788","article-title":"Elevated pleural fluid levels of defensins in patients with empyema","volume":"113","author":"Ashitani","year":"1998","journal-title":"Chest"},{"key":"10.1016\/j.lfs.2004.01.028_BIB7","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S0167-0115(00)00158-0","article-title":"Recombinant granulocyte colony-stimulating factor induces production of human neutrophil peptides in lung cancer patients with neutropenia","volume":"95","author":"Ashitani","year":"2000","journal-title":"Regl Pept"},{"key":"10.1016\/j.lfs.2004.01.028_BIB8","doi-asserted-by":"crossref","first-page":"43S","DOI":"10.1378\/chest.116.suppl_1.43S","article-title":"Polymorphonuclear leukocytes released from the bone marrow and acute lung injury","volume":"116","author":"Eeden","year":"1999","journal-title":"Chest"},{"key":"10.1016\/j.lfs.2004.01.028_BIB9","doi-asserted-by":"crossref","first-page":"1225","DOI":"10.1164\/ajrccm\/136.5.1225","article-title":"The adult respiratory distress syndrome. Cell populations and soluble mediators in the air spaces of patients at high risk","volume":"136","author":"Fowler","year":"1987","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.lfs.2004.01.028_BIB10","doi-asserted-by":"crossref","first-page":"1134","DOI":"10.1086\/516075","article-title":"Elevated concentrations of human neutrophil peptides in plasma, blood, and body fluids from patients with infections","volume":"25","author":"Ihi","year":"1997","journal-title":"Clin Infect Dis"},{"key":"10.1016\/j.lfs.2004.01.028_BIB11","doi-asserted-by":"crossref","first-page":"7793","DOI":"10.1128\/IAI.69.12.7793-7799.2001","article-title":"Dynamic changes in neutrophil defensins during endotoxemia","volume":"69","author":"Klut","year":"2001","journal-title":"Infect Immun"},{"key":"10.1016\/j.lfs.2004.01.028_BIB12","doi-asserted-by":"crossref","first-page":"391","DOI":"10.3109\/00365549609037926","article-title":"Dynamics of blood cytokine concentrations in patients with bacteremic infections","volume":"28","author":"Kragsbjerg","year":"1996","journal-title":"Scand J Infect Dis"},{"key":"10.1016\/j.lfs.2004.01.028_BIB13","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1164\/ajrccm.163.2.2005109","article-title":"Anti-interleukin 8 autoantibody: interleukin 8 complexes in the acute respiratory distress syndrome. Relationship between the complexes and clinical disease activity","volume":"163","author":"Kurdowska","year":"2001","journal-title":"Am J Respir Crit Med"},{"key":"10.1016\/j.lfs.2004.01.028_BIB14","doi-asserted-by":"crossref","first-page":"2957","DOI":"10.1001\/jama.270.24.2957","article-title":"A new Simplified Acute Physiology Score (SAPS II) based on a European\/North American multicenter study","volume":"270","author":"Le Gall","year":"1993","journal-title":"JAMA"},{"key":"10.1016\/j.lfs.2004.01.028_BIB15","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1164\/ajrccm.152.2.7633715","article-title":"Increase in activated CD8+ cells in bronchoalveolar lavage fluid in patients with diffuse panbronchiolitis","volume":"152","author":"Mukae","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"10.1016\/j.lfs.2004.01.028_BIB16","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1038\/sj.thj.6200023","article-title":"Polymorphonuclear leukocytes released from the bone marrow by granulocyte colony-stimulating factor: intravascular behavior","volume":"1","author":"Mukae","year":"2000","journal-title":"Hematol J"},{"key":"10.1016\/j.lfs.2004.01.028_BIB17","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1164\/ajrccm\/138.3.720","article-title":"An expanded definition of the adult respiratory distress syndrome","volume":"138","author":"Murray","year":"1988","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.lfs.2004.01.028_BIB18","doi-asserted-by":"crossref","first-page":"1053","DOI":"10.1006\/bbrc.1995.1918","article-title":"Isolation and sequence determination of 6- and 8-kDa precursors of human neutrophil peptides from bone marrow, plasma and peripheral blood neutrophils","volume":"211","author":"Nakazato","year":"1995","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.lfs.2004.01.028_BIB19","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1164\/ajrccm\/141.1.179","article-title":"Direct cytotoxity of polymorphonuclear leukocyte granule proteins to human lung-derived cells and endothelial cells","volume":"141","author":"Okrent","year":"1990","journal-title":"Am Rev Respir Dis"},{"key":"10.1016\/j.lfs.2004.01.028_BIB20","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1006\/bbrc.1993.2190","article-title":"Establishment of radioimmunoassay for human neutrophil peptides and their increases in plasma and neutrophil in infection","volume":"195","author":"Shiomi","year":"1993","journal-title":"Biochem Biophys Res Commun"},{"key":"10.1016\/j.lfs.2004.01.028_BIB21","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1007\/s000110050114","article-title":"Purification and characterization of defensins from cystic fibrosis sputum","volume":"46","author":"Soong","year":"1997","journal-title":"Inflamm Res"},{"key":"10.1016\/j.lfs.2004.01.028_BIB22","first-page":"L888","article-title":"Effect of defensins on interleukin-8 synthesis in airway epithelial cells","volume":"272","author":"Van Wetering","year":"1997","journal-title":"Am J Physiol"},{"key":"10.1016\/j.lfs.2004.01.028_BIB23","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1067\/mhl.2001.118298","article-title":"Reactive oxygen species in acute respiratory distress syndrome","volume":"30","author":"Wilson","year":"2001","journal-title":"Heart Lung"},{"key":"10.1016\/j.lfs.2004.01.028_BIB24","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/0167-4889(91)90207-E","article-title":"Tumor necrosis factor (TNF) inhibits interleukin (IL)-1 and\/or IL-6 stimulated synthesis of C-reactive protein (CRP) and serum amyloid A (SAA) in primary cultures of human hepatocytes","volume":"1091","author":"Yap","year":"1991","journal-title":"Biochim Biophys Acta"},{"key":"10.1016\/j.lfs.2004.01.028_BIB25","doi-asserted-by":"crossref","first-page":"6601","DOI":"10.4049\/jimmunol.167.11.6601","article-title":"Involvement of phosphoinositide 3-kinases in neutrophil activation and the development of acute lung injury","volume":"167","author":"Yum","year":"2001","journal-title":"J Immunol"},{"key":"10.1016\/j.lfs.2004.01.028_BIB26","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1152\/ajplung.2001.280.5.L947","article-title":"Neutrophil defensins mediate acute inflammatory response and lung dysfunction in dose-related fashion","volume":"280","author":"Zhang","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320504003649?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320504003649?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2023,4,28]],"date-time":"2023-04-28T19:26:00Z","timestamp":1682709960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320504003649"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,7]]},"references-count":26,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2004,7]]}},"alternative-id":["S0024320504003649"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2004.01.028","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2004,7]]}}}