{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,21]],"date-time":"2025-09-21T00:08:52Z","timestamp":1758413332905,"version":"3.44.0"},"reference-count":22,"publisher":"Elsevier BV","issue":"11","license":[{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2005,1,1]],"date-time":"2005-01-01T00:00:00Z","timestamp":1104537600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Life Sciences"],"published-print":{"date-parts":[[2005,1]]},"DOI":"10.1016\/j.lfs.2004.08.021","type":"journal-article","created":{"date-parts":[[2004,12,13]],"date-time":"2004-12-13T17:57:31Z","timestamp":1102960651000},"page":"1239-1248","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"title":["Engineered \u03b2-cells secreting dipeptidyl peptidase IV-resistant glucagon-like peptide-1 show enhanced glucose-responsiveness"],"prefix":"10.1016","volume":"76","author":[{"given":"Md. Shahidul","family":"Islam","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheikh Mohammad Atiqur","family":"Rahman","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zahra","family":"Mirzaei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Khalid Bin","family":"Islam","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.lfs.2004.08.021_bib1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1210\/endo.130.1.1370150","article-title":"Establishment of 2-mercaptoethanol-dependent differentiated insulin-secreting cell lines","volume":"130","author":"Asfari","year":"1992","journal-title":"Endocrinology"},{"issue":"2","key":"10.1016\/j.lfs.2004.08.021_bib2","doi-asserted-by":"crossref","first-page":"252","DOI":"10.1016\/S0026-0495(99)90043-4","article-title":"Long-lasting antidiabetic effect of a dipeptidyl peptidase IV-resistant analog of glucagon-like peptide-1","volume":"48","author":"Burcelin","year":"1999","journal-title":"Metabolism"},{"key":"10.1016\/j.lfs.2004.08.021_bib3","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1749-6632.1999.tb08510.x","article-title":"Encapsulated, genetically engineered cells, secreting glucagon-like peptide-1 for the treatment of non-insulin-dependent diabetes mellitus","volume":"875","author":"Burcelin","year":"1999","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"7","key":"10.1016\/j.lfs.2004.08.021_bib4","doi-asserted-by":"crossref","first-page":"856","DOI":"10.1007\/s001250051238","article-title":"Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells","volume":"42","author":"Buteau","year":"1999","journal-title":"Diabetologia"},{"issue":"2","key":"10.1016\/j.lfs.2004.08.021_bib5","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00441-001-0494-7","article-title":"Over-expression of the glucagon-like peptide-1 receptor on INS-1 cells confers autocrine stimulation of insulin gene promoter activity: a strategy for production of pancreatic [beta]-cell lines for use in transplantation","volume":"307","author":"Chepurny","year":"2002","journal-title":"Cell and Tissue Research"},{"issue":"3","key":"10.1016\/j.lfs.2004.08.021_bib6","first-page":"476","article-title":"Beta-cell differentiation from a human pancreatic cell line in vitro and in vivo","volume":"15","author":"de la","year":"2001","journal-title":"Molecular Endocrinology"},{"issue":"20","key":"10.1016\/j.lfs.2004.08.021_bib7","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1056\/NEJM199205143262003","article-title":"Antidiabetogenic effect of glucagon-like peptide-1 (7\u201336)amide in normal subjects and patients with diabetes mellitus","volume":"326","author":"Gutniak","year":"1992","journal-title":"New England Journal of Medicine"},{"key":"10.1016\/j.lfs.2004.08.021_bib8","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1146\/annurev.physiol.59.1.257","article-title":"Enteroglucagon","volume":"59","author":"Holst","year":"1997","journal-title":"Annual Review of Physiology"},{"issue":"6410","key":"10.1016\/j.lfs.2004.08.021_bib9","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1038\/361362a0","article-title":"Pancreatic beta-cells are rendered glucose-competent by the insulinotropic hormone glucagon-like peptide-1(7\u201337)","volume":"361","author":"Holz","year":"1993","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.lfs.2004.08.021_bib10","doi-asserted-by":"crossref","first-page":"3529","DOI":"10.1210\/en.2001-210979","article-title":"Transfection of pancreatic-derived beta-cells with a minigene encoding for human glucagon-like peptide-1 regulates glucose-dependent insulin synthesis and secretion","volume":"143","author":"Hui","year":"2002","journal-title":"Endocrinology"},{"issue":"Pt 2","key":"10.1016\/j.lfs.2004.08.021_bib11","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1111\/j.1469-7793.2001.0375c.xd","article-title":"cAMP-regulated guanine nucleotide exchange factor II (Epac2) mediates Ca2+-induced Ca2+ release in INS-1 pancreatic \u03b2-cells","volume":"536","author":"Kang","year":"2001","journal-title":"Journal of Physiology"},{"issue":"11","key":"10.1016\/j.lfs.2004.08.021_bib12","doi-asserted-by":"crossref","first-page":"5126","DOI":"10.1210\/endo.137.11.8895387","article-title":"Developmental expression of proprotein-processing endoprotease furin in rat pancreatic islets","volume":"137","author":"Kayo","year":"1996","journal-title":"Endocrinology"},{"issue":"Suppl 3","key":"10.1016\/j.lfs.2004.08.021_bib13","doi-asserted-by":"crossref","first-page":"S434","DOI":"10.2337\/diabetes.51.2007.S434","article-title":"The Multiple Actions of GLP-1 on the Process of Glucose-Stimulated Insulin Secretion","volume":"51","author":"MacDonald","year":"2002","journal-title":"Diabetes"},{"issue":"10","key":"10.1016\/j.lfs.2004.08.021_bib14","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1046\/j.1464-5491.2000.00367.x","article-title":"Glucagon-like peptide (GLP)-1 and leptin concentrations in obese patients with Type 2 diabetes mellitus","volume":"17","author":"Mannucci","year":"2000","journal-title":"Diabet. Med."},{"issue":"3","key":"10.1016\/j.lfs.2004.08.021_bib15","doi-asserted-by":"crossref","first-page":"669","DOI":"10.2337\/diabetes.51.3.669","article-title":"Assessment of the role of interstitial glucagon in the acute glucose secretory responsiveness of in situ pancreatic beta-cells","volume":"51","author":"Moens","year":"2002","journal-title":"Diabetes"},{"key":"10.1016\/j.lfs.2004.08.021_bib16","doi-asserted-by":"crossref","first-page":"11880","DOI":"10.1016\/S0021-9258(18)67324-7","article-title":"Preproglucagon gene expression in pancreas and intestine diversifies at the level of post-translational processing","volume":"261","author":"Mojsov","year":"1986","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.lfs.2004.08.021_bib17","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbrc.2003.08.111","article-title":"Dipeptidyl peptidase-IV expression and activity in human glomerular endothelial cells","volume":"310","author":"Pala","year":"2003","journal-title":"Biochem. Biophys. Res. Commun."},{"year":"2001","series-title":"Molecular Cloning: A Laboratory Manual","author":"Sambrook","key":"10.1016\/j.lfs.2004.08.021_bib18"},{"issue":"2","key":"10.1016\/j.lfs.2004.08.021_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0303-7207(01)00482-8","article-title":"PTHrP increases pancreatic beta-cell-specific functions in well-differentiated cells","volume":"182","author":"Sawada","year":"2001","journal-title":"Mol. Cell Endocrinol."},{"issue":"7","key":"10.1016\/j.lfs.2004.08.021_bib20","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.2337\/diabetes.49.7.1156","article-title":"Glucagon-like peptide 1 stimulates insulin gene promoter activity by protein kinase A-independent activation of the rat insulin I gene cAMP response element","volume":"49","author":"Skoglund","year":"2000","journal-title":"Diabetes"},{"issue":"9","key":"10.1016\/j.lfs.2004.08.021_bib21","first-page":"4382","article-title":"A meta-analysis of the effect of glucagon-like peptide-1 (7\u201336) amide on ad libitum energy intake in humans","volume":"86","author":"Verdich","year":"2001","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"5","key":"10.1016\/j.lfs.2004.08.021_bib22","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1016\/S0026-895X(25)10177-6","article-title":"Signal transduction by the cloned glucagon-like peptide-1 receptor: comparison with signaling by the endogenous receptors of beta cell lines","volume":"45","author":"Widmann","year":"1994","journal-title":"Mol. Pharmacol."}],"container-title":["Life Sciences"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320504009506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0024320504009506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T20:05:32Z","timestamp":1758398732000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0024320504009506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2005,1]]},"references-count":22,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2005,1]]}},"alternative-id":["S0024320504009506"],"URL":"https:\/\/doi.org\/10.1016\/j.lfs.2004.08.021","relation":{},"ISSN":["0024-3205"],"issn-type":[{"type":"print","value":"0024-3205"}],"subject":[],"published":{"date-parts":[[2005,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Engineered \u03b2-cells secreting dipeptidyl peptidase IV-resistant glucagon-like peptide-1 show enhanced glucose-responsiveness","name":"articletitle","label":"Article Title"},{"value":"Life Sciences","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.lfs.2004.08.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"Copyright \u00a9 2004 Elsevier Inc. All rights reserved.","name":"copyright","label":"Copyright"}]}}