{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T11:06:09Z","timestamp":1785323169022,"version":"3.55.0"},"reference-count":37,"publisher":"Elsevier BV","issue":"9","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1016\/j.lfs.2004.07.023","type":"journal-article","created":{"date-parts":[[2004,12,13]],"date-time":"2004-12-13T22:57:31Z","timestamp":1102978651000},"page":"997-1011","source":"Crossref","is-referenced-by-count":3,"title":["Guinea-pig lung adenylyl and guanylyl cyclase and PDE activities associated with airway hyper- and hypo-reactivity following LPS inhalation"],"prefix":"10.1016","volume":"76","author":[{"given":"Toby J.","family":"Toward","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anthony T.","family":"Nials","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frederich J.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.lfs.2004.07.023_bib1","first-page":"22","article-title":"Nomenclature Supplement","author":"Alexander","year":"2001","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.lfs.2004.07.023_bib2","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1152\/jappl.1987.63.6.2309","article-title":"Cyclic nucleotide function in trachealis muscle of dogs with and without airway hyperresponsiveness","volume":"63","author":"Austin","year":"1987","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.lfs.2004.07.023_bib3","doi-asserted-by":"crossref","first-page":"s123","DOI":"10.1164\/ajrccm.158.supplement_2.13tac800","article-title":"Pharmacology of airway smooth muscle","volume":"158","author":"Barnes","year":"1998","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.lfs.2004.07.023_bib4","first-page":"515","article-title":"Inflammatory mediators of asthma: an update","volume":"50","author":"Barnes","year":"1999","journal-title":"Pharmacological Reviews"},{"key":"10.1016\/j.lfs.2004.07.023_bib6","first-page":"131","article-title":"Mechanisms of bronchial hyperreactivity in normal subjects after upper respiratory tract infection","volume":"113","author":"Empey","year":"1976","journal-title":"American Review of Respiratory Disease"},{"key":"10.1016\/j.lfs.2004.07.023_bib7","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1152\/jappl.1994.76.4.1432","article-title":"Quantification of nasal involvement in a guinea-pig plethysmography","volume":"76","author":"Finney","year":"1994","journal-title":"Journal of Applied Physiology"},{"key":"10.1016\/j.lfs.2004.07.023_bib8","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1006\/bbrc.1998.8684","article-title":"Isolation and characterization of PDE8A, a novel human cAMP-specific phosphodiesterase","volume":"246","author":"Fisher","year":"1998","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.lfs.2004.07.023_bib9","doi-asserted-by":"crossref","first-page":"15559","DOI":"10.1074\/jbc.273.25.15559","article-title":"Isolation and characterization of PDE9A, a novel human cGMP-specific phosphodiesterase","volume":"273","author":"Fisher","year":"1998","journal-title":"Journal of Biological Chemistry"},{"key":"10.1016\/j.lfs.2004.07.023_bib10","doi-asserted-by":"crossref","first-page":"1441","DOI":"10.1164\/ajrccm\/137.6.1441","article-title":"Endotoxin-induced inflammation and injury of the guinea-pig respiratory airways cause hyporeactivity","volume":"137","author":"Folkerts","year":"1988","journal-title":"American Review of Respiratory Disease"},{"key":"10.1016\/j.lfs.2004.07.023_bib11","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1111\/j.1476-5381.1981.tb08748.x","article-title":"Effects of cyclic AMP and GMP-phosphodiesterases on immunological release of histamine and on lung contraction","volume":"73","author":"Frossard","year":"1981","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2004.07.023_bib12","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1165\/ajrcmb.20.2.3140","article-title":"Identification and function of cyclic nucleotide phophodiesterase isoenzymes in airway epithelial cells","volume":"20","author":"Fuhrmann","year":"1999","journal-title":"American Review of Respiratory Cellular Molecular Biology"},{"key":"10.1016\/j.lfs.2004.07.023_bib13","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.1016\/0006-2952(79)90313-7","article-title":"Inhibition of human lung cyclic GMP and cyclic AMP phosphodiesterases by certain nucleosides, nucleotides, and pharmacological phosphodieserase inhibitors","volume":"28","author":"Glass","year":"1979","journal-title":"Biochemical Pharmacology"},{"key":"10.1016\/j.lfs.2004.07.023_bib14","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1365-2125.1986.tb02956.x","article-title":"In vitro responsiveness of human asthmatic bronchus to carbachol, histamine, beta-adrenoceptor agonists and theophylline","volume":"22","author":"Goldie","year":"1986","journal-title":"British Journal of Clinical Pharmacology"},{"key":"10.1016\/j.lfs.2004.07.023_bib15","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1016\/0160-5402(88)90025-3","article-title":"Measurement of specific airways conductance in guinea-pigs: a non-invasive method","volume":"19","author":"Griffiths-Johnson","year":"1988","journal-title":"Journal of Pharmacological Methods"},{"key":"10.1016\/j.lfs.2004.07.023_bib16","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/j.2042-7158.1998.tb02273.x","article-title":"Differences in species response to hyperreactivity induced by lipopolysaccharide (LPS) from Escherichia coli","volume":"50","author":"Grover","year":"1998","journal-title":"Journal of Pharmacy and Pharmacology"},{"key":"10.1016\/j.lfs.2004.07.023_bib17","first-page":"L645","article-title":"Mechanism of impaired \u03b2-adrenoceptor responsiveness in atopic sensitised airway smooth muscle","volume":"269","author":"Hakonarson","year":"1995","journal-title":"American Journal of Physiology"},{"key":"10.1016\/j.lfs.2004.07.023_bib18","doi-asserted-by":"crossref","first-page":"1732","DOI":"10.1172\/JCI4141","article-title":"Mechanism of rhinovirus-induced changes in airway smooth muscle responsiveness","volume":"102","author":"Hakonarson","year":"1998","journal-title":"Journal of Clinical Investigation"},{"key":"10.1016\/j.lfs.2004.07.023_bib19","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1006\/bbrc.1998.9379","article-title":"Molecular cloning and characterization of human PDE8B, a novel thyroid-specific isozyme of 3\u2032,5\u2032-cyclic nucleotide phosphodiesterase","volume":"250","author":"Hayashi","year":"1998","journal-title":"Biochemical and Biophysical Research Communications"},{"key":"10.1016\/j.lfs.2004.07.023_bib20","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0014-2999(92)90327-Z","article-title":"Pertussis toxin induces bronchopulmonary hyperresponsiveness in guinea-pigs while antagonizing the effects of formyl-L-methionyl-L-leucyl-L-phenylalanine","volume":"212","author":"Imaizumi","year":"1992","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2004.07.023_bib21","doi-asserted-by":"crossref","first-page":"7628","DOI":"10.1073\/pnas.122041599","article-title":"Induction of the cyclic nucleotide phosphodiesterase PDE4B is essential for LPS-activated TNF-alpha responses","volume":"99","author":"Jin","year":"2002","journal-title":"Proceedings of the National Academy of Sciences USA"},{"key":"10.1016\/j.lfs.2004.07.023_bib22","first-page":"523","article-title":"Asthma: morphologic-physiologic interactions","volume":"150","author":"McFadden","year":"1994","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.lfs.2004.07.023_bib23","series-title":"Intuitive Biostatistics","author":"Motulsky","year":"1995"},{"key":"10.1016\/j.lfs.2004.07.023_bib24","doi-asserted-by":"crossref","first-page":"460","DOI":"10.1042\/bst0200460","article-title":"Inhibitors of cyclic nucleotidephosphodiesterases as therapeutic agents","volume":"20","author":"Murray","year":"1992","journal-title":"Biochemical Society Transactions"},{"key":"10.1016\/j.lfs.2004.07.023_bib26","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/S0163-7258(02)00262-0","article-title":"Nitric oxide in respiratory diseases","volume":"95","author":"Nevin","year":"2002","journal-title":"Pharmacology and Therapeutics"},{"key":"10.1016\/j.lfs.2004.07.023_bib25","first-page":"97","article-title":"Nitric oxide and bronchial hyperresponsiveness","volume":"329","author":"Nijkamp","year":"1995","journal-title":"Arch. Int. Pharmacodyn. Ther."},{"key":"10.1016\/j.lfs.2004.07.023_bib27","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1007\/BF00168758","article-title":"Effects of selective phosphodiesterase inhibitors on platelet-activating factor- and antigen-induce airways hyperreactivity, eosinophil accumulation, and microvascular leakage in guinea pigs","volume":"353","author":"Ortiz","year":"1996","journal-title":"Naunyn-Schmiedebergs Archives of Pharmacology"},{"key":"10.1016\/j.lfs.2004.07.023_bib28","doi-asserted-by":"crossref","first-page":"s187","DOI":"10.1164\/ajrccm.158.supplement_2.13tac170","article-title":"Characteristics of airway hyperresponsiveness in asthma and chronic obstructive pulmonary disease","volume":"158","author":"Postma","year":"1998","journal-title":"American Journal of Respiratory and Critical Care Medicine"},{"key":"10.1016\/j.lfs.2004.07.023_bib29","first-page":"9","article-title":"Isoenzyme-selective cyclic nucleotide phosphodiesterase inhibitors: biochemistry, pharmacology and therapeutic potential in asthma","volume":"40","author":"Raeburn","year":"1993","journal-title":"Progress in Drug Research"},{"key":"10.1016\/j.lfs.2004.07.023_bib30","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0014-2999(96)00081-7","article-title":"Induction of guinea pig airway hyperresponsiveness by inactivation of guanylate cyclase","volume":"29","author":"Sadeghi-Hashjin","year":"1996","journal-title":"European Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2004.07.023_bib31","doi-asserted-by":"crossref","first-page":"370","DOI":"10.1016\/0165-6147(94)90157-0","article-title":"\u03b2-adrenoceptors, cAMP and airway smooth muscle relaxation: challenges to the dogma","volume":"15","author":"Torphy","year":"1994","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.lfs.2004.07.023_bib33","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0165-6147(00)01478-4","article-title":"Phosphodiesterases: the journey towards therapeutics","volume":"21","author":"Torphy","year":"2000","journal-title":"Trends in Pharmacological Sciences"},{"key":"10.1016\/j.lfs.2004.07.023_bib34","first-page":"376","article-title":"Role of cyclic nucleotide phosphodiesterase isoenzymes in intact canine trachealis","volume":"39","author":"Torphy","year":"1991","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.lfs.2004.07.023_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1006\/pupt.1999.0181","article-title":"Ariflo\u2122 (SB 207499), a second generation phosphodiesterase 4 inhibitor for the treatment of asthma and COPD: from concept to clinic","volume":"12","author":"Torphy","year":"1999","journal-title":"Pulmonary Pharmacology and Therapeutics"},{"key":"10.1016\/j.lfs.2004.07.023_bib35","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1038\/sj.bjp.0703589","article-title":"Airway reactivity, inflammatory cell influx and nitric oxide in guinea-pig airways after lipopolysaccharide inhalation","volume":"131","author":"Toward","year":"2000","journal-title":"British Journal of Pharmacology"},{"key":"10.1016\/j.lfs.2004.07.023_bib36","first-page":"298","article-title":"Chronic lipopolysaccharide exposure on airway function, cell infiltration, and nitric oxide generation in conscious guinea pigs: effect of rolipram and dexamethasone","volume":"298","author":"Toward","year":"2001","journal-title":"Journal of Pharmacology and Experimental Therapeutics"},{"key":"10.1016\/j.lfs.2004.07.023_bib37","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1124\/mol.56.1.170","article-title":"Phosphodiesterase 4B2 is the predominant phosphodiesterase species and undergoes differential regulation of gene expression in human monocytes and neutrophils","volume":"56","author":"Wang","year":"1999","journal-title":"Molecular Pharmacology"},{"key":"10.1016\/j.lfs.2004.07.023_bib38","first-page":"77","article-title":"A comparison of the effects of LPS and detoxified LPS on reactivity changes induced in the guinea-pig airways","volume":"2","author":"Young","year":"1996","journal-title":"Pharmaceutical Sciences"}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320504009245?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320504009245?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2019,1,31]],"date-time":"2019-01-31T18:24:12Z","timestamp":1548959052000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320504009245"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":37,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0024320504009245"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2004.07.023","relation":{},"ISSN":["0024-3205"],"issn-type":[{"value":"0024-3205","type":"print"}],"subject":[],"published":{"date-parts":[[2005,1]]}}}